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Article ; Online: Digital dashboards visualizing public health data: a systematic review.

Schulze, Annett / Brand, Fabian / Geppert, Johanna / Böl, Gaby-Fleur

2023 Volume 11, Page(s) 999958

Abstract: Introduction: Public health is not only threatened by diseases, pandemics, or epidemics. It is also challenged by deficits in the communication of health information. The current COVID-19 pandemic demonstrates that impressively. One way to deliver ... ...

Abstract	Introduction: Public health is not only threatened by diseases, pandemics, or epidemics. It is also challenged by deficits in the communication of health information. The current COVID-19 pandemic demonstrates that impressively. One way to deliver scientific data such as epidemiological findings and forecasts on disease spread are dashboards. Considering the current relevance of dashboards for public risk and crisis communication, this systematic review examines the state of research on dashboards in the context of public health risks and diseases. Method: Nine electronic databases where searched for peer-reviewed journal articles and conference proceedings. Included articles ( Results: 65 articles were assessed in regards to the public health issues addressed by the respective dashboards, as well as the data sources, functions and information visualizations employed by the different dashboards. Furthermore, the literature review sheds light on public health challenges and objectives and analyzes the extent to which user needs play a role in the development and evaluation of a dashboard. Overall, the literature review shows that studies that do not only describe the construction of a specific dashboard, but also evaluate its content in terms of different risk communication models or constructs (e.g., risk perception or health literacy) are comparatively rare. Furthermore, while some of the studies evaluate usability and corresponding metrics from the perspective of potential users, many of the studies are limited to a purely functionalistic evaluation of the dashboard by the respective development teams. Conclusion: The results suggest that applied research on public health intervention tools like dashboards would gain in complexity through a theory-based integration of user-specific risk information needs. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=200178, identifier: CRD42020200178.
MeSH term(s)	Humans ; Public Health ; COVID-19/epidemiology ; Pandemics ; Databases, Factual
Language	English
Publishing date	2023-05-04
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.999958
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Article ; Online: Case Report: A severe case of immunosuppressant-refractory immune checkpoint inhibitor-mediated colitis rescued by tofacitinib.

Sweep, Mark W D / Tjan, Martijn J H / Gorris, Mark A J / Bol, Kalijn F / Westdorp, Harm

Frontiers in immunology

2023 Volume 14, Page(s) 1212432

Abstract: Immune checkpoint inhibitor therapy for cancer treatment can give rise to a variety of adverse events. Here we report a male patient with metastatic melanoma who experienced life-threatening colitis and duodenitis following treatment with ipilimumab and ... ...

Abstract	Immune checkpoint inhibitor therapy for cancer treatment can give rise to a variety of adverse events. Here we report a male patient with metastatic melanoma who experienced life-threatening colitis and duodenitis following treatment with ipilimumab and nivolumab. The patient did not respond to the first three lines of immunosuppressive therapy (corticosteroids, infliximab, and vedolizumab), but recovered well after administration of tofacitinib, a JAK inhibitor. Cellular and transcriptional data on colon and duodenum biopsies shows significant inflammation in the tissue, characterized by a large number of CD8 T cells and high expression of PD-L1. While cellular numbers do decrease during three lines of immunosuppressive therapy, CD8 T cells remain relatively high in the epithelium, along with PD-L1 expression in the involved tissue and expression of colitis-associated genes, indicating an ongoing colitis at that moment. Despite all immunosuppressive treatments, the patient has an ongoing tumor response with no evidence of disease. Tofacitinib might be a good candidate to consider more often for ipilimumab/nivolumab-induced colitis.
MeSH term(s)	Male ; Humans ; Immunosuppressive Agents ; Immune Checkpoint Inhibitors ; Ipilimumab/adverse effects ; B7-H1 Antigen ; Nivolumab ; Colitis/chemically induced ; Colitis/drug therapy
Chemical Substances	Immunosuppressive Agents ; Immune Checkpoint Inhibitors ; tofacitinib (87LA6FU830) ; Ipilimumab ; B7-H1 Antigen ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2023-06-26
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1212432
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Article ; Online: Personal Protective Measures during the COVID-19 Pandemic in Germany.

Kirsch, Fabian / Lindemann, Ann-Kathrin / Geppert, Johanna / Borzekowski, Dan / Lohmann, Mark / Böl, Gaby-Fleur

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2022 Volume 121, Page(s) 177–183

Abstract: Objectives: The coronavirus SARS-CoV-2 is highly contagious and can only be contained if the majority of the population takes measures to protect themselves against infection. The present study aimed to investigate personal protective measures, their ... ...

Abstract	Objectives: The coronavirus SARS-CoV-2 is highly contagious and can only be contained if the majority of the population takes measures to protect themselves against infection. The present study aimed to investigate personal protective measures, their development over the course of the pandemic in Germany, and potential differences in behavior in terms of sex, age, and education. Methods: Data from 20 waves of the serial cross-sectional study "BfR-Corona-Monitor" were analyzed. The total sample consisted of N = 20,317 respondents (about 1000 per wave). Data were collected through telephone surveys between June 2020 and March 2021. Results: To protect themselves from infection, participants primarily relied on wearing covers for mouth and nose, keeping their distance from other individuals, and washing their hands thoroughly. Analyses over time showed a strong positive correlation between the number of measures taken and the national incidence rate. Sociodemographic differences also emerged, with women and those who are higher educated as well as younger respondents taking a higher number of protective measures. Conclusions: Our results indicated that in times of greater infection risks, individuals adapted accordingly and took more protective measures. However, on the basis of sociodemographic differences, campaigns should especially focus on older individuals, the male sex, and those with lower education to enhance their protective behavior.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Cross-Sectional Studies ; Female ; Germany/epidemiology ; Humans ; Male ; Pandemics/prevention & control ; SARS-CoV-2
Language	English
Publishing date	2022-05-18
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2022.05.036
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Article ; Online: Case Report: Imaging immune checkpoint inhibitor-induced yin-yang effects in the brain.

Bol, K F / Peeters, E / van Herpen, C M L / Westdorp, H / Aarntzen, E H J G

Frontiers in immunology

2023 Volume 14, Page(s) 1199282

Abstract: Background: Treatment with immune checkpoint inhibitors (ICI) can induce durable responses in cancer patients, but it is commonly associated with serious immune-related side effects. Both effects are suggested to be mediated by CD8+ T-cell infiltration. ...

Abstract	Background: Treatment with immune checkpoint inhibitors (ICI) can induce durable responses in cancer patients, but it is commonly associated with serious immune-related side effects. Both effects are suggested to be mediated by CD8+ T-cell infiltration. Whole body CD8+ T-cell distribution can be visualized by PET imaging of a 89Zr-labeled anti-humanCD8a minibody, currently investigated in a phase 2b trial. Main body: An adult patient diagnosed with metastatic melanoma developed ICI-related hypophysitis after two courses of combined immunotherapy (ipilimumab (3 mg/kg) and nivolumab (1 mg/kg) at 3 weeks interval). On a [ Conclusions: The observations in this case report underscore the role of CD8+ T-cell in non-tumor tissues in ICI-related toxicity. In addition, it illustrates a potential role for molecular imaging by PET/CT for investigation and monitoring of ICI-induced effects.
MeSH term(s)	Adult ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Radioisotopes ; Positron Emission Tomography Computed Tomography/methods ; Zirconium ; Yin-Yang ; Melanoma ; Brain/diagnostic imaging
Chemical Substances	Immune Checkpoint Inhibitors ; Zirconium-89 (NTM296JU95) ; Radioisotopes ; Zirconium (C6V6S92N3C)
Language	English
Publishing date	2023-06-02
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1199282
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Article ; Online: Lung Mean Dose Prediction in Transarterial Radioembolization (TARE): Superiority of [

Wagemans, Martijn E H M / Braat, Arthur J A T / van Rooij, Rob / Smits, Maarten L J / Bruijnen, Rutger C G / Prince, Jip F / Bol, Guus M / de Jong, Hugo W A M / Lam, Marnix G E H

Cardiovascular and interventional radiology

2024 Volume 47, Issue 4, Page(s) 443–450

Abstract: Purpose: Radiation pneumonitis is a serious complication of radioembolization. In holmium-166 ([: Materials and methods: Patients were included if they received both scout doses ([: Results: Thirty-seven patients with unresectable liver metastases ...

Abstract	Purpose: Radiation pneumonitis is a serious complication of radioembolization. In holmium-166 ([ Materials and methods: Patients were included if they received both scout doses ([ Results: Thirty-seven patients with unresectable liver metastases were included. During follow-up, none developed symptoms of radiation pneumonitis. Median eLMD Conclusion: [ Trail registration: NCT01031784, registered December 2009. NCT01612325, registered June 2012.
MeSH term(s)	Humans ; Prospective Studies ; Technetium Tc 99m Aggregated Albumin ; Tomography, Emission-Computed, Single-Photon ; Radiation Pneumonitis/etiology ; Radiation Pneumonitis/drug therapy ; Yttrium Radioisotopes/therapeutic use ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Embolization, Therapeutic/adverse effects ; Lung/diagnostic imaging ; Microspheres ; Retrospective Studies
Chemical Substances	Technetium Tc 99m Aggregated Albumin ; Yttrium Radioisotopes
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-023-03656-y
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Zs.A 1378: Show issues

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Article ; Online: Measuring psychological flexibility and cognitive defusion in individuals with acquired brain injury.

Rauwenhoff, Johanne / Peeters, Frenk / Bol, Yvonne / Van Heugten, Caroline

Brain injury

2021 Volume 35, Issue 10, Page(s) 1301–1307

Abstract: Purpose: Acceptance and Commitment Therapy (ACT) is used increasingly for individuals with psychological distress following acquired brain injury (ABI) in different countries. However, questionnaires measuring ACT-processes are often not validated for ... ...

Abstract	Purpose: Acceptance and Commitment Therapy (ACT) is used increasingly for individuals with psychological distress following acquired brain injury (ABI) in different countries. However, questionnaires measuring ACT-processes are often not validated for this patient group and need cross-cultural validation. This study investigated the psychometric properties of the Acceptance and Action Questionnaire for Acquired Brain Injury (AAQ-ABI; measuring psychological flexibility related to thoughts and feelings about ABI) and the Cognitive Fusion Questionnaire (CFQ-7; measuring cognitive defusion). Materials and methods: Score distribution, reliability, and convergent validity of the AAQ-ABI and the CFQ-7 were examined in Dutch individuals with ABI. Results: Seventy-three patients with ABI were included. The AAQ-ABI showed good reliability (Cronbach's α = 0.87) and the CFQ-7 excellent reliability (Cronbach's α = 0.97). Both did not show a floor or ceiling effect, nor a skewed distribution. There were strong to moderate correlations between the questionnaires and measures of psychological flexibility, mood, quality of life, and value-driven behavior (AAQ-ABI: r = -0.70-0.81; CFQ-7 = -0.67-0.84). Inter-item total correlations indicate that the questions within each questionnaire measured the same construct (AAQ-ABI: r = 0.40-0.78; CFQ-7: r = 0.84-0.93). Conclusions: The current study shows that the Dutch AAQ-ABI and CFQ-7 have acceptable to good psychometric properties when measuring psychological flexibility and cognitive defusion in patients with ABI.
MeSH term(s)	Acceptance and Commitment Therapy ; Brain Injuries/complications ; Cognition ; Humans ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2021-09-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639115-1
ISSN	1362-301X ; 0269-9052
ISSN (online)	1362-301X
ISSN	0269-9052
DOI	10.1080/02699052.2021.1972155
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Article ; Online: Toolbox of Advanced Atomic Layer Deposition Processes for Tailoring Large-Area MoS

Mattinen, Miika / Schulpen, Jeff J P M / Dawley, Rebecca A / Gity, Farzan / Verheijen, Marcel A / Kessels, Wilhelmus M M / Bol, Ageeth A

ACS applied materials & interfaces

2023 Volume 15, Issue 29, Page(s) 35565–35579

Abstract: Two-dimensional ... ...

Abstract	Two-dimensional MoS
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c02466
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Article ; Online: Comparison of NTRK fusion detection methods in microsatellite-instability-high metastatic colorectal cancer.

Schraa, Suzanna J / Stelloo, Ellen / Laclé, Miangela M / Swennenhuis, Joost F / Brosens, Lodewijk A A / Fijneman, Remond J A / Feitsma, Harma / Koopman, Miriam / de Leng, Wendy W / Vink, Geraldine R / Bol, Guus M

Virchows Archiv : an international journal of pathology

2023 Volume 482, Issue 6, Page(s) 983–992

Abstract: Tropomyosin receptor kinase (TRK) inhibitors have been approved for metastatic solid tumors harboring NTRK fusions, but the detection of NTRK fusions is challenging. International guidelines recommend pan-TRK immunohistochemistry (IHC) screening followed ...

Abstract	Tropomyosin receptor kinase (TRK) inhibitors have been approved for metastatic solid tumors harboring NTRK fusions, but the detection of NTRK fusions is challenging. International guidelines recommend pan-TRK immunohistochemistry (IHC) screening followed by next generation sequencing (NGS) in tumor types with low prevalence of NTRK fusions, including metastatic colorectal cancer (mCRC). RNA-based NGS is preferred, but is expensive, time-consuming, and extracting good-quality RNA from FFPE tissue is challenging. Alternatives in daily clinical practice are warranted. We assessed the diagnostic performance of RNA-NGS, FFPE-targeted locus capture (FFPE-TLC), fluorescence in situ hybridization (FISH), and the 5'/3' imbalance quantitative RT-PCR (qRT-PCR) after IHC screening in 268 patients with microsatellite-instability-high mCRC, the subgroup in which NTRK fusions are most prevalent (1-5%). A consensus result was determined after review of all assay results. In 16 IHC positive tumors, 10 NTRK fusions were detected. In 33 IHC negative samples, no additional transcribed NTRK fusions were found, underscoring the high sensitivity of IHC. Sensitivity of RNA-NGS, FFPE-TLC, FISH, and qRT-PCR was 90%, 90%, 78%, and 100%, respectively. Specificity was 100% for all assays. Robustness, defined as the percentage of samples that provided an interpretable result in the first run, was 100% for FFPE-TLC, yet more limited for RNA-NGS (85%), FISH (70%), and qRT-PCR (70%). Overall, we do not recommend FISH for the detection of NTRK fusions in mCRC due to its low sensitivity and limited robustness. We conclude that RNA-NGS, FFPE-TLC, and qRT-PCR are appropriate assays for NTRK fusion detection, after enrichment with pan-TRK IHC, in routine clinical practice.
MeSH term(s)	Humans ; Receptor, trkA/genetics ; In Situ Hybridization, Fluorescence ; Neoplasms/genetics ; Colonic Neoplasms/genetics ; Microsatellite Repeats ; Oncogene Proteins, Fusion/genetics ; Gene Fusion
Chemical Substances	Receptor, trkA (EC 2.7.10.1) ; Oncogene Proteins, Fusion
Language	English
Publishing date	2023-04-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-023-03538-1
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Article ; Online: Fog controls biological cycling of soil phosphorus in the Coastal Cordillera of the Atacama Desert.

Sun, Xiaolei / Amelung, Wulf / Klumpp, Erwin / Walk, Janek / Mörchen, Ramona / Böhm, Christoph / Moradi, Ghazal / May, Simon Matthias / Tamburini, Federica / Wang, Ye / Bol, Roland

Global change biology

2024 Volume 30, Issue 1, Page(s) e17068

Abstract: Soils in hyper-arid climates, such as the Chilean Atacama Desert, show indications of past and present forms of life despite extreme water limitations. We hypothesize that fog plays a key role in sustaining life. In particular, we assume that fog water ... ...

Abstract	Soils in hyper-arid climates, such as the Chilean Atacama Desert, show indications of past and present forms of life despite extreme water limitations. We hypothesize that fog plays a key role in sustaining life. In particular, we assume that fog water is incorporated into soil nutrient cycles, with the inland limit of fog penetration corresponding to the threshold for biological cycling of soil phosphorus (P). We collected topsoil samples (0-10 cm) from each of 54 subsites, including sites in direct adjacency (<10 cm) and in 1 m distance to plants, along an aridity gradient across the Coastal Cordillera. Satellite-based fog detection revealed that Pacific fog penetrates up to 10 km inland, while inland sites at 10-23 km from the coast rely solely on sporadic rainfall for water supply. To assess biological P cycling we performed sequential P fractionation and determined oxygen isotope of HCl-extractable inorganic
MeSH term(s)	Soil ; Phosphorus ; Oxygen Isotopes ; Water ; Chile ; Desert Climate
Chemical Substances	Soil ; Phosphorus (27YLU75U4W) ; Oxygen Isotopes ; Water (059QF0KO0R)
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.17068
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Article ; Online: Remineralization of lytic spinal metastases after radiotherapy.

Pielkenrood, Bart J / Visser, Thomas F / van Tol, Floris R / Foppen, Wouter / Eppinga, Wietse S C / Verhoeff, Joost J C / Bol, Gijs H / Van der Velden, Joanne M / Verlaan, Jorrit-Jan

The spine journal : official journal of the North American Spine Society

2023 Volume 23, Issue 4, Page(s) 571–578

Abstract: Background context: Palliative radiotherapy (RT) can lead to remineralization of osteolytic lesions thereby potentially restoring some of the weight-bearing capacity and preventing vertebral collapse. It is not clear, however, under which circumstances ... ...

Abstract	Background context: Palliative radiotherapy (RT) can lead to remineralization of osteolytic lesions thereby potentially restoring some of the weight-bearing capacity and preventing vertebral collapse. It is not clear, however, under which circumstances remineralization of osteolytic lesions occurs. Purpose: The aim of this study was to investigate the change in bone mineral density in spinal metastases after RT compared to a reference region, and find associated factors. Study design: Retrospective analysis within prospective observational cohort OUTCOME MEASURES: change in bone mineral density measured in Hounsfield Units (HU). Patient sample: patients treated with RT for (painful) bone metastases. Methods: Patients with spinal metastases were included if computed tomography scans both pre- and post-RT were available. Bone density was measured in HU. A region of interest (ROI) was drawn manually in the metastatic lesion. As a reference, a measurement of bone density in adjacent, unaffected, and non-irradiated vertebrae was used. Factors tested for association were origin of the primary tumor, RT dose and fractionation scheme, and concomitant use of bisphosphonates. Results: A total of 31 patients with 49 spinal metastases, originating from various primary tumors, were included. The median age on baseline was 58 years (IQR: 53-63) and median time between baseline and follow-up scan was 8.2 months (IQR: 3.0-18.4). Difference in HU in the lesion before and after treatment was 146.9 HU (95% CI 68.4-225.4; p<.01). Difference in HU in the reference vertebra between baseline and first follow-up was 19.1 HU (95% CI -47.9 to 86.0; p=.58). Difference between reference vertebrae and metastatic lesions on baseline was -194.1 HU (95% CI -276.2 to -112.0; p<.01). After RT, this difference was reduced to -50.3 HU (95% CI -199.6 to 99.0; p=.52). Patients using bisphosphonates showed a greater increase in HU, 194.1 HU versus 60.6 HU, p=.01. Conclusions: Palliative radiation of osteolytic lytic spinal metastases is positively associated with an increased bone mineral density at follow-up. The use of bisphosphonates was linked to an increased bone mineral density when used during or after RT.
MeSH term(s)	Humans ; Child, Preschool ; Spinal Neoplasms/diagnostic imaging ; Spinal Neoplasms/radiotherapy ; Spinal Neoplasms/complications ; Retrospective Studies ; Bone Density ; Lumbar Vertebrae/pathology
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2037072-6
ISSN	1878-1632 ; 1529-9430
ISSN (online)	1878-1632
ISSN	1529-9430
DOI	10.1016/j.spinee.2022.12.018
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