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  1. Article ; Online: The role of Akkermansia muciniphila in colorectal cancer: A double-edged sword of treatment or disease progression?

    Faghfuri, Elnaz / Gholizadeh, Pourya

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 173, Page(s) 116416

    Abstract: Colorectal cancer (CRC) is the second most cancer-related death worldwide. In recent years, probiotics have been used to reduce the potential risks of CRC and tumors with various mechanisms. Different bacteria have been suggested to play different roles ... ...

    Abstract Colorectal cancer (CRC) is the second most cancer-related death worldwide. In recent years, probiotics have been used to reduce the potential risks of CRC and tumors with various mechanisms. Different bacteria have been suggested to play different roles in the progression, prevention, or treatment of CRC. Akkermansia muciniphila is considered a next-generation probiotic for preventing and treating some diseases. Therefore, in this review article, we aimed to describe and discuss different mechanisms of A. muciniphila as an intestinal microbiota or probiotic in CRC. Some studies suggested that the abundance of A. muciniphila was higher or increased in CRC patients compared to healthy individuals. However, the decreased abundance of A. muciniphila was associated with severe symptoms of CRC, indicating that A. muciniphila did not play a role in the development of CRC. In addition, A. muciniphila administration elevates gene expression of proliferation-associated molecules such as S100A9, Dbf4, and Snrpd1, or markers for cell proliferation. Some other studies suggested that inflammation and tumorigenesis in the intestine might promoted by A. muciniphila. Overall, the role of A. muciniphila in CRC development or inhibition is still unclear and controversial. Various methods of bacterial supplementation, such as viability, bacterial number, and abundance, could all influence the colonization effect of A. muciniphila administration and CRC progression. Overall, A. mucinipila has been revealed to modulate the therapeutic potential of immune checkpoint inhibitors. Preliminary human data propose that oral consumption of A. muciniphila is safe, but its efficacy needs to be confirmed in more human clinical studies.
    MeSH term(s) Humans ; Akkermansia ; Calgranulin B ; Disease Progression ; Colorectal Neoplasms/therapy
    Chemical Substances Calgranulin B
    Language English
    Publishing date 2024-03-11
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Withdrawal Notice: Overview of Enzyme Engineering Towards the Production of Hyaluronic Acid with Tailored Molecular Weight

    Ebrahimi, Tahereh / Hosseini, Kamran / Ahangari, Hossein / Gholizadeh, Pourya / Tarhriz, Vahideh

    Current protein & peptide science

    2021  

    Language English
    Publishing date 2021-12-21
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2045662-1
    ISSN 1875-5550 ; 1389-2037
    ISSN (online) 1875-5550
    ISSN 1389-2037
    DOI 10.2174/1389203723666211221120822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An Alliance of Carbapenem-Resistant

    Soltani, Elghar / Hasani, Alka / Rezaee, Mohammad Ahangarzadeh / Nahandi, Maryam Zaare / Hasani, Akbar / Gholizadeh, Pourya

    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

    2022  Volume 2022, Page(s) 6086979

    Abstract: Carbapenemase- ... ...

    Abstract Carbapenemase-resistant
    Language English
    Publishing date 2022-11-21
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1057056-1
    ISSN 1712-9532 ; 1180-2332
    ISSN 1712-9532 ; 1180-2332
    DOI 10.1155/2022/6086979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular typing of clinical multidrug-resistant Klebsiella pneumoniae isolates.

    Kashefieh, Mehdi / Zeighami, Habib / Samadi Kafil, Hossein / Gholizadeh, Pourya / Sadeghi, Javid / Soroush Barhaghi, Mohammad Hossein / Ebrahimzadeh Leylabadlo, Hamed / Ghotaslou, Reza

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 416

    Abstract: Introduction: Klebsiella pneumoniae is an opportunistic pathogen which is an important cause of hospital-acquired and antibiotic resistance infections. Therefore, this study aimed to determine the frequency of resistance to antibiotics, as well as the ... ...

    Abstract Introduction: Klebsiella pneumoniae is an opportunistic pathogen which is an important cause of hospital-acquired and antibiotic resistance infections. Therefore, this study aimed to determine the frequency of resistance to antibiotics, as well as the molecular typing of the associated isolates, and compare multiple-locus VNTR analysis (MLVA) and Enterobacterial Repetitive Intergenic Consensus-Polymerase Chain Reaction (ERIC-PCR) methods to specify the degree to which distinctions can be separated from each other.
    Methods and materials: One hundred K. pneumoniae isolates were obtained from different sources of infections from patients admitted to hospitals. Antibiotic susceptibility testing was then performed by applying the Kirby-Bauer disk diffusion method. Typing of K. pneumoniae was done by utilizing MLVA and ERIC-PCR methods.
    Results: Eighty-six multidrug-resistant (MDR) K. pneumoniae isolates were identified, which resistance to ampicillin, trimethoprim/sulfamethoxazole, and ceftriaxone was the most frequent in the considered isolates (100, 93, and 93%, respectively). A total of 50 different antibiotic susceptibility patterns were observed among the MDR K. pneumonia, with the most frequent pattern being resistance to all antibiotics (12.79%) and resistance to all antibiotics except amikacin (10.47%). The isolates were then divided into 37 different MLVA types and seven clonal complexes were obtained from the minimum spanning tree analysis. Finally, the isolates were assigned to 38 different ERIC types. The discriminatory power of MLVA and ERIC methods also showed a value of 0.958, and 0.974.
    Conclusion: Both PCR-typing methods with phenotypic patterns can be useful for the epidemiological typing of K. pneumoniae isolates with the highest performance in discriminating isolates.
    MeSH term(s) Humans ; Klebsiella pneumoniae/genetics ; Klebsiella Infections/drug therapy ; Klebsiella Infections/epidemiology ; Klebsiella Infections/microbiology ; Microbial Sensitivity Tests ; Molecular Typing/methods ; Anti-Bacterial Agents/pharmacology ; Enterobacteriaceae
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09278-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An eco-friendly chitosan/cellulose acetate hybrid nanostructure containing Ziziphora clinopodioides essential oils for active food packaging applications.

    Nazari, Maryam / Majdi, Hasan / Gholizadeh, Pourya / Kafil, Hossein Samadi / Hamishehkar, Hamed / Zarchi, Ali Akbar Karimi / Khoddami, Ali

    International journal of biological macromolecules

    2023  Volume 235, Page(s) 123885

    Abstract: This work presents the fabrication and characterization of a hybrid nanostructure, Ziziphora clinopodioides essential oils (ZEO)-loaded chitosan nanoparticles (CSNPs-ZEO) embedded into cellulose acetate (CA) nanofibers (CA-CSNPs-ZEO). The CSNPs-ZEO were ... ...

    Abstract This work presents the fabrication and characterization of a hybrid nanostructure, Ziziphora clinopodioides essential oils (ZEO)-loaded chitosan nanoparticles (CSNPs-ZEO) embedded into cellulose acetate (CA) nanofibers (CA-CSNPs-ZEO). The CSNPs-ZEO were first synthesized through the ionic gelation method. Then, through simultaneous electrospraying and electrospinning processes, the nanoparticles were embedded in the CA nanofibers. The morphological and physicochemical characteristics of the prepared nanostructures were evaluated using different methods, including scanning electron microscopy (SEM), water vapor permeability (WVP), moisture content (MC), mechanical testing, differential scanning calorimetry (DSC), and release profile studies. The antibacterial activity of the nanostructures was explored on raw beef as a food model during 12 days of storage at 4 °C. The obtained results indicated the successful synthesis of CSNPs-ZEO nanoparticles with an average size of 267 ± 6 nm and their incorporation into the nanofibers matrix. Moreover, the CA-CSNPs-ZEO nanostructure showed a lower water vapor barrier and higher tensile strength compared with ZEO-loaded CA (CA-ZEO) nanofiber. The CA-CSNPs-ZEO nanostructure also exhibited strong antibacterial activity, which effectively extended the shelf-life of raw beef. The results demonstrated a strong potential for innovative hybrid nanostructures in active packaging to maintain the quality of perishable food products.
    MeSH term(s) Animals ; Cattle ; Food Packaging/methods ; Chitosan/chemistry ; Oils, Volatile/chemistry ; Steam ; Lamiaceae/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Nanoparticles/chemistry ; Nanofibers
    Chemical Substances acetylcellulose (3J2P07GVB6) ; Chitosan (9012-76-4) ; Oils, Volatile ; Steam ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.123885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immune response following transcatheter aortic valve procedure.

    Anaraki, Kasra Talebi / Zahed, Zahra / Javid, Roozbeh Narimani / Shafiei, Sasan / Beiranvandi, Fereshteh / Kahrizsangi, Negin Ghasemi / Golafshan, Faraz / Arzhangzade, Alireza / Kojuri, Javad / Almassian, Samin / Hadi, Raha / Gholizadeh, Pourya / Kazeminava, Fahimeh

    Vascular pharmacology

    2024  Volume 154, Page(s) 107283

    Abstract: Aortic valve stenosis is the most common type of heart valve disease in the United States and Europe and calcific aortic stenosis (AS) affects 2-7% of people aged 65 years and older. Aortic valve replacement (AVR) is the only effective treatment for ... ...

    Abstract Aortic valve stenosis is the most common type of heart valve disease in the United States and Europe and calcific aortic stenosis (AS) affects 2-7% of people aged 65 years and older. Aortic valve replacement (AVR) is the only effective treatment for individuals with this condition. Transcatheter Aortic Valve Replacement (TAVR) has been widely accepted as a minimally invasive therapeutic approach for addressing symptomatic AS in patients who are considered to have a high risk for traditional surgical intervention. TAVR procedure may have a paradoxical effect on the immune system and inflammatory status. A major portion of these immune responses is regulated by activating or inhibiting inflammatory monocytes and the complement system with subsequent changes in inflammatory cytokines. TAVR has the potential to induce various concurrent exposures, including disruption of the native valve, hemodynamic changes, antigenicity of the bioprosthesis, and vascular damage, which finally lead to the development of inflammation. On the other hand, it is important to acknowledge that TAVR may also have anti-inflammatory effects by helping in the resolution of stenosis.The inflammation and immune response following TAVR are complex processes that significantly impact procedural outcomes and patient well-being. Understanding the underlying mechanisms, identifying biomarkers of inflammation, and exploring therapeutic interventions to modulate these responses are crucial for optimizing TAVR outcomes. Further research is warranted to elucidate the precise immunological dynamics and develop tailored strategies to attenuate inflammation and enhance post-TAVR healing while minimizing complications.
    MeSH term(s) Humans ; Aortic Valve/surgery ; Risk Factors ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis ; Treatment Outcome ; Inflammation ; Immunity ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/methods
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2024.107283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The role of

    Hasani, Alka / Ebrahimzadeh, Saba / Hemmati, Fatemeh / Khabbaz, Aytak / Hasani, Akbar / Gholizadeh, Pourya

    Journal of medical microbiology

    2021  Volume 70, Issue 10

    Abstract: Alteration in the composition of the gut microbiota can lead to a number of chronic clinical diseases. ...

    Abstract Alteration in the composition of the gut microbiota can lead to a number of chronic clinical diseases.
    MeSH term(s) Akkermansia/physiology ; Animals ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Atherosclerosis/microbiology ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/microbiology ; Energy Metabolism ; Gastrointestinal Microbiome ; Humans ; Obesity/drug therapy ; Obesity/metabolism ; Obesity/microbiology ; Probiotics/therapeutic use
    Language English
    Publishing date 2021-10-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Matricaria chamomilla essential oil-loaded hybrid electrospun nanofibers based on polycaprolactone/sulfonated chitosan/ZIF-8 nanoparticles for wound healing acceleration.

    Nezhad-Mokhtari, Parinaz / Kazeminava, Fahimeh / Abdollahi, Bahman / Gholizadeh, Pourya / Heydari, Abolfazl / Elmi, Faranak / Abbaszadeh, Mahmoud / Kafil, Hossein Samadi

    International journal of biological macromolecules

    2023  Volume 247, Page(s) 125718

    Abstract: Recently, developing antibacterial wound dressings based on biomaterials display good biocompatibility and the potential to accelerate wound healing. For this aim, we prepared eco-friendly and biodegradable nanofibers (NFs) based on N-(3-sulfopropyl) ... ...

    Abstract Recently, developing antibacterial wound dressings based on biomaterials display good biocompatibility and the potential to accelerate wound healing. For this aim, we prepared eco-friendly and biodegradable nanofibers (NFs) based on N-(3-sulfopropyl)chitosan/ poly (ε-caprolactone) incorporated by zeolite imidazolate framework-8 nanoparticles (ZIF-8 NPs) and chamomile essential oil (MCEO) via the electrospinning technique for their efficacy as wound dressing scaffolds. Fabricated NFs were characterized and studied for their structural, morphological, mechanical, hydrophilic, and thermal stability properties. The results of scanning electron microscopy (SEM) revealed that adding the ZIF-8 NPs/ MCEO, very slightly influenced the average diameter of NFs (PCL/SPCS (90:10) with 90 ± 32 nm). The developed uniform MCEO-loaded ZIF-8/PCL/SPCS NFs displayed better cytocompatibility, proliferation, and physicochemical properties (e.g. thermal stability and mechanical properties) than neat NFs. The results of cytocompatibility, DAPI (4',6-diamidino-2-phenylindole) staining study, and SEM micrographs demonstrated that formulated NFs had promising adhesion and proliferation against normal human foreskin fibroblasts-2 (HFF-2 cell line). The prepared NFs revealed excellent antibacterial activity against both Staphylococcus aureus and Escherichia coli with inhibition of 32.3 mm and 31.2 mm, respectively. Accordingly, the newly developed antibacterial NFs hold great potential as effective biomaterials for use as an active platform in wound healing applications.
    MeSH term(s) Humans ; Chitosan/chemistry ; Matricaria ; Oils, Volatile/pharmacology ; Nanofibers/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Wound Healing ; Polyesters/chemistry ; Biocompatible Materials/chemistry ; Nanoparticles/chemistry
    Chemical Substances Chitosan (9012-76-4) ; polycaprolactone (24980-41-4) ; Oils, Volatile ; Anti-Bacterial Agents ; Polyesters ; Biocompatible Materials
    Language English
    Publishing date 2023-07-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.125718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An eco-friendly chitosan/cellulose acetate hybrid nanostructure containing Ziziphora clinopodioides essential oils for active food packaging applications

    Nazari, Maryam / Majdi, Hasan / Gholizadeh, Pourya / Kafil, Hossein Samadi / Hamishehkar, Hamed / Zarchi, Ali Akbar Karimi / Khoddami, Ali

    International Journal of Biological Macromolecules. 2023 Apr., v. 235 p.123885-

    2023  

    Abstract: This work presents the fabrication and characterization of a hybrid nanostructure, Ziziphora clinopodioides essential oils (ZEO)-loaded chitosan nanoparticles (CSNPs-ZEO) embedded into cellulose acetate (CA) nanofibers (CA-CSNPs-ZEO). The CSNPs-ZEO were ... ...

    Abstract This work presents the fabrication and characterization of a hybrid nanostructure, Ziziphora clinopodioides essential oils (ZEO)-loaded chitosan nanoparticles (CSNPs-ZEO) embedded into cellulose acetate (CA) nanofibers (CA-CSNPs-ZEO). The CSNPs-ZEO were first synthesized through the ionic gelation method. Then, through simultaneous electrospraying and electrospinning processes, the nanoparticles were embedded in the CA nanofibers. The morphological and physicochemical characteristics of the prepared nanostructures were evaluated using different methods, including scanning electron microscopy (SEM), water vapor permeability (WVP), moisture content (MC), mechanical testing, differential scanning calorimetry (DSC), and release profile studies. The antibacterial activity of the nanostructures was explored on raw beef as a food model during 12 days of storage at 4 °C. The obtained results indicated the successful synthesis of CSNPs-ZEO nanoparticles with an average size of 267 ± 6 nm and their incorporation into the nanofibers matrix. Moreover, the CA-CSNPs-ZEO nanostructure showed a lower water vapor barrier and higher tensile strength compared with ZEO-loaded CA (CA-ZEO) nanofiber. The CA-CSNPs-ZEO nanostructure also exhibited strong antibacterial activity, which effectively extended the shelf-life of raw beef. The results demonstrated a strong potential for innovative hybrid nanostructures in active packaging to maintain the quality of perishable food products.
    Keywords Ziziphora clinopodioides ; antibacterial properties ; beef ; calorimetry ; cellulose acetate ; chitosan ; electron microscopy ; electrospraying ; gelation ; model food systems ; nanofibers ; nanoparticles ; perishable foods ; permeability ; shelf life ; tensile strength ; water content ; water vapor ; Electrospinning ; Cellulose acetate nanofiber ; Chitosan nanoparticles ; Essential oils
    Language English
    Dates of publication 2023-04
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.123885
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: The necessity to revise Koch's postulates and its application to infectious and non-infectious diseases: a mini-review.

    Hosainzadegan, Hasan / Khalilov, Rovshan / Gholizadeh, Pourya

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2019  Volume 39, Issue 2, Page(s) 215–218

    Abstract: Advances in the science have promoted all aspects of human's life; these, in turn, have changed many principles and scientific postulates. Koch's postulates, since the beginning of their implementation, have been one of the important subjects involving ... ...

    Abstract Advances in the science have promoted all aspects of human's life; these, in turn, have changed many principles and scientific postulates. Koch's postulates, since the beginning of their implementation, have been one of the important subjects involving complications and misinterpretations regarding the causal relationship of microbe-hosts. These postulates have been shown not to be correct in some cases including the inability of some microbes to grow in the culture medium, viruses, or anaerobic bacteria. Today, due to some new scientific facts like the social behaviors of bacteria, such as quorum sensing, there are serious problems regarding the definition of whole microbial effects; these include microbiomes and viromes, as well as their interaction with the existing eukaryotics, the complicated relations between bacteria, L-forms, and cell wall-deficient bacteria, and the important role of microbes in the development of non-infectious diseases. So, the application of Koch's postulates to explain the causal relationships between host-microbes could be difficult. Therefore, nowadays, even the molecular Koch's postulates are not accountable. Also, according to the new scientific discoveries, various criteria such as changes in the immune system, pathology, and clinical findings, along with the results of daily laboratory tests, should be used to apply Koch's postulates in the etiologic studies. Otherwise, the possible etiologic relationships between the host-microbes cannot be verified due to numerous complications; certainly, the relationship between the doctor and the lab is ultimately weakened. Therefore, public health, prevention, and much of the antimicrobial treatments will also remain in a state of ambiguity.
    MeSH term(s) Communicable Diseases/microbiology ; Host Microbial Interactions ; Humans ; Microbiota ; Noncommunicable Diseases ; Public Health
    Language English
    Publishing date 2019-08-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-019-03681-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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