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Article ; Online: Response to: 'A response to Singh. "Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?"' by Valiyil and Schechter.

Singh, Jasvinder A

2017 Volume 77, Issue 7, Page(s) e42

MeSH term(s)	Allopurinol ; Double-Blind Method ; Gout ; Humans ; Standard of Care ; Thioglycolates ; Triazoles
Chemical Substances	Thioglycolates ; Triazoles ; lesinurad (09ERP08I3W) ; Allopurinol (63CZ7GJN5I)
Language	English
Publishing date	2017-09-28
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2017-212330
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Article ; Online: Does the money matter? Disparities in total joint replacement outcomes by income.

Singh, Jasvinder A

Osteoarthritis and cartilage

2023 Volume 32, Issue 2, Page(s) 121–123

MeSH term(s)	Arthroplasty, Replacement ; Income
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Editorial
ZDB-ID	1167809-4
ISSN	1522-9653 ; 1063-4584
ISSN (online)	1522-9653
ISSN	1063-4584
DOI	10.1016/j.joca.2023.11.001
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Article ; Online: The Emerging Safety Profile of JAK Inhibitors in Rheumatic Diseases.

Singh, Jasvinder A

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

2023 Volume 37, Issue 5, Page(s) 625–635

Abstract: Janus kinase inhibitor (JAKi) medications are small-molecule drugs that affect intracellular signal transduction. They are highly effective oral medications that have been approved for the treatment of various rheumatic diseases, with rheumatoid ... ...

Abstract	Janus kinase inhibitor (JAKi) medications are small-molecule drugs that affect intracellular signal transduction. They are highly effective oral medications that have been approved for the treatment of various rheumatic diseases, with rheumatoid arthritis being a key example of an autoimmune rheumatic disease. JAKi are oral-route medications that are alternatives to injectable biologic therapies, launched in the late 1990s. While most safety concerns with JAKi are similar to the biologics, there are many differences. New data on comparative safety of JAKi versus tumor necrosis factor inhibitors (TNFi) were recently published that led to new black box warnings by the US Food and Drug Administration (FDA) about cardiovascular and cancer risks and a label change for JAKi. This review summarizes the current published data with regards to the safety of JAKi, focused on rheumatic diseases. Specifically, any risk differences between agents or across different indications are discussed, as well as the risk factors for these adverse outcomes.
MeSH term(s)	Humans ; Janus Kinase Inhibitors/adverse effects ; Rheumatic Diseases/drug therapy ; Rheumatic Diseases/chemically induced ; Arthritis, Rheumatoid/drug therapy ; Biological Products/therapeutic use ; Administration, Oral ; Antirheumatic Agents/adverse effects
Chemical Substances	Janus Kinase Inhibitors ; Biological Products ; Antirheumatic Agents
Language	English
Publishing date	2023-06-23
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	1364202-9
ISSN	1179-190X ; 1173-8804
ISSN (online)	1179-190X
ISSN	1173-8804
DOI	10.1007/s40259-023-00612-7
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Article ; Online: Making the current non-surgical treatments for knee osteoarthritis more effective: Solutions from a diverse patient group.

Singh, Jasvinder A

Joint bone spine

2023 Volume 90, Issue 3, Page(s) 105535

Abstract: Objective: To examine patient perceived solutions to barriers to effective non-surgical knee osteoarthritis (OA) treatments in a diverse racial/ethnic group.: Methods: Nominal groups were conducted with consecutive patients with knee OA at a medical ... ...

Abstract	Objective: To examine patient perceived solutions to barriers to effective non-surgical knee osteoarthritis (OA) treatments in a diverse racial/ethnic group. Methods: Nominal groups were conducted with consecutive patients with knee OA at a medical center clinic, oversampling for African Americans with knee OA. Participants discussed potential solutions and rank-ordered their concerns. Results: Thirteen nominal groups with 46 knee OA patients were conducted with mean age, 60.8 years (standard deviation [sd], 10.0) and knee OA duration, 8.1 years (sd, 5.4); 22% were men, and 56% were African American. The following solutions were in the top three ranked solutions in 13 NGTs: (A) more research, effective and/or safer new medications/treatments, and joint cartilage restoration (8 groups; 15% votes [43/276]); (B) early diagnosis (2 groups; 7% votes [20/276]); (C) better and more effective communication (5 groups; 10% votes [29/276]); (D) public and patient education (4 groups; 8% votes [22/276]); (E) motivation and behavioral modification (4 groups; 9% votes [26/276]); (F) team approach (1 group; 1% votes [2/276]); (G) personalized medicine (6 groups; 8% votes [24/276]); (H) cheaper and more affordable medications and treatments (3 groups; 5% votes [15/276]). Conclusions: A diverse group of participants with knee OA identified several solutions to barriers to the effectiveness of current knee OA treatments. This new knowledge can inform the development and implementation of future interventions to improve the outcomes of people with knee OA.
MeSH term(s)	Male ; Humans ; Middle Aged ; Female ; Osteoarthritis, Knee/diagnosis ; Osteoarthritis, Knee/therapy ; Exercise Therapy ; Treatment Outcome
Language	English
Publishing date	2023-01-25
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2023.105535
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Article ; Online: Disease modification in gout: a qualitative study of gout expert rheumatologists.

Singh, Jasvinder A

Rheumatology advances in practice

2022 Volume 6, Issue 1, Page(s) rkab107

Abstract: Objective: The aim was to examine the views of health-care providers regarding disease modification in gout, with the potential to derive a provisional set of domains for disease modification in gout.: Methods: A qualitative nominal group study was ... ...

Abstract	Objective: The aim was to examine the views of health-care providers regarding disease modification in gout, with the potential to derive a provisional set of domains for disease modification in gout. Methods: A qualitative nominal group study was performed with 20 gout experts (15 expert/expert panel members of the 2012 and/or 2020 ACR gout guidelines and/or 2015 ACR/EULAR gout classification criteria) about what constitutes disease modification in gout: 'What sorts of things do you think constitute a change in the course of disease in gout? (positive); what are all the ways in which gout as a disease can be modified?' Results: Decrease in gout flares was rated number one rank in all six nominal groups as indicative of disease modification in gout, followed by serum urate lowering, which was rated number one rank in one of the six nominal groups (tied score with flares in one nominal group). Other components of gout disease modification were to improve quality of life/productivity; restore function; reduce/eliminate pain; reduce tophi burden; and joint preservation or resolution of joint damage. Potential additional components that were not ranked in the top three votes within each nominal group were: decreasing health-care cost/utilization; reducing cardiovascular/renal morbidity/mortality; and stopping formation of urate crystals. Conclusion: This qualitative study provides a provisional set of domains for disease modification in gout. Future studies for the development of thresholds for disease modification domains and wider consensus on this definition are needed.
Language	English
Publishing date	2022-01-03
Publishing country	England
Document type	Journal Article
ISSN	2514-1775
ISSN (online)	2514-1775
DOI	10.1093/rap/rkab107
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Article ; Online: Treatment Guidelines in Rheumatoid Arthritis.

Singh, Jasvinder A

Rheumatic diseases clinics of North America

2022 Volume 48, Issue 3, Page(s) 679–689

Abstract: Rheumatoid arthritis is the most common autoimmune, destructive, inflammatory arthritis in adults. Effective treatments include oral conventional synthetic disease-modifying antirheumatic drugs (DMARDs; eg, methotrexate), injectable biologic DMARDs, and ... ...

Abstract	Rheumatoid arthritis is the most common autoimmune, destructive, inflammatory arthritis in adults. Effective treatments include oral conventional synthetic disease-modifying antirheumatic drugs (DMARDs; eg, methotrexate), injectable biologic DMARDs, and targeted synthetic DMARDs (oral). Key recommendations are to start effective treatment immediately with DMARDs to reduce disability; use effective doses of methotrexate (oral or subcutaneous) with folic acid as the initial treatment; rapidly escalate treatment with various DMARDs, if methotrexate alone is not effective in controlling rheumatoid arthritis; and aim for a treat-to-target strategy with a goal of low disease activity or remission by frequently monitoring disease activity and escalating treatment.
MeSH term(s)	Adult ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Drug Therapy, Combination ; Humans ; Methotrexate/therapeutic use ; Treatment Outcome
Chemical Substances	Antirheumatic Agents ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2022-07-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	92118-x
ISSN	1558-3163 ; 0889-857X
ISSN (online)	1558-3163
ISSN	0889-857X
DOI	10.1016/j.rdc.2022.03.005
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Article ; Online: Risks and Benefits of Janus Kinase Inhibitors in Rheumatoid Arthritis - Past, Present, and Future.

Singh, Jasvinder A

The New England journal of medicine

2022 Volume 386, Issue 4, Page(s) 387–389

MeSH term(s)	Antirheumatic Agents/adverse effects ; Arthritis, Rheumatoid/drug therapy ; Humans ; Janus Kinase Inhibitors/adverse effects ; Risk Assessment
Chemical Substances	Antirheumatic Agents ; Janus Kinase Inhibitors
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMe2117663
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Article ; Online: A comprehensive study on the arterial vasculature of the brain in water buffalo (Bubalus bubalis): Clinical correlates

John, Masuood Ahmad / Rashid, Rakshan / Malik, Abrar A. / Sasan, Jasvinder Singh / Mir, Abdul Qayoom / Choudhury, Abdur Rezzaque / Dar, Firdous Ahmad / Rafiq, Andleeb / Mahdy, Mohamed A. A.

Anatomia, Histologia, Embryologia. 2024 Jan., v. 53, no. 1 p.e12965-

2024

Abstract: The present study was designed to provide a comprehensive analysis of the anatomical aspects of arterial blood vasculature in the water buffalo brains. Fifty cranial cavities of adult water buffaloes were opened via both the dorsal and ventral approaches ...

Abstract	The present study was designed to provide a comprehensive analysis of the anatomical aspects of arterial blood vasculature in the water buffalo brains. Fifty cranial cavities of adult water buffaloes were opened via both the dorsal and ventral approaches and the arteries were exposed and photographed. The buffalo rostral epidural rete mirabile generally resembled that of large ruminants. The oculomotor, abducent and trigeminal nerves were intimately associated with the rostral rete. Similar to the majority of ruminants, the arterial circle of the brain was heart‐shaped in buffalos and presented all collateral blood vessels as mentioned in the previous literature. The study further revealed that the cranial nerve roots were closely related to the arterial circle of the brain and could be used as indicators for differentiating various branches of the arterial circle of the brain. In addition to the usual variations of the arterial circle of the brain, a bihemispheric rostral cerebral artery along with an aplastic rostral cerebral artery were reported for the first time. The deviant behaviour of the rostral cerebral artery forms a baseline to study various clinical conditions of the blood vasculature in the buffalo brain. The rostral choroidal, middle cerebral and the caudal cerebral arteries constantly were emerged as single vessels without any variations. In conclusion, the anatomy of the arterial vasculature of the buffalo brain observed in the present study provided evidence of its morphological resemblance to other species of the Bovini tribe.
Keywords	Bubalus bubalis ; abnormal behavior ; adults ; blood ; brain ; buffaloes ; nerve tissue
Language	English
Dates of publication	2024-01
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	537922-2
ISSN	1439-0264 ; 0340-2096 ; 0044-4294
ISSN (online)	1439-0264
ISSN	0340-2096 ; 0044-4294
DOI	10.1111/ahe.12965
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Prospects of chitinase in sustainable farming and modern biotechnology: an update on recent progress and challenges.

Sharma, Anindita / Arya, Shailendra Kumar / Singh, Jatinder / Kapoor, Bhupinder / Bhatti, Jasvinder Singh / Suttee, Ashish / Singh, Gursharan

Biotechnology & genetic engineering reviews

2023 , Page(s) 1–31

Abstract: Chitinases are multifunctional biocatalysts for the pest control and useful in modern biotechnology and pharmaceutical industries. Chemical-based fungicides and insecticides have caused more severe effects on environment and human health. Many pathogenic ...

Abstract	Chitinases are multifunctional biocatalysts for the pest control and useful in modern biotechnology and pharmaceutical industries. Chemical-based fungicides and insecticides have caused more severe effects on environment and human health. Many pathogenic fungal species and insects became resistant to the chemical pesticides. The resistant fungi emerged as a multidrug resistant also and less susceptible insects are not possible to control adequately. Chitinases have an immense potential to be exploited as a biopesticide against fungi and insects. The direct use of chitinase in liquid formulation or whole microbial enzyme producing cells, both act as antagonistically against the pests. Chitinase can disintegrate the fungal cell wall and insect integument that holds the chitin as a vital structural component. Moreover, chitinase is applied for the synthesis of pharmaceutically important chitooligosaccharides. Chitinase producing microbes have the huge potential to utilize against the waste management of sea food remains like shells of crustaceans. Chitinase is valuable for the synthesis of protoplasts from industrially important fungi, further it act as the biocontrol agent of malaria and dengue fever causing larvae of mosquitoes. Chitinases also have been successfully used in wine and single cell protein producing industries. Present review is illustrating the updated information on the state of the art of different applications of chitinases in agriculture and biotechnology industry. It also bestows the understanding to the readers about the areas of extensively studied and the field where there is still much left to be done.
Language	English
Publishing date	2023-03-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	49457-4
ISSN	2046-5556 ; 0264-8725
ISSN (online)	2046-5556
ISSN	0264-8725
DOI	10.1080/02648725.2023.2183593
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Article ; Online: SToRytelliing to Improve Disease outcomes in Gout (STRIDE-GO) in African American veterans with gout: a trial study protocol.

Singh, Jasvinder A

Trials

2021 Volume 22, Issue 1, Page(s) 879

Abstract: Objective: Medication adherence in gout is suboptimal, and the lack of effective interventions to address it presents a huge challenge. Medication adherence and gout outcomes are worse in racial/ethnic minorities. The objective of this paper was to ... ...

Abstract	Objective: Medication adherence in gout is suboptimal, and the lack of effective interventions to address it presents a huge challenge. Medication adherence and gout outcomes are worse in racial/ethnic minorities. The objective of this paper was to provide the details of the study protocol for randomized, controlled trial (RCT) in African Americans (AAs) with gout that will test the effectiveness of a culturally appropriate gout storytelling intervention. Methods: The SToRytelliing to Improve Disease outcomes in Gout (STRIDE-GO) study will be a 12-month, multicenter, open-label RCT that will assess the effect of a culturally appropriate gout storytelling in at least 300 AA veterans with gout. Participants will be randomized to gout-storytelling intervention vs. a stress reduction video in a 1:1 ratio. The primary outcome is urate-lowering therapy (ULT) adherence measured with MEMSCap™, an electronic monitoring system (efficacy, 6 months; sustenance of efficacy, 12 months). Secondary outcomes include gout flares, serum urate (SU), gout-specific health-related quality of life [HRQOL], self-reported ULT adherence, patient satisfaction with treatment, and patient understanding of the intervention. AA veterans with gout who met the 1977 Preliminary American College of Rheumatology (ACR) classification criteria for gout, currently prescribed an oral ULT medication (allopurinol or febuxostat) for at least 6 months, and not using a pillbox to redistribute their medications, will be invited to an in-person study visit. After the study coordinators obtain informed consent, and ensure that participants meet the inclusion criteria, the eligible participants will be provided with their current ULT in a MEMSCap™ bottle for the 1-month run-in period and asked to return to the clinic in 1 month. ULT adherence with MEMSCap™ will be recorded at a 1-month return visit. Interested participants will complete the baseline assessments, randomized using the computerized system to either gout-storytelling intervention or a stress reduction intervention video arm and watch the respective video in-clinic. Patients will be interviewed on the phone at 2 and 4 months regarding the viewing of the videos at home at each time. Participants will be assessed in-clinic at 3, 6, 9, and 12 months; MEMSCap™ data and patient surveys will be captured at each visit. For any missed visit, assessments will be completed on the phone and MEMSCap™ data captured at the next in-clinic visit. Discussion: The study will assess the efficacy of a behavioral intervention to improve ULT adherence in minority populations with gout. Trial registration: ClinicalTrials.gov NCT02741700. Registered on 14 September 2018.
MeSH term(s)	African Americans ; Ethnic and Racial Minorities ; Gout/diagnosis ; Gout/drug therapy ; Gout Suppressants/adverse effects ; Humans ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic ; United States ; Uric Acid ; Veterans
Chemical Substances	Gout Suppressants ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2021-12-04
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1468-6708
ISSN (online)	1745-6215 ; 1468-6694
ISSN	1468-6708
DOI	10.1186/s13063-021-05847-9
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