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Article ; Conference proceedings: Assessing the efficacy of preoperative procedural patient education as an intervention to mitigate stress and anxiety among otorhinolaryngology surgery patients: A randomized controlled trial

Assaf, Ranny / Busch, Chia-Jung / Brzoska, Tina / Vollmer, Marcus / Buchhold, Britta

2024 Volume 103, Issue S 02

Event/congress	95th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e. V., Bonn, Messe Essen, 2024-05-08
Language	English
Publishing date	2024-04-19
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	96005-6
ISSN	1438-8685 ; 0935-8943 ; 0340-1588
ISSN (online)	1438-8685
ISSN	0935-8943 ; 0340-1588
DOI	10.1055/s-0044-1785050
Database	Thieme publisher's database

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Article ; Online: Approach to Obesity in the Older Population.

Buch, Assaf / Marcus, Yonit / Shefer, Gabi / Zimmet, Paul / Stern, Naftali

The Journal of clinical endocrinology and metabolism

2021 Volume 106, Issue 9, Page(s) 2788–2805

Abstract: Until recently, weight loss in older obese people was feared because of ensuing muscle loss and frailty. Facing overall increasing longevity, high rates of obesity in older individuals (age ≥ 65 years) and a growing recognition of the health and ... ...

Abstract	Until recently, weight loss in older obese people was feared because of ensuing muscle loss and frailty. Facing overall increasing longevity, high rates of obesity in older individuals (age ≥ 65 years) and a growing recognition of the health and functional cost of the number of obesity years, abetted by evidence that intentional weight loss in older obese people is safe, this approach is gradually, but not unanimously, being replaced by more active principles. Lifestyle interventions that include reduced but sufficient energy intake, age-adequate protein and micronutrient intake, coupled with aerobic and resistance exercise tailored to personal limitations, can induce weight loss with improvement in frailty indices. Sustained weight loss at this age can prevent or ameliorate diabetes. More active steps are controversial. The use of weight loss medications, particularly glucagon-like peptide-1 analogs (liraglutide as the first example), provides an additional treatment tier. Its safety and cardiovascular health benefits have been convincingly shown in older obese patients with type 2 diabetes mellitus. In our opinion, this option should not be denied to obese individuals with prediabetes or other obesity-related comorbidities based on age. Finally, many reports now provide evidence that bariatric surgery can be safely performed in older people as the last treatment tier. Risk-benefit issues should be considered with extreme care and disclosed to candidates. The selection process requires good presurgical functional status, individualized consideration of the sequels of obesity, and reliance on centers that are highly experienced in the surgical procedure as well as short-term and long-term subsequent comprehensive care and support.
MeSH term(s)	Age Factors ; Aged ; Cardiovascular Diseases/etiology ; Circadian Rhythm ; Decision Trees ; Exercise ; Fasting ; Humans ; Obesity/complications ; Obesity/therapy ; Quality of Life ; Weight Loss
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgab359
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metabolically Healthy Obesity Is a Misnomer: Components of the Metabolic Syndrome Linearly Increase with BMI as a Function of Age and Gender

Marcus, Yonit / Segev, Elad / Sheffer, Gabriel / Eilam, David / Shenkerman, Galina / Buch, Assaf / Shenhar-Tsarfaty, Shani / Zeltser, David / Shapira, Itzhak / Berliner, Shlomo / Rogowski, Ori

Biology (Basel). 2023 May 15, v. 12, no. 5

2023

Abstract: Objectives: We aimed to examine the relationships between body mass index (BMI) and metabolic syndrome (MS) components as a function of age and gender across weight categories. Methods: This cross-sectional study included 19,328 subjects who participated ...

Abstract	Objectives: We aimed to examine the relationships between body mass index (BMI) and metabolic syndrome (MS) components as a function of age and gender across weight categories. Methods: This cross-sectional study included 19,328 subjects who participated in a health-screening program. We analyzed 14,093 apparently healthy subjects with a BMI ≥ 18.5 kg/m² (ranging from 18.5 to 46 kg/m²). Results: At a BMI of 18.5 kg/m², 16% of subjects had one or more MS components (MS ≥ 1). The number of MS components increased linearly with BMI. The most prevalent components for MS1-4 were hypertension (in men) and increased waist circumference (in women). Among 6391 non-obese subjects with MS = 0, there was a linear increase in blood pressure, glucose, and triglycerides, as well as a decline in high-density lipoprotein cholesterol, as BMI increased. In 2087 subjects with a BMI ≥ 30 kg/m², a true normometabolic state (MS = 0) was observed in only 7.5%, declining to less than 1% at a BMI ≥ 36 kg/m² (ATP criteria). Women were metabolically protected relative to men between the ages of 30 and 50 years. Conclusions: (A) MS components increase linearly with BMI from the lowest normal BMI and continue to increase with age and BMI; (B) metabolically healthy obesity is rare in subjects with a high BMI and declines with age; (C) hypertension is the most common component in men; and (D) in women, MS components are seen at older ages than in men for the same BMI. Metabolic health declines with age and BMI in nearly all subjects with obesity.
Keywords	blood pressure ; body mass index ; cross-sectional studies ; gender ; glucose ; high density lipoprotein cholesterol ; hypertension ; metabolic syndrome ; obesity ; waist circumference
Language	English
Dates of publication	2023-0515
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12050719
Database	NAL-Catalogue (AGRICOLA)

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Article: Metabolically Healthy Obesity Is a Misnomer: Components of the Metabolic Syndrome Linearly Increase with BMI as a Function of Age and Gender.

Marcus, Yonit / Segev, Elad / Shefer, Gabi / Eilam, David / Shenkerman, Galina / Buch, Assaf / Shenhar-Tsarfaty, Shani / Zeltser, David / Shapira, Itzhak / Berliner, Shlomo / Rogowski, Ori

Biology

2023 Volume 12, Issue 5

Abstract: Objectives: We aimed to examine the relationships between body mass index (BMI) and metabolic syndrome (MS) components as a function of age and gender across weight categories.: Methods: This cross-sectional study included 19,328 subjects who ... ...

Abstract	Objectives: We aimed to examine the relationships between body mass index (BMI) and metabolic syndrome (MS) components as a function of age and gender across weight categories. Methods: This cross-sectional study included 19,328 subjects who participated in a health-screening program. We analyzed 14,093 apparently healthy subjects with a BMI ≥ 18.5 kg/m Results: At a BMI of 18.5 kg/m Conclusions: (A) MS components increase linearly with BMI from the lowest normal BMI and continue to increase with age and BMI; (B) metabolically healthy obesity is rare in subjects with a high BMI and declines with age; (C) hypertension is the most common component in men; and (D) in women, MS components are seen at older ages than in men for the same BMI. Metabolic health declines with age and BMI in nearly all subjects with obesity.
Language	English
Publishing date	2023-05-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12050719
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 24-h Potassium Excretion Is Associated with Components of the Metabolic Syndrome: Results from a National Survey Based on Urine Collection in Adults.

Buch, Assaf / Goldsmith, Rebecca / Nitsan, Lesley / Margaliot, Miri / Shefer, Gabi / Marcus, Yonit / Stern, Naftali

Nutrients

2021 Volume 13, Issue 8

Abstract: A balanced diet and weight loss are the first lines of treatment for the prevention of metabolic syndrome (MS). Dietary strategies may include changing the composition of macronutrients, adopting a particular dietary pattern as a Mediterranean diet. ... ...

Abstract	A balanced diet and weight loss are the first lines of treatment for the prevention of metabolic syndrome (MS). Dietary strategies may include changing the composition of macronutrients, adopting a particular dietary pattern as a Mediterranean diet. However, the role of micronutrients, particularly potassium, in the propensity for or treatment of the syndrome is unclear. The study aimed to examine the relationship between the presence of the MS and its risk factors and the 24-h potassium excretion as the most valid proxy for dietary intake. The analyses were performed as part of the national survey estimating sodium and other electrolytes excretion conducted between 2014-2016 in Israel. The survey included urine collection, anthropometric and blood pressure measurements, and a comprehensive medical questionnaire that included details on the intake of medications that may affect electrolyte secretion. A model was constructed to evaluate the probability for the MS. MS score and its probability were examined in relation to potassium excretion at different levels and in stratification to sex. A total of 581 participants were included in the analysis. The mean potassium excretion was 2818 ± 1417 mg. The prevalence of the MS was 18.5% among participants with above-average potassium excretion and about 10.4% among participants with lower-than-average excretion (
MeSH term(s)	Adult ; Anthropometry ; Blood Pressure ; Cardiometabolic Risk Factors ; Diet/adverse effects ; Electrolytes/urine ; Female ; Humans ; Israel ; Male ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/etiology ; Nutrition Assessment ; Potassium/urine ; Prevalence ; Risk Assessment/methods ; Sodium/urine ; Urine Specimen Collection
Chemical Substances	Electrolytes ; Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2021-08-03
Publishing country	Switzerland
Document type	Evaluation Study ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13082689
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: 24-h Potassium Excretion Is Associated with Components of the Metabolic Syndrome: Results from a National Survey Based on Urine Collection in Adults

Buch, Assaf / Goldsmith, Rebecca / Nitsan, Lesley / Margaliot, Miri / Shefer, Gabi / Marcus, Yonit / Stern, Naftali

Nutrients. 2021 Aug. 03, v. 13, no. 8

2021

Abstract	A balanced diet and weight loss are the first lines of treatment for the prevention of metabolic syndrome (MS). Dietary strategies may include changing the composition of macronutrients, adopting a particular dietary pattern as a Mediterranean diet. However, the role of micronutrients, particularly potassium, in the propensity for or treatment of the syndrome is unclear. The study aimed to examine the relationship between the presence of the MS and its risk factors and the 24-h potassium excretion as the most valid proxy for dietary intake. The analyses were performed as part of the national survey estimating sodium and other electrolytes excretion conducted between 2014–2016 in Israel. The survey included urine collection, anthropometric and blood pressure measurements, and a comprehensive medical questionnaire that included details on the intake of medications that may affect electrolyte secretion. A model was constructed to evaluate the probability for the MS. MS score and its probability were examined in relation to potassium excretion at different levels and in stratification to sex. A total of 581 participants were included in the analysis. The mean potassium excretion was 2818 ± 1417 mg. The prevalence of the MS was 18.5% among participants with above-average potassium excretion and about 10.4% among participants with lower-than-average excretion (p = 0.007). A dose–response relationship was observed between MS score and potassium: the higher the score, the lower was the excretion of potassium. Potassium excretion, rather than sodium excretion, correlated with all components of the MS and even predicted MS independently from other variables. This is the first study based on a national survey showing that potassium consumption, as represented by daily excretion in urine, is inversely related to the presence of MS components after adjustment for several leading variables and careful exclusion of participants taking drugs which may interfere in potassium excretion.
Keywords	Mediterranean diet ; blood pressure ; dose response ; eating habits ; electrolytes ; excretion ; food intake ; metabolic syndrome ; models ; national surveys ; potassium ; questionnaires ; secretion ; sodium ; urine ; weight loss ; Israel
Language	English
Dates of publication	2021-0803
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13082689
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The role of caloric intake in the association of high salt intake with high blood pressure.

Stern, Naftali / Buch, Assaf / Goldsmith, Rebecca / Nitsan, Lesley / Margaliot, Miri / Endevelt, Ronit / Marcus, Yonit / Shefer, Gabi / Grotto, Itamar

Scientific reports

2021 Volume 11, Issue 1, Page(s) 15803

Abstract: Since current recommendations call for a substantial reduction in overall sodium consumption, we tested whether or not these recommendations are implemented in common large subpopulations such as those with abnormal weight or hypertension in the current ... ...

Abstract	Since current recommendations call for a substantial reduction in overall sodium consumption, we tested whether or not these recommendations are implemented in common large subpopulations such as those with abnormal weight or hypertension in the current high sodium, high-calorie nutritional environment. In a national representative cross-sectional survey of the community-dwelling subjects aged 25-65 years conducted in Israel between 2015 and 2017, 582 randomly selected subjects completed health and dietary questionnaires, underwent blood pressure and anthropometric measurements and collected 24-h urine specimens, to assess dietary sodium intake. Overall mean 24-h sodium excretion was 3834 mg, more than double the recommended upper intake for adults < 1500 mg/day. Sodium excretion was directly related to caloric intake and blood pressure and linked to the presence of hypertension and overweight/obesity. The highest sodium excretion was seen in overweight/obese hypertensive subjects. This recent national survey shows a high consumption of sodium in the Israeli population and a dose-response association between caloric intake and urinary sodium excretion, independent of BMI and hypertension. Nevertheless, overweight/obese subjects with hypertension consume (excrete) more sodium than other BMI/ blood pressure-related phenotypes and may thus comprise a target subpopulation for future efforts to reduce sodium intake.
MeSH term(s)	Adult ; Aged ; Blood Pressure ; Cross-Sectional Studies ; Energy Intake/physiology ; Feeding Behavior ; Female ; Humans ; Hypertension/etiology ; Hypertension/physiopathology ; Hypertension/prevention & control ; Hypertension/urine ; Independent Living ; Israel ; Male ; Middle Aged ; Obesity/etiology ; Obesity/urine ; Overweight/etiology ; Overweight/urine ; Sodium/urine ; Sodium Chloride, Dietary/administration & dosage ; Sodium Chloride, Dietary/adverse effects ; Surveys and Questionnaires ; Time Factors
Chemical Substances	Sodium Chloride, Dietary ; Sodium (9NEZ333N27)
Language	English
Publishing date	2021-08-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-95216-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dysregulated cellular functions and cell stress pathways provide critical cues for activating and targeting natural killer cells to transformed and infected cells.

Raulet, David H / Marcus, Assaf / Coscoy, Laurent

Immunological reviews

2017 Volume 280, Issue 1, Page(s) 93–101

Abstract: Natural killer (NK) cells recognize and kill cancer cells and infected cells by engaging cell surface ligands that are induced preferentially or exclusively on these cells. These ligands are recognized by activating receptors on NK cells, such as NKG2D. ... ...

Abstract	Natural killer (NK) cells recognize and kill cancer cells and infected cells by engaging cell surface ligands that are induced preferentially or exclusively on these cells. These ligands are recognized by activating receptors on NK cells, such as NKG2D. In addition to activation by cell surface ligands, the acquisition of optimal effector activity by NK cells is driven in vivo by cytokines and other signals. This review addresses a developing theme in NK cell biology: that NK-activating ligands on cells, and the provision of cytokines and other signals that drive high effector function in NK cells, are driven by abnormalities that arise from transformation or the infected state. The pathways include genomic damage, which causes self DNA to be exposed in the cytosol of affected cells, where it activates the DNA sensor cGAS. The resulting signaling induces NKG2D ligands and also mobilizes NK cell activation. Other key pathways that regulate NKG2D ligands include PI-3 kinase activation, histone acetylation, and the integrated stress response. This review summarizes the roles of these pathways and their relevance in both viral infections and cancer.
MeSH term(s)	Animals ; Cytotoxicity, Immunologic ; DNA Damage ; Humans ; Immunologic Surveillance ; Infections/immunology ; Killer Cells, Natural/immunology ; Lymphocyte Activation ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Neoplasms/immunology ; Nucleotidyltransferases/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction
Chemical Substances	NK Cell Lectin-Like Receptor Subfamily K ; Nucleotidyltransferases (EC 2.7.7.-) ; cGAS protein, human (EC 2.7.7.-)
Language	English
Publishing date	2017-10-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	391796-4
ISSN	1600-065X ; 0105-2896
ISSN (online)	1600-065X
ISSN	0105-2896
DOI	10.1111/imr.12600
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of caloric intake in the association of high salt intake with high blood pressure

Naftali Stern / Assaf Buch / Rebecca Goldsmith / Lesley Nitsan / Miri Margaliot / Ronit Endevelt / Yonit Marcus / Gabi Shefer / Itamar Grotto

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 13

Abstract: Abstract Since current recommendations call for a substantial reduction in overall sodium consumption, we tested whether or not these recommendations are implemented in common large subpopulations such as those with abnormal weight or hypertension in the ...

Abstract	Abstract Since current recommendations call for a substantial reduction in overall sodium consumption, we tested whether or not these recommendations are implemented in common large subpopulations such as those with abnormal weight or hypertension in the current high sodium, high-calorie nutritional environment. In a national representative cross-sectional survey of the community-dwelling subjects aged 25–65 years conducted in Israel between 2015 and 2017, 582 randomly selected subjects completed health and dietary questionnaires, underwent blood pressure and anthropometric measurements and collected 24-h urine specimens, to assess dietary sodium intake. Overall mean 24-h sodium excretion was 3834 mg, more than double the recommended upper intake for adults < 1500 mg/day. Sodium excretion was directly related to caloric intake and blood pressure and linked to the presence of hypertension and overweight/obesity. The highest sodium excretion was seen in overweight/obese hypertensive subjects. This recent national survey shows a high consumption of sodium in the Israeli population and a dose–response association between caloric intake and urinary sodium excretion, independent of BMI and hypertension. Nevertheless, overweight/obese subjects with hypertension consume (excrete) more sodium than other BMI/ blood pressure-related phenotypes and may thus comprise a target subpopulation for future efforts to reduce sodium intake.
Keywords	Medicine ; R ; Science ; Q
Subject code	333
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A simple and effective method for differentiating GFP and YFP by flow cytometry using the violet laser.

Marcus, Assaf / Raulet, David H

Cytometry. Part A : the journal of the International Society for Analytical Cytology

2013 Volume 83, Issue 11, Page(s) 973–974

MeSH term(s)	Animals ; Bacterial Proteins/isolation & purification ; Flow Cytometry/methods ; Green Fluorescent Proteins/isolation & purification ; Killer Cells, Natural/cytology ; Killer Cells, Natural/metabolism ; Lasers ; Luminescent Proteins/isolation & purification ; Mice
Chemical Substances	Bacterial Proteins ; Luminescent Proteins ; yellow fluorescent protein, Bacteria ; Green Fluorescent Proteins (147336-22-9)
Language	English
Publishing date	2013-09-10
Publishing country	United States
Document type	Letter
ZDB-ID	2099868-5
ISSN	1552-4930 ; 0196-4763 ; 1552-4922
ISSN (online)	1552-4930
ISSN	0196-4763 ; 1552-4922
DOI	10.1002/cyto.a.22347
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