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  1. Article ; Online: Kidney-Derived Thrombopoietin and Platelet Generation-A Proinflammatory Loop in CKD.

    Hickey, Michael J

    Journal of the American Society of Nephrology : JASN

    2023  Volume 34, Issue 7, Page(s) 1129–1131

    MeSH term(s) Humans ; Thrombopoietin ; Blood Platelets ; Platelet Count ; Kidney ; Renal Insufficiency, Chronic
    Chemical Substances Thrombopoietin (9014-42-0)
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Book ; Online: Inflammation in the CNS: Advancing the Field Using Intravital Imaging

    Hickey, Michael J. / Pai, Saparna / Weninger, Wolfgang

    2017  

    Abstract: Inflammation of the CNS can have devastating, long-lived, and in some cases fatal consequences for patients. The stimuli that can induce CNS inflammation are diverse, and include infectious agents, autoimmune responses against CNS-expressed antigens, and ...

    Abstract Inflammation of the CNS can have devastating, long-lived, and in some cases fatal consequences for patients. The stimuli that can induce CNS inflammation are diverse, and include infectious agents, autoimmune responses against CNS-expressed antigens, and sterile inflammation following ischemia or traumatic injury. In these conditions, cells of the immune system play central roles in promulgation and resolution of the inflammatory response. However, the immunological mechanisms at work in these diverse responses differ according to the nature of the response. Our understanding of the actions of immune cells in the CNS has been restricted by the difficulty in visualising leukocytes as they undergo recruitment from the cerebral microvasculature and following their entry into the CNS parenchyma. However, advances in in vivo microscopy over the last 10-15 years have overcome many of these difficulties, and studies using these forms of microscopy have revealed a wealth of new information regarding the cellular and molecular mechanisms of CNS inflammation. This Research Topic brings together state of the art reviews examining the use of in vivo imaging in investigating inflammation and leukocyte behaviour in the CNS. Papers in this Research Topic describe how in vivo microscopy has increased our understanding of the actions of immune cells in the inflamed CNS, following various stimuli including autoimmunity, infection and sterile inflammation
    Keywords Medicine (General) ; Immunologic diseases. Allergy
    Size 1 electronic resource (108 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020097494
    ISBN 9782889453641 ; 2889453642
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Intravital Imaging of Regulatory T Cells in Inflamed Skin.

    Hickey, Michael J / Norman, M Ursula

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2691, Page(s) 247–256

    Abstract: Regulatory T cells play key roles in skin homeostasis and inflammation and in regulating antitumor responses. Understanding of the biology of this cell type has been improved by the use of intravital microscopy for their visualization in various organs. ... ...

    Abstract Regulatory T cells play key roles in skin homeostasis and inflammation and in regulating antitumor responses. Understanding of the biology of this cell type has been improved by the use of intravital microscopy for their visualization in various organs. Here we describe a multiphoton microscopy-based technique for intravital imaging of regulatory T cells in the skin. We provide a protocol for a model of antigen-dependent inflammation that induces robust regulatory T cell recruitment to the skin and describe the use of a regulatory T cell reporter mouse for visualization of these cells in inflamed skin.
    MeSH term(s) Animals ; Mice ; T-Lymphocytes, Regulatory/pathology ; Skin/pathology ; Inflammation/pathology ; Antigens ; Intravital Microscopy/methods
    Chemical Substances Antigens
    Language English
    Publishing date 2023-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3331-1_19
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  4. Article ; Online: In Vitro Approaches for Investigating the Influence of MIF on Leukocyte-Endothelial Cell Interactions Under Flow Conditions.

    Hickey, Michael J

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 2080, Page(s) 19–25

    Abstract: The exit of leukocytes from the bloodstream into inflamed sites involves a sequence of interactions with vascular endothelial cells, in which leukocytes, moving rapidly in flowing blood, first tether and roll on the endothelial surface before arresting ... ...

    Abstract The exit of leukocytes from the bloodstream into inflamed sites involves a sequence of interactions with vascular endothelial cells, in which leukocytes, moving rapidly in flowing blood, first tether and roll on the endothelial surface before arresting and then transmigrating across the endothelial barrier. Examining the mechanisms of these interactions in human systems has involved the use of in vitro flow chamber assays, using a variety of cells and immobilized molecules as adhesive substrata. Here we describe how to perform these assays using human umbilical vein endothelial cells and human leukocytes.
    MeSH term(s) Cell Adhesion ; Cell Communication ; Cells, Cultured ; Endothelial Cells/physiology ; Hemodynamics ; Human Umbilical Vein Endothelial Cells/cytology ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Intramolecular Oxidoreductases/genetics ; Intramolecular Oxidoreductases/metabolism ; Leukocyte Rolling/genetics ; Leukocyte Rolling/immunology ; Leukocytes/physiology ; Macrophage Migration-Inhibitory Factors/genetics ; Macrophage Migration-Inhibitory Factors/metabolism ; Transendothelial and Transepithelial Migration
    Chemical Substances Macrophage Migration-Inhibitory Factors ; Intramolecular Oxidoreductases (EC 5.3.-) ; MIF protein, human (EC 5.3.2.1)
    Language English
    Publishing date 2019-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9936-1_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immune cell behaviour and dynamics in the kidney - insights from in vivo imaging.

    Kitching, A Richard / Hickey, Michael J

    Nature reviews. Nephrology

    2021  Volume 18, Issue 1, Page(s) 22–37

    Abstract: The actions of immune cells within the kidney are of fundamental importance in kidney homeostasis and disease. In disease settings such as acute kidney injury, anti-neutrophil cytoplasmic antibody-associated vasculitis, lupus nephritis and renal ... ...

    Abstract The actions of immune cells within the kidney are of fundamental importance in kidney homeostasis and disease. In disease settings such as acute kidney injury, anti-neutrophil cytoplasmic antibody-associated vasculitis, lupus nephritis and renal transplant rejection, immune cells resident within the kidney and those recruited from the circulation propagate inflammatory responses with deleterious effects on the kidney. As in most forms of inflammation, intravital imaging - particularly two-photon microscopy - has been critical to our understanding of immune cell responses in the renal microvasculature and interstitium, enabling visualization of immune cell dynamics over time rather than statically. These studies have demonstrated differences in the recruitment and function of these cells from those in more conventional vascular beds, and provided a wealth of information on the actions of blood-borne immune cells such as neutrophils, monocytes and T cells, as well as kidney-resident mononuclear phagocytes, in a range of diseases affecting different kidney compartments. In particular, in vivo imaging has furthered our understanding of leukocyte function within the glomerulus in acute glomerulonephritis, and in the tubulointerstitium and interstitial microvasculature during acute kidney injury and following transplantation, revealing mechanisms of immune surveillance, antigen presentation and inflammation in the kidney.
    MeSH term(s) Glomerulonephritis ; Humans ; Kidney/diagnostic imaging ; Kidney Glomerulus ; Leukocytes ; Neutrophils
    Language English
    Publishing date 2021-09-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-021-00481-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6334: Show issues Location:
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  6. Article ; Online: A rapid monocyte response team.

    Hickey, Michael J

    Blood

    2017  Volume 129, Issue 10, Page(s) 1237–1238

    MeSH term(s) Hospital Mortality ; Humans ; Intensive Care Units ; Monocytes
    Language English
    Publishing date 2017-03-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-01-759779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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  7. Article ; Online: Using imaging to study inflammatory platelet-leukocyte interactions

    Susanto, Olivia / Hickey, Michael J

    Platelets

    2020  Volume 31, Issue 5, Page(s) 610–617

    Abstract: In addition to their roles in hemostasis and thrombosis, platelets are now recognized as making important contributions to a wide variety of inflammatory responses. This function primarily occurs as a result of intravascular interactions of platelets ... ...

    Abstract In addition to their roles in hemostasis and thrombosis, platelets are now recognized as making important contributions to a wide variety of inflammatory responses. This function primarily occurs as a result of intravascular interactions of platelets with leukocytes undergoing recruitment to the site of inflammation. As these interactions occur under the shear forces of flowing blood, they are typically rapid and highly dynamic. As such, the use of rapid frame-rate forms of
    MeSH term(s) Blood Platelets/cytology ; Blood Platelets/metabolism ; Humans ; Intravital Microscopy/methods ; Leukocytes/cytology ; Leukocytes/metabolism
    Language English
    Publishing date 2020-01-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2020.1718632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2888: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Attitudes and acceptability of organ and tissue donation registration in the emergency department: a national survey of emergency physicians.

    Hickey, Michael / Yadav, Krishan / Abdulaziz, Kasim E / Taljaard, Monica / Hickey, Carly / Hartwick, Michael / Sarti, Aimee / McIntyre, Lauralyn / Perry, Jeffrey J

    CJEM

    2022  Volume 24, Issue 3, Page(s) 293–299

    Abstract: Purpose: There is a worldwide shortage of organs for transplantation. One method to increase the number of organs available for transplant is to increase the number of registered organ donors. The emergency department (ED) may be a suitable venue to ... ...

    Abstract Purpose: There is a worldwide shortage of organs for transplantation. One method to increase the number of organs available for transplant is to increase the number of registered organ donors. The emergency department (ED) may be a suitable venue to disseminate knowledge to patients about organ donation, and to offer an immediate or future opportunity to register as an organ donor. This study aimed to assess emergency physicians' attitudes and acceptability of an ED-based organ donation registration initiative.
    Methods: We developed and distributed a national postal survey using a modified Dillman's tailored design technique to a random sample of emergency physicians selected from the Canadian Medical Directory.
    Results: From a total of 474 delivered surveys, we received 228 responses (48.1%). 98.5% of emergency physicians support the concept of deceased organ donation. 85.1% felt that the emergency department is an appropriate setting to disseminate information regarding organ donation and 77.6% felt that it is an appropriate location to offer an immediate opportunity to register as an organ donor. 74.1% of physicians who responded report to be personally registered as an organ donor.
    Conclusion: Most emergency physicians are supportive of organ donation promotion in the ED, including offering an immediate opportunity to register.
    MeSH term(s) Canada ; Emergency Service, Hospital ; Health Knowledge, Attitudes, Practice ; Humans ; Physicians ; Surveys and Questionnaires ; Tissue Donors ; Tissue and Organ Procurement
    Language English
    Publishing date 2022-02-06
    Publishing country England
    Document type Journal Article
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1007/s43678-022-00262-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Using Intravital Microscopy to Study the Role of MIF in Leukocyte Trafficking In Vivo.

    Norman, M Ursula / Hickey, Michael J

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 2080, Page(s) 27–37

    Abstract: In vivo visualization of the microvasculature of the mouse cremaster muscle has been fruitful in the evaluation of the role of macrophage migration inhibitory factor in promotion of leukocyte trafficking. Here we explain how to undertake this preparation, ...

    Abstract In vivo visualization of the microvasculature of the mouse cremaster muscle has been fruitful in the evaluation of the role of macrophage migration inhibitory factor in promotion of leukocyte trafficking. Here we explain how to undertake this preparation, including details on mouse anesthesia, securing intravenous access, and cremaster muscle exteriorization. We also provide information on the various microscopy modalities now available for imaging microvascular preparations of this nature.
    MeSH term(s) Animals ; Cell Movement/genetics ; Cell Movement/immunology ; Chemotaxis/genetics ; Chemotaxis/immunology ; Intramolecular Oxidoreductases/genetics ; Intramolecular Oxidoreductases/metabolism ; Intravital Microscopy/methods ; Leukocytes/immunology ; Leukocytes/metabolism ; Macrophage Migration-Inhibitory Factors/genetics ; Macrophage Migration-Inhibitory Factors/metabolism ; Mice
    Chemical Substances Macrophage Migration-Inhibitory Factors ; Intramolecular Oxidoreductases (EC 5.3.-) ; Mif protein, mouse (EC 5.3.2.1)
    Language English
    Publishing date 2019-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9936-1_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: CD99: An endothelial passport for leukocytes.

    Hickey, Michael J

    The Journal of experimental medicine

    2015  Volume 212, Issue 7, Page(s) 977

    MeSH term(s) 12E7 Antigen ; Adenylyl Cyclases/metabolism ; Antigens, CD/metabolism ; Cell Adhesion Molecules/antagonists & inhibitors ; Cell Adhesion Molecules/metabolism ; Humans ; Models, Biological ; Signal Transduction/physiology ; Transendothelial and Transepithelial Migration/physiology
    Chemical Substances 12E7 Antigen ; Antigens, CD ; CD99 protein, human ; Cell Adhesion Molecules ; ADCY10 protein, human (EC 4.6.1.1) ; Adenylyl Cyclases (EC 4.6.1.1)
    Language English
    Publishing date 2015-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.2127insight2
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    Ua VI Zs.107: Show issues Location:
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