LIVIVO - Search results -

Search results

Result 1 - 10 of total 252

Search options

Article ; Online: Asthma and COPD in alpha-1 antitrypsin deficiency. Evidence for the Dutch hypothesis.

Eden, Edward

2010 Volume 7, Issue 5, Page(s) 366–374

Abstract: This review summarizes the current information on the relationship between severe alpha-1 antitrypsin deficiency (AATD), asthma and COPD. AATD is a genetic predisposition to the development of early COPD in susceptible individuals and reduction in known ... ...

Abstract	This review summarizes the current information on the relationship between severe alpha-1 antitrypsin deficiency (AATD), asthma and COPD. AATD is a genetic predisposition to the development of early COPD in susceptible individuals and reduction in known factors that enhance lung function loss is the paramount aim of management. Asthma is one controllable condition that leads to the accelerated decline in lung function. Current literature indicates that asthma signs and symptoms are common in those AATD with or without COPD and that bronchodilator response is a risk factor for FEV(1) decline. Furthermore AATD itself predisposes to airway hyper responsiveness, an essential ingredient for reversible airflow obstruction. In the absence of well-characterized markers to distinguish COPD from asthma, clinical diagnosis leads to a delay in the recognition that asthma symptoms such as wheezing can be an early manifestation of COPD in AATD. In addition failure to appreciate asthma overlap in AATD may lead to inadequate suppression of airway inflammation leading to the development of airflow obstruction. The implications of this are discussed as are potential approaches and recommendations for treatment.
MeSH term(s)	Asthma/epidemiology ; Asthma/etiology ; Asthma/genetics ; Genetic Predisposition to Disease ; Global Health ; Humans ; Incidence ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/genetics ; Risk Assessment ; Risk Factors ; alpha 1-Antitrypsin Deficiency/complications ; alpha 1-Antitrypsin Deficiency/epidemiology ; alpha 1-Antitrypsin Deficiency/genetics
Language	English
Publishing date	2010-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2171107-0
ISSN	1541-2563 ; 1541-2555
ISSN (online)	1541-2563
ISSN	1541-2555
DOI	10.3109/15412555.2010.510159
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5990: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Metagenomic Identification of Viral Sequences in Laboratory Reagents.

Porter, Ashleigh F / Cobbin, Joanna / Li, Ci-Xiu / Eden, John-Sebastian / Holmes, Edward C

Viruses

2021 Volume 13, Issue 11

Abstract: Metagenomic next-generation sequencing has transformed the discovery and diagnosis of infectious disease, with the power to characterise the complete 'infectome' (bacteria, viruses, fungi, parasites) of an individual host organism. However, the ... ...

Abstract	Metagenomic next-generation sequencing has transformed the discovery and diagnosis of infectious disease, with the power to characterise the complete 'infectome' (bacteria, viruses, fungi, parasites) of an individual host organism. However, the identification of novel pathogens has been complicated by widespread microbial contamination in commonly used laboratory reagents. Using total RNA sequencing ("metatranscriptomics") we documented the presence of contaminant viral sequences in multiple 'blank' negative control sequencing libraries that comprise a sterile water and reagent mix. Accordingly, we identified 14 viral sequences in 7 negative control sequencing libraries. As in previous studies, several circular replication-associated protein encoding (CRESS) DNA virus-like sequences were recovered in the blank control libraries, as well as contaminating sequences from the
MeSH term(s)	DNA Viruses/genetics ; DNA Viruses/isolation & purification ; Equipment Contamination/statistics & numerical data ; Indicators and Reagents/analysis ; Laboratories/statistics & numerical data ; Metagenome ; Viruses/classification ; Viruses/genetics ; Viruses/isolation & purification
Chemical Substances	Indicators and Reagents
Language	English
Publishing date	2021-10-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13112122
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Multiple Sources of Fast Traveling Waves during Human Seizures: Resolving a Controversy.

Schlafly, Emily D / Marshall, François A / Merricks, Edward M / Eden, Uri T / Cash, Sydney S / Schevon, Catherine A / Kramer, Mark A

The Journal of neuroscience : the official journal of the Society for Neuroscience

2022 Volume 42, Issue 36, Page(s) 6966–6982

Abstract: During human seizures, organized waves of voltage activity rapidly sweep across the cortex. Two contradictory theories describe the source of these fast traveling waves: either a slowly advancing narrow region of multiunit activity (an ictal wavefront) ... ...

Abstract	During human seizures, organized waves of voltage activity rapidly sweep across the cortex. Two contradictory theories describe the source of these fast traveling waves: either a slowly advancing narrow region of multiunit activity (an ictal wavefront) or a fixed cortical location. Limited observations and different analyses prevent resolution of these incompatible theories. Here we address this disagreement by combining the methods and microelectrode array recordings (
Language	English
Publishing date	2022-09-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.0338-22.2022
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1668: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: RAPID

Tulloch, Rachel L / Kim, Karan / Sikazwe, Chisha / Michie, Alice / Burrell, Rebecca / Holmes, Edward C / Dwyer, Dominic E / Britton, Philip N / Kok, Jen / Eden, John-Sebastian

Viruses

2023 Volume 15, Issue 4

Abstract: Emerging infectious disease threats require rapid response tools to inform diagnostics, treatment, and outbreak control. RNA-based metagenomics offers this; however, most approaches are time-consuming and laborious. Here, we present a simple and fast ... ...

Abstract	Emerging infectious disease threats require rapid response tools to inform diagnostics, treatment, and outbreak control. RNA-based metagenomics offers this; however, most approaches are time-consuming and laborious. Here, we present a simple and fast protocol, the RAPID
MeSH term(s)	Humans ; Metagenomics/methods ; High-Throughput Nucleotide Sequencing/methods ; Metagenome ; Genomics ; RNA, Viral/genetics
Chemical Substances	RNA, Viral
Language	English
Publishing date	2023-04-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15041006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Monocyte NLRP3 inflammasome and interleukin-1β activation modulated by alpha-1 antitrypsin therapy in deficient individuals.

Gogoi, Debananda / Yu, Howard / Casey, Michelle / Baird, Rory / Yusuf, Azeez / Forde, Luke / O' Brien, Michael E / West, Jesse R / Flagg, Tammy / McElvaney, Noel G / Eden, Edward / Mueller, Christian / Brantly, Mark L / Geraghty, Patrick / Reeves, Emer P

Thorax

2024

Abstract: Introduction: Altered complement component 3 (C3) activation in patients with alpha-1 antitrypsin (AAT) deficiency (AATD) has been reported. To understand the potential impact on course of inflammation, the aim of this study was to investigate whether ... ...

Abstract	Introduction: Altered complement component 3 (C3) activation in patients with alpha-1 antitrypsin (AAT) deficiency (AATD) has been reported. To understand the potential impact on course of inflammation, the aim of this study was to investigate whether C3d, a cleavage-product of C3, triggers interleukin (IL)-1β secretion via activation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome. The objective was to explore the effect of AAT augmentation therapy in patients with AATD on the C3d/complement receptor 3 (CR3) signalling axis of monocytes and on circulating pro-inflammatory markers. Methods: Inflammatory mediators were detected in blood from patients with AATD (n=28) and patients with AATD receiving augmentation therapy (n=19). Inflammasome activation and IL-1β secretion were measured in monocytes of patients with AATD, and following C3d stimulation in the presence or absence of CR3 or NLRP3 inhibitors. Results: C3d acting via CR3 induces NLRP3 and pro-IL-1β production, and through induction of endoplasmic reticulum (ER) stress and calcium flux, triggers caspase-1 activation and IL-1β secretion. Treatment of individuals with AATD with AAT therapy results in decreased plasma levels of C3d (3.0±1.2 µg/mL vs 1.3±0.5 µg/mL respectively, p<0.0001) and IL-1β (115.4±30 pg/mL vs 73.3±20 pg/mL, respectively, p<0.0001), with a 2.0-fold decrease in monocyte NLRP3 protein expression (p=0.0303), despite continued ER stress activation. Discussion: These results provide strong insight into the mechanism of complement-driven inflammation associated with AATD. Although the described variance in C3d and NLRP3 activation decreased post AAT augmentation therapy, results demonstrate persistent C3d and monocyte ER stress, with implications for new therapeutics and clinical practice.
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thorax-2023-221071
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui III Zs.83: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Impact of Undergoing Thoracolumbar Surgery on Patient Psychosocial Profiles.

Rogers, Samantha / Manson, Neil / Bigney, Erin / McPhee, Rory / Vandewint, Amanda / Richardson, Eden / El-Mughayyar, Dana / Abraham, Edward

Global spine journal

2023 , Page(s) 21925682231191693

Abstract: Study design: Prospective cohort study.: Objective: Investigate the impact of thoracolumbar surgery on patients' psychosocial profiles.: Methods: A prospective cohort study of thoracolumbar surgery patients (N = 177). Measures of interest ... ...

Abstract	Study design: Prospective cohort study. Objective: Investigate the impact of thoracolumbar surgery on patients' psychosocial profiles. Methods: A prospective cohort study of thoracolumbar surgery patients (N = 177). Measures of interest collected at baseline and 24-months after surgery were: modified Oswestry Disability Index (mODI), Numerical Rating Scores for Back Pain (NRS-B), Leg Pain (NRS-L), Pain Catastrophizing Scale (PCS), Tampa Scale of Kinesiophobia (TSK), Chronic Pain Acceptance Questionnaire-8 (CPAQ-8), Multidimensional Scale of Perceived Social Support (MSPSS), Mental Component Summary (MCS) and patient expectations for surgery impacts on mental well-being. Cohorts were separated based on attaining meaningful change defined as either 30% improvement or minimal scores in NRS-B, NRS-L and mODI. Mixed measures ANOVAs were run (α = .05). Results: Patients who showed meaningful change had significant improvements in PCS, TSK and CPAQ-8 scores but not in MSPSS scores. Patients had improvement in MCS scores over 24-months follow-up, but this change was not significantly different based on attainment of meaningful change. Overall, 75.9% of patients reported their mental well-being expectations were met. Patients who did not achieve meaningful change showed no change on any psychosocial measures with only 55.9% reporting their mental well-being expectations met. Conclusion: Thoracolumbar surgery results in significant improvement of psychosocial variables for patients who experienced meaningful change for pain and disability. Worsening of psychosocial health was not evident in patients who did not attain meaningful change.
Language	English
Publishing date	2023-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2648287-3
ISSN	2192-5690 ; 2192-5682
ISSN (online)	2192-5690
ISSN	2192-5682
DOI	10.1177/21925682231191693
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A Divergent

Ortiz-Baez, Ayda Susana / Eden, John-Sebastian / Moritz, Craig / Holmes, Edward C

Viruses

2020 Volume 12, Issue 6

Abstract: The discovery of highly divergent RNA viruses is compromised by their limited sequence similarity to known viruses. Evolutionary information obtained from protein structural modelling offers a powerful approach to detect distantly related viruses based ... ...

Abstract	The discovery of highly divergent RNA viruses is compromised by their limited sequence similarity to known viruses. Evolutionary information obtained from protein structural modelling offers a powerful approach to detect distantly related viruses based on the conservation of tertiary structures in key proteins such as the RNA-dependent RNA polymerase (RdRp). We utilised a template-based approach for protein structure prediction from amino acid sequences to identify distant evolutionary relationships among viruses detected in meta-transcriptomic sequencing data from Australian wildlife. The best predicted protein structural model was compared with the results of similarity searches against protein databases. Using this combination of meta-transcriptomics and protein structure prediction we identified the
MeSH term(s)	Animals ; Australia ; Evolution, Molecular ; Genome, Viral ; Lizards/classification ; Lizards/virology ; Phylogeny ; Protein Conformation ; RNA Viruses/chemistry ; RNA Viruses/classification ; RNA Viruses/genetics ; RNA Viruses/isolation & purification ; RNA-Dependent RNA Polymerase/genetics ; Viral Proteins/chemistry ; Viral Proteins/genetics
Chemical Substances	Viral Proteins ; RNA-Dependent RNA Polymerase (EC 2.7.7.48)
Language	English
Publishing date	2020-06-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12060613
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Metatranscriptomic Analysis of Virus Diversity in Urban Wild Birds with Paretic Disease.

Chang, Wei-Shan / Eden, John-Sebastian / Hall, Jane / Shi, Mang / Rose, Karrie / Holmes, Edward C

Journal of virology

2020 Volume 94, Issue 18

Abstract: Wild birds are major natural reservoirs and potential dispersers of a variety of infectious diseases. As such, it is important to determine the diversity of viruses they carry and use this information to help understand the potential risks of spillover ... ...

Abstract	Wild birds are major natural reservoirs and potential dispersers of a variety of infectious diseases. As such, it is important to determine the diversity of viruses they carry and use this information to help understand the potential risks of spillover to humans, domestic animals, and other wildlife. We investigated the potential viral causes of paresis in long-standing, but undiagnosed, disease syndromes in wild Australian birds. RNA from diseased birds was extracted and pooled based on tissue type, host species, and clinical manifestation for metagenomic sequencing. Using a bulk and unbiased metatranscriptomic approach, combined with clinical investigation and histopathology, we identified a number of novel viruses from the families
MeSH term(s)	Adenoviridae/classification ; Adenoviridae/genetics ; Adenoviridae/isolation & purification ; Animals ; Animals, Wild/virology ; Astroviridae/classification ; Astroviridae/genetics ; Astroviridae/isolation & purification ; Australia/epidemiology ; Bird Diseases/epidemiology ; Bird Diseases/virology ; Birds/virology ; Circoviridae/classification ; Circoviridae/genetics ; Circoviridae/isolation & purification ; Cities ; DNA Virus Infections/epidemiology ; DNA Virus Infections/veterinary ; DNA Virus Infections/virology ; High-Throughput Nucleotide Sequencing ; Humans ; Metagenome ; Paramyxoviridae/classification ; Paramyxoviridae/genetics ; Paramyxoviridae/isolation & purification ; Parvoviridae/classification ; Parvoviridae/genetics ; Parvoviridae/isolation & purification ; Phylogeny ; Picornaviridae/classification ; Picornaviridae/genetics ; Picornaviridae/isolation & purification ; Polyomaviridae/classification ; Polyomaviridae/genetics ; Polyomaviridae/isolation & purification ; RNA Virus Infections/epidemiology ; RNA Virus Infections/veterinary ; RNA Virus Infections/virology ; Transcriptome
Keywords	covid19
Language	English
Publishing date	2020-08-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.00606-20
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 609: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Metagenomic Identification of Viral Sequences in Laboratory Reagents

Porter, Ashleigh F. / Cobbin, Joanna / Li, Ci-Xiu / Eden, John-Sebastian / Holmes, Edward C.

Viruses. 2021 Oct. 21, v. 13, no. 11

2021

Abstract: Metagenomic next-generation sequencing has transformed the discovery and diagnosis of infectious disease, with the power to characterise the complete ‘infectome’ (bacteria, viruses, fungi, parasites) of an individual host organism. However, the ... ...

Abstract	Metagenomic next-generation sequencing has transformed the discovery and diagnosis of infectious disease, with the power to characterise the complete ‘infectome’ (bacteria, viruses, fungi, parasites) of an individual host organism. However, the identification of novel pathogens has been complicated by widespread microbial contamination in commonly used laboratory reagents. Using total RNA sequencing (“metatranscriptomics”) we documented the presence of contaminant viral sequences in multiple ‘blank’ negative control sequencing libraries that comprise a sterile water and reagent mix. Accordingly, we identified 14 viral sequences in 7 negative control sequencing libraries. As in previous studies, several circular replication-associated protein encoding (CRESS) DNA virus-like sequences were recovered in the blank control libraries, as well as contaminating sequences from the Totiviridae, Tombusviridae and Lentiviridae families of RNA virus. These data suggest that viral contamination of common laboratory reagents is likely commonplace and can comprise a wide variety of viruses.
Keywords	DNA ; RNA ; Tombusviridae ; Totiviridae ; infectious diseases ; metagenomics ; viral contamination
Language	English
Dates of publication	2021-1021
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13112122
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Over the counter low-dose cannabidiol: A viewpoint from the ACRE Capacity Building Group.

Hallinan, Christine Mary / Eden, Edward / Graham, Myfanwy / Greenwood, Lisa-Marie / Mills, Jessica / Popat, Amirali / Truong, Linda / Bonomo, Yvonne

Journal of psychopharmacology (Oxford, England)

2021 Volume 36, Issue 6, Page(s) 661–665

Abstract: Amidst growing global acceptance of medicinal cannabinoids as a potential therapeutic interest in cannabidiol (CBD) is increasing. In Australia in 2020, a government inquiry examined the barriers that the public are experiencing in accessing medicinal ... ...

Abstract	Amidst growing global acceptance of medicinal cannabinoids as a potential therapeutic interest in cannabidiol (CBD) is increasing. In Australia in 2020, a government inquiry examined the barriers that the public are experiencing in accessing medicinal cannabis. A number of recommendations to improve access were made. In response to these recommendations, the Australian therapeutics regulatory authority down-scheduled CBD from Prescription Only (Schedule 4) to Pharmacist Only (Schedule 3). As a group of early to mid-career researchers of the Australian Centre for Cannabinoid Clinical and Research Excellence (ACRE), we propose some considerations in relation to over-the-counter availability of CBD and opportunities to improve knowledge about its potential therapeutic benefits alongside its increased uptake.
MeSH term(s)	Australia ; Cannabidiol/therapeutic use ; Cannabinoids/therapeutic use ; Cannabis ; Capacity Building ; Dronabinol
Chemical Substances	Cannabinoids ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
Language	English
Publishing date	2021-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639313-5
ISSN	1461-7285 ; 0269-8811
ISSN (online)	1461-7285
ISSN	0269-8811
DOI	10.1177/02698811211035394
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2311: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito