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  1. Article ; Online: Characterization of Selective M

    Zell, Vivien / Teuns, Greetje / Needham, Alexandra Stormy / Mukherjee, Sruti / Roscoe, Nathaniel / Le, Michelle / Fourgeaud, Lawrence / Woodruff, Grace / Bhattacharya, Anindya / Marella, Mathieu / Bonaventure, Pascal / Drevets, Wayne C / Balana, Bartosz

    The Journal of pharmacology and experimental therapeutics

    2023  Volume 387, Issue 2, Page(s) 226–234

    Abstract: The type-5 muscarinic acetylcholine receptor (mAChR, M ...

    Abstract The type-5 muscarinic acetylcholine receptor (mAChR, M
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.123.001737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: First International M‐Libraries Conference 13th – 14th November 2007

    Gillian Needham

    Evidence Based Library and Information Practice, Vol 2, Iss 3, Pp 132-

    2007  Volume 132

    Keywords Bibliography. Library science. Information resources ; Z
    Language English
    Publishing date 2007-09-01T00:00:00Z
    Publisher University of Alberta
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: First International M-Libraries Conference 13th – 14th November 2007

    Gillian Needham

    Evidence Based Library and Information Practice, Vol 2, Iss

    2007  Volume 3

    Abstract: The Open University (UK) and Athabasca University (Canada) are hosting the very first international conference to focus on the delivery of library services and resources to users via mobile and handheld devices. This event on November 13th and 14th at ... ...

    Abstract The Open University (UK) and Athabasca University (Canada) are hosting the very first international conference to focus on the delivery of library services and resources to users via mobile and handheld devices. This event on November 13th and 14th at the Open University in Milton Keynes will bring together researchers, managers and practitioners from around the world who are interested in extending the value and flexibility of libraries in new and exciting ways. For more details and to register, please visit the website at: http://library.open.ac.uk/mLibraries/.
    Keywords Bibliography. Library science. Information resources ; Z
    Language English
    Publishing date 2007-09-01T00:00:00Z
    Publisher University of Alberta
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Physical rehabilitation while awake, intubated and proned for COVID-19-associated severe acute respiratory distress syndrome.

    Seth, Bhavna / Oakman, Brittany / Needham, Dale M

    BMJ case reports

    2024  Volume 17, Issue 2

    Abstract: This case study demonstrates the implementation of evidence-based guidelines in the intensive care unit setting, including light sedation and early physical rehabilitation while receiving prone positioning and lung protective mechanical ventilation for ... ...

    Abstract This case study demonstrates the implementation of evidence-based guidelines in the intensive care unit setting, including light sedation and early physical rehabilitation while receiving prone positioning and lung protective mechanical ventilation for severe acute respiratory distress syndrome from SARS-CoV-2 infection.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Wakefulness ; Prone Position ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Respiration, Artificial
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-251772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Manchester is Epic too.

    Ashley, M / Needham, R

    British dental journal

    2022  Volume 233, Issue 6, Page(s) 441–442

    Language English
    Publishing date 2022-09-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-022-5044-6
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    Ul III Zs.143: Show issues Location:
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    Zs.MO 447: Show issues

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  6. Article ; Online: Improving management of ARDS: uniting acute management and long-term recovery.

    Latronico, Nicola / Eikermann, M / Ely, E W / Needham, D M

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 58

    Abstract: Acute Respiratory Distress Syndrome (ARDS) is an important global health issue with high in-hospital mortality. Importantly, the impact of ARDS extends beyond the acute phase, with increased mortality and disability for months to years after ... ...

    Abstract Acute Respiratory Distress Syndrome (ARDS) is an important global health issue with high in-hospital mortality. Importantly, the impact of ARDS extends beyond the acute phase, with increased mortality and disability for months to years after hospitalization. These findings underscore the importance of extended follow-up to assess and address the Post-Intensive Care Syndrome (PICS), characterized by persistent impairments in physical, cognitive, and/or mental health status that impair quality of life over the long-term. Persistent muscle weakness is a common physical problem for ARDS survivors, affecting mobility and activities of daily living. Critical illness and related interventions, including prolonged bed rest and overuse of sedatives and neuromuscular blocking agents during mechanical ventilation, are important risk factors for ICU-acquired weakness. Deep sedation also increases the risk of delirium in the ICU, and long-term cognitive impairment. Corticosteroids also may be used during management of ARDS, particularly in the setting of COVID-19. Corticosteroids can be associated with myopathy and muscle weakness, as well as prolonged delirium that increases the risk of long-term cognitive impairment. The optimal duration and dosage of corticosteroids remain uncertain, and there's limited long-term data on their effects on muscle weakness and cognition in ARDS survivors. In addition to physical and cognitive issues, mental health challenges, such as depression, anxiety, and post-traumatic stress disorder, are common in ARDS survivors. Strategies to address these complications emphasize the need for consistent implementation of the evidence-based ABCDEF bundle, which includes daily management of analgesia in concert with early cessation of sedatives, avoidance of benzodiazepines, daily delirium monitoring and management, early mobilization, and incorporation of family at the bedside. In conclusion, ARDS is a complex global health challenge with consequences extending beyond the acute phase. Understanding the links between critical care management and long-term consequences is vital for developing effective therapeutic strategies and improving the quality of life for ARDS survivors.
    MeSH term(s) Humans ; Quality of Life ; Activities of Daily Living ; Hypnotics and Sedatives/therapeutic use ; Delirium/complications ; Muscle Weakness/etiology ; Respiratory Distress Syndrome ; Adrenal Cortex Hormones/therapeutic use ; Intensive Care Units
    Chemical Substances Hypnotics and Sedatives ; Adrenal Cortex Hormones
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-024-04810-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Multimodal, patient-centred symptom control: a strategy to replace sedation in the ICU.

    Eikermann, Matthias / Needham, Dale M / Devlin, John W

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 6, Page(s) 506–509

    MeSH term(s) Humans ; Hypnotics and Sedatives/therapeutic use ; Intensive Care Units ; Respiration, Artificial ; Conscious Sedation ; Critical Care
    Chemical Substances Hypnotics and Sedatives
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00141-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7041: Show issues Location:
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  8. Article ; Online: The client and family experience of attending a nurse-led clinic for chronic wounds.

    Dhar, Anusuya / Needham, Judith / Gibb, Michelle / Coyne, Elisabeth

    Australian journal of primary health

    2023  Volume 30, Issue 1, Page(s) NULL

    Abstract: Background: The quality of life for individuals with chronic wounds is diminished due to poor health-related outcomes and the financial burden of wound care. The literature has shown nurse-led wound care to have a positive impact on wound healing and ... ...

    Abstract Background: The quality of life for individuals with chronic wounds is diminished due to poor health-related outcomes and the financial burden of wound care. The literature has shown nurse-led wound care to have a positive impact on wound healing and psychosocial wellbeing. However, there is minimal research investigating the lived experience of attending a nurse-led clinic for chronic wounds. The purpose of this study was to explore the client and family experience of attending a nurse-led clinic for chronic wounds.
    Methods: Qualitative descriptive study. Semi-structured telephone interviews were transcribed verbatim and thematic analysis was undertaken.
    Results: Twelve clients and two family members participated, and the average length of interviews was 20min. Three main themes emerged: (1) expecting and managing pain; (2) receiving expert advice and reflecting on previous care; and (3) managing the cost of care. There was an emphasis on the impact of chronic wounds on pain and the ability to complete the activities of daily living. Expert advice, client satisfaction and physical accessibility were highlighted as benefits of the clinic. Cost and minimal client education were identified as challenges of the clinic.
    Conclusions: The findings demonstrated that chronic wounds have a significant impact on the client and family attending the nurse-led clinic. Comprehensive pain assessment, improved social support, better client education and cost-effective care is required to optimise the experience for people attending the nurse-led clinic.
    MeSH term(s) Humans ; Practice Patterns, Nurses' ; Quality of Life ; Activities of Daily Living ; Patient Satisfaction ; Qualitative Research ; Pain
    Language English
    Publishing date 2023-11-04
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2566332-X
    ISSN 1836-7399 ; 1448-7527
    ISSN (online) 1836-7399
    ISSN 1448-7527
    DOI 10.1071/PY23081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Long-Term Outcomes after Delirium in the ICU: Addressing Gaps in Our Knowledge.

    Devlin, John W / Needham, Dale M

    American journal of respiratory and critical care medicine

    2021  Volume 204, Issue 4, Page(s) 383–385

    MeSH term(s) Delirium/therapy ; Humans ; Intensive Care Units
    Language English
    Publishing date 2021-07-12
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202104-0910ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh II Zs.80: Show issues Location:
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  10. Article ; Online: Clinical prognostic factors predicting survival of motor neuron disease patients with gastrostomy: A retrospective analysis.

    Yang, Jie / Zhao, Yun / Soares, Mario / Needham, Merrilee / Begley, Andrea / Calton, Emily

    Muscle & nerve

    2024  Volume 69, Issue 4, Page(s) 440–447

    Abstract: ... body mass index <18.5 kg/m: Discussion: Preventing or minimizing weight loss from MND diagnosis and encouraging ...

    Abstract Introduction/aims: Enteral feeding via gastrostomy is a key intervention to prevent significant weight loss in Motor Neuron Disease (MND). The aim of this study was to explore demographic, clinical, and nutritional factors associated with survival time in MND patients with gastrostomy.
    Methods: The retrospective study analyzed 94 MND patients (n = 58 bulbar-onset and n = 36 limb-onset) who underwent gastrostomy between 2015 and 2021. The primary outcome was the survival time from gastrostomy insertion to death. Independent variables of interest explored were: age at gastrostomy insertion, disease onset type, known genetic cause, use of riluzole, non-invasive ventilation (NIV) use, forced vital capacity prior to gastrostomy, weight loss from diagnosis to gastrostomy insertion, and body mass index (BMI) at the time of gastrostomy insertion.
    Results: The median survival time from gastrostomy to death was 357 days (± 29.3, 95%CI: 299.5, 414.5). Kaplan-Meier method and log-rank test revealed patients with lower body mass index <18.5 kg/m
    Discussion: Preventing or minimizing weight loss from MND diagnosis and encouraging NIV use when clinically indicated are modifiable factors that may prolong the survival of MND patients with gastrostomy.
    MeSH term(s) Humans ; Retrospective Studies ; Gastrostomy/methods ; Amyotrophic Lateral Sclerosis/complications ; Prognosis ; Motor Neuron Disease/therapy ; Motor Neuron Disease/complications ; Weight Loss ; Survival Analysis
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.28064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 551: Show issues

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