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Article ; Online: M-TAG

Liam Carroll / Shirin A. Enger

Heliyon, Vol 9, Iss 10, Pp e20229- (2023)

A modular teaching-aid for Geant4

2023

Abstract: ... learning curve. This work introduces a user-code called M-TAG (Modular Radiation Teaching-Aid for Geant4), built ... on top of Geant4. M-TAG is designed to help gradually introduce the Geant4 toolkit to new users.The goal ... of Geant4 is to record quantities from the simulated radiation as it is transported through geometries. M ...

Abstract	Geant4 is a versatile Monte Carlo radiation transport simulation toolkit with a steep learning curve. This work introduces a user-code called M-TAG (Modular Radiation Teaching-Aid for Geant4), built on top of Geant4. M-TAG is designed to help gradually introduce the Geant4 toolkit to new users.The goal of Geant4 is to record quantities from the simulated radiation as it is transported through geometries. M-TAG simplifies the inclusion of new geometric elements and detector components in the simulation by including new classes. M-TAG also provides basic validated examples for some common detector development tasks. Geant4 intercom modules, called messenger classes, manage these classes. To validate M-TAG, simulations were performed to calculate the range of positrons in water. One hundred million decays at the center of a water-filled sphere with a radius of 1 m were allowed for fluorine-18, carbon-11, oxygen-15 and gallium-68. These results were compared to literature values. An inexperienced Geant4 user was tasked with creating a simulation model for a plastic scintillator-based detector and conducting basic tests to assess the effectiveness of M-TAG as a teaching tool. The simulation involved calculating the dose to the detector's sensitive volume using a 2x2 cm planar monoenergetic photon source spanning energies from 20 to 100 keV. One billion particles were simulated twice: once with the actual detector geometry and once with the sensitive volume replaced by water. The validity of M-TAG was also verified by computing dose ratios and comparing them with mass-attenuation ratios obtained from NIST XCOM data sets.The mean positron travel distances were within the distribution of literature values. Simulated positron energy spectra means were within 1.8% of literature means. Simulated dose ratios agreed with literature values within uncertainties.We have developed and verified a modular Geant4 teaching aid called M-TAG. It was used to introduce a new user to Geant4, who used it to perform further validation ...
Keywords	Monte Carlo simmulation ; Geant4 simulation toolkit ; Teaching aid ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	690
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The RNA m

Ivanova, Ivayla / Much, Christian / Di Giacomo, Monica / Azzi, Chiara / Morgan, Marcos / Moreira, Pedro N / Monahan, Jack / Carrieri, Claudia / Enright, Anton J / O'Carroll, Dónal

Molecular cell

2017 Volume 67, Issue 6, Page(s) 1059–1067.e4

Abstract: YTHDF2 binds and destabilizes ... ...

Abstract	YTHDF2 binds and destabilizes N
MeSH term(s)	Animals ; Binding Sites ; Female ; Fertility ; Gene Expression Regulation, Developmental ; Genotype ; Infertility, Female/genetics ; Infertility, Female/metabolism ; Infertility, Female/pathology ; Meiosis ; Mice, Inbred C57BL ; Mice, Knockout ; Oocytes/metabolism ; Oocytes/pathology ; Phenotype ; Protein Binding ; RNA Processing, Post-Transcriptional ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Transcription, Genetic ; Transcriptome ; Zygote/metabolism ; Zygote/pathology
Chemical Substances	RNA, Messenger ; RNA-Binding Proteins ; YTHDF2 protein, mouse
Language	English
Publishing date	2017-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2017.08.003
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Article ; Online: Targeting the RNA m

Paris, Jasmin / Morgan, Marcos / Campos, Joana / Spencer, Gary J / Shmakova, Alena / Ivanova, Ivayla / Mapperley, Christopher / Lawson, Hannah / Wotherspoon, David A / Sepulveda, Catarina / Vukovic, Milica / Allen, Lewis / Sarapuu, Annika / Tavosanis, Andrea / Guitart, Amelie V / Villacreces, Arnaud / Much, Christian / Choe, Junho / Azar, Ali /

van de Lagemaat, Louie N / Vernimmen, Douglas / Nehme, Ali / Mazurier, Frederic / Somervaille, Tim C P / Gregory, Richard I / O'Carroll, Dónal / Kranc, Kamil R

Cell stem cell

2019 Volume 25, Issue 1, Page(s) 137–148.e6

Abstract: ... stem cells (LSCs). Here, we show that the mRNA m ...

Abstract	Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differentiation, generating self-renewing leukemic stem cells (LSCs). Here, we show that the mRNA m
MeSH term(s)	Animals ; Cell Self Renewal ; Hematopoiesis ; Hematopoietic Stem Cells ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplastic Stem Cells/physiology ; RNA, Small Interfering/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; THP-1 Cells
Chemical Substances	RNA, Small Interfering ; RNA-Binding Proteins ; YTHDF2 protein, human ; YTHDF2 protein, mouse
Language	English
Publishing date	2019-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2019.03.021
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Article: M-TAG: A modular teaching-aid for Geant4.

Carroll, Liam / Enger, Shirin A

Heliyon

2023 Volume 9, Issue 10, Page(s) e20229

Abstract: ... learning curve. This work introduces a user-code called M-TAG (Modular Radiation Teaching-Aid for Geant4), built ... on top of Geant4. M-TAG is designed to help gradually introduce the Geant4 toolkit to new users. The goal ... of Geant4 is to record quantities from the simulated radiation as it is transported through geometries. M ...

Abstract	Geant4 is a versatile Monte Carlo radiation transport simulation toolkit with a steep learning curve. This work introduces a user-code called M-TAG (Modular Radiation Teaching-Aid for Geant4), built on top of Geant4. M-TAG is designed to help gradually introduce the Geant4 toolkit to new users. The goal of Geant4 is to record quantities from the simulated radiation as it is transported through geometries. M-TAG simplifies the inclusion of new geometric elements and detector components in the simulation by including new classes. M-TAG also provides basic validated examples for some common detector development tasks. Geant4 intercom modules, called messenger classes, manage these classes. To validate M-TAG, simulations were performed to calculate the range of positrons in water. One hundred million decays at the center of a water-filled sphere with a radius of 1 m were allowed for fluorine-18, carbon-11, oxygen-15 and gallium-68. These results were compared to literature values. An inexperienced Geant4 user was tasked with creating a simulation model for a plastic scintillator-based detector and conducting basic tests to assess the effectiveness of M-TAG as a teaching tool. The simulation involved calculating the dose to the detector's sensitive volume using a 2x2 cm planar monoenergetic photon source spanning energies from 20 to 100 keV. One billion particles were simulated twice: once with the actual detector geometry and once with the sensitive volume replaced by water. The validity of M-TAG was also verified by computing dose ratios and comparing them with mass-attenuation ratios obtained from NIST XCOM data sets. The mean positron travel distances were within the distribution of literature values. Simulated positron energy spectra means were within 1.8% of literature means. Simulated dose ratios agreed with literature values within uncertainties. We have developed and verified a modular Geant4 teaching aid called M-TAG. It was used to introduce a new user to Geant4, who used it to perform further validation simulations.
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e20229
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Article: Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.

Abud, A Abed / Abi, B / Acciarri, R / Acero, M A / Adames, M R / Adamov, G / Adamowski, M / Adams, D / Adinolfi, M / Aduszkiewicz, A / Aguilar, J / Ahmad, Z / Ahmed, J / Aimard, B / Ali-Mohammadzadeh, B / Alion, T / Allison, K / Monsalve, S Alonso / AlRashed, M /

Alt, C / Alton, A / Alvarez, R / Amedo, P / Anderson, J / Andreopoulos, C / Andreotti, M / Andrews, M / Andrianala, F / Andringa, S / Anfimov, N / Ankowski, A / Antoniassi, M / Antonova, M / Antoshkin, A / Antusch, S / Aranda-Fernandez, A / Arellano, L / Arnold, L O / Arroyave, M A / Asaadi, J / Asquith, L / Aurisano, A / Aushev, V / Autiero, D / Lara, V Ayala / Ayala-Torres, M / Azfar, F / Back, A / Back, H / Back, J J / Backhouse, C / Bagaturia, I / Bagby, L / Balashov, N / Balasubramanian, S / Baldi, P / Baller, B / Bambah, B / Barao, F / Barenboim, G / Alzas, P Barham / Barker, G / Barkhouse, W / Barnes, C / Barr, G / Monarca, J Barranco / Barros, A / Barros, N / Barrow, J L / Basharina-Freshville, A / Bashyal, A / Basque, V / Batchelor, C / Chagas, E Batista das / Battat, J B R / Battisti, F / Bay, F / Bazetto, M C Q / Alba, J L L Bazo / Beacom, J F / Bechetoille, E / Behera, B / Beigbeder, C / Bellantoni, L / Bellettini, G / Bellini, V / Beltramello, O / Benekos, N / Montiel, C Benitez / Neves, F Bento / Berger, J / Berkman, S / Bernardini, P / Berner, R M / Bersani, A / Bertolucci, S / Betancourt, M / Rodríguez, A Betancur / Bevan, A / Bezawada, Y / Bezerra, T J C / Bhardwaj, A / Bhatnagar, V / Bhattacharjee, M / Bhattarai, D / Bhuller, S / Bhuyan, B / Biagi, S / Bian, J / Biassoni, M / Biery, K / Bilki, B / Bishai, M / Bitadze, A / Blake, A / Blaszczyk, F / Blazey, G C / Blucher, E / Boissevain, J / Bolognesi, S / Bolton, T / Bomben, L / Bonesini, M / Bongrand, M / Bonilla-Diaz, C / Bonini, F / Booth, A / Boran, F / Bordoni, S / Borkum, A / Bostan, N / Bour, P / Bourgeois, C / Boyden, D / Bracinik, J / Braga, D / Brailsford, D / Branca, A / Brandt, A / Bremer, J / Breton, D / Brew, C / Brice, S J / Brizzolari, C / Bromberg, C / Brooke, J / Bross, A / Brunetti, G / Brunetti, M / Buchanan, N / Budd, H / Butorov, I / Cagnoli, I / Cai, T / Caiulo, D / Calabrese, R / Calafiura, P / Calcutt, J / Calin, M / Calvez, S / Calvo, E / Caminata, A / Campanelli, M / Caratelli, D / Carber, D / Carceller, J C / Carini, G / Carlus, B / Carneiro, M F / Carniti, P / Terrazas, I Caro / Carranza, H / Carroll, T / Forero, J F Castaño / Castillo, A / Castromonte, C / Catano-Mur, E / Cattadori, C / Cavalier, F / Cavallaro, G / Cavanna, F / Centro, S / Cerati, G / Cervelli, A / Villanueva, A Cervera / Chalifour, M / Chappell, A / Chardonnet, E / Charitonidis, N / Chatterjee, A / Chattopadhyay, S / Neyra, M S S Chavarry / Chen, H / Chen, M / Chen, Y / Chen, Z / Chen-Wishart, Z / Cheon, Y / Cherdack, D / Chi, C / Childress, S / Chirco, R / Chiriacescu, A / Chisnall, G / Cho, K / Choate, S / Chokheli, D / Chong, P S / Christensen, A / Christian, D / Christodoulou, G / Chukanov, A / Chung, M / Church, E / Cicero, V / Clarke, P / Cline, G / Coan, T E / Cocco, A G / Coelho, J A B / Colton, N / Conley, E / Conley, R / Conrad, J / Convery, M / Copello, S / Cova, P / Cremaldi, L / Cremonesi, L / Crespo-Anadón, J I / Crisler, M / Cristaldo, E / Crnkovic, J / Cross, R 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Englezos, P / Ereditato, A / Erjavec, T / Escobar, C / Eurin, G / Evans, J J / Ewart, E / Ezeribe, A C / Fahey, K / Falcone, A / Fani', M / Farnese, C / Farzan, Y / Fedoseev, D / Felix, J / Feng, Y / Fernandez-Martinez, E / Menendez, P Fernandez / Morales, M Fernandez / Ferraro, F / Fields, L / Filip, P / Filthaut, F / Fiorini, M / Fischer, V / Fitzpatrick, R S / Flanagan, W / Fleming, B / Flight, R / Fogarty, S / Foreman, W / Fowler, J / Fox, W / Franc, J / Francis, K / Franco, D / Freeman, J / Freestone, J / Fried, J / Friedland, A / Robayo, F Fuentes / Fuess, S / Furic, I K / Furman, K / Furmanski, A P / Gabrielli, A / Gago, A / Gallagher, H / Gallas, A / Gallego-Ros, A / Gallice, N / Galymov, V / Gamberini, E / Gamble, T / Ganacim, F / Gandhi, R / Gandrajula, R / Gao, F / Gao, S / Garcia-Gamez, D / García-Peris, M Á / Gardiner, S / Gastler, D / Gauvreau, J / Ge, G / Geffroy, N / Gelli, B / Gendotti, A / Gent, S / Ghorbani-Moghaddam, Z / Giammaria, P / Giammaria, T / Giangiacomi, N 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Muramatsu, H / Murphy, S / Musser, J / Nachtman, J / Nagu, S / Nalbandyan, M / Nandakumar, R / Naples, D / Narita, S / Nath, A / Navrer-Agasson, A / Nayak, N / Nebot-Guinot, M / Negishi, K / Nelson, J K / Nesbit, J / Nessi, M / Newbold, D / Newcomer, M / Newton, H / Nichol, R / Nicolas-Arnaldos, F / Nikolica, A / Niner, E / Nishimura, K / Norman, A / Norrick, A / Northrop, R / Novella, P / Nowak, J A / Oberling, M / Ochoa-Ricoux, J / Olivier, A / Olshevskiy, A / Onel, Y / Onishchuk, Y / Ott, J / Pagani, L / Palacio, G / Palamara, O / Palestini, S / Paley, J M / Pallavicini, M / Palomares, C / Vazquez, W Panduro / Pantic, E / Paolone, V / Papadimitriou, V / Papaleo, R / Papanestis, A / Paramesvaran, S / Parke, S / Parozzi, E / Parsa, Z / Parvu, M / Pascoli, S / Pasqualini, L / Pasternak, J / Pater, J / Patrick, C / Patrizii, L / Patterson, R B / Patton, S J / Patzak, T / Paudel, A / Paulos, B / Paulucci, L / Pavlovic, Z / Pawloski, G / Payne, D / Pec, V / Peeters, S J M / Perez, A Pena 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Rigamonti, A / Rigaut, Y / Rincón, E V / Ritchie-Yates, H / Rivera, D / Robert, A / Rochester, L / Roda, M / Rodrigues, P / Alonso, M J Rodriguez / Bonilla, E Rodriguez / Rondon, J Rodriguez / Rosauro-Alcaraz, S / Rosenberg, M / Rosier, P / Roskovec, B / Rossella, M / Rossi, M / Rout, J / Roy, P / Rubbia, A / Rubbia, C / Russell, B / Ruterbories, D / Rybnikov, A / Saa-Hernandez, A / Saakyan, R / Sacerdoti, S / Safford, T / Sahu, N / Sakashita, K / Sala, P / Samios, N / Samoylov, O / Sanchez, M C / Sandberg, V / Sanders, D A / Sankey, D / Santana, S / Santos-Maldonado, M / Saoulidou, N / Sapienza, P / Sarasty, C / Sarcevic, I / Savage, G / Savinov, V / Scaramelli, A / Scarff, A / Scarpelli, A / Schefke, T / Schellman, H / Schifano, S / Schlabach, P / Schmitz, D / Schneider, A W / Scholberg, K / Schukraft, A / Segreto, E / Selyunin, A / Senise, C R / Sensenig, J / Sergi, A / Sgalaberna, D / Shaevitz, M H / Shafaq, S / Shaker, F / Shamma, M / Sharankova, R / Sharma, H R / Sharma, R / 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Zennamo, J / Zeug, K / Zhang, C / Zhang, S / Zhang, Y / Zhao, M / Zhivun, E / Zhu, G / Zimmerman, E D / Zucchelli, S / Zuklin, J / Zutshi, V / Zwaska, R

The European physical journal. C, Particles and fields

2022 Volume 82, Issue 7, Page(s) 618

Abstract: DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a ... ...

Abstract	DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6
Language	English
Publishing date	2022-07-16
Publishing country	France
Document type	Journal Article
ZDB-ID	1459069-4
ISSN	1434-6052 ; 1434-6044
ISSN (online)	1434-6052
ISSN	1434-6044
DOI	10.1140/epjc/s10052-022-10549-w
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Article ; Online: Letter to the editor regarding: Chan, G. K., Cummins, M. R., Taylor, C. S., Rambur, B., Auerbach, D. I., Meadows-Oliver, M., ... & Pittman, P. P. (2023). An overview and policy implications of national nurse identifier systems: A call for unity and integration. Nursing Outlook, 101892.

Kulhanek, Brenda / Carroll, Whende / Sensmeier, Joyce / Rajwany, Nur / Bensinger, Dana / Aldrich, Kelly / Alexander, Susan

Nursing outlook

2023 Volume 71, Issue 3, Page(s) 101980

MeSH term(s)	Humans ; Policy ; Nursing
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	300568-9
ISSN	1528-3968 ; 0029-6554
ISSN (online)	1528-3968
ISSN	0029-6554
DOI	10.1016/j.outlook.2023.101980
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Article ; Online: A Novel Standardized Morbidity and Mortality Process to Promote Discourse, Improve Education, and Facilitate Practice Change: The M-PROVE Model.

Bowman, Max / Yang, Heiko / Ahn, Justin / Carroll, Peter R / Hampson, Lindsay A

Urology practice

2023 Volume 10, Issue 4, Page(s) 391–397

Abstract: Introduction: The morbidity and mortality conference is essential to medical education and quality improvement. Ideally, the conference is inclusive, judgment-free, and focused on practice improvement. In reality, it may not meet these goals. We ... ...

Abstract	Introduction: The morbidity and mortality conference is essential to medical education and quality improvement. Ideally, the conference is inclusive, judgment-free, and focused on practice improvement. In reality, it may not meet these goals. We reimagined the process by standardizing presentations and creating an oversight committee to improve the perceived value of the conference and identify opportunities for improvement. This study evaluates the subjective impact of the redesigned process at our institution and provides a blueprint for our reproducible model. Methods: We created a faculty and resident committee to review all submitted cases, implemented a standardized presentation template and moderating structure, and tracked quality improvement measures from proposed improvement initiatives. Attitudes toward the conference, including perceived quality/relevance, identification of potential systems changes, inclusiveness, and educational value, were assessed among faculty and trainees using pre- and postintervention Likert-style surveys. Results: Of 45 eligible department members, 41 (91%) completed the preintervention and 36 (80%) completed the postintervention survey. We found a statistically significant improvement in all questions between pre- and postintervention surveys except on the question about the conference environment being nonthreatening, which also improved but was not statistically significant. The overall average answer improved on the postintervention survey compared to the preintervention survey (3.36 vs 4.20, Conclusions: Redesigning and standardizing the morbidity and mortality conference with greater attention to education, inclusion, systems change, and quality improvement improves the attitudes of conference attendees and increases the perceived value of the conference.
MeSH term(s)	Quality Improvement ; Education, Medical ; Educational Status ; Clinical Competence ; Morbidity
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article
ISSN	2352-0787
ISSN (online)	2352-0787
DOI	10.1097/UPJ.0000000000000411
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Article ; Online: Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid.

Velazquez, Fabiola N / Hernandez-Corbacho, Maria / Trayssac, Magali / Stith, Jeffrey L / Bonica, Joseph / Jean, Bernandie / Pulkoski-Gross, Michael J / Carroll, Brittany L / Salama, Mohamed F / Hannun, Yusuf A / Snider, Ashley J

Cellular signalling

2020 Volume 79, Page(s) 109875

Abstract: ... the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive ...

Abstract	Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation.
MeSH term(s)	Aging/genetics ; Aging/metabolism ; Aging/pathology ; Animals ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Laboratories ; Lysophospholipids/genetics ; Lysophospholipids/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Signal Transduction ; Sphingolipids/genetics ; Sphingolipids/metabolism ; Sphingosine/analogs & derivatives ; Sphingosine/genetics ; Sphingosine/metabolism
Chemical Substances	Lysophospholipids ; Neoplasm Proteins ; Sphingolipids ; sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42)
Language	English
Publishing date	2020-12-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2020.109875
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Article ; Online: Treatment of multiple myeloma with monoclonal antibodies and the dilemma of false positive M-spikes in peripheral blood.

Murata, Kazunori / McCash, Samuel I / Carroll, Brittany / Lesokhin, Alexander M / Hassoun, Hani / Lendvai, Nikoletta / Korde, Neha S / Mailankody, Sham / Landau, Heather J / Koehne, Guenther / Chung, David J / Giralt, Sergio A / Ramanathan, Lakshmi V / Landgren, Ola

Clinical biochemistry

2016 Volume 51, Page(s) 66–71

Abstract: ... in a visible and quantifiable M-protein on SPEP and a visible IgGκ band by IFE. Increases were also noted ... drug showed similar findings with an additional IgGκ band and quantifiable M-protein with similar ... of multiple myeloma patients with monoclonal antibodies results in a visible and quantifiable M-protein that has ...

Abstract	Objectives: To characterize the effect of three humanized IgG κ monoclonal antibodies (daratumumab, isatuximab, and elotuzumab) on the interpretation of results generated by protein electrophoresis, immunofixation, free light chain, and heavy/light chain assays performed on human serum. Methods: Healthy volunteer serum and serum from multiple myeloma patients were supplemented with clinically relevant concentrations of each of the three monoclonal antibodies. These specimens then underwent analysis via serum protein electrophoresis, immunofixation, serum free light chain quantification, heavy/light chain quantification, total IgG, and total protein. In addition, serum specimens from patients who had undergone treatment with elotuzumab for multiple myeloma underwent similar analysis. Results: Addition of the study drugs to serum from both the healthy donor as well as multiple myeloma patients resulted in a visible and quantifiable M-protein on SPEP and a visible IgGκ band by IFE. Increases were also noted in total IgG, IgGκ, and IgGκ/IgGλ-ratios. Analysis of serum from multiple myeloma patients receiving study drug showed similar findings with an additional IgGκ band and quantifiable M-protein with similar migration patterns in specimens drawn after administration. Conclusion: The treatment of multiple myeloma patients with monoclonal antibodies results in a visible and quantifiable M-protein that has the potential to falsely indicate poor response to therapy.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Blood Protein Electrophoresis/methods ; Case-Control Studies ; False Positive Reactions ; Humans ; Male ; Multiple Myeloma/blood ; Multiple Myeloma/therapy ; Myeloma Proteins/metabolism
Chemical Substances	Antibodies, Monoclonal ; Myeloma Proteins ; multiple myeloma M-proteins
Language	English
Publishing date	2016-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2016.09.015
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Article ; Online: Biographical feature: John Matsen, M.D.

Carroll, Karen C

Journal of clinical microbiology

2014 Volume 52, Issue 8, Page(s) 2750–2752

MeSH term(s)	Clinical Laboratory Techniques/methods ; Communicable Diseases/diagnosis ; History, 20th Century ; History, 21st Century ; Humans ; Medical Laboratory Science/methods ; Medical Laboratory Science/trends
Language	English
Publishing date	2014-06-11
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.01542-14
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