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Article ; Online: A spatial registration method based on 2D-3D registration for an augmented reality spinal surgery navigation system.

Zhang, Jingqi / Yang, Zhiyong / Jiang, Shan / Zhou, Zeyang

The international journal of medical robotics + computer assisted surgery : MRCAS

2023 , Page(s) e2612

Abstract: Background: In order to provide accurate and reliable image guidance for augmented reality (AR) spinal surgery navigation, a spatial registration method has been proposed.: Methods: In the AR spinal surgery navigation system, grayscale-based 2D/3D ... ...

Abstract	Background: In order to provide accurate and reliable image guidance for augmented reality (AR) spinal surgery navigation, a spatial registration method has been proposed. Methods: In the AR spinal surgery navigation system, grayscale-based 2D/3D registration technology has been used to register preoperative computed tomography images with intraoperative X-ray images to complete the spatial registration, and then the fusion of virtual image and real spine has been realised. Results: In the image registration experiment, the success rate of spine model registration was 90%. In the spinal model verification experiment, the surface registration error of the spinal model ranged from 0.361 to 0.612 mm, and the total average surface registration error was 0.501 mm. Conclusion: The spatial registration method based on 2D/3D registration technology can be used in AR spinal surgery navigation systems and is highly accurate and minimally invasive.
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2612
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Article ; Online: Functional identification of two HMGB1 paralogues provides insights into autophagic machinery in teleost.

Wang, Dan / Ma, Xiaoyu / Hu, Hengyi / Ren, Jingqi / Liu, Jiaxi / Zhou, Hong

Fish & shellfish immunology

2024 Volume 147, Page(s) 109457

Abstract: High mobility group box 1 (HMGB1) is a multifunctional regulator that plays different roles in various physiological and pathological processes including cell development, autophagy, inflammation, tumor metastasis, and cell death based on its cellular ... ...

Abstract	High mobility group box 1 (HMGB1) is a multifunctional regulator that plays different roles in various physiological and pathological processes including cell development, autophagy, inflammation, tumor metastasis, and cell death based on its cellular localization. Unlike mammalian HMGB1, two HMGB1 paralogues (HMGB1a and HMGB1b) have been found in fathead minnow and other fish species and its function as an inflammatory cytokine has been well investigated. However, the role of fish HMGB1 in autophagy regulation has not been well clarified. In the present study, we generated HMGB1 paralogues single (HMGB1a
MeSH term(s)	Animals ; HMGB1 Protein/genetics ; Autophagy ; Cells, Cultured ; Beclin-1 ; Mammals/metabolism
Chemical Substances	HMGB1 Protein ; Beclin-1
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2024.109457
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Article ; Online: Communication mediated interaction between bacteria and microalgae advances photogranulation.

Wu, Xiaogang / Kong, Lingrui / Feng, Yiming / Zheng, Ru / Zhou, Jianhang / Sun, Jingqi / Liu, Sitong

The Science of the total environment

2024 Volume 914, Page(s) 169975

Abstract: Recently, photogranules composed of bacteria and microalgae for carbon-negative nitrogen removal receive extensive attention worldwide, yet which type of bacteria is helpful for rapid formation of photogranules and whether they depend on signaling ... ...

Abstract	Recently, photogranules composed of bacteria and microalgae for carbon-negative nitrogen removal receive extensive attention worldwide, yet which type of bacteria is helpful for rapid formation of photogranules and whether they depend on signaling communication remain elusive. Varied signaling communication was analyzed using metagenomic method among bacteria and microalgae in via of two types of experimentally verified signaling molecule from bacteria to microalgae, which include indole-3-acetic acid (IAA) and N-acyl homoserine lactones (AHLs) during the operation of photo-bioreactors. Signaling communication is helpful for the adaptability of bacteria to survive with algae. Compared with non-signaling bacteria, signaling bacteria more easily adapt to the varied conditions, evidenced by the increased abundance in the operated reactors. Signaling bacteria are easier to enter the phycosphere, and they dominate the interactions between bacteria and algae rather than non-signaling bacteria. The co-abundance groups (CAGs) with signaling bacteria possess higher abundance than that without signaling bacteria (22.27 % and 6.67 %). Importantly, signaling bacteria accessibly interact with microalgae, which possess higher degree centralities and 32.50 % of them are keystone nodes in the network, in contrast to only 18.66 % of non-signaling bacteria. Thauera carrying both IAA and AHLs synthase genes are highly enriched and positively correlated with nitrogen removal rate. Our work not only highlights the essential roles of signaling communication between microalgae and bacteria in the development of photogranules, but also enriches our understanding of microbial sociobiology.
MeSH term(s)	Quorum Sensing ; Microalgae ; Bacteria ; Acyl-Butyrolactones ; Communication
Chemical Substances	Acyl-Butyrolactones
Language	English
Publishing date	2024-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.169975
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Article: Towards the Clinical Translation of 3D PLGA/β-TCP/Mg Composite Scaffold for Cranial Bone Regeneration.

Zhou, Yongsen / Hu, Jingqi / Li, Binhan / Xia, Jingjing / Zhang, Ting / Xiong, Zhuo

Materials (Basel, Switzerland)

2024 Volume 17, Issue 2

Abstract: Recent years have witnessed the rapid development of 3D porous scaffolds with excellent biocompatibility, tunable porosity, and pore interconnectivity, sufficient mechanical strength, controlled biodegradability, and favorable osteogenesis for improved ... ...

Abstract	Recent years have witnessed the rapid development of 3D porous scaffolds with excellent biocompatibility, tunable porosity, and pore interconnectivity, sufficient mechanical strength, controlled biodegradability, and favorable osteogenesis for improved results in cranioplasty. However, clinical translation of these scaffolds has lagged far behind, mainly because of the absence of a series of biological evaluations. Herein, we designed and fabricated a composite 3D porous scaffold composed of poly (lactic-co-glycolic) acid (PLGA), β-tricalcium phosphate (β-TCP), and Mg using the low-temperature deposition manufacturing (LDM) technique. The LDM-engineered scaffolds possessed highly porous and interconnected microstructures with a porosity of 63%. Meanwhile, the scaffolds exhibited mechanical properties close to that of cancellous bone, as confirmed by the compression tests. It was also found that the original composition of scaffolds could be maintained throughout the fabrication process. Particularly, two important biologic evaluations designed for non-active medical devices, i.e., local effects after implantation and subchronic systemic toxicity tests, were conducted to evaluate the local and systemic toxicity of the scaffolds. Additionally, the scaffolds exhibited significant higher mRNA levels of osteogenic genes compared to control scaffolds, as confirmed by an in vitro osteogenic differentiation test of MC3T3-E1 cells. Finally, we demonstrated the improved cranial bone regeneration performance of the scaffolds in a rabbit model. We envision that our investigation could pave the way for translating the LDM-engineered composite scaffolds into clinical products for cranial bone regeneration.
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17020352
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Article: A pharmacokinetic analysis of amisulpride in adult Chinese patients with schizophrenia: Impact of creatinine clearance.

Liu, Wei / Zhou, Jingqi / Cao, Minjuan / Zhang, Fangming / Sun, Xiaoming

International journal of clinical pharmacology and therapeutics

2023

Abstract: Objective: To develop a stable population pharmacokinetic (PPK) model of amisulpride and to investigate the effects of covariates on the pharmacokinetic parameters in adult Chinese patients with schizophrenia.: Materials and methods: This ... ...

Abstract	Objective: To develop a stable population pharmacokinetic (PPK) model of amisulpride and to investigate the effects of covariates on the pharmacokinetic parameters in adult Chinese patients with schizophrenia. Materials and methods: This retrospective study was carried out using 168 serum samples from 88 patients collected during routine clinical monitoring. Covariates recorded included demographic parameters (gender, age, weight), clinical parameters (serum creatinine, creatinine clearance), and intake of co-medications. The amisulpride PPK model was established using a nonlinear mixed effects modeling (NONMEM) approach. Goodness-of-fit (GOF) plots, bootstrap validation (1,000 runs), and normalized prediction distribution error (NPDE) were used in the evaluation of the final model. Results: A one-compartment model with first-order absorption and elimination was developed. The population estimates for apparent clearance (CL/F) and apparent volume of distribution (V/F) were 32.6 L/h and 391 L, respectively. Estimated creatinine clearance (eCLcr) was a significant covariate for CL/F. The established model was: CL/F = 32.6 × (eCLcr/114.3)0.485 (L/h). The stability of the model was confirmed using GOF plots, bootstrap, and NPDE. Conclusion: Creatinine clearance is a major covariate which is positively correlated with CL/F. Therefore, additional dose adjustments of amisulpride may be required on the basis of eCLcr. An ethnic difference may exist in the pharmacokinetics of amisulpride, but further research is needed in order to confirm this possibility. The PPK model of amisulpride for adult Chinese schizophrenic patients established here using NONMEM, is potentially an important tool for individualizing drug dosage and therapeutic drug monitoring.
Language	English
Publishing date	2023-03-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124384-6
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
DOI	10.5414/CP204334
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Zs.A 467: Show issues

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Article ; Online: Non-obese or lean non-alcoholic fatty liver disease was associated with increased risk of cancer in patients with type 2 diabetes mellitus.

Chen, Ning / Zhou, Jingqi / Wang, Kai / Li, Xiaoying / Li, Zhibin

BMJ open diabetes research & care

2023 Volume 11, Issue 1

Abstract: Introduction: Risk of non-obese or lean non-alcoholic fatty liver disease (NAFLD) for cancer in patients with type 2 diabetes mellitus (T2DM) is less known. We aimed to evaluate independent associations of NAFLD, especially non-obese or lean NAFLD, and ... ...

Abstract	Introduction: Risk of non-obese or lean non-alcoholic fatty liver disease (NAFLD) for cancer in patients with type 2 diabetes mellitus (T2DM) is less known. We aimed to evaluate independent associations of NAFLD, especially non-obese or lean NAFLD, and body mass index (BMI) on risks of cancer in patients with T2DM. Research design and methods: Cross-sectional analyses of baseline information on a cohort of 233 patients with T2DM were conducted in Xiamen, China. NAFLD was identified by hepatic ultrasonography diagnosis of hepatic steatosis without excessive alcohol consumption, viral or autoimmune liver disease. Fibrosis-4 (FIB-4) score was calculated to quantify severity of hepatic fibrosis. Results: All types of cancers were diagnosed on 19 (8.2%) patients. Prevalence of cancer was significantly higher in those with NAFLD than those without (15.5% vs 4.0%, p=0.002), but were not significantly different among BMI categories (6.8%, 13.7% and 6.5% for those with underweight or normal weight (n=74), overweight (n=51) and obesity (n=108), respectively, p=0.258). With adjustment for potential confounding factors in the multivariable logistic regression models, NAFLD was significantly associated with increased risk of cancer with the adjusted OR (95% CI) of 5.969 (1.349 to 26.413, p=0.019). Stratified analyses across BMI categories found similar association of NAFLD with risk of cancer for those non-obese or lean (the adjusted OR (95% CI) 17.446 (1.690 to 180.095, p=0.016)) but not for those with either overweight (OR (95% CI) 11.642 (0.832 to 162.963, p=0.068) or obesity (OR (95% CI) 0.917 (0.170 to 4.954, p=0.920). FIB-4 score was not significantly associated with risk of cancer for all subjects or stratified across BMI categories. BMI was not significantly associated with risk of cancer for all patients or stratified by NAFLD. Conclusions: NAFLD, even non-obese or lean NAFLD, was independently associated with increased risk of cancer in patients with T2DM. Screening and management of NAFLD, especially for those with underweight or normal weight, should be strengthened from the perspective of improving prevention and management of cancer in patients with T2DM.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/diagnosis ; Diabetes Mellitus, Type 2/complications ; Overweight/complications ; Thinness/complications ; Thinness/epidemiology ; Cross-Sectional Studies ; Obesity/complications ; Neoplasms
Language	English
Publishing date	2023-02-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2732918-5
ISSN	2052-4897 ; 2052-4897
ISSN (online)	2052-4897
ISSN	2052-4897
DOI	10.1136/bmjdrc-2022-003066
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Article ; Online: Composite carrier enhanced bacterial adhesion and nitrogen removal in partial nitrification/anammox process.

Li, Xinjue / Feng, Yiming / Zhang, Kuo / Zhou, Jianhang / Sun, Jingqi / Rong, Kaiyu / Liu, Sitong

The Science of the total environment

2023 Volume 868, Page(s) 161659

Abstract: The rapid start-up and stable operation of one-stage (Partial nitrification/anammox) PN/A process for low-ammonium wastewater are difficult to be achieved, and many carriers are designed to solve this problem. Here, a composite carrier was developed, in ... ...

Abstract	The rapid start-up and stable operation of one-stage (Partial nitrification/anammox) PN/A process for low-ammonium wastewater are difficult to be achieved, and many carriers are designed to solve this problem. Here, a composite carrier was developed, in which sepiolite and non-woven fabrics were assembled in polypropylene spherical shells. At the start-up phase, P
MeSH term(s)	Nitrification ; Sewage ; Denitrification ; Bacterial Adhesion ; Nitrogen ; Anaerobic Ammonia Oxidation ; Oxidation-Reduction ; Bioreactors ; Ammonium Compounds
Chemical Substances	Sewage ; magnesium trisilicate (C2E1CI501T) ; Nitrogen (N762921K75) ; Ammonium Compounds
Language	English
Publishing date	2023-01-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.161659
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Article ; Online: Plumeriapropionics A-E, Carboxyl-Substituted Phenylpropionic Acid Derivatives with Anti-Inflammatory Activity from

Zhou, Xueming / Gan, Minlin / Wu, Meizhu / Zheng, Ting / Enkhchimeg, Chuluunbaatar / Li, Haixiang / Feng, Shuo / Zhou, Jingqi / Song, Xinming

Molecules (Basel, Switzerland)

2023 Volume 29, Issue 1

Abstract: Five rare carboxyl-substituted phenylpropionic acid derivatives, plumeriapropionics A-E ( ...

Abstract	Five rare carboxyl-substituted phenylpropionic acid derivatives, plumeriapropionics A-E (
MeSH term(s)	Animals ; Mice ; Anti-Inflammatory Agents/pharmacology ; Apocynaceae ; Flowers ; Lipopolysaccharides/pharmacology ; Nitric Oxide ; Organic Chemicals
Chemical Substances	Anti-Inflammatory Agents ; Lipopolysaccharides ; Nitric Oxide (31C4KY9ESH) ; Organic Chemicals
Language	English
Publishing date	2023-12-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29010115
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Article ; Online: Anciently duplicated genes continuously recruited to heart expression in vertebrate evolution are associated with heart chamber increase.

Zou, Yangyun / Yang, Jingwen / Zhou, Jingqi / Liu, Gangbiao / Shen, Libing / Zhou, Zhan / Su, Zhixi / Gu, Xun

Journal of experimental zoology. Part B, Molecular and developmental evolution

2024 Volume 342, Issue 2, Page(s) 106–114

Abstract: Although gene/genome duplications in the early stage of vertebrates have been thought to provide major resources of raw genetic materials for evolutionary innovations, it is unclear whether they continuously contribute to the evolution of morphological ... ...

Abstract	Although gene/genome duplications in the early stage of vertebrates have been thought to provide major resources of raw genetic materials for evolutionary innovations, it is unclear whether they continuously contribute to the evolution of morphological complexity during the course of vertebrate evolution, such as the evolution from two heart chambers (fishes) to four heart chambers (mammals and birds). We addressed this issue by our heart RNA-Seq experiments combined with published data, using 13 vertebrates and one invertebrate (sea squirt, as an outgroup). Our evolutionary transcriptome analysis showed that number of ancient paralogous genes expressed in heart tends to increase with the increase of heart chamber number along the vertebrate phylogeny, in spite that most of them were duplicated at the time near to the origin of vertebrates or even more ancient. Moreover, those paralogs expressed in heart exert considerably different functions from heart-expressed singletons: the former are functionally enriched in cardiac muscle and muscle contraction-related categories, whereas the latter play more basic functions of energy generation like aerobic respiration. These findings together support the notion that recruiting anciently paralogous genes that are expressed in heart is associated with the increase of chamber number in vertebrate evolution.
MeSH term(s)	Animals ; Evolution, Molecular ; Vertebrates/genetics ; Invertebrates/genetics ; Fishes/genetics ; Gene Duplication ; Phylogeny ; Multigene Family ; Mammals/genetics
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2103823-5
ISSN	1552-5015 ; 0022-104X ; 1552-5007
ISSN (online)	1552-5015
ISSN	0022-104X ; 1552-5007
DOI	10.1002/jez.b.23248
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Article ; Online: Extensive Mendelian randomization study identifies potential causal risk factors for severe COVID-19

Yitang Sun / Jingqi Zhou / Kaixiong Ye

Communications Medicine, Vol 1, Iss 1, Pp 1-

2021 Volume 11

Abstract: Sun et al. perform a two-sample Mendelian randomization study of a large number of traits with the aim of identifying risk factors of severe COVID-19. They show that body mass index-related traits, specific white blood cells, and some circulating ... ...

Abstract	Sun et al. perform a two-sample Mendelian randomization study of a large number of traits with the aim of identifying risk factors of severe COVID-19. They show that body mass index-related traits, specific white blood cells, and some circulating proteins are risk factors for the development of severe COVID-19.
Keywords	Medicine ; R
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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