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Article ; Online: Discussion: Health Care Value in Plastic Surgery Practice.

Bailey, Chad M / Goldman, Joshua J

2024 Volume 153, Issue 5, Page(s) 1184–1185

MeSH term(s)	Humans ; Surgery, Plastic ; Plastic Surgery Procedures/methods ; Plastic Surgery Procedures/economics ; Health Care Costs ; United States
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000010982
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Uk I Zs.142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 293: Show issues

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Article ; Online: Remyelination in the Central Nervous System.

Franklin, Robin J M / Bodini, Benedetta / Goldman, Steven A

Cold Spring Harbor perspectives in biology

2024 Volume 16, Issue 3

Abstract: The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, while this is largely true of the neuronal elements of the adult mammalian CNS, save for ... ...

Abstract	The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, while this is largely true of the neuronal elements of the adult mammalian CNS, save for discrete populations of granule neurons, the same is not true of its glial elements. In particular, the loss of oligodendrocytes, which results in demyelination, triggers a spontaneous and often highly efficient regenerative response, remyelination, in which new oligodendrocytes are generated and myelin sheaths are restored to denuded axons. Yet remyelination in humans is not without limitation, and a variety of demyelinating conditions are associated with sustained and disabling myelin loss. In this work, we will (1) review the biology of remyelination, including the cells and signals involved; (2) describe when remyelination occurs and when and why it fails, including the consequences of its failure; and (3) discuss approaches for therapeutically enhancing remyelination in demyelinating diseases of both children and adults, both by stimulating endogenous oligodendrocyte progenitor cells and by transplanting these cells into demyelinated brain.
MeSH term(s)	Animals ; Adult ; Child ; Humans ; Remyelination/physiology ; Demyelinating Diseases ; Nerve Regeneration/physiology ; Myelin Sheath/physiology ; Central Nervous System ; Mammals
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1943-0264
ISSN (online)	1943-0264
DOI	10.1101/cshperspect.a041371
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Article: Chromosome-level changes and genome elimination by manipulation of

Meyer, Chandler M / Goldman, Irwin L / Krysan, Patrick J

Frontiers in plant science

2023 Volume 14, Page(s) 1294551

Abstract: Hybrid cultivars are valuable in many crop species due to their high yield, uniformity, and other desirable traits. Doubled haploids, which have two identical sets of chromosomes, are valuable for hybrid breeding because they can be produced in one ... ...

Abstract	Hybrid cultivars are valuable in many crop species due to their high yield, uniformity, and other desirable traits. Doubled haploids, which have two identical sets of chromosomes, are valuable for hybrid breeding because they can be produced in one generation, in comparison to the multigenerational process typically used to produce inbred parents for hybrid production. One method to produce haploid plants is manipulation of centromeric histone H3 (
Language	English
Publishing date	2023-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1294551
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Article ; Online: New plasma LC-MS/MS assays for the quantitation of beta-amyloid peptides and identification of apolipoprotein E proteoforms for Alzheimer's disease risk assessment.

Weber, Darren M / Kim, Jueun C / Goldman, Scott M / Clarke, Nigel J / Racke, Michael K

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

2024 , Page(s) 10815589241246537

Abstract: Early detection of Alzheimer's disease (AD) represents an unmet clinical need. Beta-amyloid (Aβ) plays an important role in AD pathology, and the Aβ42/40 peptide ratio is a good indicator for amyloid deposition. In addition, variants of the ... ...

Abstract	Early detection of Alzheimer's disease (AD) represents an unmet clinical need. Beta-amyloid (Aβ) plays an important role in AD pathology, and the Aβ42/40 peptide ratio is a good indicator for amyloid deposition. In addition, variants of the apolipoprotein E (
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1217870-6
ISSN	1708-8267 ; 0009-9279 ; 1081-5589
ISSN (online)	1708-8267
ISSN	0009-9279 ; 1081-5589
DOI	10.1177/10815589241246537
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Article ; Online: Plant-based and Early Time-restricted Eating for Prevention and Treatment of Type 2 Diabetes in Adults: A Narrative Review.

Goldman, David M / Warbeck, Cassandra B / Waterfall, Thomas J / Sud, Adam / Quarshie, Michael / Craddock, Joel C

Canadian journal of diabetes

2024

Abstract: Type 2 diabetes (T2D) is a significant public health challenge for which effective lifestyle interventions are needed. A growing body of evidence supports the use of both plant-based eating patterns and early time-restricted eating (eTRE) for the ... ...

Abstract	Type 2 diabetes (T2D) is a significant public health challenge for which effective lifestyle interventions are needed. A growing body of evidence supports the use of both plant-based eating patterns and early time-restricted eating (eTRE) for the prevention and treatment of T2D, but research has not yet explored the potential of these dietary strategies in combination. In this narrative review we assessed the evidence by which plant-based diets, in conjunction with eTRE, could support T2D care. The electronic databases MEDLINE and the Web of Science were searched for relevant articles published throughout the last decade. Observational research has shown that healthy plant-based eating patterns and eTRE are associated with reductions in T2D risk. Interventional trials demonstrated that plant-based diets promote improvements in glycated hemoglobin, insulin resistance, glycemic control, and cardiometabolic risk factors. These changes may be mediated, in part, by reductions in oxidative stress, dietary acid load, and hepatocellular and intramyocellular lipids. The eTRE strategies were also shown to improve insulin resistance and glycemic control, and mechanisms of action included enhanced regulation of circadian rhythm and increased metabolic flexibility. Integrating these dietary strategies may produce additive benefits, mediated by reduced visceral adiposity and beneficial shifts in gut microbiota composition. However, potential barriers to concurrent implementation of these interventions may exist, including social challenges, scheduling constraints, and tolerance. Prospective trials are needed to examine their acceptability and clinical effects.
Language	English
Publishing date	2024-03-19
Publishing country	Canada
Document type	Journal Article ; Review
ISSN	2352-3840
ISSN (online)	2352-3840
DOI	10.1016/j.jcjd.2024.03.002
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Article ; Online: Pain in alcohol use disorder: Evaluating effects of childhood trauma, perceived stress, and psychological comorbidity.

Schwandt, M L / Ramchandani, V A / Upadhyay, J / Ramsden, C / Diazgranados, N / Goldman, D

Alcohol (Fayetteville, N.Y.)

2024 Volume 117, Page(s) 43–54

Abstract: The relationship between pain and alcohol use disorder (AUD) is complex and bidirectional. The current study examines risk factors for pain in a large comprehensively phenotyped sample including individuals from across the spectrum of alcohol use and ... ...

Abstract	The relationship between pain and alcohol use disorder (AUD) is complex and bidirectional. The current study examines risk factors for pain in a large comprehensively phenotyped sample including individuals from across the spectrum of alcohol use and misuse. Participants (n = 1101) were drawn from the National Institute on Alcohol Abuse and Alcoholism Natural History Protocol and included treatment-seeking AUD inpatients (AUD+Tx, n = 369), individuals with AUD not seeking treatment (AUD+, n = 161), and individuals without AUD (AUD-, n = 571). General linear models were utilized to test the effects of AUD status, history of childhood trauma exposure, perceived stress, and psychological comorbidity on daily percent time in pain, as well as change in daily percent time in pain across the inpatient stay in AUD+Tx individuals. Overall, 60.2% individuals reported any pain, with a significantly higher prevalence in the AUD+Tx group (82.1%) compared to the AUD+ (56.5%) and AUD- (47.1%) groups. Daily percent time in pain was also highest in the AUD+Tx group (30.2%) and was further increased in those with a history of childhood abuse and comorbid posttraumatic stress disorder (PTSD). Years of heavy drinking and craving were also associated with increased percent time in pain in the AUD+Tx group. Percent time in pain decreased following acute withdrawal in the AUD+Tx group but plateaued around 25% just prior to discharge. Individuals seeking inpatient treatment for AUD, especially those with a history of childhood trauma and/or comorbid PTSD, report greater percent time in pain compared to those not seeking treatment and those without AUD. The prolonged experience of pain in abstinent AUD inpatients after the resolution of acute withdrawal may signal the early stages of protracted withdrawal. Integrative treatments targeting pain and other symptoms of protracted withdrawal may be effective in improving overall function in people with severe AUD.
MeSH term(s)	Humans ; Female ; Male ; Alcoholism/epidemiology ; Alcoholism/psychology ; Adult ; Comorbidity ; Middle Aged ; Stress, Psychological/epidemiology ; Stress, Psychological/psychology ; Pain/psychology ; Pain/epidemiology ; Adverse Childhood Experiences/psychology ; Risk Factors
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605912-0
ISSN	1873-6823 ; 0741-8329
ISSN (online)	1873-6823
ISSN	0741-8329
DOI	10.1016/j.alcohol.2024.03.013
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Zs.A 2011: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Incidental deep venous thrombosis diagnosed on lower extremity computed tomography is a rare but clinically impactful finding.

Barros, Peter A L / Castro, Daniel J / Goldman, Roger E / Kwong, Mimmie

Journal of vascular surgery. Venous and lymphatic disorders

2024 Volume 12, Issue 3, Page(s) 101858

Abstract: Background: In the setting of a known thrombotic event, computed tomography (CT) studies provide reasonable sensitivity for the diagnosis of deep venous thrombosis (DVT). However, the incidence and accuracy of a DVT diagnosis on CT studies not targeted ... ...

Abstract	Background: In the setting of a known thrombotic event, computed tomography (CT) studies provide reasonable sensitivity for the diagnosis of deep venous thrombosis (DVT). However, the incidence and accuracy of a DVT diagnosis on CT studies not targeted for the detection of DVT are not well described. In addition, the clinical impact of DVTs incidentally identified on CT is unknown. Methods: In this single-institution retrospective study, we queried all contrasted CT studies of the lower extremities performed over a 10-year period. Regular expressions applied to the radiology reports associated with the CT studies identified studies with positive findings associated with DVT. These selected reports were then manually reviewed to confirm the presence of a DVT. Patient demographics and relevant medical and surgical history were obtained through a chart review. Follow-up information was obtained for 1 year after the incident CT and included treatment course, additional imaging, and adverse events. An incidental DVT was one identified in a patient in whom the DVT was not noted in a prior study and for whom the study indication did not include concern for DVT or pulmonary embolism. Results: Of 16,637 lower extremity contrasted CT studies queried, 37 study reports identified a DVT. However, only 13 patients had a finding of an incidental DVT (10-year incidence of 0.08%). Among these 13 patients, 11 underwent additional imaging, including 9 who had a subsequent venous duplex and 2 who had subsequent CT studies. Among those with a subsequent duplex, DVT was not identified in eight cases, whereas in one case, DVT was confirmed. Among those with subsequent CT studies, DVT was not identified in one case and was confirmed in one case. Of the 13 patients with incidental DVTs, 3 were initiated on anticoagulation based on their initial CT findings alone. Among these, two did not experience any complications from their DVT or anticoagulation regimen. One did experience major bleeding complications, requiring additional procedures. Conclusions: Incidental DVTs are a rare finding in lower extremity CT studies, noted to occur in only 0.08% of studies. Most patients with incidental DVTs receive additional imaging, with negative findings in 80% of cases. This study identified that 23% of patients were initiated on anticoagulation due to the CT findings, with a 33% rate of significant complications. Currently, a CT venogram is not recommended as a first-line modality for the diagnosis of DVT. However, there is no guidance regarding the need for repeat imaging in patients with incidentally diagnosed lower extremity DVTs identified on CT. Additional study is needed to provide evidence for guideline development.
MeSH term(s)	Humans ; Retrospective Studies ; Risk Factors ; Ultrasonography, Doppler, Duplex/adverse effects ; Venous Thrombosis/etiology ; Pulmonary Embolism/etiology ; Lower Extremity ; Tomography, X-Ray Computed ; Anticoagulants/therapeutic use ; Tomography/adverse effects
Chemical Substances	Anticoagulants
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ISSN	2213-3348
ISSN (online)	2213-3348
DOI	10.1016/j.jvsv.2024.101858
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lewis Structures and the Bonding Classification of End-on Bridging Dinitrogen Transition Metal Complexes.

Hasanayn, Faraj / Holland, Patrick L / Goldman, Alan S / Miller, Alexander J M

Journal of the American Chemical Society

2023 Volume 145, Issue 8, Page(s) 4326–4342

Abstract: The activation of dinitrogen by coordination to transition metal ions is a widely used and promising approach to the utilization of Earth's most abundant nitrogen source for chemical synthesis. End-on bridging ... ...

Abstract	The activation of dinitrogen by coordination to transition metal ions is a widely used and promising approach to the utilization of Earth's most abundant nitrogen source for chemical synthesis. End-on bridging N
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c12243
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Z 7.3: Show issues

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Article ; Online: Clinical Evaluation of the Knee Arthritis Patient.

Duffaut, Calvin J / Goldman, Joshua / Miller, Emily M

Techniques in vascular and interventional radiology

2022 Volume 26, Issue 1, Page(s) 100876

Abstract: The evaluation of a patient with knee osteoarthritis (OA) has 3 main components: clinical history, physical examination, and radiographic imaging. The clinician should assess for inciting and aggravating factors for the knee pain as well as for the ... ...

Abstract	The evaluation of a patient with knee osteoarthritis (OA) has 3 main components: clinical history, physical examination, and radiographic imaging. The clinician should assess for inciting and aggravating factors for the knee pain as well as for the presence of any mechanical symptoms. A history of prior knee injury or surgery can suggest the development of early osteoarthritis. A thorough physical examination of the knee should be performed. Some features of OA include limited range of motion, crepitus in the patellofemoral compartment, and joint line tenderness. Depending on the severity of OA varus or valgus alignment can develop. Special tests such as the McMurray for meniscal tears may cause increased pain as patients with OA will often have degenerative meniscal tears. Weight bearing radiographs can confirm the diagnosis of OA. Several scales exist to grade the severity of OA with the Kellgren-Lawrence being one that is often used. Radiographic features of OA include joint space narrowing, osteophytes, sclerosis of bone and bone end deformities. If after the above evaluation the diagnosis is still unclear, advanced imaging or laboratory testing can be performed to evaluate for alternative diagnoses.
MeSH term(s)	Humans ; Knee Joint/diagnostic imaging ; Osteoarthritis, Knee/diagnostic imaging ; Radiography ; Pain/etiology
Language	English
Publishing date	2022-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2170922-1
ISSN	1557-9808 ; 1089-2516
ISSN (online)	1557-9808
ISSN	1089-2516
DOI	10.1016/j.tvir.2022.100876
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Zs.A 6023: Show issues

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Article ; Online: Developing 3D models using photogrammetry for virtual reality training in anatomy.

Krause, Kayla J / Mullins, Drew D / Kist, Madison N / Goldman, Evan M

Anatomical sciences education

2023 Volume 16, Issue 6, Page(s) 1033–1040

Abstract: Virtual reality (VR) is an increasingly available resource with numerous applications to medical education, and as a teaching tool has been widely validated in the literature. Photogrammetry, the process of overlapping two-dimensional (2D) photographic ... ...

Abstract	Virtual reality (VR) is an increasingly available resource with numerous applications to medical education, and as a teaching tool has been widely validated in the literature. Photogrammetry, the process of overlapping two-dimensional (2D) photographic images of three-dimensional (3D) objects to create a 3D image or "model," can be used in conjunction with VR to create pedagogically sound learning modules for anatomy education. However, to date, there has not been a detailed description of the process of developing and implementing an in-house VR tool to supplement anatomy instruction. In this article, we examine the methods, benefits, and challenges of using photogrammetry to implement a VR classroom that capitalizes on the strengths of a traditional body donor-based course and the unique strengths of VR. Using off-the-shelf equipment, developing VR content and a VR curriculum is both feasible and approachable for medical educators.
MeSH term(s)	Anatomy/education ; Virtual Reality ; Learning ; Curriculum ; Photogrammetry
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483491-9
ISSN	1935-9780 ; 1935-9772
ISSN (online)	1935-9780
ISSN	1935-9772
DOI	10.1002/ase.2301
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