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  1. Article ; Online: Mind the (CRISPR) gaps: The European Commission's proposal for the use of NGTs in the EU.

    Vighi, German / De Storme, Nico

    EMBO reports

    2023  Volume 24, Issue 12, Page(s) e58109

    Abstract: The proposal by the European Commission to regulate New Genome Technique (NGT) plants is a leap forward, but it does not revise the current legislation on GMOs and includes many inconsistencies that may hinder the adoption of specific NGTs. ...

    Abstract The proposal by the European Commission to regulate New Genome Technique (NGT) plants is a leap forward, but it does not revise the current legislation on GMOs and includes many inconsistencies that may hinder the adoption of specific NGTs.
    MeSH term(s) European Union ; Clustered Regularly Interspaced Short Palindromic Repeats
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202358109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Uptake of cyclic C

    Bizzotto, Elisa C / Libralato, Giovanni / de Natale, Antonino / Scanferla, Petra / Vighi, Marco / Marcomini, Antonio

    The Science of the total environment

    2024  Volume 924, Page(s) 171613

    Abstract: ... Cyclic ... ...

    Abstract Cyclic C
    MeSH term(s) Solanum lycopersicum ; Zea mays ; Biological Transport ; Plants
    Language English
    Publishing date 2024-03-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Toxicity and bioaccumulation of the fluorosurfactant cC

    Bizzotto, Elisa Chiara / Libralato, Giovanni / Breda, Silvia / Siciliano, Antonietta / Scanferla, Petra / Vighi, Marco / Marcomini, Antonio

    The Science of the total environment

    2024  Volume 919, Page(s) 170677

    Abstract: ... Cyclic ... ...

    Abstract Cyclic C
    MeSH term(s) Animals ; Oligochaeta ; Bioaccumulation ; Soil Pollutants/toxicity ; Soil Pollutants/analysis ; Soil ; Fluorocarbons
    Chemical Substances Soil Pollutants ; Soil ; Fluorocarbons
    Language English
    Publishing date 2024-02-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: What are the Characteristics of Patients Experiencing Adverse Drug Reactions to Oral Anticogulants and How Can Such Reactions be Prevented?

    Spada, G / Vighi, G V / Pagani, S / Vighi, G D / Venegoni, M / Ruocco, M

    Current drug safety

    2019  Volume 15, Issue 1, Page(s) 38–44

    Abstract: Introduction: Oral anticoagulants, including vitamin K inhibitors (VKAs) and direct anticoagulants (DOACs) are important for preventing and treating thromboembolic diseases. However, they are not recommended for use in all patients due to negative side ... ...

    Abstract Introduction: Oral anticoagulants, including vitamin K inhibitors (VKAs) and direct anticoagulants (DOACs) are important for preventing and treating thromboembolic diseases. However, they are not recommended for use in all patients due to negative side effects and adverse drug reactions (ADRs). Currently, there is a paucity of information about their use in real life. Therefore, the aim of this pilot study is to report on the rate of serious ADRs in oral anticoagulant users, determine patient characteristics associated with increased risk of ADRs, and identify possible management strategies for reducing risk of ADRs within a hospital setting.
    Methods: Patients admitted to the Internal Medicine Department of the Vimercate Hospital were recruited between November 1, 2015 and October 31, 2016. All patients reporting an ADR associated with anticoagulant use were selected. Demographic, clinical, and observational data were extracted from electronic hospital records, in particular, by the hospital discharge letters and other clinical records. The main outcome of the study was to evaluate the incidence of anticoagulants serious adverse drug reactions conditioning hospital admission, the percentage of preventable reactions, and the determinants of those.
    Results and discussion: Of the 2,064 admissions, 102 (4.9%) eligible patients were identified. Age ranged from 60-95 years (mean = 81.9, standard deviation = 6,59) and 47.1% (n=48) were female. Of the 102 cases, 68 used VKAs and 34 used DOACs. The most common admission diagnosis was heart failure following anemia or hemorrhage (56 cases), followed by acute hemorrhage (with or without anemia; 29 cases), and anemia not associated with evident hemorrhage (17cases). The majority of VKA users (n=65, 95.6%) had a high risk of major bleeding. ADRs were found to be preventable in 96% of VKA users and 68% of DOACs users.
    Conclusion: This study highlights the large percentage of ADRs from oral anticoagulants that can be avoided with more careful patient management. Periodic check-up of cardiac and renal function, as well as blood count, may be useful for reducing the risk of ADRs, especially in older DOACs users. Further research is needed to get new data to improve the patients monitoring system.
    MeSH term(s) Aged ; Aged, 80 and over ; Anemia/chemically induced ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Female ; Hemorrhage/chemically induced ; Hospital Records ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Monitoring, Physiologic ; Vitamin K/antagonists & inhibitors
    Chemical Substances Anticoagulants ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2019-11-13
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2250840-5
    ISSN 2212-3911 ; 1574-8863
    ISSN (online) 2212-3911
    ISSN 1574-8863
    DOI 10.2174/1574886314666191003162104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Concentrations of bisphenols and phthalate esters in the muscle of Mediterranean striped dolphins (Stenella coeruleoalba)

    Vighi, Morgana / Borrell, Asunción / Sahyoun, Wissam / Net, Sopheak / Aguilar, Alex / Ouddane, Baghdad / Garcia-Garin, Odei

    Chemosphere. 2023 Oct., v. 339 p.139686-

    2023  

    Abstract: ... BPZ) was detected in all the samples, at the highest concentration (mean 16.06 μg g⁻¹ lipid weight ...

    Abstract Bisphenols (BPs) and phthalate esters (PAEs) are important compounds for the plastics industry, also called “everywhere chemicals” due to their ubiquity in daily use products. Both chemical groups are well-known environmental contaminants, whose presence has been reported in all environmental compartments, and whose effects, mainly associated to endocrine disruption, are detrimental to living organisms. Cetaceans, due to their long life-span, low reproduction rate and high position in the trophic web, are especially vulnerable to the effects of contaminants. However, little is known about BP and PAE concentrations in cetacean tissues, their potential relation to individual biological variables, or their trends over time. Here, the concentration of 10 BPs and 13 PAEs was assessed in the muscle of 30 striped dolphins (Stenella coeruleoalba) stranded along the Spanish Catalan coast (NW Mediterranean) between 1990 and 2018. Six BP and 6 PAE compounds were detected, of which only 4,4′-(cyclohexane-1,1-diyl)diphenol (BPZ) was detected in all the samples, at the highest concentration (mean 16.06 μg g⁻¹ lipid weight). Sex or reproductive condition were largely uninfluential on concentrations: only dimethylphthalate (DMP) concentrations were significantly higher in immature individuals than in adults, and the overall PAE concentrations were significantly higher in males than in females. Temporal variations were only detected in bis(4-hydroxyphenyl)ethane (BPE), diethylphthalate (DEP) and dimethylphthalate (DMP), whose concentrations were lower, and 9,9-Bis(4-hydroxyphenyl)fluorene (BPFL), which were higher, respectively, in samples taken between 2014 and 2018, probably reflecting shifts in the production and use of these chemicals. These results provide the first assessment of concentrations of several BP and PAE compounds in the muscle of an odontocete cetacean.
    Keywords Stenella coeruleoalba ; coasts ; diethyl phthalate ; ethane ; fluorenes ; food webs ; industry ; lipids ; muscles ; pollution ; reproduction ; Pollutants ; Plastic additives ; Plasticizers ; Contamination ; Marine mammals ; Cetaceans
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.139686
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Occurrence, Fate and Fluxes of Plastics and Microplastics in Terrestrial and Freshwater Ecosystems.

    Schell, Theresa / Rico, Andreu / Vighi, Marco

    Reviews of environmental contamination and toxicology

    2020  Volume 250, Page(s) 1–43

    Abstract: ... from soils towards aquatic environments (e.g. by surface water runoff, soil infiltration) are still poorly ...

    Abstract Plastics and microplastics are nowadays ubiquitously found in the environment. This has raised concerns on possible adverse effects for human health and the environment. To date, extensive information exists on their occurrence in the marine environment. However, information on their different sources and their transport within and across different freshwater and terrestrial ecosystems is still limited. Therefore, we assessed the current knowledge regarding the industrial sources of plastics and microplastics, their environmental pathways and load rates and their occurrence and fate in different environmental compartments, thereby highlighting important data gaps which are needed to better describe their global environmental cycle and exposure. This study shows that the quantitative assessment of the contribution of the different major sources of plastics, microplastics and nanoplastics to aquatic and terrestrial ecosystems is challenged by some data limitations. While the presence of microplastics in wastewater and freshwater is relatively well studied, data on sediments and especially soil ecosystems are too limited. Moreover, the overall occurrence of large-sized plastics, the patterns of microplastic and nanoplastic formation from them, the presence and deposition of plastic particles from the atmosphere and the fluxes of all kinds of plastics from soils towards aquatic environments (e.g. by surface water runoff, soil infiltration) are still poorly understood. Finally, this study discusses several research areas that need urgent development in order to better understand the potential ecological risks of plastic pollution and provides some recommendations to better manage and control plastic and microplastic inputs into the environment.
    MeSH term(s) Ecosystem ; Environmental Monitoring ; Fresh Water ; Humans ; Microplastics ; Plastics/toxicity ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity
    Chemical Substances Microplastics ; Plastics ; Water Pollutants, Chemical
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 90606-2
    ISSN 0179-5953
    ISSN 0179-5953
    DOI 10.1007/398_2019_40
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modelling micropollutant cycle in Lake Como in a winter scenario: Implications for water use and reuse, ecosystem services, and the EU zero pollution action plan.

    Di Guardo, Antonio / Castiglioni, Sara / Gambino, Isabella / Sailis, Alessia / Salmoiraghi, Giulia / Schiarea, Silvia / Vighi, Marco / Terzaghi, Elisa

    The Science of the total environment

    2023  Volume 906, Page(s) 167594

    Abstract: The fate and effects of 42 pharmaceuticals was studied in Lake Como (Italy), in wastewater treatment plants delivering water to the lake, in two rivers and in potable water obtained from lake water. Lake Como is one of the deepest and largest lakes in ... ...

    Abstract The fate and effects of 42 pharmaceuticals was studied in Lake Como (Italy), in wastewater treatment plants delivering water to the lake, in two rivers and in potable water obtained from lake water. Lake Como is one of the deepest and largest lakes in Northern Italy, serving important ecosystem services (i.e., drinking water, recreational, industrial, irrigation uses), some of which are currently at risk giving the current water scarcity and climate change scenarios. The highest concentrations measured in lake water were those of diclofenac, followed by carbamazepine, its metabolite, and clarithromycin. The data measured allowed to calibrate and run a fugacity-based lake model, which showed that the most important chemical load generally comes from the advective water from the north of the lake, rather than from the direct wastewater treatment plant (WWTP) discharges. This indicates that only an important reduction of chemical discharge (reduced use or extensive treatment) at a drainage basin level could significantly reduce concentrations in water. This has strong implications on how to implement the EU zero pollution action plan to significantly improve water ecosystem and human health protection.
    MeSH term(s) Humans ; Lakes ; Ecosystem ; Water ; Water Pollutants, Chemical/analysis ; Wastewater ; Environmental Monitoring
    Chemical Substances Water (059QF0KO0R) ; Water Pollutants, Chemical ; Wastewater
    Language English
    Publishing date 2023-10-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.167594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effects of Polyester Fibers and Car Tire Particles on Freshwater Invertebrates.

    Schell, Theresa / Martinez-Perez, Sara / Dafouz, Raquel / Hurley, Rachel / Vighi, Marco / Rico, Andreu

    Environmental toxicology and chemistry

    2022  Volume 41, Issue 6, Page(s) 1555–1567

    Abstract: ... on Daphnia magna, Hyalella azteca, Asellus aquaticus, and Lumbriculus variegatus using water only (up to 0.15 g/L ... or spiked sediment (up to 2 g/kg dry wt), depending on the habitat of the species. Daphnia magna did ...

    Abstract Microplastic ingestion has been shown for various organisms, but knowledge of the potential adverse effects on freshwater invertebrates remains limited. We assessed the ingestion capacity and the associated effects of polyester fibers (26-5761 µm) and car tire particles (25-75 µm) on freshwater invertebrates under acute and chronic exposure conditions. A range of microplastic concentrations was tested on Daphnia magna, Hyalella azteca, Asellus aquaticus, and Lumbriculus variegatus using water only (up to 0.15 g/L) or spiked sediment (up to 2 g/kg dry wt), depending on the habitat of the species. Daphnia magna did not ingest any fibers, but low levels of fibers were ingested by all tested benthic invertebrate species. Car tire particle ingestion rose with increasing exposure concentration for all tested invertebrates and was highest in D. magna and L. variegatus. In most cases, no statistically significant effects on mobility, survival, or reproductive output were observed after acute and chronic exposure at the tested concentrations. However, fibers affected the reproduction and survival of D. magna (no-observed-effect concentration [NOEC]: 0.15 mg/L) due to entanglement and limited mobility under chronic conditions. Car tire particles affected the reproduction (NOEC: 1.5 mg/L) and survival (NOEC: 0.15 mg/L) of D. magna after chronic exposure at concentrations in the same order of magnitude as modeled river water concentrations, suggesting that refined exposure and effect studies should be performed with these microplastics. Our results confirm that microplastic ingestion by freshwater invertebrates depends on particle shape and size and that ingestion quantity depends on the exposure pathway and the feeding strategy of the test organism. Environ Toxicol Chem 2022;41:1555-1567. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
    MeSH term(s) Animals ; Automobiles ; Daphnia ; Fresh Water ; Invertebrates ; Microplastics ; Oligochaeta ; Plastics ; Polyesters/toxicity ; Water ; Water Pollutants, Chemical/analysis
    Chemical Substances Microplastics ; Plastics ; Polyesters ; Water Pollutants, Chemical ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 46234-2
    ISSN 1552-8618 ; 0730-7268
    ISSN (online) 1552-8618
    ISSN 0730-7268
    DOI 10.1002/etc.5337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Biomagnification and temporal trends (1990-2021) of perfluoroalkyl substances in striped dolphins (Stenella coeruleoalba) from the NW Mediterranean sea.

    Garcia-Garin, Odei / Borrell, Asunción / Colomer-Vidal, Pere / Vighi, Morgana / Trilla-Prieto, Núria / Aguilar, Alex / Gazo, Manel / Jiménez, Begoña

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 339, Page(s) 122738

    Abstract: ... respectively, at concentrations ranging between 43 and 1609 ng/g wet weight, and 254 and 7010 ng/g wet weight ...

    Abstract Poly- and Perfluoroalkyl Substances (PFAS) are a well-known class of pollutants which can bioaccumulate and biomagnify with a vast majority being highly persistent. This study aims to determine the biomagnification rates of PFAS in sexually mature striped dolphins and to assess temporal trends on PFAS concentrations over the past three decades (1990-2021) in the North-Western Mediterranean Sea. Thirteen and 17 of the 19 targeted PFAS were detected in the samples of the dolphins' digestive content and liver, respectively, at concentrations ranging between 43 and 1609 ng/g wet weight, and 254 and 7010 ng/g wet weight, respectively. The most abundant compounds in both types of samples were linear perfluorooctanesulfonic acid (n-PFOS) and perfluorooctanesulfonamide (FOSA), which were present in all samples, followed by perfluoroundecanoic acid (PFUnDA), perfluorotridecanoic acid (PFTrDA) and perfluorononanoic acid (PFNA). Long-chain PFAS (i.e., PFCAs C ≥ 7 and PFSAs C ≥ 6) biomagnified to a greater extent than short-chain PFAS, suggesting a potential effect on the health of striped dolphins. Environmental Quality Standards concentrations set in 2014 by the European Union were exceeded in half of the samples of digestive content, suggesting that polluted prey may pose potential health risks for striped dolphins. Concentrations of most long-chain PFAS increased from 1990 to 2004-2009, then stabilized during 2014-2021, possibly following country regulations and industrial initiatives. The current study highlights the persistent presence of banned PFAS and may contribute to future ecological risk assessments and the design of management strategies to mitigate PFAS pollution in marine ecosystems.
    MeSH term(s) Animals ; Stenella ; Environmental Monitoring ; Ecosystem ; Mediterranean Sea ; Bioaccumulation ; Fluorocarbons/analysis ; Dolphins ; Alkanesulfonic Acids/analysis
    Chemical Substances perfluorotridecanoic acid ; Fluorocarbons ; Alkanesulfonic Acids
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.122738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Drug-Related Hypersensitivity Reactions Leading to Emergency Department: Original Data and Systematic Review.

    Pagani, Silvia / Lombardi, Niccolò / Crescioli, Giada / Vighi, Violetta Giuditta / Spada, Giulia / Andreetta, Paola / Capuano, Annalisa / Vannacci, Alfredo / Venegoni, Mauro / Vighi, Giuseppe Danilo / On Behalf Of The MEREAFaPS Study Group

    Journal of clinical medicine

    2022  Volume 11, Issue 10

    Abstract: The aim of the present study is to describe pharmacological characteristics of drug-related allergies and anaphylaxis leading to the emergency department (ED). An 8-year post hoc analysis on the MEREAFaPS Study database was performed (2012−2019). ... ...

    Abstract The aim of the present study is to describe pharmacological characteristics of drug-related allergies and anaphylaxis leading to the emergency department (ED). An 8-year post hoc analysis on the MEREAFaPS Study database was performed (2012−2019). Subjects who experienced drug-related hypersensitivity leading to an ED visit were selected. Logistic regression analyses were used to estimate the reporting odds ratios (RORs) of drug-related allergies and anaphylaxis adjusting for sex, age classes, and ethnicity. In addition, a systematic review of observational studies evaluating drug-related hypersensitivity reactions leading to ED visits in outpatients was performed. Out of 94,073 ED visits, 14.4% cases were drug-related allergies and 0.6% were anaphylaxis. Females accounted for 56%. Multivariate logistic regression showed a higher risk of drug-related allergy among males and all age classes < 65 years, while a higher risk of anaphylaxis was observed for females (ROR 1.20 [1.01−1.42]) and adults (ROR 2.63 [2.21−3.14]). The systematic review included 37 studies. ED visits related to allergy and anaphylaxis ranged from 0.004% to 88%, and drug-related allergies and anaphylaxis ranged from 0.007% to 88%. Both in our analysis and in primary studies, antibacterials, analgesics, and radiocontrast agents were identified as the most common triggers of hypersensitivity.
    Language English
    Publishing date 2022-05-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11102811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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