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Article ; Online: Serial Sampling of the Small Airway Epithelium to Identify Persistent Smoking-dysregulated Genes.

Strulovici-Barel, Yael / Rostami, Mahboubeh R / Kaner, Robert J / Mezey, Jason G / Crystal, Ronald G

American journal of respiratory and critical care medicine

2023 Volume 208, Issue 7, Page(s) 780–790

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Smoking/adverse effects ; Smoking/genetics ; Smoking/metabolism ; Smoking Cessation ; Tobacco Smoking ; Transcriptome ; Epithelium/metabolism ; Tripartite Motif Proteins ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	TRIM16 protein, human (EC 2.3.2.27) ; Tripartite Motif Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202204-0786OC
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Article ; Online: Current role of sentinel lymph node biopsy in early-stage melanoma.

Rivalland, Gareth / Stephens, Rosalie / McCrystal, Michael

The New Zealand medical journal

2022 Volume 135, Issue 1557, Page(s) 97–99

MeSH term(s)	Humans ; Lymph Node Excision ; Lymph Nodes/pathology ; Melanoma/pathology ; New Zealand ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/pathology
Language	English
Publishing date	2022-07-01
Publishing country	New Zealand
Document type	Letter
ZDB-ID	390590-1
ISSN	1175-8716 ; 0028-8446 ; 0110-7704
ISSN (online)	1175-8716
ISSN	0028-8446 ; 0110-7704
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Article ; Online: Phytoplankton optical fingerprint libraries for development of phytoplankton ocean color satellite products.

Lomas, Michael W / Neeley, Aimee R / Vandermeulen, Ryan / Mannino, Antonio / Thomas, Crystal / Novak, Michael G / Freeman, Scott A

Scientific data

2024 Volume 11, Issue 1, Page(s) 168

Abstract: Phytoplankton respond to physical and hydrographic forcing on time and space scales up to and including those relevant to climate change. Quantifying changes in phytoplankton communities over these scales is essential for predicting ocean food resources, ...

Abstract	Phytoplankton respond to physical and hydrographic forcing on time and space scales up to and including those relevant to climate change. Quantifying changes in phytoplankton communities over these scales is essential for predicting ocean food resources, occurrences of harmful algal blooms, and carbon and other elemental cycles, among other predictions. However, one of the best tools for quantifying phytoplankton communities across relevant time and space scales, ocean color sensors, is constrained by its own spectral capabilities and availability of adequately vetted and relevant optical models. To address this later shortcoming, greater than fifty strains of phytoplankton, from a range of taxonomic lineages, geographic locations, and time in culture, alone and in mixtures, were grown to exponential and/or stationary phase for determination of hyperspectral UV-VIS absorption coefficients, multi-angle and multi-spectral backscatter coefficients, volume scattering functions, particle size distributions, pigment content, and fluorescence. The aim of this publication is to share these measurements to expedite their utilization in the development of new optical models for the next generation of ocean color satellites.
MeSH term(s)	Carbon ; Climate Change ; Oceans and Seas ; Phytoplankton
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-024-03001-z
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Article ; Online: Management of Select Adverse Events Following Delandistrogene Moxeparvovec Gene Therapy for Patients With Duchenne Muscular Dystrophy.

Zaidman, Craig M / Goedeker, Natalie L / Aqul, Amal A / Butterfield, Russell J / Connolly, Anne M / Crystal, Ronald G / Godwin, Kara E / Hor, Kan N / Mathews, Katherine D / Proud, Crystal M / Smyth, Elizabeth Kula / Veerapandiyan, Aravindhan / Watkins, Paul B / Mendell, Jerry R

Journal of neuromuscular diseases

2024

Abstract: Background: Duchenne muscular dystrophy (DMD) is a rare, degenerative, recessive X-linked neuromuscular disease. Mutations in the gene encoding dystrophin lead to the absence of functional dystrophin protein. Individuals living with DMD exhibit ... ...

Abstract	Background: Duchenne muscular dystrophy (DMD) is a rare, degenerative, recessive X-linked neuromuscular disease. Mutations in the gene encoding dystrophin lead to the absence of functional dystrophin protein. Individuals living with DMD exhibit progressive muscle weakness resulting in loss of ambulation and limb function, respiratory insufficiency, and cardiomyopathy, with multiorgan involvement. Adeno-associated virus vector-mediated gene therapy designed to enable production of functional dystrophin protein is a new therapeutic strategy. Delandistrogene moxeparvovec (Sarepta Therapeutics, Cambridge, MA) is indicated for treatment of ambulatory pediatric patients aged 4 through 5 years with DMD who have an indicated mutation in the DMD gene. Objective: Evidence-based considerations for management of potential adverse events following gene therapy treatment for DMD are lacking in clinical literature. Our goal was to provide interdisciplinary consensus considerations for selected treatment-related adverse events (TRAEs) (vomiting, acute liver injury, myocarditis, and immune-mediated myositis) that may arise following gene therapy dosing with delandistrogene moxeparvovec. Methods: An interdisciplinary panel of 12 specialists utilized a modified Delphi process to develop consensus considerations for the evaluation and management of TRAEs reported in delandistrogene moxeparvovec clinical studies. Panelists completed 2 Questionnaires prior to gathering for an in-person discussion. Consensus was defined as a majority (≥58% 7/12) of panelists either agreeing or disagreeing. Results: Panelists agreed that the choice of baseline assessments should be informed by individual clinical indications, the treating provider's judgment, and prescribing information. Corticosteroid dosing for treatment of TRAEs should be optimized by considering individual risk versus benefit for each indication. In all cases involving patients with a confirmed TRAE, consultations with appropriate specialists were suggested. Conclusions: The Delphi Panel established consensus considerations for the evaluation and management of potential TRAEs for patients receiving delandistrogene moxeparvovec, including vomiting, acute liver injury, myocarditis, and immune-mediated myositis.
Language	English
Publishing date	2024-04-11
Publishing country	Netherlands
Document type	Journal Article
ISSN	2214-3602
ISSN (online)	2214-3602
DOI	10.3233/JND-230185
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Article ; Online: Working together to understand community health literacy

Crystal Shannon

Cogent Medicine, Vol 4, Iss

2017 Volume 1

Abstract: ... many providers (e.g. nurses) continue to struggle in methods of assessment and improvement. First year ...

Abstract	Health literacy is an important predictor of overall health outcomes. The lack of knowledge, skills, and ability to safety navigate and act on health information impacts a person’s understanding of their health status. Although health care professionals readily acknowledge the impact of low health literacy, many providers (e.g. nurses) continue to struggle in methods of assessment and improvement. First year baccalaureate nursing students worked in collaboration with a local community healthcare center to understand the current level of health literacy of the provider’s service region. The students used a modified version of the Rapid Estimate of Adult Literacy in Medicine (REALM) with a convenience sample of community members (N = 401) and patients seeking health care treatment at a Midwestern facility (N = 210) to evaluate understanding of basic health care terminology. Participants also offered insight into their preferred methods of learning (visual, auditory, read/write, kinesthetic). Results suggest the community and patient population of the facility were significantly impacted by low health literacy and the preferred methods of learning were potentially misaligned with the current approaches for delivering health care support. This paper will present the community-based collaborative process for assessment and offer recommendations for improved continued delivery of care.
Keywords	health literacy ; nursing students ; nurses ; health collaboration ; Medicine ; R
Subject code	302 ; 360
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
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Article ; Online: Systematic Review of Kangaroo Care Duration's Impact in Neonatal Intensive Care Units on Infant-Maternal Health.

Clarke-Sather, Abigail R / Compton, Crystal / Roberts, Kari / Brearley, Ann / Wang, Sonya G

American journal of perinatology

2023

Abstract: Kangaroo care (KC), skin-to-skin contact between infants and caregivers, is encouraged in neonatal intensive care units (NICUs) to support health through improved weight, growth, and infant-maternal attachment while reducing the incidence of sepsis and ... ...

Abstract	Kangaroo care (KC), skin-to-skin contact between infants and caregivers, is encouraged in neonatal intensive care units (NICUs) to support health through improved weight, growth, and infant-maternal attachment while reducing the incidence of sepsis and infant pain. However, the optimal duration and frequency of KC to maximize health outcomes is unknown. Given parents' time stressors, identifying optimal KC time is critical. A literature review was undertaken on May 28, 2021 via querying the PubMed database from January 1, 1995, to May 28, 2021, regarding KC and NICUs with 442 results. Eleven studies met the eligibility criteria of (1) comparative KC between infants and adult caregivers in NICUs as a randomized controlled trial, (2) peer-reviewed articles in English, (3) study subjects ≥5, (4) health outcomes, and (5) KC sessions >1. Infant physical growth parameters, infant neurodevelopment, infant stress via salivary cortisol levels, and breastfeeding outcomes appear to increase with KC as compared with standard care (SC) without KC. Improvements were observed with longer KC duration, 2 h/d as compared with 1 h/d, for neurodevelopment and breastfeeding outcomes, but no greater improvement with longer KC duration was shown for reducing infant stress through salivary cortisol levels. Regarding maternal stress, the influence of KC duration showed mixed Parental Stressor Score: NICU scores. Further study on the impact of KC duration and frequency on health outcomes and dose-response relationship would help determine how much and how frequent KC is needed to improve specific health outcomes for infants and their mothers. KEY POINTS: · Data on kangaroo care duration's health impacts is lacking.. · Establishing dose-response for kangaroo care is needed.. · Kangaroo care for longer improves some but not all outcomes..
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/a-2003-3935
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Article: Predicted deleterious variants in the human genome relevant to gene therapy with adeno-associated virus vectors.

Rostami, Mahboubeh R / Leopold, Philip L / Vasquez, Jenifer M / de Mulder Rougvie, Miguel / Al Shakaki, Alya / Hssain, Ali Ait / Robay, Amal / Hackett, Neil R / Mezey, Jason G / Crystal, Ronald G

Molecular therapy. Methods & clinical development

2023 Volume 31, Page(s) 101136

Abstract: Based on the observation that humans have variable responses of gene expression with the same dose of an adeno-associated vector, we hypothesized that there are deleterious variants in genes coding for processes required for adeno-associated virus (AAV)- ... ...

Abstract	Based on the observation that humans have variable responses of gene expression with the same dose of an adeno-associated vector, we hypothesized that there are deleterious variants in genes coding for processes required for adeno-associated virus (AAV)-mediated gene transfer/expression that may hamper or enhance the effectiveness of AAV-mediated gene therapy. To assess this hypothesis, we evaluated 69,442 whole genome sequences from three populations (European, African/African American, and Qatari) for predicted deleterious variants in 62 genes known to play a role in AAV-mediated gene transfer/expression. The analysis identified 5,564 potentially deleterious mutations of which 27 were classified as common based on an allele frequency ≥1% in at least one population studied. Many of these deleterious variants are predicated to prevent while others enhance effective AAV gene transfer/expression, and several are linked to known hereditary disorders. The data support the hypothesis that, like other drugs, human genetic variability contributes to the person-to-person effectiveness of AAV gene therapy and the screening for genetic variability should be considered as part of future clinical trials.
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2872938-9
ISSN	2329-0501 ; 2329-0501
ISSN (online)	2329-0501
ISSN	2329-0501
DOI	10.1016/j.omtm.2023.101136
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Article ; Online: Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart.

Guevara, Amanda / Smith, Charlotte E R / Caldwell, Jessica L / Ngo, Lena / Mott, Lilian R / Lee, I-Ju / Tapa, Srinivas / Wang, Zhen / Wang, Lianguo / Woodward, William R / Ng, G Andre / Habecker, Beth A / Ripplinger, Crystal M

American journal of physiology. Heart and circulatory physiology

2024

Abstract: Nicotine is the primary addictive component in tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. To assess ... ...

Abstract	Nicotine is the primary addictive component in tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. To assess underlying mechanisms, we treated rabbits with transdermal nicotine (NIC, 21 mg/day) or control (CT) patches for 28 days prior to performing dual optical mapping of transmembrane potential (RH237) and intracellular Ca
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00749.2023
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Article ; Online: Psychometric evaluation of the Chinese version of new fear of the coronavirus questionnaire.

Zha, PeiJia / Zhang, Crystal / Qureshi, Rubab / Cai, GuiGui / Huang, LiHong / Liu, Yang

Medicine

2024 Volume 103, Issue 9, Page(s) e37282

Abstract: The fear of COVID-19 significantly impacting the health of people globally. This study translated newly developed measurement tool New Fear of the Coronavirus Questionnaire (New_FCQ) into Chinese language and evaluated the psychometric properties of the ... ...

Abstract	The fear of COVID-19 significantly impacting the health of people globally. This study translated newly developed measurement tool New Fear of the Coronavirus Questionnaire (New_FCQ) into Chinese language and evaluated the psychometric properties of the Chinese version of New_FCQ among Chinese population. A total of 522 participants were included in the study. Internal consistency, construct validity, criterion validity, and concurrent validity of the Chinese version of New_FCQ were assessed in this study. The Chinese version of New_FCQ had excellent internal consistency (α = 0.97) and exploratory factor analysis demonstrated one-dimensional structure of the Chinese version of New_FCQ. The preliminary criterion validity revealed statistically significant differences in the fear of COVID-19 scores based on age and education level (P = .002 and P = .03, respectively). The good concurrent validity also established with the Chinese version Fear of COVID-19 Scale(P < .001). Psychometric proportions of the Chinese version of New_FCQ were established, which exhibited sufficient validity and reliability among Chinese population.
MeSH term(s)	Humans ; Coronavirus ; Psychometrics/methods ; Reproducibility of Results ; Fear ; Surveys and Questionnaires ; Language ; COVID-19
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037282
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Article ; Online: P2Y2 receptor decreases blood pressure by inhibiting ENaC

Antonio G. Soares / Jorge Contreras / Elena Mironova / Crystal R. Archer / James D. Stockand / Tarek Mohamed Abd El-Aziz

JCI Insight, Vol 8, Iss

2023 Volume 14

Abstract: Stimulating the Gq-coupled P2Y2 receptor (P2ry2) lowers blood pressure. Global knockout of P2ry2 increases blood pressure. Vascular and renal mechanisms are believed to participate in P2ry2 effects on blood pressure. To isolate the role of the kidneys in ...

Abstract	Stimulating the Gq-coupled P2Y2 receptor (P2ry2) lowers blood pressure. Global knockout of P2ry2 increases blood pressure. Vascular and renal mechanisms are believed to participate in P2ry2 effects on blood pressure. To isolate the role of the kidneys in P2ry2 effects on blood pressure and to reveal the molecular and cellular mechanisms of this action, we test here the necessity of the P2ry2 and the sufficiency of Gq-dependent signaling in renal principal cells to the regulation of the epithelial Na+ channel (ENaC), sodium excretion, and blood pressure. Activating P2ry2 in littermate controls but not principal cell–specific P2ry2-knockout mice decreased the activity of ENaC in renal tubules. Moreover, deletion of P2ry2 in principal cells abolished increases in sodium excretion in response to stimulation of P2ry2 and compromised the normal ability to excrete a sodium load. Consequently, principal cell–specific knockout of P2ry2 prevented decreases in blood pressure in response to P2ry2 stimulation in the deoxycorticosterone acetate–salt (DOCA-salt) model of hypertension. In wild-type littermate controls, such stimulation decreased blood pressure in this model of hypertension by promoting a natriuresis. Pharmacogenetic activation of Gq exclusively in principal cells using targeted expression of Gq–designer receptors exclusively activated by designer drugs and clozapine N-oxide decreased the activity of ENaC in renal tubules, promoting a natriuresis that lowered elevated blood pressure in the DOCA-salt model of hypertension. These findings demonstrate that the kidneys play a major role in decreasing blood pressure in response to P2ry2 activation and that inhibition of ENaC activity in response to P2ry2-mediated Gq signaling lowered blood pressure by increasing renal sodium excretion.
Keywords	Cell biology ; Nephrology ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	American Society for Clinical investigation
Document type	Article ; Online
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