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  1. Article ; Online: Alogliptin benzoate for the treatment of type 2 diabetes.

    Rendell, Marc / Drincic, Andjela / Andukuri, Radha

    Expert opinion on pharmacotherapy

    2012  Volume 13, Issue 4, Page(s) 553–563

    Abstract: Introduction: Alogliptin is a highly selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). It is one of several agents of this class now available for treatment of type 2 diabetes.: Areas covered: This review is based upon a PubMed search ...

    Abstract Introduction: Alogliptin is a highly selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). It is one of several agents of this class now available for treatment of type 2 diabetes.
    Areas covered: This review is based upon a PubMed search and personal experience with alogliptin. The pharmacokinetics and pharmacodynamics of alogliptin are reviewed. The glucose-lowering effect of this agent is discussed as monotherapy and in combination with metformin, sulfonylurea, piogilitazone and insulin. The potential adverse effects of alogliptin are summarized. Alogliptin is compared with the other available DPP-4 inhibitors.
    Expert opinion: Alogliptin is an additional choice in the group of DPP-4 inhibitors. As a group, these agents have a relatively modest glucose-lowering effect, inferior to that of metformin, sulfonylureas, and insulin. They do not have the benefit of weight loss offered by the glucagon-like polypeptide (GLP)-1 agonists. The primary use of DPP-4 inhibitors is in combination with other hypoglycemic agents, mainly metformin. Their principal advantage is a low incidence of hypoglycemia, making these agents desirable in patients such as the elderly and those with cardiac disease. A greater use of alogliptin and other DPP-4 inhibitors will occur if long-term studies show reduced cardiac events or long-term retention of insulin secretory capacity. The Examine Trial, a large study of alogliptin in coronary disease patients, is now underway and could provide important supportive data.
    MeSH term(s) Animals ; Blood Glucose/drug effects ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Humans ; Piperidines/pharmacokinetics ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Randomized Controlled Trials as Topic ; Uracil/analogs & derivatives ; Uracil/pharmacokinetics ; Uracil/pharmacology ; Uracil/therapeutic use
    Chemical Substances Blood Glucose ; Dipeptidyl-Peptidase IV Inhibitors ; Piperidines ; Uracil (56HH86ZVCT) ; alogliptin (JHC049LO86)
    Language English
    Publishing date 2012-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1517/14656566.2012.656088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Alogliptin: a new addition to the class of DPP-4 inhibitors.

    Andukuri, Radha / Drincic, Andjela / Rendell, Marc

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2009  Volume 2, Page(s) 117–126

    Abstract: Background: Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Inhibition of DPP-4 elevates levels of the incretin hormones glucagon-like peptide (GLP-1) and glucose-dependent ... ...

    Abstract Background: Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Inhibition of DPP-4 elevates levels of the incretin hormones glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) by preventing their degradation.
    Objective: To review the evolution of alogliptin and its pharmacokinetics, pharmacodynamics, clinical efficacy and adverse effects. In addition, we compared alogliptin to other DPP-4 inhibitors.
    Methods: A comprehensive literature search was performed using the term 'alogliptin'. Original research articles and review articles as well as scientific abstracts were included.
    Results: Alogliptin raises postprandial levels of GLP-1. It has excellent bioavailability exhibiting a median T(max) ranging from 1 to 2 hours and a mean half-life of 12.4 to 21.4 hours across all doses. When given as monotherapy, mean hemoglobin A(1c) (HbA(1c)) reductions achieved were 0.5% to 0.6%. Combination therapy yielded similar reductions (-0.5% with metformin, -0.6% with glyburide, -0.8% with pioglitazone and -0.6% with insulin). Administration of alogliptin does not promote weight loss but has not resulted in weight gain. The agent is relatively well tolerated with few adverse effects, the major finding being a marginally higher rate of skin events, primarily pruritus.
    Conclusions: Alogliptin causes significant reductions in HbA(1c) when used alone or in combination with other oral agents in patients with type 2 diabetes similar to other DPP-4 inhibitors in current clinical use. The side effect profile also does not differ from that of other DPP-4 inhibitors. However, long-term studies are necessary before the place of alogliptin in the management of type 2 diabetes can be established.
    Language English
    Publishing date 2009-07-21
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Alogliptin

    Radha Andukuri / Andjela Drincic / Marc Rendell

    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2009, Iss default, Pp 117-

    a new addition to the class of DPP-4 inhibitors

    2009  Volume 126

    Abstract: Radha Andukuri, Andjela Drincic, Marc RendellDivision of Endocrinology, Department of Medicine ...

    Abstract Radha Andukuri, Andjela Drincic, Marc RendellDivision of Endocrinology, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska, USABackground: Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Inhibition of DPP-4 elevates levels of the incretin hormones glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) by preventing their degradation.Objective: To review the evolution of alogliptin and its pharmacokinetics, pharmacodynamics, clinical efficacy and adverse effects. In addition, we compared alogliptin to other DPP-4 inhibitors.Methods: A comprehensive literature search was performed using the term ‘alogliptin’. Original research articles and review articles as well as scientific abstracts were included. Results: Alogliptin raises postprandial levels of GLP-1. It has excellent bioavailability exhibiting a median Tmax ranging from 1 to 2 hours and a mean half-life of 12.4 to 21.4 hours across all doses. When given as monotherapy, mean hemoglobin A1c (HbA1c) reductions achieved were 0.5% to 0.6%. Combination therapy yielded similar reductions (−0.5% with metformin, −0.6% with glyburide, −0.8% with pioglitazone and –0.6% with insulin). Administration of alogliptin does not promote weight loss but has not resulted in weight gain. The agent is relatively well tolerated with few adverse effects, the major finding being a marginally higher rate of skin events, primarily pruritus.Conclusions: Alogliptin causes significant reductions in HbA1c when used alone or in combination with other oral agents in patients with type 2 diabetes similar to other DPP-4 inhibitors in current clinical use. The side effect profile also does not differ from that of other DPP-4 inhibitors. However, long-term studies are necessary before the place of alogliptin in the management of type 2 diabetes can be established.Keywords: alogliptin, DPP-4 inhibitors, GLP-1, vildagliptin, sitagliptin, saxagliptin
    Keywords Specialties of internal medicine ; RC581-951
    Language English
    Publishing date 2009-07-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: 25-Hydroxyvitamin D response to cholecalciferol supplementation in hemodialysis.

    Armas, Laura A G / Andukuri, Radha / Barger-Lux, Janet / Heaney, Robert P / Lund, Richard

    Clinical journal of the American Society of Nephrology : CJASN

    2012  Volume 7, Issue 9, Page(s) 1428–1434

    Abstract: Background and objectives: Recent understanding of extrarenal production of calcitriol has led to the exploration of native vitamin D treatment in dialysis patients. This paper reports the pharmacokinetics of 25-hydroxyvitamin D response to 10,333 IU ... ...

    Abstract Background and objectives: Recent understanding of extrarenal production of calcitriol has led to the exploration of native vitamin D treatment in dialysis patients. This paper reports the pharmacokinetics of 25-hydroxyvitamin D response to 10,333 IU cholecalciferol given weekly in subjects on chronic dialysis.
    Design, setting, participants, & measurements: This randomized, double-blind, placebo-controlled trial of 15 weeks of oral cholecalciferol in subjects with stage 5 CKD requiring maintenance hemodialysis was conducted from November of 2007 to March of 2010. The time course of serum 25-hydroxyvitamin D was measured over the course of treatment. Additionally, blood was drawn at baseline and last visit for calcium, phosphorus, calcitriol, and parathyroid hormone levels.
    Results: The median (interquartile range) baseline 25-hydroxyvitamin D level was 13.3 (11.1-16.2) ng/ml for the treatment group and 15.2 (10.7-19.9) ng/ml for the placebo group. 25-hydroxyvitamin D steady state levels rose by 23.6 (19.2-29.9) ng/ml in the treatment group, and there was no change in the placebo group. Calcitriol levels also increased significantly in the treatment group. There were no significant changes in levels of calcium, albumin, phosphorus, and parathyroid hormone in either group.
    Conclusions: Cholecalciferol (10,333 IU) given weekly in patients on chronic hemodialysis produces a steady state in 25-hydroxyvitamin D of approximately 24 ng/ml.
    MeSH term(s) Administration, Oral ; Aged ; Biomarkers/blood ; Calcium/blood ; Chi-Square Distribution ; Cholecalciferol/administration & dosage ; Cholecalciferol/blood ; Cholecalciferol/pharmacokinetics ; Dietary Supplements ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/therapy ; Linear Models ; Male ; Middle Aged ; Nebraska ; Parathyroid Hormone/blood ; Phosphorus/blood ; Renal Dialysis/adverse effects ; Treatment Outcome ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/pharmacokinetics ; Vitamins/administration & dosage ; Vitamins/blood ; Vitamins/pharmacokinetics
    Chemical Substances Biomarkers ; PTH protein, human ; Parathyroid Hormone ; Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; Phosphorus (27YLU75U4W) ; 25-hydroxyvitamin D (A288AR3C9H) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2012-07-12
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.12761211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6584: Show issues Location:
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