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  1. Article ; Online: Reprogramming Stars #10: Modeling Cancer with Cellular Reprogramming-An Interview with Dr. Dung-Fang Lee.

    Lee, Dung-Fang / Pereira, Carlos-Filipe

    Cellular reprogramming

    2023  Volume 25, Issue 1, Page(s) 2–6

    MeSH term(s) Humans ; Cellular Reprogramming ; Neoplasms
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Interview
    ZDB-ID 2542436-1
    ISSN 2152-4998 ; 1557-7457 ; 2152-4971
    ISSN (online) 2152-4998 ; 1557-7457
    ISSN 2152-4971
    DOI 10.1089/cell.2023.29081.dfl
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5452: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Therapeutic Strategies for RB1-Deficient Cancers: Intersecting Gene Regulation and Targeted Therapy.

    Huang, Mo-Fan / Wang, Yuan-Xin / Chou, Yu-Ting / Lee, Dung-Fang

    Cancers

    2024  Volume 16, Issue 8

    Abstract: The retinoblastoma (RB) transcriptional corepressor 1 (RB1) is a critical tumor suppressor gene, governing diverse cellular processes implicated in cancer biology. Dysregulation or deletion in RB1 contributes to the development and progression of various ...

    Abstract The retinoblastoma (RB) transcriptional corepressor 1 (RB1) is a critical tumor suppressor gene, governing diverse cellular processes implicated in cancer biology. Dysregulation or deletion in RB1 contributes to the development and progression of various cancers, making it a prime target for therapeutic intervention. RB1's canonical function in cell cycle control and DNA repair mechanisms underscores its significance in restraining aberrant cell growth and maintaining genomic stability. Understanding the complex interplay between RB1 and cellular pathways is beneficial to fully elucidate its tumor-suppressive role across different cancer types and for therapeutic development. As a result, investigating vulnerabilities arising from RB1 deletion-associated mechanisms offers promising avenues for targeted therapy. Recently, several findings highlighted multiple methods as a promising strategy for combating tumor growth driven by RB1 loss, offering potential clinical benefits in various cancer types. This review summarizes the multifaceted role of RB1 in cancer biology and its implications for targeted therapy.
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16081558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reprogramming and cancer.

    Papapetrou, Eirini P / Lee, Dung-Fang

    Stem cell research

    2021  Volume 52, Page(s) 102249

    MeSH term(s) Cellular Reprogramming ; Humans ; Neoplasms
    Language English
    Publishing date 2021-02-13
    Publishing country England
    Document type Editorial
    ISSN 1876-7753
    ISSN (online) 1876-7753
    DOI 10.1016/j.scr.2021.102249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bcl11b and Atoh8 Coordinate Cellular Plasticity for Reprogramming and Transformation.

    Huang, Mo-Fan / Shoemaker, Rachel / Lee, Dung-Fang

    Cellular reprogramming

    2022  Volume 24, Issue 6, Page(s) 324–326

    Abstract: By dissecting and comparing the transcriptional trajectories and epigenomic traits of reprogramming and transforming cells at the single-cell resolution, Huyghe et al discovered Bcl11b and Atoh8, two key transcription factors controlling cell plasticity ... ...

    Abstract By dissecting and comparing the transcriptional trajectories and epigenomic traits of reprogramming and transforming cells at the single-cell resolution, Huyghe et al discovered Bcl11b and Atoh8, two key transcription factors controlling cell plasticity during pluripotent reprogramming and oncogenic transformation.
    MeSH term(s) Humans ; Cell Plasticity ; Transcription Factors ; Cell Transformation, Neoplastic/genetics ; Tumor Suppressor Proteins ; Cellular Reprogramming ; Repressor Proteins
    Chemical Substances Transcription Factors ; Tumor Suppressor Proteins ; BCL11B protein, human ; Repressor Proteins
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type News ; Research Support, N.I.H., Extramural
    ZDB-ID 2542436-1
    ISSN 2152-4998 ; 1557-7457 ; 2152-4971
    ISSN (online) 2152-4998 ; 1557-7457
    ISSN 2152-4971
    DOI 10.1089/cell.2022.0128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5452: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Reprogramming and cancer

    Eirini P. Papapetrou / Dung-Fang Lee

    Stem Cell Research, Vol 52, Iss , Pp 102249- (2021)

    2021  

    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Corrigendum to "Generation of a homozygous knock-in human embryonic stem cell line expressing SNAP-tagged SOD1" [Stem Cell Res. 54 (2021) 102415].

    Huang, Pei-San / Wen, Meng-Hsuan / Xie, Xihong / Xu, An / Lee, Dung-Fang / Chen, Tai-Yen

    Stem cell research

    2021  Volume 55, Page(s) 102483

    Language English
    Publishing date 2021-07-27
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2393143-7
    ISSN 1876-7753 ; 1873-5061
    ISSN (online) 1876-7753
    ISSN 1873-5061
    DOI 10.1016/j.scr.2021.102483
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  7. Article ; Online: Wearable Biosensor with Molecularly Imprinted Conductive Polymer Structure to Detect Lentivirus in Aerosol.

    Batra, Jaskirat Singh / Chi, Ting-Yen / Huang, Mo-Fan / Zhu, Dandan / Chen, Zheyuan / Lee, Dung-Fang / Kameoka, Jun

    Biosensors

    2023  Volume 13, Issue 9

    Abstract: The coronavirus disease (COVID-19) pandemic has increased pressure to develop low-cost, compact, user-friendly, and ubiquitous virus sensors for monitoring infection outbreaks in communities and preventing economic damage resulting from city lockdowns. ... ...

    Abstract The coronavirus disease (COVID-19) pandemic has increased pressure to develop low-cost, compact, user-friendly, and ubiquitous virus sensors for monitoring infection outbreaks in communities and preventing economic damage resulting from city lockdowns. As proof of concept, we developed a wearable paper-based virus sensor based on a molecular imprinting technique, using a conductive polyaniline (PANI) polymer to detect the lentivirus as a test sample. This sensor detected the lentivirus with a 4181 TU/mL detection limit in liquid and 0.33% to 2.90% detection efficiency in aerosols at distances ranging from 30 cm to 60 cm. For fabrication, a mixture of a PANI monomer solution and virus were polymerized together to form a conductive PANI sensing element on a polyethylene terephthalate (PET) paper substrate. The sensing element exhibited formation of virus recognition sites after the removal of the virus via ultrasound sonication. A dry measurement technique was established that showed aerosol virus detection by the molecularly imprinted sensors within 1.5 h of virus spraying. This was based on the mechanism via which dispensing virus droplets on the PANI sensing element induced hybridization of the virus and molecularly imprinted virus recognition templates in PANI, influencing the conductivity of the PANI film upon drying. Interestingly, the paper-based virus sensor was easily integrated with a wearable face mask for the detection of viruses in aerosols. Since the paper sensor with molecular imprinting of virus recognition sites showed excellent stability in dry conditions for long periods of time, unlike biological reagents, this wearable biosensor will offer an alternative approach to monitoring virus infections in communities.
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13090861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ihor R. Lemischka (1953-2017).

    Ivanova, Natalia / Pereira, Carlos-Filipe / Lee, Dung-Fang

    Cell stem cell

    2018  Volume 22, Issue 1, Page(s) 16–17

    Language English
    Publishing date 2018-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2017.12.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 75: Show issues

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  9. Article ; Online: Modeling of osteosarcoma with induced pluripotent stem cells

    Lon Kai Pang / Mezthly Pena / Ruiying Zhao / Dung-Fang Lee

    Stem Cell Research, Vol 49, Iss , Pp 102006- (2020)

    2020  

    Abstract: Osteosarcoma is the most common type of bone cancer. Osteosarcoma is commonly associated with TP53 inactivation (around 95% of cases) and RB1 inactivation (around 28% of cases). With the discovery of reprogramming factors to induce pluripotency even in ... ...

    Abstract Osteosarcoma is the most common type of bone cancer. Osteosarcoma is commonly associated with TP53 inactivation (around 95% of cases) and RB1 inactivation (around 28% of cases). With the discovery of reprogramming factors to induce pluripotency even in terminally differentiated cells, induced pluripotent stem cells (iPSCs) have emerged as a promising disease model. iPSC-based disease modeling uniquely recapitulates disease phenotypes and can support discoveries into disease etiology and is used extensively today to study a variety of diseases, including cancers. This paper focuses on iPSC-based modeling of Li-Fraumeni syndrome (LFS), an autosomal dominant disorder commonly associated with TP53 mutation and high osteosarcoma incidence. As iPSCs are increasingly utilized as a platform for cancer modeling, the experimental approaches that we discuss here may serve as a guide for future studies.
    Keywords Dinduced pluripotent stem cells ; Osteosarcoma ; Cancer etiology ; p53 mutation ; Li-Fraumeni syndrome ; H19 ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    Mo-Fan Huang / Lon Kai Pang / Yi-Hung Chen / Ruiying Zhao / Dung-Fang Lee

    Cells, Vol 10, Iss 2823, p

    2021  Volume 2823

    Abstract: The therapeutic landscape for the treatment of cancer has evolved significantly in recent decades, aided by the development of effective oncology drugs. However, many cancer drugs are often poorly tolerated by the body and in particular the ... ...

    Abstract The therapeutic landscape for the treatment of cancer has evolved significantly in recent decades, aided by the development of effective oncology drugs. However, many cancer drugs are often poorly tolerated by the body and in particular the cardiovascular system, causing adverse and sometimes fatal side effects that negate the chemotherapeutic benefits. The prevalence and severity of chemotherapy-induced cardiotoxicity warrants a deeper investigation of the mechanisms and implicating factors in this phenomenon, and a consolidation of scientific efforts to develop mitigating strategies. Aiding these efforts is the emergence of induced pluripotent stem cells (iPSCs) in recent years, which has allowed for the generation of iPSC-derived cardiomyocytes (iPSC-CMs): a human-based, patient-derived, and genetically variable platform that can be applied to the study of chemotherapy-induced cardiotoxicity and beyond. After surveying chemotherapy-induced cardiotoxicity and the associated chemotherapeutic agents, we discuss the use of iPSC-CMs in cardiotoxicity modeling, drug screening, and other potential applications. Improvements to the iPSC-CM platform, such as the development of more adult-like cardiomyocytes and ongoing advances in biotechnology, will only enhance the utility of iPSC-CMs in both basic science and clinical applications.
    Keywords stem cell ; disease model ; induced pluripotency ; reprogramming ; differentiation ; chemotherapy ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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