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  1. Article: Evaluation von M.O.B.I.L.I.S light - ein Gesundheitsprogramm für Übergewichtige

    Hänsel, F. / Zocher, C. / Ennigkeit, F. / Rühl, J.

    Deutsche Zeitschrift für Sportmedizin

    2013  Volume 64, Issue 4, Page(s) 108

    Language German
    Document type Article
    ZDB-ID 542455-0
    ISSN 0371-3059 ; 0344-5925
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.474: Show issues Location:
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  2. Article ; Online: Naturally grown duckweeds as quasi-hyperaccumulators of rare earth elements and yttrium in aquatic systems and the biounavailability of gadolinium-based MRI contrast agents.

    Zocher, Anna-Lena / Klimpel, Franziska / Kraemer, Dennis / Bau, Michael

    The Science of the total environment

    2022  Volume 838, Issue Pt 2, Page(s) 155909

    Abstract: The use of rare earths and yttrium (REY) in high-technology products is accompanied by their increasing release into the environment. Concerns regarding the (eco-)toxicity and bioaccumulation of these emerging contaminants highlight the need for research ...

    Abstract The use of rare earths and yttrium (REY) in high-technology products is accompanied by their increasing release into the environment. Concerns regarding the (eco-)toxicity and bioaccumulation of these emerging contaminants highlight the need for research on REY uptake by (aquatic) plants. Duckweeds are widespread macrophytes in lentic waters and receive increasing attention as a potential protein-rich food additive. We here provide a baseline dataset for the complete set of REY in naturally grown duckweed assemblages and ambient freshwater and coastal brackish seawater. Our results show that duckweeds strongly bioaccumulate REY and incorporate them at the μg/kg level (dry matter basis). Their shale-normalised (
    MeSH term(s) Araceae ; Contrast Media ; Gadolinium ; Magnetic Resonance Imaging ; Metals, Rare Earth ; Water Pollutants, Chemical/analysis ; Yttrium
    Chemical Substances Contrast Media ; Metals, Rare Earth ; Water Pollutants, Chemical ; Yttrium (58784XQC3Y) ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2022-05-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.155909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 949: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Loss of individualized behavioral trajectories in adult neurogenesis-deficient cyclin D2 knockout mice.

    Lopes, Jadna Bogado / Małz, Monika / Senko, Anna N / Zocher, Sara / Kempermann, Gerd

    Hippocampus

    2023  Volume 33, Issue 4, Page(s) 360–372

    Abstract: There is still limited mechanistic insight into how the interaction of individuals with their environment results in the emergence of individuality in behavior and brain structure. Nevertheless, the idea that personal activity shapes the brain is ... ...

    Abstract There is still limited mechanistic insight into how the interaction of individuals with their environment results in the emergence of individuality in behavior and brain structure. Nevertheless, the idea that personal activity shapes the brain is implicit in strategies for healthy cognitive aging as well as in the idea that individuality is reflected in the brain's connectome. We have shown that even isogenic mice kept in a shared enriched environment (ENR) developed divergent and stable social and exploratory trajectories. As these trajectories-measured as roaming entropy (RE)-positively correlated with adult hippocampal neurogenesis, we hypothesized that a feedback between behavioral activity and adult hippocampal neurogenesis might be a causal factor in brain individualization. We used cyclin D2 knockout mice with constitutively extremely low levels of adult hippocampal neurogenesis and their wild-type littermates. We housed them for 3 months in a novel ENR paradigm, consisting of 70 connected cages equipped with radio frequency identification antennae for longitudinal tracking. Cognitive performance was evaluated in the Morris Water Maze task (MWM). With immunohistochemistry we confirmed that adult neurogenesis correlated with RE in both genotypes and that D2 knockout mice had the expected impaired performance in the reversal phase of the MWM. But whereas the wild-type animals developed stable exploratory trajectories with increasing variance, correlating with adult neurogenesis, this individualizing phenotype was absent in D2 knockout mice. Here the behaviors started out more random and revealed less habituation and low variance. Together, these findings suggest that adult neurogenesis contributes to experience-dependent brain individualization.
    MeSH term(s) Mice ; Animals ; Mice, Knockout ; Cyclin D2/genetics ; Maze Learning ; Hippocampus ; Neurogenesis/genetics ; Mice, Inbred C57BL
    Chemical Substances Cyclin D2
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.23522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3227: Show issues Location:
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  4. Book ; Thesis: Ferromagnetische Resonanz (Breitband-Verfahren) an 3d-Ferromagnet-Dünnfilmen

    Zocher, Michael

    2015  

    Author's details vorgelegt von Michael Zocher
    Language German
    Size 88 S., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., FB Physik, Masterarbeit--Hamburg, 2015
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: Exploring divalent conjugates of 5-

    Johansson, Emil / Caraballo, Rémi / Zocher, Georg / Mistry, Nitesh / Arnberg, Niklas / Stehle, Thilo / Elofsson, Mikael

    RSC advances

    2022  Volume 12, Issue 4, Page(s) 2319–2331

    Abstract: Coxsackievirus A24 variant (CVA24v) is responsible for several outbreaks and two pandemics of the highly contagious eye infection acute hemorrhagic conjunctivitis (AHC). Currently, neither prevention (vaccines) nor treatments (antivirals) are available ... ...

    Abstract Coxsackievirus A24 variant (CVA24v) is responsible for several outbreaks and two pandemics of the highly contagious eye infection acute hemorrhagic conjunctivitis (AHC). Currently, neither prevention (vaccines) nor treatments (antivirals) are available for combating this disease. CVA24v attaches to cells by binding Neu5Ac-containing glycans on the surface of cells which facilitates entry. Previously, we have demonstrated that pentavalent Neu5Ac conjugates attenuate CVA24v infection of human corneal epithelial (HCE) cells. In this study, we report on the structure-based design of three classes of divalent Neu5Ac conjugates, with varying spacer lengths, and their effect on CVA24v transduction in HCE cells. In relative terms, the most efficient class of divalent Neu5Ac conjugates are more efficient than the pentavalent Neu5Ac conjugates previously reported.
    Language English
    Publishing date 2022-01-14
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra08968d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Digital health applications in the self-management of epilepsy-A survey on patients' perspective.

    Houta, Salima / Bader, Alisa / Effert, Jana-Sophie / Esser, Birgitta / Henze, Jasmin / Spaic, Alexandra / Zocher, Feline / Lauerer, Michael / Surges, Rainer

    Epilepsia open

    2023  Volume 8, Issue 4, Page(s) 1288–1299

    Abstract: Objective: Digital health applications can be prescribed since 2019 in Germany, which is likely to facilitate a broad use of epilepsy self-management applications, possibly directly connected to clinical systems via telematics infrastructures. This ... ...

    Abstract Objective: Digital health applications can be prescribed since 2019 in Germany, which is likely to facilitate a broad use of epilepsy self-management applications, possibly directly connected to clinical systems via telematics infrastructures. This article reports on patients' interest in digital support for epilepsy self-management, influencing factors and patients' knowledge about digitization of health care in Germany.
    Methods: This work is based on self-reported data from 115 people with epilepsy participating in an anonymous online survey with a total of 54 questions covering several topics, including sociodemographics and epilepsy manifestation, use of technology in general and for treatment support, training programs, affinity for technology, knowledge on the digital infrastructure in Germany, and self-efficacy in dealing with chronic illness. The self-constructed questionnaire uses existing instruments like TA-EG, SES6G, and Hoffmeyer-Zlotnik sociodemographic questionnaire. To analyze the knowledge about digitalization in health care, a combination of self-assessment and knowledge quiz was used. The analysis was performed using descriptive methods and inferential statistics (t-test, reliability analysis, and correlations).
    Results: Participants were most interested in seizure alerting and documentation with the possibility to share documentation with physicians. The analysis of technology affinity showed medium enthusiasm, with positively perceived consequences being rated higher than the negatively perceived consequences of technology use. Knowledge on national health infrastructures was mediocre and training on this was judged to be essential and desired. Furthermore, a significant correlation was found between interest in use and affinity for technology (enthusiasm for technology [r = 0.29; P = 0.00]) and positively perceived consequences of technology (r = 0.33; P = 0.00).
    Significance: Our results underline the high relevance of digital solutions for patients and the importance of individual training opportunities in digital health literacy, thereby enabling patients to decide competently for or against offered digital solutions.
    MeSH term(s) Humans ; Self-Management ; Reproducibility of Results ; Epilepsy/therapy ; Surveys and Questionnaires ; Seizures
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: N-acetylmuramic acid recognition by MurK kinase from the MurNAc auxotrophic oral pathogen Tannerella forsythia.

    Stasiak, Aleksandra Cecylia / Gogler, Karolin / Borisova, Marina / Fink, Phillipp / Mayer, Christoph / Stehle, Thilo / Zocher, Georg

    The Journal of biological chemistry

    2023  Volume 299, Issue 9, Page(s) 105076

    Abstract: The bacterial cell wall consists of a three-dimensional peptidoglycan layer, composed of peptides linked to the sugars N-acetylmuramic acid (MurNAc) and GlcNAc. Unlike other bacteria, the pathogenic Tannerella forsythia, a member of the red complex group ...

    Abstract The bacterial cell wall consists of a three-dimensional peptidoglycan layer, composed of peptides linked to the sugars N-acetylmuramic acid (MurNAc) and GlcNAc. Unlike other bacteria, the pathogenic Tannerella forsythia, a member of the red complex group of bacteria associated with the late stages of periodontitis, lacks biosynthetic pathways for MurNAc production and therefore obtains MurNAc from the environment. Sugar kinases play a crucial role in the MurNAc recycling process, activating the sugar molecules by phosphorylation. In this study, we present the first crystal structures of a MurNAc kinase, called murein sugar kinase (MurK), in its unbound state as well as in complexes with the ATP analog β-γ-methylene adenosine triphosphate (AMP-PCP) and with MurNAc. We also determined the crystal structures of K1058, a paralogous MurNAc kinase of T. forsythia, in its unbound state and in complex with MurNAc. We identified the active site and residues crucial for MurNAc specificity as the less bulky side chains of S133, P134, and L135, which enlarge the binding cavity for the lactyl ether group, unlike the glutamate or histidine residues present in structural homologs. In establishing the apparent kinetic parameters for both enzymes, we showed a comparable affinity for MurNAc (K
    MeSH term(s) Muramic Acids/metabolism ; Peptidoglycan/metabolism ; Tannerella forsythia/enzymology ; Phosphotransferases/chemistry ; Phosphotransferases/metabolism ; Protein Structure, Tertiary ; Models, Molecular ; Crystallography, X-Ray ; Catalytic Domain ; Enzyme Activation
    Chemical Substances Muramic Acids ; N-acetylmuramic acid (246FXU111L) ; Peptidoglycan ; Phosphotransferases (EC 2.7.-)
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.108: Show issues Location:
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  8. Article ; Online: Lifelong persistence of nuclear RNAs in the mouse brain.

    Zocher, Sara / McCloskey, Asako / Karasinsky, Anne / Schulte, Roberta / Friedrich, Ulrike / Lesche, Mathias / Rund, Nicole / Gage, Fred H / Hetzer, Martin W / Toda, Tomohisa

    Science (New York, N.Y.)

    2024  Volume 384, Issue 6691, Page(s) 53–59

    Abstract: Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. ... ...

    Abstract Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type-specific manner and were required for the maintenance of heterochromatin. Thus, the life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information and also the extreme stability of RNA for the functional organization of chromatin.
    MeSH term(s) Animals ; Mice ; Brain/metabolism ; Chromatin ; Gene Expression Regulation ; Heterochromatin/genetics ; RNA, Nuclear/genetics
    Chemical Substances Chromatin ; Heterochromatin ; RNA, Nuclear
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adf3481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 77: Show issues

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  9. Book: Schaltungstechnik mit konzentrierten Elementen

    Zocher, Michael

    (Hochfrequenztechnik ; ; 1)

    2013  

    Author's details Michael Zocher
    Series title Hochfrequenztechnik
    ; 1
    Keywords Hochfrequenztechnik
    Language German
    Size VIII, 196 S., zahlr. Ill., graph. Darst., 210 mm x 148 mm, 373 g
    Edition 2., überarb. Aufl.
    Publisher Vogt
    Publishing place Dresden
    Document type Book
    ISBN 9783938860649 ; 3938860642
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book ; Thesis: Methoden zur Bestimmung des winkelabhängigen Schaltfeldes von einzelnen CoxNi100-x-Nanostäben via MOKE

    Zocher, Michael

    2013  

    Author's details vorgelegt von Michael Zocher
    Language German
    Size 71 S., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., FB Physik, Bachelorarbeit--Hamburg, 2013
    Accompanying material 1 CD-ROM (12 cm)
    Database Former special subject collection: coastal and deep sea fishing

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