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  1. Book: Emerging Modalities in Mitigation of Antimicrobial Resistance

    Akhtar, Nadeem / Goyal, Dinesh / Prerna / Singh, Kumar Siddharth

    2022  

    Author's details Nadeem Akhtar, PhD, Department of Animal Biosciences, University of Guelph, Ontario N1G 2W1, Canada. Email: nadeembiotech@gmail.com. Dr. Nadeem Akhtar, Ph.D., currently works at the University of Guelph, Canada as a Research Associate. His current research focuses on biotechnology in animal nutrition, where the main objective is to improve animals' health for a better and disease-free lifestyle. Before the Research Associate role, he has worked as a Post-doctoral Researcher in the Department of Chemical Engineering, University of Waterloo, Canada (2019-2020), and in the Department of Animal Biosciences, University of Guelph, Canada (2015-2019). Dr. Akhtar was awarded a Ph.D. from the Department of Biotechnology, Thapar University, India. He has qualified National Eligibility test (NET-2010) and Graduate Aptitude Test (GATE) in Life Sciences (2010) and Biotechnology (2011). His scientific contributions include more than 22 articles in peer-reviewed international journals, 10 book cha
    Keywords Bacteriophage ; Nanotherapeutics ; MicrobialCommunity ; high-throughputsequencing ; ArtificialIntelligence ; microbialstewardship ; Novelmitigationtechnologies ; RapidDetection ; surveillance ; Multidrugresistance ; nanoparticle ; Microbial community ; High-throughput sequencing ; artificial intelligence ; microbial stewardship ; Novel mitigation technologies ; Rapid detection ; Surveillance ; Multidrug resistance ; Nanoparticle
    Language English
    Size 592 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_13
    Format 160 x 241 x 38
    ISBN 9783030841256 ; 3030841251
    Database PDA

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  2. Article ; Online: Positioning therapies for the management of inflammatory bowel disease.

    Singh, Siddharth

    Nature reviews. Gastroenterology & hepatology

    2023  Volume 20, Issue 7, Page(s) 411–412

    MeSH term(s) Humans ; Inflammatory Bowel Diseases/therapy
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-023-00744-9
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  3. Article ; Online: Evidence Synthesis to Advance Clinical Practice and Scientific Research: A CGH Pillar.

    Singh, Siddharth

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  

    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2023.02.018
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  4. Article: Network Meta-Analyses in Inflammatory Bowel Disease.

    Singh, Siddharth

    Gastroenterology & hepatology

    2021  Volume 16, Issue 6, Page(s) 315–318

    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
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  5. Article ; Online: Reply.

    Singh, Siddharth

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2020  Volume 19, Issue 10, Page(s) 2221

    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2020.11.036
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  6. Article ; Online: Quantifying Endoscopic Activity in Ulcerative Colitis: Innovation, Powered by Artificial Intelligence.

    Lee, Han Hee / Singh, Siddharth

    Gastroenterology

    2023  Volume 166, Issue 1, Page(s) 25–26

    MeSH term(s) Humans ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/therapy ; Artificial Intelligence ; Colonoscopy ; Severity of Illness Index
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.10.025
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  7. Article ; Online: Effect of twisting of intravitreal injections on ocular bio-mechanics: a novel insight to ocular surgery.

    Siddharth, Ashish / Bhandari, Ajay / Singh, Sarthak S / Udai, Arun Dayal

    Biomechanics and modeling in mechanobiology

    2024  

    Abstract: Although intravitreal (IVT) injections provide several advantages in treating posterior segment eye diseases, several associated challenges remain. The current study uses the finite element method (FEM) to highlight the effect of IVT needle rotation ... ...

    Abstract Although intravitreal (IVT) injections provide several advantages in treating posterior segment eye diseases, several associated challenges remain. The current study uses the finite element method (FEM) to highlight the effect of IVT needle rotation along the insertion axis on the reaction forces and deformation inside the eye. A comparison of the reaction forces at the eye's key locations has been made with and without rotation. In addition, a sensitivity analysis of various parameters, such as the needle's angular speed, insertion location, angle, gauge, shape, and intraocular pressure (IOP), has been carried out to delineate the individual parameter's effect on reaction forces during rotation. Results demonstrate that twisting the needle significantly reduces the reaction forces at the penetration location and throughout the needle travel length, resulting in quicker penetration. Moreover, ocular biomechanics are influenced by needle insertion location, angle, shape, size, and IOP. The reaction forces incurred by the patient may be reduced by using a bevel needle of the higher gauge when inserted close to the normal of the local scleral surface toward the orra serrata within the Pars Plana region. Results obtained from the current study can deepen the understanding of the twisting needle's interaction with the ocular tissue.
    Language English
    Publishing date 2024-02-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093052-5
    ISSN 1617-7940 ; 1617-7959
    ISSN (online) 1617-7940
    ISSN 1617-7959
    DOI 10.1007/s10237-024-01819-5
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  8. Article ; Online: Reply.

    Zamani, Mohammad / Mattay, Shivani Shah / Singh, Siddharth / Deepak, Parakkal

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2024  

    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Letter
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2024.01.025
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  9. Article ; Online: COVID-19 genome surveillance: A geographical landscape and mutational mapping of SARS-CoV-2 variants in central India over two years.

    Khairnar, Krishna / Tomar, Siddharth Singh

    Virus research

    2024  Volume 344, Page(s) 199365

    Abstract: Reading the viral genome through whole genome sequencing (WGS) enables the detection of changes in the viral genome. The rapid changes in the SARS-CoV-2 viral genome may cause immune escape leading to an increase in the pathogenicity or infectivity. ... ...

    Abstract Reading the viral genome through whole genome sequencing (WGS) enables the detection of changes in the viral genome. The rapid changes in the SARS-CoV-2 viral genome may cause immune escape leading to an increase in the pathogenicity or infectivity. Monitoring mutations through genomic surveillance helps understand the amino acid changes resulting from the mutation. These amino acid changes, especially in the spike glycoprotein, may have implications on the pathogenicity of the virus by rendering it immune-escape. The region of Vidarbha in Maharashtra represents 31.6 % of the state's total area. It holds 21.3 % of the total population. In total, 7457 SARS-CoV-2 positive samples belonging to 16 Indian States were included in the study, out of which 3002 samples passed the sequencing quality control criteria. The metadata of 7457 SARS-CoV-2 positive samples included in the study was sourced from the Integrated Health Information Platform (IHIP). The metadata of 3002 sequenced samples, including the FASTA sequence, was submitted to the Global Initiative on Sharing Avian Influenza Data (GISAID) and the Indian biological data centre (IBDC). This study identified 104 different SARS-CoV-2 pango-lineages classified into 19 clades. We have also analysed the mutation profiles of the variants found in the study, which showed eight mutations of interest, including L18F, K417N, K417T, L452R, S477N, N501Y, P681H, P681R, and mutation of concern E484K in the spike glycoprotein region. The study was from November 2020 to December 2022, making this study the most comprehensive genomic surveillance of SARS-CoV-2 conducted for the region.
    MeSH term(s) India/epidemiology ; SARS-CoV-2/genetics ; SARS-CoV-2/classification ; SARS-CoV-2/isolation & purification ; COVID-19/virology ; COVID-19/epidemiology ; Humans ; Genome, Viral ; Mutation ; Whole Genome Sequencing ; Spike Glycoprotein, Coronavirus/genetics ; Phylogeny ; Female ; Male ; Adult ; Middle Aged ; Aged ; Adolescent ; Child
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2024.199365
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  10. Article ; Online: To Combine or Not to Combine: Do We Need Concomitant Immunomodulators When Using Non-TNF-Targeting Biologics?

    Singh, Siddharth / Hou, Jason K

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  Volume 21, Issue 11, Page(s) 2743–2745

    MeSH term(s) Humans ; Biological Products/therapeutic use ; Immunologic Factors/therapeutic use ; Antibodies, Monoclonal ; Tumor Necrosis Factor-alpha
    Chemical Substances Biological Products ; Immunologic Factors ; Antibodies, Monoclonal ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2023.01.041
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