Article: Almotriptan: a review of pharmacology, clinical efficacy, and tolerability.
The American journal of managed care
2002 Volume 8, Issue 3 Suppl, Page(s) S74–9
Abstract: Objective: This article summarizes preclinical and clinical data for almotriptan.: Methods: Almotriptan has been evaluated in more than 3,500 acute migraine patients in phase 2 and 3 double-blind, randomized trials and in 1,500 patients in long-term ... ...
| Abstract | Objective: This article summarizes preclinical and clinical data for almotriptan. Methods: Almotriptan has been evaluated in more than 3,500 acute migraine patients in phase 2 and 3 double-blind, randomized trials and in 1,500 patients in long-term open-label trials. Results: Controlled clinical trials show that almotriptan 12.5 mg is significantly more effective than placebo. These results are observed across different endpoints examined, including pain relief at 2 hours, pain-free outcome at 2 hours, recurrence rate, use of escape medication, and sustained pain-free outcome. The onset of pain relief is observed as early as 30 minutes after administration. Results from a multiple-attack study show that almotriptan maintains a consistency of response across 3 attacks, and results from long-term studies confirm that patients continue to respond to almotriptan for up to 1 year. Results from 2 comparative studies show that almotriptan 12.5 mg has comparable efficacy to sumatriptan 50 or 100 mg, but almotriptan has a superior tolerability profile. Early use of almotriptan results in a higher proportion of patients achieving pain relief or complete freedom from pain. Conclusions: Because almotriptan has a tolerability profile comparable to that of placebo, it may be more acceptable for early administration. The incidence of treatment-related adverse events with almotriptan is comparable to that of placebo and significantly lower than recorded with sumatriptan. In addition, almotriptan has a low incidence of chest symptoms, an adverse event associated with triptan use. Because of its comparable efficacy and superior tolerability profile, almotriptan offers a potential improvement over existing triptans for the treatment of acute migraine. |
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| MeSH term(s) | Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Double-Blind Method ; Humans ; Indoles/adverse effects ; Indoles/pharmacology ; Indoles/therapeutic use ; Migraine Disorders/drug therapy ; Randomized Controlled Trials as Topic ; Serotonin Receptor Agonists/adverse effects ; Serotonin Receptor Agonists/pharmacology ; Serotonin Receptor Agonists/therapeutic use ; Tryptamines ; United States | ||||||||||
| Chemical Substances | Indoles ; Serotonin Receptor Agonists ; Tryptamines ; almotriptan (1O4XL5SN61) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2002-02 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Review | ||||||||||
| ZDB-ID | 2035781-3 | ||||||||||
| ISSN | 1936-2692 ; 1088-0224 ; 1096-1860 | ||||||||||
| ISSN (online) | 1936-2692 | ||||||||||
| ISSN | 1088-0224 ; 1096-1860 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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