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  1. Article ; Online: A New Method for Classifying Scenes for Simultaneous Localization and Mapping Using the Boundary Object Function Descriptor on RGB-D Points.

    Lomas-Barrie, Victor / Suarez-Espinoza, Mario / Hernandez-Chavez, Gerardo / Neme, Antonio

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 21

    Abstract: ... descriptor on RGB-D points. Our method aims to reduce complexity with almost no performance cost. All the BOF ... Through an RGB-D camera, we capture points and adjust them onto layers than are perpendicular to the camera plane ...

    Abstract Scene classification in autonomous navigation is a highly complex task due to variations, such as light conditions and dynamic objects, in the inspected scenes; it is also a challenge for small-factor computers to run modern and highly demanding algorithms. In this contribution, we introduce a novel method for classifying scenes in simultaneous localization and mapping (SLAM) using the boundary object function (BOF) descriptor on RGB-D points. Our method aims to reduce complexity with almost no performance cost. All the BOF-based descriptors from each object in a scene are combined to define the scene class. Instead of traditional image classification methods such as ORB or SIFT, we use the BOF descriptor to classify scenes. Through an RGB-D camera, we capture points and adjust them onto layers than are perpendicular to the camera plane. From each plane, we extract the boundaries of objects such as furniture, ceilings, walls, or doors. The extracted features compose a bag of visual words classified by a support vector machine. The proposed method achieves almost the same accuracy in scene classification as a SIFT-based algorithm and is 2.38× faster. The experimental results demonstrate the effectiveness of the proposed method in terms of accuracy and robustness for the 7-Scenes and SUNRGBD datasets.
    Language English
    Publishing date 2023-10-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23218836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An intron c.149-2632T>A change in RHD is associated with aberrant transcription and very weak D phenotype.

    Floch, Aline / Vege, Sunitha / Berardi, Philip / Hannon, Judith / Ochoa-Garay, Gorka / Lomas-Francis, Christine / Westhoff, Connie M

    Transfusion

    2021  Volume 62, Issue 2, Page(s) E14–E16

    MeSH term(s) Alleles ; Blood Group Antigens ; Genotype ; Humans ; Introns/genetics ; Phenotype ; Rh-Hr Blood-Group System/genetics ; Rho(D) Immune Globulin/genetics
    Chemical Substances Blood Group Antigens ; Rh-Hr Blood-Group System ; Rho(D) Immune Globulin
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intramolecular O-H⋯O and C-H⋯O hydrogen bond cooperativity in D-glucopyranose and D-galactopyranose-A DFT/GIAO, QTAIM/IQA, and NCI approach.

    Lomas, John S

    Magnetic resonance in chemistry : MRC

    2018  Volume 56, Issue 8, Page(s) 748–766

    Abstract: ... structures and conformers of α-D-glucopyranose, β-D-glucopyranose, and α-D-galactopyranose built up ...

    Abstract Density functional theory calculations are used to compute proton nuclear magnetic resonance (NMR) chemical shifts, interatomic distances, atom-atom interaction energies, and atomic charges for partial structures and conformers of α-D-glucopyranose, β-D-glucopyranose, and α-D-galactopyranose built up by introducing OH groups into 2-methyltetrahydropyran stepwisely. For the counterclockwise conformers, the most marked effects on the NMR shift and the charge on the OH1 proton are produced by OH2, those of OH3 and OH4 being somewhat smaller. This argues for a diminishing cooperative effect. The effect of OH6 depends on the configuration of the hydroxymethyl group and the position, axial or equatorial, of OH4, which controls hydrogen bonding in the 1,3-diol motif. Variations in the interaction energies reveal that a "new" hydrogen bond is sometimes formed at the expense of a preexisting one, probably due to geometrical constraints. Whereas previous work showed that complexing a conformer with pyridine affects only the nearest neighbour, successive OH groups increase the interaction energy of the N⋯H1 hydrogen bond and reduce its length. Analogous results are obtained for the clockwise conformers. The interaction energies for C-H⋯OH hydrogen bonding between axial CH protons and OH groups in certain conformers are much smaller than for O-H⋯OH bonds but they are largely covalent, whereas those of the latter are predominantly coulombic. These interactions are modified by complexation with pyridine in the same way as O-H⋯OH interactions: the computed NMR shifts of the CH protons increase, the atom-atom distances are shorter, and interaction energies are enhanced.
    MeSH term(s) Density Functional Theory ; Galactose/chemistry ; Glucose/chemistry ; Hydrogen Bonding ; Magnetic Resonance Spectroscopy/statistics & numerical data ; Models, Chemical ; Molecular Conformation ; Pyridines/chemistry ; Thermodynamics
    Chemical Substances Pyridines ; Glucose (IY9XDZ35W2) ; pyridine (NH9L3PP67S) ; Galactose (X2RN3Q8DNE)
    Language English
    Publishing date 2018-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1475029-6
    ISSN 1097-458X ; 0749-1581
    ISSN (online) 1097-458X
    ISSN 0749-1581
    DOI 10.1002/mrc.4728
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  4. Article ; Online: Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis.

    Sexauer, William P / Hadeh, Anas / Ohman-Strickland, Pamela A / Zanni, Robert L / Varlotta, Laurie / Holsclaw, Douglas / Fiel, Stanley / Graff, Gavin R / Atlas, Arthur / Bisberg, Dorothy / Hadjiliadis, Denis / Michel, Suzanne H / Mintz, Daria / Chakraborty, Rebanta / Marra, Bridget / Lomas, Paula / Ward, Tara / Sassman, Meagen / Imbesi, Giovanna C /
    Kitch, Diane M / Mallowe, Allison M

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2015  Volume 14, Issue 4, Page(s) 497–506

    Abstract: Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function ... function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2 months ... Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8 ng/ml (SD). Serum 25(OH)D levels showed ...

    Abstract Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown.
    Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2 months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF.
    Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8 ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function.
    Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.
    MeSH term(s) Adolescent ; Adult ; Child ; Cystic Fibrosis/blood ; Cystic Fibrosis/complications ; Cystic Fibrosis/physiopathology ; Female ; Forced Expiratory Volume/physiology ; Humans ; Male ; Retrospective Studies ; Vital Capacity/physiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/physiopathology ; Young Adult
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2015-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2091075-7
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2014.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Experience with RHD*weak D type 4.0 in the USA.

    Westhoff, Connie M / Nance, Sandra / Lomas-Francis, Christine / Keller, Margaret / Chou, Stella T

    Blood transfusion = Trasfusione del sangue

    2018  Volume 17, Issue 2, Page(s) 91–93

    MeSH term(s) Alleles ; Blood Transfusion/methods ; Female ; Genotype ; Humans ; Phenotype ; Pregnancy ; Rh-Hr Blood-Group System/genetics ; Rh-Hr Blood-Group System/immunology ; United States
    Chemical Substances Rh-Hr Blood-Group System
    Language English
    Publishing date 2018-07-06
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/2018.0114-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Equine urinary N-acetyl-β-D-glucosaminidase assay validation and correlation with other markers of kidney injury.

    Bayless, Rosemary L / Moore, A Russell / Hassel, Diana M / Byer, Brittney J / Landolt, Gabriele A / Nout-Lomas, Yvette S

    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

    2019  Volume 31, Issue 5, Page(s) 688–695

    Abstract: ... in horses. N-acetyl-β-D-glucosaminidase (NAG), a lysosomal enzyme in renal tubular epithelium released ...

    Abstract Detection of equine acute kidney injury (AKI) is hindered by limited markers of early renal damage in horses. N-acetyl-β-D-glucosaminidase (NAG), a lysosomal enzyme in renal tubular epithelium released into urine during tubular insult, has shown promise for early identification of AKI in humans and other species. We validated an assay for NAG in equine urine and measured urinary NAG in 7 azotemic and 7 non-azotemic client-owned adult horses. The enzymatic NAG assay was validated using within- and between-run coefficients of variation (CVs), recovery following standard addition, and linearity of dilution. Intra- and inter-run CVs (21% and 3.2%, respectively), average recovery following standard addition (99-109%), and linearity under serial dilution (
    MeSH term(s) Acetylglucosaminidase/urine ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/urine ; Acute Kidney Injury/veterinary ; Animals ; Biomarkers/urine ; Creatinine/blood ; Female ; Horse Diseases/diagnosis ; Horse Diseases/urine ; Horses ; Humans ; Male ; Sodium/urine ; gamma-Glutamyltransferase/urine
    Chemical Substances Biomarkers ; Sodium (9NEZ333N27) ; Creatinine (AYI8EX34EU) ; gamma-Glutamyltransferase (EC 2.3.2.2) ; Acetylglucosaminidase (EC 3.2.1.52)
    Language English
    Publishing date 2019-07-26
    Publishing country United States
    Document type Journal Article ; Validation Study
    ZDB-ID 287603-6
    ISSN 1943-4936 ; 1040-6387
    ISSN (online) 1943-4936
    ISSN 1040-6387
    DOI 10.1177/1040638719867124
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  7. Article ; Online: On the importance of intramolecular hydrogen bond cooperativity in d-glucose - an NMR and QTAIM approach.

    Lomas, John S / Joubert, Laurent

    Magnetic resonance in chemistry : MRC

    2017  Volume 55, Issue 10, Page(s) 893–901

    Abstract: ... on the known conformers of the α and β anomers of d-glucopyranose in the gas phase are used to compute proton ...

    Abstract The idea that hydrogen bond cooperativity is responsible for the structure and reactivity of carbohydrates is examined. Density functional theory and gauge-including atomic orbital calculations on the known conformers of the α and β anomers of d-glucopyranose in the gas phase are used to compute proton NMR chemical shifts and interatomic distances, which are taken as criteria for probing intramolecular interactions. Atom-atom interaction energies are calculated by the interacting quantum atoms approach in the framework of the quantum theory of atoms in molecules. Association of OH1 in the counterclockwise conformers with a strong acceptor, pyridine, is accompanied by cooperative participation from OH2, but there is no significant change in the bonding of the two following 1,2-diol motifs. The OH6
    MeSH term(s) Glucose/chemistry ; Glucosephosphates/chemistry ; Hydrogen Bonding ; Magnetic Resonance Spectroscopy ; Molecular Conformation ; Molecular Structure ; Quantum Theory
    Chemical Substances Glucosephosphates ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2017-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1475029-6
    ISSN 1097-458X ; 0749-1581
    ISSN (online) 1097-458X
    ISSN 0749-1581
    DOI 10.1002/mrc.4599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease.

    Foreman, Marilyn G / Kong, Xiangyang / DeMeo, Dawn L / Pillai, Sreekumar G / Hersh, Craig P / Bakke, Per / Gulsvik, Amund / Lomas, David A / Litonjua, Augusto A / Shapiro, Steven D / Tal-Singer, Ruth / Silverman, Edwin K

    American journal of respiratory cell and molecular biology

    2010  Volume 44, Issue 3, Page(s) 316–322

    Abstract: ... inflammatory responses to noxious stimuli. Surfactant protein-D (SFTPD) is immunomodulatory and essential ... We genotyped six single-nucleotide polymorphisms (SNPs) in surfactant protein D in 389 patients with COPD ... of surfactant protein-D (SP-D) in the ECLIPSE Study. In the NETT-NAS case-control analysis, four SFTPD SNPs were ...

    Abstract Chronic obstructive pulmonary disease (COPD) is characterized by alveolar destruction and abnormal inflammatory responses to noxious stimuli. Surfactant protein-D (SFTPD) is immunomodulatory and essential to host defense. We hypothesized that polymorphisms in SFTPD could influence the susceptibility to COPD. We genotyped six single-nucleotide polymorphisms (SNPs) in surfactant protein D in 389 patients with COPD in the National Emphysema Treatment Trial (NETT) and 472 smoking control subjects from the Normative Aging Study (NAS). Case-control association analysis was performed using Cochran-Armitage trend tests and multivariate logistic regression. The replication of significant associations was attempted in the Boston Early-Onset COPD Study, the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study, and the Bergen Cohort. We also correlated SFTPD genotypes with serum concentrations of surfactant protein-D (SP-D) in the ECLIPSE Study. In the NETT-NAS case-control analysis, four SFTPD SNPs were associated with susceptibility to COPD: rs2245121 (P = 0.01), rs911887 (P = 0.006), rs6413520 (P = 0.004), and rs721917 (P = 0.006). In the family-based analysis of the Boston Early-Onset COPD Study, rs911887 was associated with prebronchodilator and postbronchodilator FEV(1) (P = 0.003 and P = 0.02, respectively). An intronic SNP in SFTPD, rs7078012, was associated with COPD in the ECLIPSE Study and the Bergen Cohort. Multiple SFTPD SNPs were associated with serum SP-D concentrations in the ECLIPSE Study. We demonstrated an association of polymorphisms in SFTPD with COPD in multiple populations. We demonstrated a correlation between SFTPD SNPs and SP-D protein concentrations. The SNPs associated with COPD and SP-D concentrations differed, suggesting distinct genetic influences on susceptibility to COPD and SP-D concentrations.
    MeSH term(s) Aged ; Aging ; Case-Control Studies ; Cohort Studies ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Inflammation ; Longitudinal Studies ; Male ; Middle Aged ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Surfactant-Associated Protein D/genetics
    Chemical Substances Pulmonary Surfactant-Associated Protein D
    Language English
    Publishing date 2010-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2009-0360OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluation of full-length, cleaved and nitrosylated serum surfactant protein D as biomarkers for COPD.

    Duvoix, Annelyse / Miranda, Elena / Perez, Juan / Sorensen, Grith L / Holmskov, Uffe / Trapnell, Bruce C / Madsen, Jens / Clark, Howard W / Edwards, Lisa D / Miller, Bruce E / Tal-Singer, Ruth M / Lomas, David A

    COPD

    2011  Volume 8, Issue 2, Page(s) 79–95

    Abstract: ... by partially reversible airflow obstruction. Serum surfactant protein D (SP-D) is synthesized by type II ... levels of SP-D are raised in individuals with COPD but there is no correlation between the serum level ... of SP-D and the severity of airflow obstruction. Serum SP-D is present in different forms that may have ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a multicomponent condition that is characterized by partially reversible airflow obstruction. Serum surfactant protein D (SP-D) is synthesized by type II pneumocytes and Clara cells and participates in surfactant homeostasis and pulmonary host defense. Serum levels of SP-D are raised in individuals with COPD but there is no correlation between the serum level of SP-D and the severity of airflow obstruction. Serum SP-D is present in different forms that may have more utility as a biomarker for COPD. We report here the development of new monoclonal antibodies to full length and cleaved SP-D. We have assessed these and existing antibodies in 98 individuals with COPD recruited to the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) cohort. Our data show that neither monoclonal antibodies to full length nor cleaved SP-D provide additional information over that obtained with a polyclonal antibody. Moreover, levels of serum nitrosylated-SP-D did not correlate with serum level of SP-D or any clinical phenotype of COPD. The measurement of modified SP-D is of limited value in characterising individuals with COPD.
    MeSH term(s) Adult ; Aged ; Animals ; Antibodies, Monoclonal/immunology ; Biomarkers/blood ; Disease Progression ; Forced Expiratory Volume ; Humans ; Mice ; Middle Aged ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Surfactant-Associated Protein D/blood ; Pulmonary Surfactant-Associated Protein D/immunology ; Statistics, Nonparametric ; Vital Capacity
    Chemical Substances Antibodies, Monoclonal ; Biomarkers ; Pulmonary Surfactant-Associated Protein D
    Language English
    Publishing date 2011-04-14
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2171107-0
    ISSN 1541-2563 ; 1541-2555
    ISSN (online) 1541-2563
    ISSN 1541-2555
    DOI 10.3109/15412555.2011.558542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Equine urinary N-acetyl-β-D-glucosaminidase assay validation and correlation with other markers of kidney injury

    Bayless, Rosemary L. / Moore, A Russell / Hassel, Diana M. / Byer, Brittney J. / Landolt, Gabriele A. / Nout-Lomas, Yvette S.

    Journal of Veterinary Diagnostic Investigation. 2019 Sept., v. 31, no. 5 p.688-695

    2019  

    Abstract: ... in horses. N-acetyl-β-D-glucosaminidase (NAG), a lysosomal enzyme in renal tubular epithelium released ...

    Abstract Detection of equine acute kidney injury (AKI) is hindered by limited markers of early renal damage in horses. N-acetyl-β-D-glucosaminidase (NAG), a lysosomal enzyme in renal tubular epithelium released into urine during tubular insult, has shown promise for early identification of AKI in humans and other species. We validated an assay for NAG in equine urine and measured urinary NAG in 7 azotemic and 7 non-azotemic client-owned adult horses. The enzymatic NAG assay was validated using within- and between-run coefficients of variation (CVs), recovery following standard addition, and linearity of dilution. Intra- and inter-run CVs (21% and 3.2%, respectively), average recovery following standard addition (99–109%), and linearity under serial dilution (R² = 0.997) were satisfactory. Urine NAG index was significantly correlated with urinary fractional excretion of sodium (FENₐ; ρ = 0.76, p < 0.001) and plasma creatinine (ρ = 0.74, p = 0.001). Median urine NAG indices were higher in azotemic horses (p = 0.006), in horses with increased urinary FENₐ (p = 0.006), and in horses with increased urine gamma-glutamyl transferase index (p = 0.032). Urine NAG can be measured in horses and shows positive correlation with 2 current renal biomarkers. Additional work is needed to establish normal equine reference intervals and characterize the increase of urine NAG index in horses in relation to tubular injury.
    Keywords acute kidney injury ; adults ; biomarkers ; creatinine ; epithelium ; excretion ; gamma-glutamyltransferase ; horses ; kidneys ; sodium ; urine ; N-acetyl-beta-D-glucosaminidase ; renal
    Language English
    Dates of publication 2019-09
    Size p. 688-695.
    Publishing place SAGE Publications
    Document type Article ; Online
    Note Resource is Open Access
    ZDB-ID 287603-6
    ISSN 1943-4936 ; 1040-6387
    ISSN (online) 1943-4936
    ISSN 1040-6387
    DOI 10.1177/1040638719867124
    Database NAL-Catalogue (AGRICOLA)

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