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Article ; Online: s-CRIq: the online short version of the Cognitive Reserve Index Questionnaire.

Mondini, Sara / Pucci, Veronica / Pastore, Massimiliano / Gaggi, Ombretta / Tricomi, Pier Paolo / Nucci, Massimo

Aging clinical and experimental research

2023 Volume 35, Issue 12, Page(s) 2903–2910

Abstract: ... for the people of today. This study describes the online short CRIq (s-CRIq), the new shorter version of the CRIq ... The s-CRIq was administered online to 435 people while another 440 filled out the s-CRIq ... the online long CRIq.: Results: The major difference in the databases of s-CRIq versus the long versions ...

Abstract	Background: The wide use of the term Cognitive Reserve (CR) is in need of a clear and shared definition of its concept and of the development of new tools, quick and easy to use and updated for the people of today. This study describes the online short CRIq (s-CRIq), the new shorter version of the CRIq, following an item analysis revision, and compares the data distribution of different samples. Methods: The s-CRIq was administered online to 435 people while another 440 filled out the s-CRIq in self-administration. A further 588 participants had been administered the original paper-and-pencil long CRIq and 344 the online long CRIq. Results: The major difference in the databases of s-CRIq versus the long versions is an increased score in education and in leisure activity. However, the density distributions of the total score of CRI in the 4 databases share 64% of their areas, and at least two of them share 84%. Conclusion: The s-CRIq proved to be a simple and easy-to-administer tool. Similarly, to the original version, the s-CRIq is freely available on the web, and it is our hope that it will be of fruitful use for researchers and clinicians alike.
MeSH term(s)	Humans ; Cognitive Reserve ; Neuropsychological Tests ; Surveys and Questionnaires ; Educational Status ; Leisure Activities
Language	English
Publishing date	2023-09-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-023-02561-1
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Article ; Online: Vaccine-induced massive pulmonary embolism and thrombocytopenia following a single dose of Janssen Ad26.COV2.S vaccination.

Curcio, Rosa / Gandolfo, Vito / Alcidi, Riccardo / Giacomino, Luciano / Campanella, Tommaso / Casarola, Genni / Rossi, Rachele / Chiatti, Lorenzo / D'Abbondanza, Marco / Commissari, Rita / Gresele, Paolo / Pucci, Giacomo / Vaudo, Gaetano

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2022 Volume 116, Page(s) 154–156

Abstract: ... the administration of the single-dose adenoviral vector-based vaccine Ad26.COV2.S (Janssen Vaccines). Based on early ...

Abstract	Vaccine-induced immune thrombotic thrombocytopenia (VITT) has emerged as a rare side effect of adenoviral vector-based vaccines against coronavirus disease 2019 (COVID-19), and is most frequently reported after use of the Vaxzevria (AstraZeneca) vaccine. This report describes a case of severe thrombocytopenia associated with massive pulmonary embolism and portal vein thrombosis occurring 13 days after the administration of the single-dose adenoviral vector-based vaccine Ad26.COV2.S (Janssen Vaccines). Based on early clinical suspicion, the patient quickly received treatment with corticosteroids and intravenous immunoglobulin, followed by a rapid increase in platelet count that allowed timely administration of full-dose anticoagulation. Treatment with intravenous immunoglobulin, however, could mask the ability of anti-platelet factor 4-heparin antibodies to bind and activate platelets in the presence of heparin, leading to false-negative results on the immunoassay functional test. Therefore, if VITT is suspected, blood samples for diagnostic confirmation should be collected prior to any treatment to improve diagnostic performance.
MeSH term(s)	Ad26COVS1 ; COVID-19 ; COVID-19 Vaccines/adverse effects ; Humans ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/etiology ; SARS-CoV-2 ; Thrombocytopenia/diagnosis ; Thrombocytopenia/etiology ; Vaccination/adverse effects ; Vaccines
Chemical Substances	Ad26COVS1 ; COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2022-01-02
Publishing country	Canada
Document type	Case Reports
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2021.12.345
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Article ; Online: Association of high TUBB3 with resistance to adjuvant docetaxel-based chemotherapy in gastric cancer: translational study of ITACA-S.

Di Bartolomeo, Maria / Raimondi, Alessandra / Cecchi, Fabiola / Catenacci, Daniel V T / Schwartz, Sarit / Sellappan, Shankar / Tian, Yuan / Miceli, Rosalba / Pellegrinelli, Alessandro / Giommoni, Elisa / Aitini, Enrico / Spada, Francesca / Rosati, Gerardo / Marchet, Alberto / Pucci, Francesca / Zaniboni, Alberto / Tamberi, Stefano / Pressiani, Tiziana / Sanna, Gianni /

Cantore, Maurizio / Mosconi, Stefania / Bolzoni, Paola / Pinto, Carmine / Landi, Lorenza / Soto Parra, Hector Josè / Cavanna, Luigi / Corallo, Salvatore / Martinetti, Antonia / Hembrough, Todd A / Pietrantonio, Filippo

Tumori

2020 Volume 107, Issue 2, Page(s) 150–159

Abstract: ... in the Intergroup Trial of Adjuvant Chemotherapy in Adenocarcinoma of the Stomach (ITACA-S), a randomized adjuvant ...

Abstract	Background: No predictive markers for chemotherapy activity have been validated in gastric cancer (GC). The potential value of class III β-tubulin (TUBB3) as biomarker for prognosis and resistance to taxane-based therapy was reported. Methods: We analyzed GC samples of patients enrolled in the Intergroup Trial of Adjuvant Chemotherapy in Adenocarcinoma of the Stomach (ITACA-S), a randomized adjuvant study comparing 5-fluorouracil/leucovorin (5-FU/LV) and docetaxel-based sequential chemotherapy. TUBB3 was quantitated by selected reaction monitoring mass spectrometry and patients were stratified using a threshold of 750 attomoles per microgram (amol/µg). Cox proportional modeling and Kaplan-Meier survival analysis were used to assess the impact of TUBB3 expression on overall survival (OS) and disease-free survival. Results: Patients with TUBB3 protein levels >750 and <750 amol/µg were 21.9% and 78.1%, respectively, and were well-balanced between treatment arms. TUBB3 protein levels were not prognostic. Whereas no survival differences according to the 2 arms were observed in the subgroup with low TUBB3 expression (5-year OS 47% vs 40%; Conclusions: The quantification of TUBB3 might be considered as a negative predictive biomarker of benefit from taxane-based therapy in GC. Studies are needed to evaluate its role in the neoadjuvant setting.
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/metabolism ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/metabolism ; Chemotherapy, Adjuvant/methods ; Cisplatin/administration & dosage ; Docetaxel/administration & dosage ; Drug Resistance, Neoplasm/drug effects ; Female ; Fluorouracil/administration & dosage ; Humans ; Kaplan-Meier Estimate ; Leucovorin/administration & dosage ; Male ; Prognosis ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/metabolism ; Translational Research, Biomedical/methods ; Tubulin/metabolism
Chemical Substances	Biomarkers, Tumor ; TUBB3 protein, human ; Tubulin ; Docetaxel (15H5577CQD) ; Cisplatin (Q20Q21Q62J) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2020-06-11
Publishing country	United States
Document type	Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/0300891620930803
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Article ; Online: S-glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia.

Butturini, Elena / Cozzolino, Flora / Boriero, Diana / Carcereri de Prati, Alessandra / Monti, Maria / Rossin, Michele / Canetti, Diana / Cellini, Barbara / Pucci, Piero / Mariotto, Sofia

Free radical biology & medicine

2018 Volume 117, Page(s) 191–201

Abstract: STAT1 and STAT3 are two transcription factors involved in a lot of cellular functions such as immune response, proliferation, apoptosis, and cell survival. A number of literature evidences described a yin-yang relationship between activation of STAT1 and ...

Abstract	STAT1 and STAT3 are two transcription factors involved in a lot of cellular functions such as immune response, proliferation, apoptosis, and cell survival. A number of literature evidences described a yin-yang relationship between activation of STAT1 and STAT3 in neurodegenerative disorders where STAT1 exerts a pro-apoptotic effect whereas STAT3 shows neuroprotective properties through the inhibition of apoptosis. Although the role of oxidative-stress in the pathogenesis of neurodegeneration is clearly described, its influence in the regulation of these pathways is poorly understood. Herein, we demonstrate that H
MeSH term(s)	Animals ; Cell Line ; Enzyme Activation/physiology ; Glutathione/metabolism ; Hydrogen Peroxide/pharmacology ; Mice ; Microglia/metabolism ; Oxidants/pharmacology ; Oxidative Stress/physiology ; Phosphorylation ; STAT1 Transcription Factor/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction/physiology
Chemical Substances	Oxidants ; STAT1 Transcription Factor ; STAT3 Transcription Factor ; Stat1 protein, mouse ; Stat3 protein, mouse ; Hydrogen Peroxide (BBX060AN9V) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2018-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2018.02.005
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Zs.A 2109: Show issues

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Article ; Online: S-Glutathionylation at Cys328 and Cys542 impairs STAT3 phosphorylation.

Butturini, Elena / Darra, Elena / Chiavegato, Giulia / Cellini, Barbara / Cozzolino, Flora / Monti, Maria / Pucci, Piero / Dell'Orco, Daniele / Mariotto, Sofia

ACS chemical biology

2014 Volume 9, Issue 8, Page(s) 1885–1893

Abstract: ... modulated by S-glutathionylation, a reversible redox modification of cysteine residues. This suggests ... we demonstrate that GSH/diamide treatment induces S-glutathionylation of STAT3 in the recombinant purified form ... This effect was completely reversed by treatment with the reducing agent dithiothreitol, indicating that S ...

Abstract	STAT3 is a latent transcription factor that promotes cell survival and proliferation and is often constitutively active in cancers. Although many reports provide evidence that STAT3 is a direct target of oxidative stress, its redox regulation is poorly understood. Under oxidative conditions STAT3 activity can be modulated by S-glutathionylation, a reversible redox modification of cysteine residues. This suggests the possible cross-talk between phosphorylation and glutathionylation and points out that STAT3 is susceptible to redox regulation. Recently, we reported that decreasing the GSH content in different cell lines induces inhibition of STAT3 activity through the reversible oxidation of thiol groups. In the present work, we demonstrate that GSH/diamide treatment induces S-glutathionylation of STAT3 in the recombinant purified form. This effect was completely reversed by treatment with the reducing agent dithiothreitol, indicating that S-glutathionylation of STAT3 was related to formation of protein-mixed disulfides. Moreover, addition of the bulky negatively charged GSH moiety impairs JAK2-mediated STAT3 phosphorylation, very likely interfering with tyrosine accessibility and thus affecting protein structure and function. Mass mapping analysis identifies two glutathionylated cysteine residues, Cys328 and Cys542, within the DNA-binding domain and the linker domain, respectively. Site direct mutagenesis and in vitro kinase assay confirm the importance of both cysteine residues in the complex redox regulatory mechanism of STAT3. Cells expressing mutant were resistant in this regard. The data presented herein confirmed the occurrence of a redox-dependent regulation of STAT3, identified the more redox-sensitive cysteines within STAT3 structure, and may have important implications for development of new drugs.
MeSH term(s)	Cysteine/metabolism ; Glutathione/metabolism ; HeLa Cells ; Humans ; Oxidation-Reduction ; Phosphorylation ; STAT3 Transcription Factor/chemistry ; STAT3 Transcription Factor/metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Chemical Substances	STAT3 Transcription Factor ; STAT3 protein, human ; Glutathione (GAN16C9B8O) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2014-08-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/cb500407d
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Article ; Online: Towards Universally Designed Communication: Opportunities and Challenges in the Use of Automatic Speech Recognition Systems to Support Access, Understanding and Use of Information in Communicative Settings.

Pucci, Martina

Studies in health technology and informatics

2023 Volume 303, Page(s) 18–25

Abstract: ... It is essential to weigh the strengths and weaknesses of technology when choosing which device(s) to use ...

Abstract	Unlike physical barriers, communication barriers do not have an easy solution: people speak or sign in different languages and may have wide-ranging proficiency levels in the languages they understand and produce. Universal Design (UD) principles in the domain of language and communication have guided the production of multimodal (audio, visual, written) information. For example, UD guidelines encourage websites to provide information in alternative formats (for example, a video with captions; a sign language version). The same UD for Learning principles apply in the classroom, and instructors are encouraged to prepare content to be presented multimodally, making use of increasingly available technology. In this chapter, I will address some of the opportunities and challenges offered by automatic speech recognition (ASR) systems. These systems have many strengths, and the most evident is the time they employ to convert speech sounds into a written form, faster than the time human transcribers need to perform the same process. These systems also present weaknesses, for example, a higher rate of errors when compared to human-generated transcriptions. It is essential to weigh the strengths and weaknesses of technology when choosing which device(s) to use in a universally designed environment to enhance access to information and communication. It is equally imperative to understand which tools are most appropriate for diverse populations. Therefore, researchers should continue investigating how people process information in a multimodal format, and how technology can be improved based on this knowledge and users' needs and feedback.
MeSH term(s)	Humans ; Speech Perception ; Communication ; Language ; Sign Language ; Learning
Language	English
Publishing date	2023-06-22
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI230394
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Article ; Online: Polyphenolic profiles and antioxidant and antiradical activity of Italian berries from Vaccinium myrtillus L. and Vaccinium uliginosum L. subsp. gaultherioides (Bigelow) S.B. Young.

Ancillotti, Claudia / Ciofi, Lorenzo / Pucci, Daniele / Sagona, Eva / Giordani, Edgardo / Biricolti, Stefano / Gori, Massimo / Petrucci, William Antonio / Giardi, Fabio / Bartoletti, Riccardo / Chiuminatto, Ugo / Orlandini, Serena / Mosti, Stefano / Del Bubba, Massimo

Food chemistry

2016 Volume 204, Page(s) 176–184

Abstract: Total soluble polyphenols (TSP), total monomeric anthocyanins (TMA), radical scavenging activity (RSA), ferric reducing antioxidant power (FRAP), and a number of anthocyanins, phenolic acids, coumarins, flavanols, dihydrochalcones and flavonols were ... ...

Abstract	Total soluble polyphenols (TSP), total monomeric anthocyanins (TMA), radical scavenging activity (RSA), ferric reducing antioxidant power (FRAP), and a number of anthocyanins, phenolic acids, coumarins, flavanols, dihydrochalcones and flavonols were investigated in Tuscan bilberry (i.e. Vaccinium myrtillus) and "false bilberry" (i.e. Vaccinium uliginosum subsp. gaultherioides Bigelow). V. myrtillus berries showed much higher TSP, TMA, RSA and FRAP values than V. uliginosum subsp. gaultherioides fruits. Moreover, very different profiles of individual phenolics were observed in the two species, being V. myrtillus mainly characterised by delphinidin and cyanidin glycosides, together with chlorogenic acid, and V. uliginosum subsp. gaultherioides dominated by malvidin derivatives and flavonols. Strong differences between the two species regarded also metabolites investigated herein for the first time, such as scopoletin, which was approximately two magnitude orders higher in V. uliginosum subsp. gaultherioides than in V. myrtillus berries. Very different abundances were also highlighted for cryptochlorogenic acid and quercetin-3-rhamnoside that were about ten-fold higher in bilberry than in "false bilberry". When the anthocyanin composition pattern of Tuscan "false bilberry" was compared to those elsewhere reported for V. uliginosum fruits harvested in different world areas, some important differences were observed.
MeSH term(s)	Anthocyanins/analysis ; Antioxidants/analysis ; Free Radical Scavengers/analysis ; Fruit/chemistry ; Fruit/growth & development ; Italy ; Plant Extracts/chemistry ; Polyphenols/analysis ; Species Specificity ; Vaccinium/chemistry ; Vaccinium/growth & development ; Vaccinium myrtillus/chemistry ; Vaccinium myrtillus/growth & development
Chemical Substances	Anthocyanins ; Antioxidants ; Free Radical Scavengers ; Plant Extracts ; Polyphenols
Language	English
Publishing date	2016-02-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2016.02.106
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Article ; Online: Serratiopeptidase: a well-known metalloprotease with a new non-proteolytic activity against S. aureus biofilm.

Selan, L / Papa, R / Tilotta, M / Vrenna, G / Carpentieri, A / Amoresano, A / Pucci, P / Artini, M

BMC microbiology

2015 Volume 15, Page(s) 207

Abstract: ... of infections by Staphylococcus aureus (S. aureus) which possesses a variety of virulence factors including many toxins and ... The virulence factors above described are often related to proteins exposed on the bacterial surface. Blocking S. aureus ... sterilized by filtration were separately used to condition biofilm formation of S. aureus. Quantification was ...

Abstract	Background: The use of indwelling medical devices is associated with a significant risk of infections by Staphylococcus aureus (S. aureus) which possesses a variety of virulence factors including many toxins and the ability to invade eukaryotic cells or to form biofilm on biotic and abiotic surfaces. The virulence factors above described are often related to proteins exposed on the bacterial surface. Blocking S. aureus colonization may reduce the incidence of invasive infectious diseases. Previously reports evaluated the anti-infective properties of serratiopeptidase (Spep), an extracellular metalloprotease produced by Serratia marcescens ATCC 21074 (E-15), in impairing virulence-related staphylococcal properties, such as attachment to inert surfaces and adhesion/invasion on eukaryotic cells. However, to date its mechanism of action is unknown. Methods: Spep gene was PCR amplified and cloned into expression vector pET28b(+). The mutant EspepA was constructed from plasmid pET28b-Spep applying the one-step overlap extension PCR strategy. There sulting plasmids were costransformed in EcBL21(DE3) cells with the plasmid pRuW4inh1 harboring the Erwinia chrysanthemi secretion system. Bacterial pellets and supernatants were collected and analyzed by SDS-PAGE and zymography. The unambiguous identification and a detailed structure characterization of both the wild type and the mutant Spep were obtained by mass spectrometric analyses. The resultant supernatants sterilized by filtration were separately used to condition biofilm formation of S. aureus. Quantification was based on crystal violet method. Results: In this work we constructed Spep mutant by substituting the glutamic acid in the catalytic site with a residue of alanine. In this manner we were able to evaluate the anti-biofilm activity of Spep mutant in absence of proteolytic activity. As expected, this mutant did not display protease activity but it retained its anti-biofilm properties, suggesting that this action is independent by enzymatic activity. Conclusions: New knowledge obtained from data reported in this paper calls attention to a novel mechanism of action of Spep. This protein could be developed as a potential "antipathogenic agent" capable to impair the ability of S. aureus to form biofilm on prostheses, catheters and medical devices, exploiting a mechanism different from the proteolytic activity.
MeSH term(s)	Amino Acid Substitution ; Anti-Infective Agents/metabolism ; Biofilms/drug effects ; Cloning, Molecular ; Escherichia coli/genetics ; Gene Expression ; Mass Spectrometry ; Metalloproteases/chemistry ; Metalloproteases/genetics ; Metalloproteases/metabolism ; Mutagenesis, Site-Directed ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/isolation & purification ; Mutant Proteins/metabolism ; Peptide Hydrolases/chemistry ; Peptide Hydrolases/genetics ; Peptide Hydrolases/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/physiology
Chemical Substances	Anti-Infective Agents ; Mutant Proteins ; Recombinant Proteins ; Metalloproteases (EC 3.4.-) ; Peptide Hydrolases (EC 3.4.-) ; serratiopeptidase (NL053ABE4J)
Language	English
Publishing date	2015-10-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2180
ISSN (online)	1471-2180
DOI	10.1186/s12866-015-0548-8
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Article: Pancreatic cancer-derived S-100A8 N-terminal peptide: a diabetes cause?

Basso, Daniela / Greco, Eliana / Fogar, Paola / Pucci, Piero / Flagiello, Angela / Baldo, Goretta / Giunco, Silvia / Valerio, Anna / Navaglia, Filippo / Zambon, Carlo-Federico / Falda, Alessandra / Pedrazzoli, Sergio / Plebani, Mario

Clinica chimica acta; international journal of clinical chemistry

2006 Volume 372, Issue 1-2, Page(s) 120–128

Abstract: Background: Our aim was to identify the pancreatic cancer diabetogenic peptide.: Methods: Pancreatic tumor samples from patients with (n=15) or without (n=7) diabetes were compared with 6 non-neoplastic pancreas samples using SDS-PAGE.: Results: A ...

Abstract	Background: Our aim was to identify the pancreatic cancer diabetogenic peptide. Methods: Pancreatic tumor samples from patients with (n=15) or without (n=7) diabetes were compared with 6 non-neoplastic pancreas samples using SDS-PAGE. Results: A band measuring approximately 1500 Da was detected in tumors from diabetics, but not in neoplastic samples from non-diabetics or samples from non-neoplastic subjects. Sequence analysis revealed a 14 amino acid peptide (1589.88 Da), corresponding to the N-terminal of the S100A8. At 50 nmol/L and 2 mmol/L, this peptide significantly reduced glucose consumption and lactate production by cultured C(2)C(12) myoblasts. The 14 amino acid peptide caused a lack of myotubular differentiation, the presence of polynucleated cells and caspase-3 activation. Conclusions: The 14 amino acid peptide from S100A8 impairs the catabolism of glucose by myoblasts in vitro and may cause hyperglycemia in vivo. Its identification in biological fluids might be helpful in diagnosing pancreatic cancer in patients with recent onset diabetes mellitus.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cell Line, Tumor ; Diabetes Mellitus/etiology ; Female ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/chemistry ; S100 Proteins/chemistry ; S100 Proteins/physiology ; Spectrometry, Mass, Electrospray Ionization
Chemical Substances	S-100A8 N-terminal peptide, human ; S100 Proteins
Language	English
Publishing date	2006-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2006.03.027
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Article: Prevalenza delle cefalee primarie in rapporto all'attività lavorativa in un gruppo di lavoratori ospedalieri sottoposti a visita periodica (D.Lgs. 626/94 s.s.m. ed i.).

Pucci, E / Matozzo, F / Arrigo, A / Mazza, S / Sandrini, G / Nappi, G

Giornale italiano di medicina del lavoro ed ergonomia

2003 Volume 25, Issue 4, Page(s) 448–452

Abstract: Since headache is one of the most frequent complaints in clinical practice, its burden in terms of the both social cost and individual sufference is considerable. Headache is a frequent cause of absence from work and decreased productivity; it is ... ...

Title translation	Prevalence of primary headache related to work activity in a group of hospital workers undergoing periodic visits (D. Lgs. 626/94 s.s.m. ed i.).
Abstract	Since headache is one of the most frequent complaints in clinical practice, its burden in terms of the both social cost and individual sufference is considerable. Headache is a frequent cause of absence from work and decreased productivity; it is therefore clear that investigating its possible relationship with working conditions represents a topic of increasing interest for the scientific community. This study was aimed at identifying specific occupational factors able to modify the prevalence of headache in a population of hospital workers undergoing periodic examinations. It was indeed suspected that the hospital environment could be per se a predisposing factor for headache onset, due to the considerable impact of stress on such working environment. The results obtained suggest that specific occupational conditions such as shift work and P.C. use may play an important role in headache development even in the presence of a wide number of professional risk factors.
MeSH term(s)	Adult ; Female ; Headache/epidemiology ; Humans ; Italy ; Male ; Middle Aged ; Occupational Diseases/epidemiology ; Occupational Medicine/legislation & jurisprudence ; Personnel, Hospital ; Prevalence ; Surveys and Questionnaires
Language	Italian
Publishing date	2003-10
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	603103-1
ISSN	1592-7830 ; 0391-9889
ISSN	1592-7830 ; 0391-9889
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