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Article ; Online: Development and Regulation of Novel Influenza Virus Vaccines

Surender Khurana

Vaccines, Vol 6, Iss 2, p

A United States Young Scientist Perspective

2018 Volume 24

Abstract: Vaccination against influenza is the most effective approach for reducing influenza morbidity and mortality. However, influenza vaccines are unique among all licensed vaccines as they are updated and administered annually to antigenically match the ... ...

Abstract	Vaccination against influenza is the most effective approach for reducing influenza morbidity and mortality. However, influenza vaccines are unique among all licensed vaccines as they are updated and administered annually to antigenically match the vaccine strains and currently circulating influenza strains. Vaccine efficacy of each selected influenza virus vaccine varies depending on the antigenic match between circulating strains and vaccine strains, as well as the age and health status of the vaccine recipient. Low vaccine effectiveness of seasonal influenza vaccines in recent years provides an impetus to improve current seasonal influenza vaccines, and for development of next-generation influenza vaccines that can provide broader, long-lasting protection against both matching and antigenically diverse influenza strains. This review discusses a perspective on some of the issues and formidable challenges facing the development and regulation of the next-generation influenza vaccines.
Keywords	influenza ; vaccine ; correlates ; universal ; next-generation ; animal model ; human challenge ; adjuvants ; vaccine safety ; regulatory pathway ; Medicine ; R
Subject code	570
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Therapeutic potential of convalescent plasma and hyperimmune immunoglobulins against SARS-CoV-2 BQ.1, BQ.1.1, and XBB variants

Lorenza Bellusci / Hana Golding / Surender Khurana

The Journal of Clinical Investigation, Vol 133, Iss

2023 Volume 8

Keywords	COVID-19 ; Therapeutics ; Medicine ; R
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	American Society for Clinical Investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: All India Institute of Medical Sciences, Jodhpur

Surender Deora

Journal of the Practice of Cardiovascular Sciences, Vol 3, Iss 3, Pp 171-

A new hope

2017 Volume 173

Keywords	Medicine ; R ; Surgery ; RD1-811 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Dermatitis artefacta: A diagnostic dilemma.

Singh, Surender / Chikhalkar, Siddhi / Kabbannavar, Yallappa R

Indian journal of psychiatry

2023 Volume 65, Issue 6, Page(s) 703–705

Abstract: Dermatitis artefacta (DA) is a rare psychological disorder in which patients self-inflict cutaneous lesions to satisfy an emotional need. Here, we describe a case of DA initially misdiagnosed as pemphigus. This case represents the importance of the ... ...

Abstract	Dermatitis artefacta (DA) is a rare psychological disorder in which patients self-inflict cutaneous lesions to satisfy an emotional need. Here, we describe a case of DA initially misdiagnosed as pemphigus. This case represents the importance of the timely recognition and treatment of DA to prevent its progression like in our case scarring alopecia.
Language	English
Publishing date	2023-06-19
Publishing country	India
Document type	Case Reports
ZDB-ID	221523-8
ISSN	0019-5545
ISSN	0019-5545
DOI	10.4103/indianjpsychiatry.indianjpsychiatry_54_23
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Article: Alexidine: a Safer and an Effective Root Canal Irrigant than Chlorhexidine.

Surender, L R / Shikha, A / Swathi, A / Manaswini, C / Habeeb, Aisha / Prabha, S Shashi

Journal of clinical and diagnostic research : JCDR

2017 Volume 11, Issue 7, Page(s) ZC18–ZC21

Abstract: Introduction: Chlorhexidine (CHX) is generally used as the final irrigating solution in root canal therapy. Recent studies have reported that, toxic precipitates containing parachloroaniline (PCA) are formed when CHX reacts with sodium hypochlorite ( ... ...

Abstract	Introduction: Chlorhexidine (CHX) is generally used as the final irrigating solution in root canal therapy. Recent studies have reported that, toxic precipitates containing parachloroaniline (PCA) are formed when CHX reacts with sodium hypochlorite (NaOCl). Whereas, Alexidine (ALX), a bisbiguanide disinfectant similar to CHX, has proven to form no precipitates with NaOCl. Aim: To compare antimicrobial activity of different concentrations of ALX with CHX individually and when combined with NaOCl against Materials and methods: Different concentrations of ALX and CHX (0.5%, 1%, and 2%) were tested individually and when mixed with 2.5% NaOCl (1:1 ratio) using disc diffusion method against Results: Regardless of the concentrations, ALX obtained the best results in comparison to CHX. There was no statistically significant difference between ALX + NaOCl and CHX + NaOCl mixtures. Conclusion: The present study showed that, the antimicrobial property of ALX against
Language	English
Publishing date	2017-07-01
Publishing country	India
Document type	Journal Article
ZDB-ID	2775283-5
ISSN	0973-709X ; 2249-782X
ISSN (online)	0973-709X
ISSN	2249-782X
DOI	10.7860/JCDR/2017/27429.10160
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Article ; Online: Scaffold identification and drug repurposing for finding potential Dengue envelope inhibitors through ligand-based pharmacophore model.

Priya, Sasi / Alli, Vidya Jyothi / Jadav, Surender Singh

Journal of biomolecular structure & dynamics

2023 Volume 41, Issue 21, Page(s) 11916–11929

Abstract: ... A- accepter, D- donor, R-ring) to screen public and DrugBank datasets. Further, approximately 36000 molecules ...

Abstract	Most of the existing DENV entry inhibitors were discovered through structure-based, high-throughput screening techniques and optimization approaches by aiming β-OG pocket. However, the class of precise chemical scaffolds with superior antiviral activity targeting the early stages of virus infection that is considered to be beneficial in therapeutics and is still in process. In this study, ligand-based pharmacophore modeling using existing DENV entry inhibitors provided two best models, AADRR-2 and AAADR-2 (A- accepter, D- donor, R-ring) to screen public and DrugBank datasets. Further, approximately 36000 molecules were filtered using Zinc13 by employing the ideal validated models. Additionally, using β-OG binding pocket as target site, molecular docking experiments including induced-fit studies were conducted that provided further structurally divergent ligands. Moreover, the refined list of preferential hits were filtered out based on the best fitness score, binding energy and interaction paradigm, among them fused pyrimidine, hydrazone and biphenyl core comprising scaffolds were identified possessing profound interaction profile with key amino acid residues, ALA-50, GLN-200, PHE-193 and PHE-279 in 100 ns MD simulations. Additionally, the search for similar chemical fingerprints from DrugBank library was also carried out and Eltrombopag (Promacta/Revolade® prescribed in thrombocytopenia) was identified as a preferential β-OG pocket binder. The identified pyrazole-based hydrazone class of drug, Eltrombopag is in phase II clinical trials employed to treat dengue-mediated thrombocytopenia.Communicated by Ramaswamy H. Sarma.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pharmacophore ; Ligands ; Drug Repositioning ; Dengue/drug therapy ; Hydrazones ; Thrombocytopenia ; Quantitative Structure-Activity Relationship
Chemical Substances	eltrombopag (S56D65XJ9G) ; Ligands ; Hydrazones
Language	English
Publishing date	2023-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2171135
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Article ; Online: Insect cell expression and purification of recombinant SARS-COV-2 spike proteins that demonstrate ACE2 binding.

Struble, Lucas R / Smith, Audrey L / Lutz, William E / Grubbs, Gabrielle / Sagar, Satish / Bayles, Kenneth W / Radhakrishnan, Prakash / Khurana, Surender / El-Gamal, Dalia / Borgstahl, Gloria E O

Protein science : a publication of the Protein Society

2022 Volume 31, Issue 5, Page(s) e4300

Abstract: The COVID-19 pandemic caused by SARS-CoV-2 infection has led to socio-economic shutdowns and the loss of over 5 million lives worldwide. There is a need for the identification of therapeutic targets to treat COVID-19. SARS-CoV-2 spike is a target of ... ...

Abstract	The COVID-19 pandemic caused by SARS-CoV-2 infection has led to socio-economic shutdowns and the loss of over 5 million lives worldwide. There is a need for the identification of therapeutic targets to treat COVID-19. SARS-CoV-2 spike is a target of interest for the development of therapeutic targets. We developed a robust SARS-CoV-2 S spike expression and purification protocol from insect cells and studied four recombinant SARS-CoV-2 spike protein constructs based on the original SARS-CoV-2 sequence using a baculovirus expression system: a spike protein receptor-binding domain that includes the SD1 domain (RBD) coupled to a fluorescent tag (S-RBD-eGFP), spike ectodomain coupled to a fluorescent tag (S-Ecto-eGFP), spike ectodomain with six proline mutations and a foldon domain (S-Ecto-HexaPro(+F)), and spike ectodomain with six proline mutations without the foldon domain (S-Ecto-HexaPro(-F)). We tested the yield of purified protein expressed from the insect cell lines Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tni) and compared it to previous research using mammalian cell lines to determine changes in protein yield. We demonstrated quick and inexpensive production of functional glycosylated spike protein of high purity capable of recognizing and binding to the angiotensin converting enzyme 2 (ACE2) receptor. To further confirm functionality, we demonstrate binding of eGFP fused construct of the spike ectodomain (S-Ecto-eGFP) to surface ACE2 receptors on lung epithelial cells by flow cytometry analysis and show that it can be decreased by means of receptor manipulation (blockade or downregulation).
MeSH term(s)	Angiotensin-Converting Enzyme 2/genetics ; Animals ; COVID-19 ; Humans ; Insecta/metabolism ; Mammals ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Proline ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
Chemical Substances	Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Proline (9DLQ4CIU6V) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1106283-6
ISSN	1469-896X ; 0961-8368
ISSN (online)	1469-896X
ISSN	0961-8368
DOI	10.1002/pro.4300
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Article ; Online: Immune Response to SARS-CoV-2 Vaccine and Following Breakthrough Omicron Infection in an Autoimmune Patient with Hashimoto’s Thyroiditis, Pernicious Anemia, and Chronic Atrophic Autoimmune Gastritis

Emily Cluff / Lorenza Bellusci / Hana Golding / Surender Khurana

Vaccines, Vol 10, Iss 450, p

A Case Report

2022 Volume 450

Abstract: In healthy adults, hybrid immunity induced by prior SARS-CoV-2 infection followed by two doses of mRNA vaccination provide protection against symptomatic SARS-CoV-2 infection. However, the role of hybrid immunity in autoimmune patients against Omicron is ...

Abstract	In healthy adults, hybrid immunity induced by prior SARS-CoV-2 infection followed by two doses of mRNA vaccination provide protection against symptomatic SARS-CoV-2 infection. However, the role of hybrid immunity in autoimmune patients against Omicron is not well documented. Here, we report a young autoimmune patient with prior infection and two doses of mRNA-1273 vaccination who was exposed to Omicron and developed a symptomatic disease. Prior to Omicron infection, the patient had strong neutralizing antibody titers against the vaccine strain, but no neutralization of Omicron. Post Omicron infection, high neutralizing titers against Omicron were observed. Furthermore, enhanced neutralizing antibody titers against other variants of concern—Alpha, Beta, Gamma, and Delta—were observed, suggesting an expansion of cross-reactive memory B-cell response by the SARS-CoV-2 Omicron infection. Autoimmune patients may require careful monitoring of immune function over time to optimize booster vaccine administration.
Keywords	COVID-19 ; Omicron ; SARS-CoV-2 ; neutralization ; autoimmune ; Hashimoto’s ; Medicine ; R
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Perceptions and Experience of Medical Students Regarding E-learning during COVID-19 Lockdown

Manisha Bhardwaj / Surender Kashyap / Deepak Aggarwal / Rajesh Bhawani

Journal of Clinical and Diagnostic Research, Vol 16, Iss 3, Pp IC01-IC

A Cross-sectional Study

2022 Volume 06

Abstract: Introduction: Medical education has been adversely affected during Coronavirus Disease-19 (COVID-19) pandemic. Imparting medical education through e-platforms exclusively was a novel experience both for students and teachers. Even though online classes ... ...

Abstract	Introduction: Medical education has been adversely affected during Coronavirus Disease-19 (COVID-19) pandemic. Imparting medical education through e-platforms exclusively was a novel experience both for students and teachers. Even though online classes have been ongoing since almost one and half year, not much data on perception and experience about e-learning among medical students is available from India. Aim: To evaluate perceptions, experiences and challenges faced by medical students regarding e-learning during lockdown period owing to COVID-19 along with their future preferences. Materials and Methods: The present study was a questionnaire based cross-sectional survey regarding use of e-learning during COVID-19 pandemic among 340 Bachelor of Medicine and Bachelor of Surgery (MBBS) and Bachelor of Science Nursing (BSc-NUR) students. It was conducted in the Department of Pulmonary Medicine at Shri Lal Bahadur Shastri Medical College and Hospital Mandi, Himachal Pradesh, India from May 2021 to July 2021. Students perceptions’ of e-learning were assessed using the validated Technology Acceptance Model (TAM) model and responses were measured on 5-point Likert scale. Quantitative data was expressed by mean and standard deviation and significant level of differences between means were tested by Student’s t-test (unpaired). Proportions were compared by Chi-square test or Fisher’s-exact test. A p-value of <0.05 was considered statistically significant. Results: Out of 400 students, 340 responded of which 225 were females. Of the total 340 students, (n=333; 97.9%) respondents, had an idea of e-learning and more than half (n=188; 55.3%) had used any type of e-learning platform prior to onset of COVID-19. More number of MBBS students had used e-learning than BSc-NUR students (55% v/s 41%; p=0.033). Cell phone was the most common device (n=324; 95.3%) used. The quick sharing of material (n=258; 76%) and flexibility (n=233; 68.5%) were top rated benefits of e-learning. The key disadvantages were suboptimal practical ...
Keywords	alternative learning ; e-platforms ; hybrid learning ; online classes ; pandemic ; Medicine ; R
Subject code	370
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Type 1 diabetes mellitus-common cases

Surender Kumar

Indian Journal of Endocrinology and Metabolism, Vol 19, Iss 7, Pp 76-

2015 Volume 77

Abstract: Tight glycemic control in type 1 diabetes mellitus patients is associated with the risk of hypoglycemia. Diabetic patients are forced to change their lifestyle to adjust to the disease condition and survive it. The best way to manage diabetes would be to ...

Abstract	Tight glycemic control in type 1 diabetes mellitus patients is associated with the risk of hypoglycemia. Diabetic patients are forced to change their lifestyle to adjust to the disease condition and survive it. The best way to manage diabetes would be to develop a therapy, which could adjust to the patient′s conditions. Here, I present few cases wherein switching to a long-acting basal insulin analog helped combat recurrent hypoglycemic episodes experienced by the patients.
Keywords	Basal insulin analog ; hypoglycemia ; type 1 diabetes mellitus ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Endocrine Society of India
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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