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  1. Article: Demographics and prognosis of patients with pyogenic liver abscess due to

    Xu, Qiaomai / Liu, Changhong / Wu, Zhengjie / Zhang, Shumeng / Chen, Zhuoling / Shi, Yu / Gu, Silan

    Heliyon

    2024  Volume 10, Issue 8, Page(s) e29463

    Abstract: Background: Pyogenic liver abscess (PLA) is a potentially life-threatening intra-abdominal infection. We compared the clinical features, treatments, and prognoses of patients who had : Methods: A retrospective analysis was used to compare the medical ...

    Abstract Background: Pyogenic liver abscess (PLA) is a potentially life-threatening intra-abdominal infection. We compared the clinical features, treatments, and prognoses of patients who had
    Methods: A retrospective analysis was used to compare the medical records of KPPLA and non-KPPLA patients with positive pus cultures at a single hospital in China from January 2017 to December 2019.
    Results: We examined 279 patients with definitively established PLA, 207 (74.2 %) with KPPLA, and 72 with non-KPPLA. The non-KPPLA group had a higher Charlson comorbidity index, longer hospital stay, longer duration of fever, and greater hospital costs. Multivariate analysis showed that alcohol intake (OR: 2.44,
    Conclusion: KPPLA and non-KPPLA patients had some differences in comorbidities and treatment strategies, and non-KPPLA patients had a significantly worse prognosis.
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29463
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  2. Article ; Online: Reply to Marcialis et al.

    Gu, Silan / Chen, Yanfei / Lv, Longxian / Li, Lanjuan

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 12, Page(s) 2246–2247

    MeSH term(s) COVID-19 ; Gastrointestinal Microbiome ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human ; SARS-CoV-2
    Language English
    Publishing date 2020-07-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa966
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 480: Show issues

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  3. Article ; Online: Reply to Klann et al.

    Gu, Silan / Lv, Longxian / Wu, Zhengjie / Li, Lanjuan

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 12, Page(s) 2248–2249

    MeSH term(s) COVID-19 ; Gastrointestinal Microbiome ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human ; SARS-CoV-2
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1194
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  4. Article ; Online: Disordered Intestinal Microbial Communities During

    Chen, Yunbo / Lv, Tao / Yan, Dong / Zheng, Lisi / Zheng, Beiwen / Wang, Jingxia / Gu, Silan / Li, Lanjuan

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 825189

    Abstract: Patients with hepatic cirrhosis are more susceptible ... ...

    Abstract Patients with hepatic cirrhosis are more susceptible to
    MeSH term(s) Clostridioides ; Clostridioides difficile/genetics ; Clostridium Infections/microbiology ; Humans ; Intestinal Diseases ; Liver Cirrhosis/complications ; Microbiota ; RNA, Ribosomal, 16S/genetics ; Tertiary Care Centers
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-04-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.825189
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  5. Article: Akkermansia muciniphila

    Wu, Zhengjie / Xu, Qiaomai / Gu, Silan / Chen, Yunbo / Lv, Longxian / Zheng, Beiwen / Wang, Qiangqiang / Wang, Kaicen / Wang, Shuting / Xia, Jiafeng / Yang, Liya / Bian, Xiaoyuan / Jiang, Xianwan / Zheng, Lisi / Li, Lanjuan

    Frontiers in microbiology

    2022  Volume 13, Page(s) 841920

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    Language English
    Publishing date 2022-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.841920
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  6. Article: Short- and Long-Term Effects of Different Antibiotics on the Gut Microbiota and Cytokines Level in Mice.

    Wang, Jingxia / Xiang, Qiangqiang / Gu, Silan / Gu, Yudan / Yao, Mingfei / Huang, Weixin / Gao, Wang / Tang, Ling-Ling

    Infection and drug resistance

    2022  Volume 15, Page(s) 6785–6797

    Abstract: Background: Antibiotics are the first line of treatment for infectious diseases. However, their overuse can increase the spread of drug-resistant bacteria. The present study analyzed the impact of different types of antibiotics on the gut microbiome and ...

    Abstract Background: Antibiotics are the first line of treatment for infectious diseases. However, their overuse can increase the spread of drug-resistant bacteria. The present study analyzed the impact of different types of antibiotics on the gut microbiome and cytokines level of mice.
    Methods: A total of five groups of 8-week-old male BALB/c mice (n = 35) were treated with piperacillin-tazobactam (TZP), ceftriaxone (CRO), tigecycline (TGC), levofloxacin (LEV) or normal saline (Ctrl), respectively, for up to 4 weeks. Fecal samples were analyzed by bacterial 16S rRNA gene sequencing for bacterial identification. Blood samples were used for the determination of 23 serum cytokines using multiplex immunoassay.
    Results: Exposure to antibiotics was shown to affect the normal weight gain of mice. Significant changes in gut composition caused by TZP, CRO and TGC treatment included the decreased abundance of
    Conclusion: This study demonstrates the effects of various antibiotics on the intestinal microflora and immune status of mice. Compared with TZP, CRO and TGC, LEV had minimal impact on the gut microbiota. In addition to TGC, long-term TZP, CRO and LEV intervention can lead to a decrease in serum cytokine levels, which may depend on the intestinal microflora, antibiotic used and the duration of treatment.
    Language English
    Publishing date 2022-11-23
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S388687
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  7. Article ; Online: Modulation of

    Wu, Zhengjie / Xu, Qiaomai / Gu, Silan / Wang, Qiangqiang / Chen, Yunbo / Lv, Longxian / Zheng, Beiwen / Wang, Kaicen / Wang, Shuting / Xia, Jiafeng / Li, Lanjuan

    Food & function

    2022  Volume 13, Issue 10, Page(s) 5667–5679

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Clostridium Infections/drug therapy ; Disease Models, Animal ; Gastrointestinal Microbiome ; Lactobacillus rhamnosus/metabolism ; Mice ; Mice, Inbred C57BL ; Probiotics/therapeutic use ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/metabolism ; Vancomycin/metabolism ; Vancomycin/pharmacology ; Weight Loss
    Chemical Substances Anti-Bacterial Agents ; RNA, Ribosomal, 16S ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d2fo00374k
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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  8. Article ; Online: Close contact behaviors of university and school students in 10 indoor environments.

    Zhang, Nan / Liu, Li / Dou, Zhiyang / Liu, Xiyue / Yang, Xueze / Miao, Doudou / Guo, Yong / Gu, Silan / Li, Yuguo / Qian, Hua / Wei, Jianjian

    Journal of hazardous materials

    2023  Volume 458, Page(s) 132069

    Abstract: Close contact routes, including short-range airborne and large-droplet routes, play an important role in the transmission of SARS-CoV-2 in indoor environments. However, the exposure risk of such routes is difficult to quantify due to the lack of data on ... ...

    Abstract Close contact routes, including short-range airborne and large-droplet routes, play an important role in the transmission of SARS-CoV-2 in indoor environments. However, the exposure risk of such routes is difficult to quantify due to the lack of data on the close contact behavior of individuals. In this study, a digital wearable device, based on semi-supervised learning, was developed to automatically record human close contact behavior. We collected 337,056 s of indoor close contact of school and university students from 194.5 h of depth video recordings in 10 types of indoor environments. The correlation between aerosol exposure and close contact behaviors was then evaluated. Individuals in restaurants had the highest close contact ratio (64%), as well as the highest probability of face-to-face pattern (78%) during close contact. Accordingly, university students showed greater exposure potential in dormitories than school students in homes, however, a lower exposure was observed in classrooms and postgraduate student offices in comparison with school students in classrooms. In addition, restaurants had the highest aerosol exposure volume for both short-range inhalation and direct deposition on the facial mucosa. Thus, the classroom was established as the primary indoor environment where school students are exposed to aerosols.
    MeSH term(s) Humans ; Universities ; SARS-CoV-2 ; COVID-19 ; Respiratory Aerosols and Droplets ; Students
    Language English
    Publishing date 2023-07-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2023.132069
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  9. Article ; Online: The evaluation of fecal microbiota transplantation vs vancomycin in a Clostridioides difficile infection model.

    Xu, Qiaomai / Zhang, Shumeng / Quan, Jiazheng / Wu, Zhengjie / Gu, Silan / Chen, Yunbo / Zheng, Beiwen / Lv, Longxian / Li, Lanjuan

    Applied microbiology and biotechnology

    2022  Volume 106, Issue 19-20, Page(s) 6689–6700

    Abstract: Vancomycin is the preferred treatment for Clostridioides difficile infection (CDI) but has been associated with a high recurrence rate of CDI in treated patients. Fecal microbiota transplantation (FMT) has emerged as a remarkably successful treatment for ...

    Abstract Vancomycin is the preferred treatment for Clostridioides difficile infection (CDI) but has been associated with a high recurrence rate of CDI in treated patients. Fecal microbiota transplantation (FMT) has emerged as a remarkably successful treatment for recurrent CDI (rCDI). Herein, we present a mouse model of CDI to further define the changes in intestinal inflammation, flora, and metabolites following FMT versus vancomycin treatment and to find the potential therapy to restore colonization resistance. Both FMT and vancomycin treatment could ameliorate CDI-induced clinical features and intestinal tissue damage, with decrease in the levels of inflammatory mediators like IL-1β, IL-6, TNF-α, G-CSF, and MCP-1 in the colon and plasma. Observing the fecal gut microbiome profile revealed that unlike vancomycin, FMT could replenish intestinal microbiota by augmenting the relative abundance of the phylum Bacteroidetes and eliminating the abundance of the phylum Proteobacteria. FMT also reduced the levels of several carbohydrates, such as raffinose and fructose-6-phosphate, and amino acids, including tryptophan and glutamyl-valine, in the gut metabolome, thus suppressing C. difficile germination and growth. Our results suggest that the FMT-induced reconstruction of a specific gut community structure and restoration of metabolites promote the recovery of colonization resistance in mice better than vancomycin, thus offering new insights for the prevention of rCDI. KEY POINTS: • Both FMT and vancomycin ameliorate CDI-induced inflammatory response. • FMT restores a specific community structure and gut metabolites. • Mice treated with FMT may promote the recovery of colonization resistance and has a better outcome.
    MeSH term(s) Animals ; Clostridioides difficile ; Clostridium Infections/microbiology ; Clostridium Infections/therapy ; Fecal Microbiota Transplantation/methods ; Granulocyte Colony-Stimulating Factor ; Inflammation Mediators ; Interleukin-6 ; Mice ; Raffinose ; Recurrence ; Treatment Outcome ; Tryptophan ; Tumor Necrosis Factor-alpha ; Valine ; Vancomycin/therapeutic use
    Chemical Substances Inflammation Mediators ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Vancomycin (6Q205EH1VU) ; Tryptophan (8DUH1N11BX) ; Valine (HG18B9YRS7) ; Raffinose (N5O3QU595M)
    Language English
    Publishing date 2022-09-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-022-12154-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2229: Show issues Location:
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  10. Article: Regulatory long non-coding RNAs of hepatic stellate cells in liver fibrosis (Review).

    Wu, Zhengjie / Huang, Shunmei / Zheng, Xiaoqin / Gu, Silan / Xu, Qiaomai / Gong, Yiwen / Zhang, Jiaying / Fu, Bin / Tang, Lingling

    Experimental and therapeutic medicine

    2021  Volume 21, Issue 4, Page(s) 351

    Abstract: Liver fibrosis (LF) is a continuous wound healing process caused by numerous chronic hepatic diseases and poses a major threat to human health. Activation of hepatic stellate cells (HSCs) is a critical event in the development of hepatic fibrosis. Long ... ...

    Abstract Liver fibrosis (LF) is a continuous wound healing process caused by numerous chronic hepatic diseases and poses a major threat to human health. Activation of hepatic stellate cells (HSCs) is a critical event in the development of hepatic fibrosis. Long non-coding RNAs (lncRNAs) that are involved in HSC activation, participate in the development of LF and are likely to be therapeutic targets for LF. In the present review, the cellular signaling pathways of LF with respect to HSCs were discussed. In particular, this present review highlighted the current knowledge on the role of lncRNAs in activating or inhibiting LF, revealing lncRNAs that are likely to be biomarkers or therapeutic targets for LF. Additional studies should be performed to elucidate the potential of lncRNAs in the diagnosis and prognosis of LF and to provide novel therapeutic approaches for the reversion of LF.
    Language English
    Publishing date 2021-02-11
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.9782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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