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  1. Article ; Online: ZnIn

    Zang, Shaohong / Cai, Xiaorong / Zang, Yixian / Jing, Fei / Lu, Youwei / Tang, Shuting / Lin, Feng / Mo, Liuye

    Inorganic chemistry

    2024  Volume 63, Issue 14, Page(s) 6546–6554

    Abstract: ... ...

    Abstract Znln
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.4c00645
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  2. Article ; Online: The SSEPs may not reflect the patient's true neurological status during Targeted Temperature Management.

    Zhang, Yixian / Yuan, Jing / Wu, Mengjun

    Resuscitation

    2021  Volume 165, Page(s) 192–193

    MeSH term(s) Evoked Potentials, Somatosensory ; Humans ; Hypothermia, Induced
    Language English
    Publishing date 2021-06-02
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2021.05.023
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Investigating the Potential Shared Molecular Mechanisms between COVID-19 and Alzheimer's Disease via Transcriptomic Analysis.

    Fan, Yixian / Liu, Xiaozhao / Guan, Fei / Hang, Xiaoyi / He, Ximiao / Jin, Jing

    Viruses

    2024  Volume 16, Issue 1

    Abstract: SARS-CoV-2 caused the COVID-19 pandemic. COVID-19 may elevate the risk of cognitive impairment and even cause dementia in infected individuals; it may accelerate cognitive decline in elderly patients with dementia, possibly in Alzheimer's disease (AD) ... ...

    Abstract SARS-CoV-2 caused the COVID-19 pandemic. COVID-19 may elevate the risk of cognitive impairment and even cause dementia in infected individuals; it may accelerate cognitive decline in elderly patients with dementia, possibly in Alzheimer's disease (AD) patients. However, the mechanisms underlying the interplay between AD and COVID-19 are still unclear. To investigate the underlying mechanisms and associations between AD progression and SARS-CoV-2 infection, we conducted a series of bioinformatics research into SARS-CoV-2-infected cells, COVID-19 patients, AD patients, and SARS-CoV-2-infected AD patients. We identified the common differentially expressed genes (DEGs) in COVID-19 patients, AD patients, and SARS-CoV-2-infected cells, and these DEGs are enriched in certain pathways, such as immune responses and cytokine storms. We constructed the gene interaction network with the signaling transduction module in the center and identified
    MeSH term(s) Aged ; Humans ; COVID-19/genetics ; SARS-CoV-2 ; Alzheimer Disease/genetics ; Angiotensin-Converting Enzyme 2 ; Endothelial Cells ; Pandemics ; Gene Expression Profiling
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16010100
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  4. Article: Ferroptosis in hematological malignant tumors.

    Liu, Yong / Du, Zefan / Huang, Junbin / Li, Tianwen / Zhang, Jing / Li, Yixian / Yi, Wenfang / Chen, Chun

    Frontiers in oncology

    2023  Volume 13, Page(s) 1127526

    Abstract: Ferroptosis is a kind of iron-dependent programmed cell death discovered in recent years. Its main feature is the accumulation of lipid reactive oxygen species in cells, eventually leading to oxidative stress and cell death. It plays a pivotal role in ... ...

    Abstract Ferroptosis is a kind of iron-dependent programmed cell death discovered in recent years. Its main feature is the accumulation of lipid reactive oxygen species in cells, eventually leading to oxidative stress and cell death. It plays a pivotal role in normal physical conditions and the occurrence and development of various diseases. Studies have shown that tumor cells of the blood system, such as leukemia cells and lymphoma cells, are sensitive to the response to ferroptosis. Regulators that modulate the Ferroptosis pathway can accelerate or inhibit tumor disease progression. This article reviews the mechanism of ferroptosis and its research status in hematological malignancies. Understanding the mechanisms of ferroptosis could provide practical guidance for treating and preventing these dreaded diseases.
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1127526
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  5. Article: Effects of altered excitation-inhibition imbalance by repetitive transcranial magnetic stimulation for self-limited epilepsy with centrotemporal spikes.

    Yang, Yujiao / Han, Yixian / Wang, Jing / Zhou, Yongkang / Chen, Dong / Wang, Mengyang / Li, Tianfu

    Frontiers in neurology

    2023  Volume 14, Page(s) 1164082

    Abstract: Objectives: Patients with self-limited epilepsy with centrotemporal spikes (SeLECTS) with electrical status epilepticus in sleep (ESES) have generalized cognitive impairment, yet treatment options are limited. Our study aimed to examine the therapeutic ... ...

    Abstract Objectives: Patients with self-limited epilepsy with centrotemporal spikes (SeLECTS) with electrical status epilepticus in sleep (ESES) have generalized cognitive impairment, yet treatment options are limited. Our study aimed to examine the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on SeLECTS with ESES. In addition, we applied electroencephalography (EEG) aperiodic components (offset and slope) to investigate the improvement of rTMS on the excitation-inhibition imbalance (E-I imbalance) in the brain of this group of children.
    Methods: Eight SeLECTS patients with ESES were included in this study. Low-frequency rTMS (≤1 Hz) was applied for 10 weekdays in each patient. To assess the clinical efficacy and changes in E-I imbalance, EEG recordings were performed both before and after rTMS. Seizure-reduction rate and spike-wave index (SWI) were measured to investigate the clinical effects of rTMS. The aperiodic offset and slope were calculated to explore the effect of rTMS on E-I imbalance.
    Results: Five of the eight patients (62.5%) were seizure-free within 3 months after stimulation, with treatment effects decreasing with longer follow-ups. The SWI decreased significantly at 3 and 6 months after rTMS compared with the baseline (
    Conclusion: Patients achieved favorable outcomes in the first 3 months after rTMS. The ameliorative effect of rTMS on SWI may last up to 6 months. Low-frequency rTMS could reduce firing rates in neuronal populations throughout the brain, which was most pronounced at the site of stimulation. A significant reduction in the slope after rTMS treatment suggested an improvement in the E-I imbalance in the SeLECTS.
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1164082
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  6. Article ; Online: Rhombohedral/Cubic In

    Cai, Xiaorong / Wang, Yaning / Tang, Shuting / Mo, Liuye / Leng, Zhe / Zang, Yixian / Jing, Fei / Zang, Shaohong

    International journal of molecular sciences

    2022  Volume 23, Issue 22

    Abstract: In recent studies, phase junctions constructed as photocatalysts have been found to possess great prospects for organic degradation with visible light. In this study, we designed an elaborate rhombohedral corundum/cubic ... ...

    Abstract In recent studies, phase junctions constructed as photocatalysts have been found to possess great prospects for organic degradation with visible light. In this study, we designed an elaborate rhombohedral corundum/cubic In
    MeSH term(s) Photolysis ; Environmental Pollutants ; Catalysis ; Pregnenolone Carbonitrile ; Polymers
    Chemical Substances cyanogen (534Q0F66RK) ; Environmental Pollutants ; Pregnenolone Carbonitrile (1434-54-4) ; Polymers
    Language English
    Publishing date 2022-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232214293
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  7. Article ; Online: First mapping of China surface movement using supercomputing interferometric SAR technique.

    Wang, Chao / Tang, Yixian / Zhang, Hong / You, Haihang / Zhang, Weikang / Duan, Wei / Wang, Jing / Dong, Longkai / Zhang, Bo

    Science bulletin

    2021  Volume 66, Issue 16, Page(s) 1608–1610

    MeSH term(s) Computing Methodologies ; Interferometry ; China
    Language English
    Publishing date 2021-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2021.04.026
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  8. Article ; Online: Alterations of Urinary Microbial Metabolites and Immune Indexes Linked With COVID-19 Infection and Prognosis.

    Jing, Yixian / Wang, Jing / Zhang, Haiyan / Yang, Kun / Li, Jungang / Zhao, Ting / Liu, Jiaxiu / Wu, Jing / Chen, Yaokai

    Frontiers in immunology

    2022  Volume 13, Page(s) 841739

    Abstract: Coronavirus disease 2019 (COVID-19) has evolved into an established global pandemic. Metabolomic studies in COVID-19 patients is worth exploring for further available screening methods. In our study, we recruited a study cohort of 350 subjects comprising ...

    Abstract Coronavirus disease 2019 (COVID-19) has evolved into an established global pandemic. Metabolomic studies in COVID-19 patients is worth exploring for further available screening methods. In our study, we recruited a study cohort of 350 subjects comprising 248 COVID-19 patients (161 non-severe cases, 60 asymptomatic cases, and 27 severe cases) and 102 healthy controls (HCs), and herein present data with respect to their demographic features, urinary metabolome, immunological indices, and follow-up health status. We found that COVID-19 resulted in alterations of 39 urinary, mainly microbial, metabolites. Using random forest analysis, a simplified marker panel including three microbial metabolites (oxoglutaric acid, indoxyl, and phenylacetamide) was constructed (AUC=0.963, 95% CI, 0.930-0.983), which exhibited higher diagnostic performance than immune feature-based panels between COVID-19 and HC groups (
    MeSH term(s) CD8-Positive T-Lymphocytes ; COVID-19 ; Humans ; Metabolome ; Prognosis ; SARS-CoV-2
    Language English
    Publishing date 2022-03-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.841739
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  9. Article ; Online: Rifabutin-Containing Triple Therapy Versus Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Multicenter, Randomized Controlled Trial.

    Chen, Jinnan / Guo, Yixian / Huang, Yu / Ding, Zhaohui / Wang, Jing / Liang, Xiao / Xu, Ping / Han, Yaohua / Lu, Hong

    The Journal of infectious diseases

    2023  Volume 228, Issue 5, Page(s) 511–518

    Abstract: Background: We compared the efficacy and safety of rifabutin-containing triple therapy with bismuth quadruple therapy for rescue treatment of Helicobacter pylori.: Methods: This was a noninferiority study trial of H. pylori treatment for subjects who ...

    Abstract Background: We compared the efficacy and safety of rifabutin-containing triple therapy with bismuth quadruple therapy for rescue treatment of Helicobacter pylori.
    Methods: This was a noninferiority study trial of H. pylori treatment for subjects who had failed at least 2 prior treatments. Subjects were randomly assigned to receive rifabutin triple therapy with 14-day esomeprazole (20 mg), amoxicillin (1.0 g), and rifabutin (150 mg) twice a day; or bismuth quadruple therapy with esomeprazole (20 mg) and bismuth (220 mg) twice a day, plus metronidazole (400 mg) and tetracycline (500 mg) 4 times a day. Antimicrobial susceptibility was assessed by agar dilution and E-test.
    Results: From May 2021 to October 2022, a total of 364 subjects were randomized. The eradication rates by intention-to-treat, per-protocol, and modified intention-to-treat were 89.0% (162/182; 95% confidence interval [CI], 83.6%-92.8%), 94.0% (157/167; 95% CI, 89.3%-96.7%), and 93.6% (162/173; 95% CI, 89.0%-96.4%) for rifabutin triple group. For bismuth quadruple group, they were 89.6% (163/182; 95% CI, 84.3%-93.2%), 95.3% (143/150; 95% CI, 90.7%-97.7%), and 93.7% (163/174; 95% CI, 89.0%-96.4%).
    Conclusions: The rifabutin triple therapy is an alternative to classical bismuth quadruple therapy for the rescue treatment of H. pylori with fewer side effects and higher compliance.
    Clinical trials registration: NCT04879992.
    MeSH term(s) Humans ; Bismuth/therapeutic use ; Helicobacter pylori ; Helicobacter Infections/drug therapy ; Esomeprazole/therapeutic use ; Rifabutin/therapeutic use ; Drug Therapy, Combination ; Anti-Bacterial Agents/therapeutic use ; Amoxicillin/therapeutic use ; Metronidazole/therapeutic use ; Treatment Outcome ; Proton Pump Inhibitors/therapeutic use
    Chemical Substances Bismuth (U015TT5I8H) ; Esomeprazole (N3PA6559FT) ; Rifabutin (1W306TDA6S) ; Anti-Bacterial Agents ; Amoxicillin (804826J2HU) ; Metronidazole (140QMO216E) ; Proton Pump Inhibitors
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad114
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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
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    Zs.MO 445: Show issues

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  10. Article ; Online: Mechanism of Sophorae Flavescentis Radix (Kushen) in treating NSCLC: Insights from miRNA-mRNA network analysis.

    Li, Jing / Huang, Yixian / Xu, Jiatong / Zuo, Huali / Tang, Yun / Huang, Hsi-Yuan / Chen, Jihang / Lin, Yang-Chi-Dung / Huang, Hsien-Da

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 3, Page(s) 117232

    Abstract: Ethnopharmacological relevance: Sophorae Flavescentis Radix (Kushen) is the primary herb component of Compound Kushen Injection (CKI), an approved clinical treatment for tumors. Despite CKI's widespread use, the underlying mechanisms of Kushen regarding ...

    Abstract Ethnopharmacological relevance: Sophorae Flavescentis Radix (Kushen) is the primary herb component of Compound Kushen Injection (CKI), an approved clinical treatment for tumors. Despite CKI's widespread use, the underlying mechanisms of Kushen regarding microRNA-target and pathway remain unclear in non-small cell lung cancer (NSCLC).
    Aim of the study: This study aimed to elucidate the crucial miRNAs-targets and pathways responsible for the Kushen's impact on NSCLC.
    Materials and methods: CCK8, colony formation, and apoptosis assays were performed to assess the effects of Kushen on NSCLC cells. Subsequently, we treated the A549 cell line with varying concentrations of Kushen to obtain mRNA and miRNA expression profiles. A DE (differentially expressed) miRNAs-DEGs network was then constructed to identify the critical miRNA-mRNA interaction influenced by Kushen. Furthermore, we performed clinical significance and prognosis analyses of hub genes to narrow down key genes and their corresponding miRNAs. Finally, the effects of Kushen on critical miRNA-mRNA interaction and related pathway were verified by in vitro and in vivo experiments.
    Results: In this study, we initially demonstrated that Kushen significantly inhibited cell proliferation, suppressed colony formation, and induced apoptosis in the A549 cells, PC9 cells, and the A549 zebrafish xenograft model. Through expression profile analysis, a DE miRs-DEGs network was constructed with 16 DE miRs and 68 DEGs. Through the network analysis and expression validation, we found Kushen could significantly down-regulate miR-183-5p expression and up-regulate EGR1 expression. Additionally, Kushen affected the PTEN/Akt pathway, increasing PTEN expression and decreasing pAkt expression. Finally, matrine, the essential active compound of Kushen, also inhibited cell growth, induced apoptosis, and regulated miR-183-5p/EGR1 and PTEN/AKT pathway.
    Conclusions: Altogether, these findings supported the critical role of miR-183-5p/EGR1 and the PTEN/AKT pathway in the beneficial effects of Kushen on NSCLC, highlighting the therapeutic potential of Kushen in NSCLC treatment.
    MeSH term(s) Humans ; Animals ; MicroRNAs/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Proto-Oncogene Proteins c-akt ; Zebrafish ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Biological Products
    Chemical Substances MicroRNAs ; kushen (IYR6K8KQ5K) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Biological Products
    Language English
    Publishing date 2023-09-25
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117232
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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