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Article ; Online: Re Letter to the editor re: Compalati E, Canonica GW. Efficacy and safety of rupatadine for allergic rhinoconjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. Curr Med Res Opin 2013 Jul 5.

Compalati, Enrico / Canonica, Giorgio Walter

2014 Volume 30, Issue 2, Page(s) 207–209

MeSH term(s)	Conjunctivitis, Allergic/drug therapy ; Cyproheptadine/analogs & derivatives ; Histamine Antagonists/therapeutic use ; Humans ; Rhinitis, Allergic, Perennial/drug therapy ; Rhinitis, Allergic, Seasonal/drug therapy
Chemical Substances	Histamine Antagonists ; Cyproheptadine (2YHB6175DO)
Language	English
Publishing date	2014-02
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1185/03007995.2013.855191
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Article ; Online: The Importance of the Diaphragm in Neuromotor Function in the Patient with Chronic Obstructive Pulmonary Disease.

Bordoni, Bruno / Escher, Allan / Compalati, Elena / Mapelli, Luca / Toccafondi, Anastasia

International journal of chronic obstructive pulmonary disease

2023 Volume 18, Page(s) 837–848

Abstract: Chronic obstructive pulmonary disease (COPD) is a constant and chronic narrowing of the respiratory airways, with numerous associated symptoms, not always related to the pathological adaptation of the lungs. Statistical projections show that COPD could ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) is a constant and chronic narrowing of the respiratory airways, with numerous associated symptoms, not always related to the pathological adaptation of the lungs. Statistical projections show that COPD could become the third leading cause of death globally by 2030, with a significant increase in deaths by 2060. Skeletal muscle dysfunction, including the diaphragm, is one of the causes linked to the increase in mortality and hospitalization. Little emphasis is given by the scientific literature to the importance of the diaphragm towards functional neuromotor pathological expressions. The article reviews the adaptation of the skeletal muscles, with greater attention to the adaptations of the diaphragm, thereby highlighting the non-physiological variations that the main respiratory muscle undergoes and the neuromotor impairment found in COPD. The text could be an important reflection from a clinical and rehabilitation point of view, to direct greater attention to the function and adaptation of the diaphragm muscle.
MeSH term(s)	Humans ; Diaphragm ; Pulmonary Disease, Chronic Obstructive/complications ; Respiratory Muscles ; Lung ; Muscle, Skeletal
Language	English
Publishing date	2023-05-11
Publishing country	New Zealand
Document type	Review ; Journal Article
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S404190
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Article: Update meta-analysis on the efficacy and safety issues of fexofenadine.

Gómez, René Maximiliano / Moreno, Pablo / Compalati, Enrico / Canonica, Giorgio Walter / Ansotegui Zubeldia, Ignacio Javier

The World Allergy Organization journal

2023 Volume 16, Issue 7, Page(s) 100795

Abstract: Background: Fexofenadine emerged as one of the most representative second generation histamine H1 antagonist drugs since the 1990s, with an outstanding efficacy and appreciable safety for the treatment of allergic patients. While allergic rhino- ... ...

Abstract	Background: Fexofenadine emerged as one of the most representative second generation histamine H1 antagonist drugs since the 1990s, with an outstanding efficacy and appreciable safety for the treatment of allergic patients. While allergic rhino-conjunctivitis represents the most frequent atopic disease globally, an update of fexofenadine efficacy and safety on this entity was proposed as a surrogate of allergic condition. Methods: Double blind, placebo controlled, randomized clinical trials investigating the efficacy and safety of fexofenadine for the treatment of Allergic Rhinitis were searched in 5 major global databases. Eligibility criteria and characteristics, risk of bias, and validity assessment, data extraction and heterogeneity evaluation are described. Primary outcome selected corresponded to 12-reflective and instantaneous total symptom scores (TSS), besides morning instantaneous TSS and the frequency of reported adverse events (AEs); analysis was planned on the intention-to-treat population.Standardized mean differences of scoring systems were analyzed, and Cochran's Q statistic test and the I Results: From the initial 83 identified records, 12 eligible studies were selected. In the evaluated patients, individuals receiving fexofenadine (1910) showed a significant reduction of TSS compared with those who received placebo (1777), change from baseline: standardized mean difference (SMD) -0.33; 95% CI-0.47 to -0.18, p < 0.0001. Morning instantaneous TSS also demonstrated lower symptoms (change from baseline: SMS -1.42; 95% CI -2.22 to -0.62, p = 0.0005). Heterogeneity was found across selected studies.Frequency of AEs was similar compared to placebo (OR = 1.04; 0.88-1.21), with no detection of heterogeneity across these 12 studies. Conclusions: According to this new evidence, fexofenadine maintains its beneficial profile on signs and symptoms of patients with allergic conditions, as well as its attributes as one of the major candidates for an ideal antihistamine medication (including special conditions such as pregnancy and pre-school age), providing support to its over-the-counter condition in several countries.
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2581968-9
ISSN	1939-4551
ISSN	1939-4551
DOI	10.1016/j.waojou.2023.100795
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Article ; Online: Safety of subcutaneous and sublingual immunotherapy with allergoids in children: a real-life pharmacovigilance study.

Frati, Franco / Beni, Noemi De / Marastoni, Laura / Compalati, Enrico / Ciprandi, Giorgio

Immunotherapy

2023 Volume 16, Issue 1, Page(s) 43–53

Abstract: Aims: ...

Abstract	Aims:
MeSH term(s)	Child ; Humans ; Sublingual Immunotherapy/adverse effects ; Allergoids ; Pharmacovigilance ; Desensitization, Immunologic/adverse effects ; Desensitization, Immunologic/methods ; Injections, Subcutaneous ; Allergens/therapeutic use ; Rhinitis, Allergic
Chemical Substances	Allergoids ; Allergens
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2023-0126
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Article: Caregivers of Neuromuscular Patients Living with Tracheostomy during COVID-19 Pandemic: Their Experience.

Pierucci, Paola / Volpato, Eleonora / Grosso, Francesca / De Candia, Maria Luisa / Casparrini, Massimo / Compalati, Elena / Pagnini, Francesco / Banfi, Paolo / Carpagnano, Giovanna Elisiana

Journal of clinical medicine

2023 Volume 12, Issue 2

Abstract: Background: During a pandemic, tracheostomy management in neuromuscular disease (NMD) patients can be complex. Methods: Using a multicentre, multiple case study approach, we sought perspectives through semi-structured interviews via hybrid quali- ... ...

Abstract	Background: During a pandemic, tracheostomy management in neuromuscular disease (NMD) patients can be complex. Methods: Using a multicentre, multiple case study approach, we sought perspectives through semi-structured interviews via hybrid quali-quantitative analysis. The qualitative analysis involved a semi-structured interview and the quantitative analysis the completion of a battery of questionnaires. Aim: To investigate the caregivers’ experiences, burden and beliefs regarding tracheostomy during the Italian COVID-19 pandemic. The following instruments were administered: Connor and Davidson Resilience Scale (CD-RISC-25); Acceptance and Action Questionnaire-II (AAQ-II); State-Trait Anxiety Inventory (STAI); Langer Mindfulness Scale (LMS); Zarit Burden Interview (ZBI). Results: Fifty-three caregivers (62.3% female, mean age 52.2 (SD = 18.2)) participated in the study. The more resilient the carers, the more they were psychologically flexible (r = 0.380, p = 0.014) and able to cope adaptively with the emergency (r = 0.378, p < 0.006). Similarly, perceived control was higher the more resilient they were (r = 0.897, p < 0.001). The main emotions emerging were isolation and loneliness (15; 34.88%). The perception of tracheostomy meant that it could be seen as a lifesaver or as a condemnation. Similarly, the relationship with health professionals moves from satisfaction to a feeling of abandonment over the course of the pandemic. Conclusions: These findings offer a unique opportunity to understand the point of view of caregivers of NMD patients living with tracheotomy during the COVID-19 pandemic, when going to the hospital may have been hampered.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12020555
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Article ; Online: The pathogenesis of OSA-related hypertension: what are the determining factors?

Battaglia, Elvia / Banfi, Paolo / Compalati, Elena / Nicolini, Antonello / Diaz DE Teran, Teresa / Gonzales, Monica / Solidoro, Paolo

Minerva medica

2023 Volume 115, Issue 1, Page(s) 68–82

Abstract: Sleep-disordered breathing has a relatively high prevalence, which varies from 3-7% in males and from 2-5% in females in the adult population. Studies published in the literature have shown that sleep apnea is closely related to an increased risk of ... ...

Abstract	Sleep-disordered breathing has a relatively high prevalence, which varies from 3-7% in males and from 2-5% in females in the adult population. Studies published in the literature have shown that sleep apnea is closely related to an increased risk of developing various pathologies, among which arterial hypertension stands out. The prevalence of hypertension in patients suffering from obstructive sleep apnea (OSA) ranges from 35-80% and appears to be related to OSA severity. Approximately 40-50% of patients affected by hypertension are also affected by OSA and this association seems to be stronger in young and middle-aged adults (<50 years of age). The primary objective of this narrative review is to provide an update on what are the main contributing comorbidities to the development of a hypertensive state in patients suffering from OSA, an independent risk factor for diurnal hypertension, implicated as a risk factor for the first stroke, recurrent stroke, and post-stroke mortality. There are a lot of factors that contribute to developing a hypertensive state in OSA patients, some more decisive, others less. More evidence from longitudinal studies is needed on the impact of OSA on cardiovascular risk in females, on the causal link between OSA and arterial hypertension or metabolic diseases, like diabetes and glucose intolerance, and the effect of different kinds of OSA treatment.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Comorbidity ; Diabetes Mellitus/epidemiology ; Hypertension/complications ; Hypertension/epidemiology ; Risk Factors ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Young Adult
Language	English
Publishing date	2023-11-10
Publishing country	Italy
Document type	Review ; Journal Article
ZDB-ID	123586-2
ISSN	1827-1669 ; 0026-4806
ISSN (online)	1827-1669
ISSN	0026-4806
DOI	10.23736/S0026-4806.23.08466-5
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Article: Feasibility of high-frequency percussions in people with severe acquired brain injury and tracheostomy: an observational study.

Sciurello, Salvatore Andrea / Graziano, Francesca / Laganà, Maria Marcella / Compalati, Elena / Pappacoda, Gabriele / Gambazza, Simone / Navarro, Jorge / Cecconi, Pietro / Baglio, Francesca / Banfi, Paolo

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2024

Abstract: People with severe acquired brain injury (pwSABI) frequently experience pulmonary complications. Among these, atelectasis can occur as a result of pneumonia, thus increasing the chance of developing acute respiratory failure. Respiratory physiotherapy ... ...

Abstract	People with severe acquired brain injury (pwSABI) frequently experience pulmonary complications. Among these, atelectasis can occur as a result of pneumonia, thus increasing the chance of developing acute respiratory failure. Respiratory physiotherapy contribution to the management of atelectasis in pwSABI is yet poorly understood. We conducted a retrospective analysis on 15 non-cooperative pwSABI with tracheostomy and spontaneously breathing, hospitalized and treated with high-frequency percussion physiotherapy between September 2018 and February 2021 at the Neurological Rehabilitation Unit of the IRCCS "S.Maria Nascente - Fondazione Don Gnocchi", Milan. Our primary aim was to investigate the feasibility of such a physiotherapy intervention method. Then, we assessed changes in respiratory measures (arterial blood gas analysis and peripheral night-time oxygen saturation) and high-resolution computed tomography lung images, evaluated before and after the physiotherapy treatment. The radiological measures were a modified radiological atelectasis score (mRAS) assigned by two radiologists, and an opacity score automatically provided by the software CT Pneumonia Analysis® that identifies the regions of abnormal lung patterns. Treatment diaries showed that all treatments were completed, and no adverse events during treatment were registered. Among the 15 pwSABI analyzed, 8 were treated with IPV® and 7 with MetaNeb®. After a median of 14 (I-III quartile=12.5-14.5) days of treatment, we observed a statistical improvement in various arterial blood gas measures and peripheral night-time oxygen saturation measures. We also found radiological improvement or stability in more than 80% of pwSABI. In conclusion, our physiotherapy approach was feasible, and we observed respiratory parameters and radiological improvements. Using technology to assess abnormal tomographic patterns could be of interest to disentangle the short-term effects of respiratory physiotherapy on non-collaborating people.
Language	English
Publishing date	2024-01-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2024.2734
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Article ; Online: The safety of carbamylated monomeric allergoids for sublingual immunotherapy. Data from a pharmacovigilance study.

Compalati, Enrico / Incorvaia, Cristoforo / Urbano, Sara / Strada, Paola / Frati, Franco

Immunotherapy

2020 Volume 12, Issue 3, Page(s) 195–202

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Allergens/chemistry ; Allergoids/administration & dosage ; Allergoids/adverse effects ; Allergoids/chemistry ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Humans ; Italy/epidemiology ; Pharmacovigilance ; Protein Carbamylation ; Safety ; Sublingual Immunotherapy/adverse effects ; Sublingual Immunotherapy/statistics & numerical data
Chemical Substances	Allergens ; Allergoids
Language	English
Publishing date	2020-01-23
Publishing country	England
Document type	Journal Article
ISSN	1750-7448
ISSN (online)	1750-7448
DOI	10.2217/imt-2019-0095
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Article: The role of allergoids in allergen immunotherapy: from injective to sublingual route.

Compalati, E / Incorvaia, C / Cavaliere, C / Masieri, S / Gargiulo, A / Mistrello, G / Frati, F

European annals of allergy and clinical immunology

2020 Volume 52, Issue 5, Page(s) 195–204

Abstract: Summary: ... ...

Abstract	Summary: Summary
MeSH term(s)	Administration, Sublingual ; Allergoids/immunology ; Animals ; Antigens, Dermatophagoides/immunology ; Antigens, Fungal/immunology ; Fungi/immunology ; Humans ; Hypersensitivity/immunology ; Immune Tolerance ; Injections ; Plants ; Pollen/immunology ; Pyroglyphidae
Chemical Substances	Allergoids ; Antigens, Dermatophagoides ; Antigens, Fungal
Language	English
Publishing date	2020-09-08
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2105540-3
ISSN	1764-1489 ; 0397-9148
ISSN	1764-1489 ; 0397-9148
DOI	10.23822/EurAnnACI.1764-1489.142
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Article: Efficacy of Nasal High-Flow Oxygen Therapy in Chronic Obstructive Pulmonary Disease Patients in Long-Term Oxygen and Nocturnal Non-Invasive Ventilation during Exercise Training.

Volpi, Valeria / Volpato, Eleonora / Compalati, Elena / Lebret, Marius / Russo, Giuseppe / Sciurello, Salvatore / Pappacoda, Gabriele / Nicolini, Antonello / Banfi, Paolo

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 10

Abstract: High-flow oxygen therapy (HFOT) improves gas exchange and dead space washout and reduces the level of work required for breathing. This study aimed to evaluate pulmonary rehabilitation (PR) combined with HFOT in COPD patients treated with nocturnal non- ... ...

Abstract	High-flow oxygen therapy (HFOT) improves gas exchange and dead space washout and reduces the level of work required for breathing. This study aimed to evaluate pulmonary rehabilitation (PR) combined with HFOT in COPD patients treated with nocturnal non-invasive ventilation (NIV) and long-term oxygen therapy (LTOT). In particular, we sought to discover whether the addition of HFOT during exercise training could improve patients’ performance, mainly with regard to their Six-Minute Walking Test (6MWT) outcomes, and reduce the exacerbation rates, periods of rehospitalization or need to resort to unscheduled visits. Thirty-one COPD subjects (13 female) who used nocturnal NIV were included in a randomized controlled trial and allocated to one of two groups: the experimental group (EG), with 15 subjects, subjected to PR with HFOT; and the control group (CG), with 16 subjects, subjected to PR without HFOT. The primary outcome of the study was the observation of changes in the 6MWT. The secondary outcome of the study was related to the rate of exacerbation and hospitalization. Data were collected at baseline and after one, two and three cycles of cycle-ergometer exercise training performed in 20 supervised sessions of 40 min thrice per week, with a washout period of 3 months between each rehabilitation cycle. Statistical significance was not found for the 6MWT distance (W = 0.974; p = 0.672) at the last follow-up, but statistical significance was found for the Borg scale in regard to dyspnea (W = 2.50; p < 0.001) and fatigue (W = 2.00; p < 0.001). HFOT may offer a positive option for dyspnea-affected COPD patients in the context of LTOT and nocturnal NIV.
Language	English
Publishing date	2022-10-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10102001
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