Article ; Online: Exploring the rationale for thermotherapy in COVID-19.
2021 Volume 38, Issue 1, Page(s) 202–212
Abstract: Increased transmissibility of the pandemic severe acute respiratory coronavirus 2 (SARS-CoV-2) has been noted to occur at lower ambient temperatures. This is seemingly related to a better replication of most respiratory viruses, including SARS-CoV-2, at ... ...
| Abstract | Increased transmissibility of the pandemic severe acute respiratory coronavirus 2 (SARS-CoV-2) has been noted to occur at lower ambient temperatures. This is seemingly related to a better replication of most respiratory viruses, including SARS-CoV-2, at lower-than-core body temperatures (i.e., 33 °C vs 37 °C). Also, intrinsic characteristics of SARS-CoV-2 make it a heat-susceptible pathogen. Thermotherapy has successfully been used to combat viral infections in plants which could otherwise result in great economic losses; 90% of viruses causing infections in plants are positive-sense single-stranded ribonucleic acid (+ssRNA) viruses, a characteristic shared by SARS-CoV-2. Thus, it is possible to envision the use of heat-based interventions (thermotherapy or mild-temperature hyperthermia) in patients with COVID-19 for which moderate cycles (every 8-12 h) of mild-temperature hyperthermia (1-2 h) have been proposed. However, there are potential safety and mechanistic concerns which could limit the use of thermotherapy only to patients with mild-to-moderate COVID-19 to prevent disease progression rather than to treat patients who have already progressed to severe-to-critical COVID-19. Here, we review the characteristics of SARS-CoV-2 which make it a heat-susceptible virus, potential host mechanisms which could be enhanced at higher temperatures to aid viral clearance, and how thermotherapy could be investigated as a modality of treatment in patients with COVID-19 while taking into consideration potential risks. |
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| MeSH term(s) | Animals ; Body Temperature ; COVID-19/therapy ; COVID-19/virology ; Genes, Viral ; Humans ; Hyperthermia/immunology ; Hyperthermia, Induced ; Plants/virology ; RNA Interference ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification |
| Language | English |
| Publishing date | 2021-03-07 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 632526-9 |
| ISSN | 1464-5157 ; 0265-6736 |
| ISSN (online) | 1464-5157 |
| ISSN | 0265-6736 |
| DOI | 10.1080/02656736.2021.1883127 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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