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  1. Article: Large conductance voltage-and calcium-activated K

    Echeverría, Felipe / Gonzalez-Sanabria, Naileth / Alvarado-Sanchez, Rosangelina / Fernández, Miguel / Castillo, Karen / Latorre, Ramon

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1373507

    Abstract: Large Conductance Voltage- and Calcium-activated ... ...

    Abstract Large Conductance Voltage- and Calcium-activated K
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1373507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Profile of David Julius and Ardem Patapoutian: 2021 Nobel Laureates in Physiology or Medicine.

    Latorre, Ramon / Díaz-Franulic, Ignacio

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 119, Issue 1

    MeSH term(s) History, 21st Century ; Medicine ; Nobel Prize ; Physiology
    Language English
    Publishing date 2021-12-30
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2121015119
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Ion channel thermodynamics studied with temperature jumps measured at the cell membrane.

    Bassetto, Carlos A Z / Pinto, Bernardo I / Latorre, Ramon / Bezanilla, Francisco

    Biophysical journal

    2023  Volume 122, Issue 4, Page(s) 661–671

    Abstract: Perturbing the temperature of a system modifies its energy landscape, thus providing a ubiquitous tool to understand biological processes. Here, we developed a framework to generate sudden temperature jumps (Tjumps) and sustained temperature steps ( ... ...

    Abstract Perturbing the temperature of a system modifies its energy landscape, thus providing a ubiquitous tool to understand biological processes. Here, we developed a framework to generate sudden temperature jumps (Tjumps) and sustained temperature steps (Tsteps) to study the temperature dependence of membrane proteins under voltage clamp while measuring the membrane temperature. Utilizing the melanin under the Xenopus laevis oocytes membrane as a photothermal transducer, we achieved short Tjumps up to 9°C in less than 1.5 ms and constant Tsteps for durations up to 150 ms. We followed the temperature at the membrane with sub-ms time resolution by measuring the time course of membrane capacitance, which is linearly related to temperature. We applied Tjumps in Kir1.1 isoform b, which reveals a highly temperature-sensitive blockage relief, and characterized the effects of Tsteps on the temperature-sensitive channels TRPM8 and TRPV1. These newly developed approaches provide a general tool to study membrane protein thermodynamics.
    MeSH term(s) Animals ; Temperature ; Membrane Potentials ; Ion Channels/metabolism ; Cell Membrane/metabolism ; Thermodynamics ; Xenopus laevis/metabolism ; Oocytes/metabolism
    Chemical Substances Ion Channels
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2023.01.015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 235: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 2: Show issues

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  4. Article: Colour Stability, Fatty Acid Profile, and Lipid Oxidation in Meat Stored in Modified Atmosphere Packaging from Light Lambs Fed with Concentrate with Carob Pulp (

    Bottegal, Diego Nicolas / Lobón, Sandra / Latorre, María Ángeles / Bertolín, Juan Ramón / Álvarez-Rodríguez, Javier

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: There is a growing interest in using by-products rich in polyphenols, such as carob pulp (Cp, ...

    Abstract There is a growing interest in using by-products rich in polyphenols, such as carob pulp (Cp,
    Language English
    Publishing date 2023-07-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12081482
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  5. Article ; Online: Ca

    Ancatén-González, Carlos / Segura, Ignacio / Alvarado-Sánchez, Rosangelina / Chávez, Andrés E / Latorre, Ramon

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: BK channels are large conductance potassium channels characterized by four pore-forming α subunits, often co-assembled with auxiliary β and γ subunits to regulate ... ...

    Abstract BK channels are large conductance potassium channels characterized by four pore-forming α subunits, often co-assembled with auxiliary β and γ subunits to regulate Ca
    MeSH term(s) Humans ; Large-Conductance Calcium-Activated Potassium Channels/genetics ; Genes, vif ; Neurons/metabolism ; Cell Membrane/metabolism ; Epilepsy/genetics ; Calcium/metabolism
    Chemical Substances Large-Conductance Calcium-Activated Potassium Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043407
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  6. Book: Ionic channels in cells and model systems

    Latorre, Ramón

    (Series of the Centro de Estudios Cientificos de Santiago)

    1986  

    Author's details ed. by Ramon Latorre
    Series title Series of the Centro de Estudios Cientificos de Santiago
    Keywords Ion Channels ; Ionenkanal ; Zelle ; Biologisches System
    Language English
    Size XXIII, 437 S. : zahlr. graph. Darst.
    Publisher Plenum Pr
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT002914027
    ISBN 0-306-42194-1 ; 978-0-306-42194-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1987 A 1112 order for loan Magazin

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  7. Article: Machine learning combining multi-omics data and network algorithms identifies adrenocortical carcinoma prognostic biomarkers.

    Martin-Hernandez, Roberto / Espeso-Gil, Sergio / Domingo, Clara / Latorre, Pablo / Hervas, Sergi / Hernandez Mora, Jose Ramon / Kotelnikova, Ekaterina

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1258902

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-11-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1258902
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  8. Article: The Membrane Cholesterol Modulates the Interaction Between 17-βEstradiol and the BK Channel.

    Granados, Sara T / Latorre, Ramon / Torres, Yolima P

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 687360

    Abstract: BK channels are composed by the pore forming α subunit and, in some tissues, is associated with different accessory β subunits. These proteins modify the biophysical properties of the channel, amplifying the range of BK channel activation according to ... ...

    Abstract BK channels are composed by the pore forming α subunit and, in some tissues, is associated with different accessory β subunits. These proteins modify the biophysical properties of the channel, amplifying the range of BK channel activation according to the physiological context. In the vascular cells, the pore forming BKα subunit is expressed with the β1 subunit, where they play an essential role in the modulation of arterial tone and blood pressure. In eukaryotes, cholesterol is a structural lipid of the cellular membrane. Changes in the ratio of cholesterol content in the plasma membrane (PM) regulates the BK channel activation altering its open probability, and hence, vascular contraction. It has been shown that the estrogen 17β-Estradiol (E2) causes a vasodilator effect in vascular cells, inducing a leftward shift in the V
    Language English
    Publishing date 2021-06-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.687360
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  9. Article ; Online: Colour Stability, Fatty Acid Profile, and Lipid Oxidation in Meat Stored in Modified Atmosphere Packaging from Light Lambs Fed with Concentrate with Carob Pulp (Ceratonia siliqua L.)

    Bottegal, Diego Nicolas / Lobón, Sandra / Latorre, María Ángeles / Bertolín, Juan Ramón / Álvarez-Rodríguez, Javier

    Antioxidants. 2023 July 25, v. 12, no. 8

    2023  

    Abstract: There is a growing interest in using by-products rich in polyphenols, such as carob pulp (Cp, Ceratonia siliqua L.), as a dietary source of antioxidants for animals. This study assesses the effects of including Cp in lambs’ diet and meat display time (0, ...

    Abstract There is a growing interest in using by-products rich in polyphenols, such as carob pulp (Cp, Ceratonia siliqua L.), as a dietary source of antioxidants for animals. This study assesses the effects of including Cp in lambs’ diet and meat display time (0, 7, 9, and 11 days) in modified atmosphere packaging on meat colour, fatty acid (FA) composition, tocopherol levels, and lipid oxidation values in the Semimembranosus muscle of 40 light lambs. The lambs were fed with concentrates supplemented with increasing Cp levels (0, 150, and 300 g/kg) for 45 days before slaughter. Metmyoglobin (MMb) and malondialdehyde (MDA) contents increased linearly with display time (p < 0.05), regardless of diet (p > 0.05). At 11 days of display, MMb (28 ± 0.8%) and MDA (0.6 ± 0.1 mg MDA/kg of meat) contents remained within the acceptable limits. The α-tocopherol content was lower in the 30% Cp group and meat (p < 0.05). Total saturated and monounsaturated FA contents (934 ± 64 and 823 ± 65 mg/100 g of meat, respectively) did not differ significantly among the groups. However, the meat from lambs fed with 30% Cp showed reduced levels of branched-chain FAs, while polyunsaturated FAs increased (p < 0.05) compared to the control lambs. The inclusion of Cp in the lamb’s diet, up to 30%, did not lead to meat deterioration and improved certain quality parameters, including a healthier FA profile. These findings highlight Cp’s potential as an alternative antioxidant source in animal diets.
    Keywords Ceratonia siliqua ; alpha-tocopherol ; animals ; antioxidants ; carob ; color ; diet ; fatty acid composition ; lipid peroxidation ; malondialdehyde ; meat ; monounsaturated fatty acids ; polyphenols ; polyunsaturated fatty acids ; pulp ; semimembranosus muscle ; slaughter
    Language English
    Dates of publication 2023-0725
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12081482
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer.

    Manzano, Ramon Gonzalez / Catalan-Latorre, Ana / Brugarolas, Antonio

    BMC cancer

    2021  Volume 21, Issue 1, Page(s) 432

    Abstract: Background: Muscle invasive urothelial bladder carcinoma (MIBC) present RB1 and TP53 somatic alterations in a variable percentage of tumors throughout all molecular subtypes. MIBCs with neuroendocrine features have a high response rate to immunity ... ...

    Abstract Background: Muscle invasive urothelial bladder carcinoma (MIBC) present RB1 and TP53 somatic alterations in a variable percentage of tumors throughout all molecular subtypes. MIBCs with neuroendocrine features have a high response rate to immunity checkpoint inhibitors (ICIs). Whether the presence of somatic co-alterations in these 2 genes in MIBCs is relevant to their responsiveness to ICIs is not known.
    Methods: The potential correlation of different genomic biomarkers of response to ICIs like tumor mutational burden (TMB), single nucleotide variants (SNV) predicted neoantigens, DNA damage response (DDR) genes, DNA somatic signatures and TILs infiltrate was explored in patients with somatic co-alterations in RB1 and TP53 (RB1&TP53) as compared with patients with no alterations in any (double wild type, DWT) or with alterations in just one of the 2 genes. The Cancer Genome Atlas (TCGA) pancancer BLCA dataset of cystectomy specimens (n = 407) with mutation, copy number alterations and transcriptomic (RNA sequencing) data as well as the IMVigor 210 study (n = 348) of metastatic urothelial bladder cancers treated with atezolizumab (PD-L1 inhibitor) with clinical response data containing transcriptomic (RNA sequencing), along with a subset (n = 274) with mutation and copy number data were used for this purpose. A novel tumor microenvironment metascore (TMM) was developed based in a LASSO regularized Cox model with predictive and prognostic ability.
    Results: Samples with co-altered RB1&TP53: a) were enriched in immunity effectors (CD8 cytotoxic lymphocytes, NK cells) and display higher scores of a T cell inflamed signature; b) have a higher TMB, higher number of SNV predicted neoantigens and higher TILs fractions; c) have a higher number of DDR mutated and deep deleted DDR genes; d) have DNA somatic signatures 2 and 13 related to APOBEC mutagenesis. Using the IMVigor 210 dataset, RB1&TP53 samples had the highest response rate to atezolizumab and a strong correlation with TMB and TMM. The consensus molecular subtype classification in the IMVigor 210 dataset showed a significant correlation with both the response to treatment (p = 0.001, Chisquare) and the presence of RB1 and TP53 genomic alterations (p < 0.001, Chisquare).
    Conclusions: RB1&TP53 co-alterations are strongly associated with genomic biomarkers of response to ICIs in MIBCs.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor ; DNA Damage ; Female ; Genomics/methods ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Mutation ; Neoplasm Staging ; Polymorphism, Single Nucleotide ; Prognosis ; Proportional Hazards Models ; Retinoblastoma Binding Proteins/genetics ; Retinoblastoma Binding Proteins/metabolism ; Treatment Outcome ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/etiology ; Urinary Bladder Neoplasms/mortality
    Chemical Substances Biomarkers, Tumor ; Immune Checkpoint Inhibitors ; RB1 protein, human ; Retinoblastoma Binding Proteins ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Journal Article
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-021-08078-y
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