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  1. Article: Insulin-like growth factor 2 (IGF-2) rescues social deficits in NLG3

    Pizzarelli, Rocco / Pimpinella, Domenico / Jacobs, Christian / Tartacca, Alice / Kullolli, Uarda / Monyer, Hannah / Alberini, Cristina M / Griguoli, Marilena

    Frontiers in cellular neuroscience

    2024  Volume 17, Page(s) 1332179

    Abstract: Autism spectrum disorders (ASDs) comprise developmental disabilities characterized by impairments of social interaction and repetitive behavior, often associated with cognitive deficits. There is no current treatment that can ameliorate most of the ASDs ... ...

    Abstract Autism spectrum disorders (ASDs) comprise developmental disabilities characterized by impairments of social interaction and repetitive behavior, often associated with cognitive deficits. There is no current treatment that can ameliorate most of the ASDs symptomatology; thus, identifying novel therapies is urgently needed. Here, we used the Neuroligin 3 knockout mouse (NLG3
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1332179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Molecular Imaging of Tau Protein: New Insights and Future Directions.

    Pizzarelli, Rocco / Pediconi, Natalia / Di Angelantonio, Silvia

    Frontiers in molecular neuroscience

    2020  Volume 13, Page(s) 586169

    Abstract: Tau is a microtubule-associated protein (MAPT) that is highly expressed in neurons and implicated in several cellular processes. Tau misfolding and self-aggregation give rise to proteinaceous deposits known as neuro-fibrillary tangles. Tau tangles play a ...

    Abstract Tau is a microtubule-associated protein (MAPT) that is highly expressed in neurons and implicated in several cellular processes. Tau misfolding and self-aggregation give rise to proteinaceous deposits known as neuro-fibrillary tangles. Tau tangles play a key role in the genesis of a group of diseases commonly referred to as tauopathies; notably, these aggregates start to form decades before any clinical symptoms manifest. Advanced imaging methodologies have clarified important structural and functional aspects of tau and could have a role as diagnostic tools in clinical research. In the present review, recent progresses in tau imaging will be discussed. We will focus mainly on super-resolution imaging methods and the development of near-infrared fluorescent probes.
    Language English
    Publishing date 2020-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2020.586169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Dopamine, Alpha-Synuclein, and Mitochondrial Dysfunctions in Parkinsonian Eyes.

    Indrieri, Alessia / Pizzarelli, Rocco / Franco, Brunella / De Leonibus, Elvira

    Frontiers in neuroscience

    2020  Volume 14, Page(s) 567129

    Abstract: Parkinson's disease (PD) is characterized by motor dysfunctions including bradykinesia, tremor at rest and motor instability. These symptoms are associated with the progressive degeneration of dopaminergic neurons originating in ... ...

    Abstract Parkinson's disease (PD) is characterized by motor dysfunctions including bradykinesia, tremor at rest and motor instability. These symptoms are associated with the progressive degeneration of dopaminergic neurons originating in the
    Language English
    Publishing date 2020-10-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2020.567129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Developmental regulation of GABAergic signalling in the hippocampus of neuroligin 3 R451C knock-in mice: an animal model of Autism.

    Pizzarelli, Rocco / Cherubini, Enrico

    Frontiers in cellular neuroscience

    2013  Volume 7, Page(s) 85

    Abstract: Autism Spectrum Disorders (ASDs) comprise an heterogeneous group of neuro-developmental abnormalities, mainly of genetic origin, characterized by impaired social interactions, communications deficits, and stereotyped behaviors. In a small percentage of ... ...

    Abstract Autism Spectrum Disorders (ASDs) comprise an heterogeneous group of neuro-developmental abnormalities, mainly of genetic origin, characterized by impaired social interactions, communications deficits, and stereotyped behaviors. In a small percentage of cases, ASDs have been found to be associated with single mutations in genes involved in synaptic function. One of these involves the postsynaptic cell adhesion molecule neuroligin (NL) 3. NLs interact with presynaptic neurexins (Nrxs) to ensure a correct cross talk between post and presynaptic specializations. Here, transgenic mice carrying the human R451C mutation of Nlgn3, were used to study GABAergic signaling in the hippocampus early in postnatal life. Whole cell recordings from CA3 pyramidal neurons in slices from NL3(R451C) knock-in mice revealed an enhanced frequency of Giant Depolarizing Potentials (GDPs), as compared to controls. This effect was probably dependent on an increased GABAergic drive to principal cells as demonstrated by the enhanced frequency of miniature GABAA-mediated (GPSCs), but not AMPA-mediated postsynaptic currents (EPSCs). Changes in frequency of mGPSCs were associated with an acceleration of their decay kinetics, in the absence of any change in unitary synaptic conductance or in the number of GABAA receptor channels, as assessed by peak scaled non-stationary fluctuation analysis. The enhanced GABAergic but not glutamatergic transmission early in postnatal life may change the excitatory/inhibitory balance known to play a key role in the construction and refinement of neuronal circuits during postnatal development. This may lead to behavioral deficits reminiscent of those observed in ASDs patients.
    Language English
    Publishing date 2013-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2013.00085
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  5. Article ; Online: Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions.

    Pizzarelli, Rocco / Griguoli, Marilena / Zacchi, Paola / Petrini, Enrica Maria / Barberis, Andrea / Cattaneo, Antonino / Cherubini, Enrico

    Neuroscience

    2019  Volume 439, Page(s) 125–136

    Abstract: To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine and ... ...

    Abstract To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine and GABA
    MeSH term(s) Carrier Proteins ; Humans ; Membrane Proteins/metabolism ; Receptors, GABA-A ; Synapses/metabolism
    Chemical Substances Carrier Proteins ; Membrane Proteins ; Receptors, GABA-A ; gephyrin
    Language English
    Publishing date 2019-07-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2019.07.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Alterations of GABAergic signaling in autism spectrum disorders.

    Pizzarelli, Rocco / Cherubini, Enrico

    Neural plasticity

    2011  Volume 2011, Page(s) 297153

    Abstract: Autism spectrum disorders (ASDs) comprise a heterogeneous group of pathological conditions, mainly of genetic origin, characterized by stereotyped behavior, marked impairment in verbal and nonverbal communication, social skills, and cognition. ... ...

    Abstract Autism spectrum disorders (ASDs) comprise a heterogeneous group of pathological conditions, mainly of genetic origin, characterized by stereotyped behavior, marked impairment in verbal and nonverbal communication, social skills, and cognition. Interestingly, in a small number of cases, ASDs are associated with single mutations in genes encoding for neuroligin-neurexin families. These are adhesion molecules which, by regulating transsynaptic signaling, contribute to maintain a proper excitatory/inhibitory (E/I) balance at the network level. Furthermore, GABA, the main inhibitory neurotransmitter in adult life, at late embryonic/early postnatal stages has been shown to depolarize and excite targeted cell through an outwardly directed flux of chloride. The depolarizing action of GABA and associated calcium influx regulate a variety of developmental processes from cell migration and differentiation to synapse formation. Here, we summarize recent data concerning the functional role of GABA in building up and refining neuronal circuits early in development and the molecular mechanisms regulating the E/I balance. A dysfunction of the GABAergic signaling early in development leads to a severe E/I unbalance in neuronal circuits, a condition that may account for some of the behavioral deficits observed in ASD patients.
    MeSH term(s) Brain/physiopathology ; Child ; Child Development Disorders, Pervasive/physiopathology ; Humans ; Neural Inhibition/physiology ; Neurons/physiology ; Synaptic Transmission/physiology ; gamma-Aminobutyric Acid/physiology
    Chemical Substances gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2011-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1454938-4
    ISSN 1687-5443 ; 2090-5904 ; 0792-8483
    ISSN (online) 1687-5443
    ISSN 2090-5904 ; 0792-8483
    DOI 10.1155/2011/297153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3305: Show issues Location:
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  7. Article ; Online: Alterations of GABAergic Signaling in Autism Spectrum Disorders

    Enrico Cherubini / Rocco Pizzarelli

    Neural Plasticity, Vol

    2011  Volume 2011

    Keywords Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Computational Modeling of Inhibitory Transsynaptic Signaling in Hippocampal and Cortical Neurons Expressing Intrabodies Against Gephyrin.

    Lupascu, Carmen A / Morabito, Annunziato / Ruggeri, Federica / Parisi, Chiara / Pimpinella, Domenico / Pizzarelli, Rocco / Meli, Giovanni / Marinelli, Silvia / Cherubini, Enrico / Cattaneo, Antonino / Migliore, Michele

    Frontiers in cellular neuroscience

    2020  Volume 14, Page(s) 173

    Abstract: GABAergic transmission regulates neuronal excitability, dendritic integration of synaptic signals and oscillatory activity, thought to be involved in high cognitive functions. By anchoring synaptic receptors just opposite to release sites, the scaffold ... ...

    Abstract GABAergic transmission regulates neuronal excitability, dendritic integration of synaptic signals and oscillatory activity, thought to be involved in high cognitive functions. By anchoring synaptic receptors just opposite to release sites, the scaffold protein gephyrin plays a key role in these tasks. In addition, by regulating GABA
    Language English
    Publishing date 2020-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2020.00173
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  9. Article: Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis.

    Grimaldi, Alfonso / Pediconi, Natalia / Oieni, Francesca / Pizzarelli, Rocco / Rosito, Maria / Giubettini, Maria / Santini, Tiziana / Limatola, Cristina / Ruocco, Giancarlo / Ragozzino, Davide / Di Angelantonio, Silvia

    Frontiers in neuroscience

    2019  Volume 13, Page(s) 925

    Abstract: Alzheimer's disease (AD), a primary cause of dementia in the aging population, is characterized by extracellular amyloid-beta peptides aggregation, intracellular deposits of hyperphosphorylated tau, neurodegeneration and glial activation in the brain. It ...

    Abstract Alzheimer's disease (AD), a primary cause of dementia in the aging population, is characterized by extracellular amyloid-beta peptides aggregation, intracellular deposits of hyperphosphorylated tau, neurodegeneration and glial activation in the brain. It is commonly thought that the lack of early diagnostic
    Language English
    Publishing date 2019-09-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2019.00925
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  10. Article ; Online: SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.

    Fossati, Matteo / Pizzarelli, Rocco / Schmidt, Ewoud R / Kupferman, Justine V / Stroebel, David / Polleux, Franck / Charrier, Cécile

    Neuron

    2016  Volume 91, Issue 2, Page(s) 356–369

    Abstract: The proper function of neural circuits requires spatially and temporally balanced development of excitatory and inhibitory synapses. However, the molecular mechanisms coordinating excitatory and inhibitory synaptogenesis remain unknown. Here we ... ...

    Abstract The proper function of neural circuits requires spatially and temporally balanced development of excitatory and inhibitory synapses. However, the molecular mechanisms coordinating excitatory and inhibitory synaptogenesis remain unknown. Here we demonstrate that SRGAP2A and its human-specific paralog SRGAP2C co-regulate the development of excitatory and inhibitory synapses in cortical pyramidal neurons in vivo. SRGAP2A promotes synaptic maturation, and ultimately the synaptic accumulation of AMPA and GABAA receptors, by interacting with key components of both excitatory and inhibitory postsynaptic scaffolds, Homer and Gephyrin. Furthermore, SRGAP2A limits the density of both types of synapses via its Rac1-GAP activity. SRGAP2C inhibits all identified functions of SRGAP2A, protracting the maturation and increasing the density of excitatory and inhibitory synapses. Our results uncover a molecular mechanism coordinating critical features of synaptic development and suggest that human-specific duplication of SRGAP2 might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance.
    MeSH term(s) Excitatory Postsynaptic Potentials/physiology ; GTPase-Activating Proteins/metabolism ; Humans ; Neural Inhibition/physiology ; Neurogenesis/genetics ; Neurogenesis/physiology ; Patch-Clamp Techniques/methods ; Receptors, GABA-A/metabolism ; Synapses/physiology ; Synaptic Transmission/physiology
    Chemical Substances GTPase-Activating Proteins ; Receptors, GABA-A ; SRGAP2 protein, human
    Language English
    Publishing date 2016-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2016.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MG 92: Show issues

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