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Book ; Online ; Thesis: Elektrophysiologische Veränderungen des Netzwerkverhaltens im MK-801 Tiermodell

Kehrer, Colin [Verfasser]

2010

Author's details	Colin Kehrer
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Medizinische Fakultät Charité - Universitätsmedizin Berlin
Publishing place	Berlin
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Altered Excitatory-Inhibitory Balance in the NMDA-Hypofunction Model of Schizophrenia.

Kehrer, Colin / Maziashvili, Nino / Dugladze, Tamar / Gloveli, Tengis

Frontiers in molecular neuroscience

2008 Volume 1, Page(s) 6

Abstract: Schizophrenia is a common psychiatric disorder of high incidence, affecting approximately 1% of the world population. The essential neurotransmitter pathology of schizophrenia remains poorly defined, despite huge advances over the past half-century in ... ...

Abstract	Schizophrenia is a common psychiatric disorder of high incidence, affecting approximately 1% of the world population. The essential neurotransmitter pathology of schizophrenia remains poorly defined, despite huge advances over the past half-century in identifying neurochemical and pathological abnormalities in the disease. The dopamine/serotonin hypothesis has originally provided much of the momentum for neurochemical research in schizophrenia. In recent years, the attention has, however, shifted to the glutamate system, the major excitatory neurotransmitter in the CNS and towards a concept of functional imbalance between excitatory and inhibitory transmission at the network level in various brain regions in schizophrenia. The evidence indicating a central role for the NMDA-receptor subtype in the aetiology of schizophrenia has led to the NMDA-hypofunction model of this disease and the use of phencyclidines as a means to induce the NMDA-hypofunction state in animal models. The purpose of this review is to discuss recent findings highlighting the importance of the NMDA-hypofunction model of schizophrenia, both from a clinical perspective, as well as in opening a line of research, which enables electrophysiological studies at the cellular and network level in vitro. In particular, changes in excitation-inhibition (E/I) balance in the NMDA-hypofunction model of the disease and the resulting changes in network behaviours, particularly in gamma frequency oscillatory activity, will be discussed.
Language	English
Publishing date	2008-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452967-9
ISSN	1662-5099 ; 1662-5099
ISSN (online)	1662-5099
ISSN	1662-5099
DOI	10.3389/neuro.02.006.2008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants.

Duty, J Andrew / Kraus, Thomas / Zhou, Heyue / Zhang, Yanliang / Shaabani, Namir / Yildiz, Soner / Du, Na / Singh, Alok / Miorin, Lisa / Li, Donghui / Stegman, Karen / Ophir, Sabrina / Cao, Xia / Atanasoff, Kristina / Lim, Reyna / Mena, Ignacio / Bouvier, Nicole M / Kowdle, Shreyas / Carreño, Juan Manuel /

Rivero-Nava, Laura / Raskin, Ariel / Moreno, Elena / Johnson, Sachi / Rathnasinghe, Raveen / Pai, Chin I / Kehrer, Thomas / Cabral, Elizabeth Paz / Jangra, Sonia / Healy, Laura / Singh, Gagandeep / Warang, Prajakta / Simon, Viviana / Sordillo, Emilia Mia / van Bakel, Harm / Liu, Yonghong / Sun, Weina / Kerwin, Lisa / Teijaro, John / Schotsaert, Michael / Krammer, Florian / Bresson, Damien / García-Sastre, Adolfo / Fu, Yanwen / Lee, Benhur / Powers, Colin / Moran, Thomas / Ji, Henry / Tortorella, Domenico / Allen, Robert

Med (New York, N.Y.)

2022 Volume 3, Issue 10, Page(s) 705–721.e11

Abstract: Background: The continual emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern, in particular the newly emerged Omicron (B.1.1.529) variant and its BA.X lineages, has rendered ineffective a number of previously ... ...

Abstract	Background: The continual emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern, in particular the newly emerged Omicron (B.1.1.529) variant and its BA.X lineages, has rendered ineffective a number of previously FDA emergency use authorized SARS-CoV-2 neutralizing antibody therapies. Furthermore, those approved antibodies with neutralizing activity against Omicron BA.1 are reportedly ineffective against the subset of Omicron subvariants that contain a R346K substitution, BA.1.1, and the more recently emergent BA.2, demonstrating the continued need for discovery and characterization of candidate therapeutic antibodies with the breadth and potency of neutralizing activity required to treat newly diagnosed COVID-19 linked to recently emerged variants of concern. Methods: Following a campaign of antibody discovery based on the vaccination of Harbor H2L2 mice with defined SARS-CoV-2 spike domains, we have characterized the activity of a large collection of spike-binding antibodies and identified a lead neutralizing human IgG1 LALA antibody, STI-9167. Findings: STI-9167 has potent, broad-spectrum neutralizing activity against the current SARS-COV-2 variants of concern and retained activity against each of the tested Omicron subvariants in both pseudotype and live virus neutralization assays. Furthermore, STI-9167 nAb administered intranasally or intravenously provided protection against weight loss and reduced virus lung titers to levels below the limit of quantitation in Omicron-infected K18-hACE2 transgenic mice. Conclusions: With this established activity profile, a cGMP cell line has been developed and used to produce cGMP drug product intended for intravenous or intranasal use in human clinical trials. Funding: Funded by CRIPT (no. 75N93021R00014), DARPA (HR0011-19-2-0020), and NCI Seronet (U54CA260560).
MeSH term(s)	Administration, Intranasal ; Animals ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/therapeutic use ; Humans ; Immunoglobulin G ; Membrane Glycoproteins ; Mice ; Neutralization Tests ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Viral Envelope Proteins ; COVID-19 Drug Treatment
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Membrane Glycoproteins ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2666-6340
ISSN (online)	2666-6340
DOI	10.1016/j.medj.2022.08.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex.

Gallinat, Jürgen / Schubert, Florian / Brühl, Rüdiger / Hellweg, Rainer / Klär, Andreas A / Kehrer, Colin / Wirth, Christoph / Sander, Thomas / Lang, Undine E

NeuroImage

2010 Volume 49, Issue 1, Page(s) 767–771

Abstract: Decreased levels of N-acetylaspartate (NAA) and brain-derived neurotrophic factor (BDNF) in the anterior cingulate cortex (ACC) have been linked to neuronal loss and psychiatric disorders like schizophrenia and bipolar disorder. We previously found that ... ...

Abstract	Decreased levels of N-acetylaspartate (NAA) and brain-derived neurotrophic factor (BDNF) in the anterior cingulate cortex (ACC) have been linked to neuronal loss and psychiatric disorders like schizophrenia and bipolar disorder. We previously found that BDNF serum concentration was predicted by the concentration of NAA in the ACC, indicating that neuronal integrity and vitality of a cortical region like the ACC, as reflected by a high concentration of NAA, might be related to high concentrations of BDNF in serum. Moreover, our recent finding that Val66Met genotype appears to predict the BDNF serum level in healthy human volunteers suggests the Met allele to be connected to higher concentrations of BDNF in serum. We examined absolute NAA concentrations in the ACC and hippocampus of 40 male and 42 female healthy volunteers (age: 33.3+/-9 years). We found NAA in the ACC to be significantly increased in Met carriers (F=5.2, df=1, p=0.025). On the other hand, the concentration of creatine+phosphocreatine in the hippocampus was significantly decreased in Met carriers. We hypothesize that higher NAA levels in the ACC might contribute to the protection of Met allele carriers against major psychiatric disorders as schizophrenia and bipolar disorder.
MeSH term(s)	Adult ; Amino Acid Substitution ; Analysis of Variance ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Brain Chemistry/genetics ; Brain Chemistry/physiology ; Brain-Derived Neurotrophic Factor/genetics ; Cerebral Cortex/metabolism ; Choline/metabolism ; Creatine/metabolism ; Female ; Genotype ; Heterozygote ; Hippocampus/metabolism ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Methionine/genetics ; Methionine/physiology ; Neurons/physiology ; Polymorphism, Single Nucleotide ; Valine/genetics ; Valine/physiology
Chemical Substances	Brain-Derived Neurotrophic Factor ; Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7) ; Methionine (AE28F7PNPL) ; Valine (HG18B9YRS7) ; Creatine (MU72812GK0) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2010-01-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2009.08.018
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Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis.

Kehrer, Colin / Dugladze, Tamar / Maziashvili, Nino / Wójtowicz, Anna / Schmitz, Dietmar / Heinemann, Uwe / Gloveli, Tengis

Neurobiology of disease

2007 Volume 25, Issue 3, Page(s) 545–552

Abstract: The phencyclidine compound MK-801 can induce psychosis with symptoms which closely resemble those observed in an acute schizophrenic episode. Here we used an in vitro model of psychosis after systemic administration of MK-801. We found that kainate- ... ...

Abstract	The phencyclidine compound MK-801 can induce psychosis with symptoms which closely resemble those observed in an acute schizophrenic episode. Here we used an in vitro model of psychosis after systemic administration of MK-801. We found that kainate-induced gamma frequency field oscillations in animals previously exposed to MK-801 have significantly higher power than in control animals. The intrinsic membrane properties of pyramidal cells, such as membrane input resistance and time constant, were not found to be different. In contrast, the MK-801 cells exhibited significantly more depolarized resting membrane potentials than control cells. We propose cellular alterations in Na+-K+-pump activity and increases in phasic inhibition in MK-801 cells to be the respective underlying mechanisms responsible for the more depolarized resting membrane potentials and the increased power of gamma frequency oscillations observed in MK-801 pretreated animals.
MeSH term(s)	Acute Disease ; Animals ; Disease Models, Animal ; Dizocilpine Maleate/pharmacology ; Enzyme Inhibitors/pharmacology ; Excitatory Amino Acid Agonists/pharmacology ; Excitatory Amino Acid Antagonists/pharmacology ; Hippocampus/cytology ; Hippocampus/drug effects ; Hippocampus/physiopathology ; Inhibitory Postsynaptic Potentials/drug effects ; Inhibitory Postsynaptic Potentials/physiology ; Kainic Acid/pharmacology ; Mice ; Mice, Inbred C57BL ; Neural Inhibition/drug effects ; Organ Culture Techniques ; Ouabain/pharmacology ; Psychoses, Substance-Induced/physiopathology ; Pyramidal Cells/drug effects ; Pyramidal Cells/physiology ; Schizophrenia/chemically induced ; Schizophrenia/physiopathology ; Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors ; Sodium-Potassium-Exchanging ATPase/metabolism
Chemical Substances	Enzyme Inhibitors ; Excitatory Amino Acid Agonists ; Excitatory Amino Acid Antagonists ; Ouabain (5ACL011P69) ; Dizocilpine Maleate (6LR8C1B66Q) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9) ; Kainic Acid (SIV03811UC)
Language	English
Publishing date	2007-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2006.10.015
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Zs.A 4444: Show issues

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Article ; Online: Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

Duty, J. Andrew / Kraus, Thomas A / Zhou, Heyue / Zhang, Yanliang / Shaabani, Namir / Yildiz, Soner / Du, Na / Singh, Alok / Miorin, Lisa / Li, Donghui / Stegman, Karen / Ophir, Sabrina I / Cao, Xia / Atanasoff, Kristina / Lim, Reyna / Kowdle, Shreyas S / Carreno, Juan Manuel / Rivero-Nava, Laura / Raskin, Ariel /

Moreno, Elena / Johnson, Sachi / Rathnasinghe, Raveen / Pai, Chin I / Kehrer, Thomas / Paz Cabral, Elizabeth / Jangra, Sonia / Healy, Laura D / Singh, Gagandeep / Warang, Prajakta / Simon, Viviana / Sordillo, Mia Emilia / van Bakel, Harm / Liu, Yonghong / Sun, Weina / Kerwin, Lisa / Palese, Peter / Teijaro, John / Schotsaert, Michael / Krammer, Florian / Bresson, Damien / Garcia-Sastre, Adolfo / Fu, Yanwen / Lee, Benhur / Powers, Colin / Moran, Thomas M / Ji, Henry / Tortorella, Domenico / Allen, Robert D

bioRxiv

Abstract: The continual emergence of SARS-CoV-2 variants of concern, in particular the newly emerged Omicron (B.1.1.529) variant, has rendered ineffective a number of previously EUA approved SARS-CoV-2 neutralizing antibody therapies. Furthermore, even those ... ...

Abstract	The continual emergence of SARS-CoV-2 variants of concern, in particular the newly emerged Omicron (B.1.1.529) variant, has rendered ineffective a number of previously EUA approved SARS-CoV-2 neutralizing antibody therapies. Furthermore, even those approved antibodies with neutralizing activity against Omicron are reportedly ineffective against the subset of Omicron variants that contain a R346K substitution, demonstrating the continued need for discovery and characterization of candidate therapeutic antibodies with the breadth and potency of neutralizing activity required to treat newly diagnosed COVID-19 linked to recently emerged variants of concern. Following a campaign of antibody discovery based on the vaccination of Harbour H2L2 mice with defined SARS-CoV-2 spike domains, we have characterized the activity of a large collection of Spike-binding antibodies and identified a lead neutralizing human IgG1 LALA antibody, STI-9167. STI-9167 has potent, broad-spectrum neutralizing activity against the current SARS-COV-2 variants of concern and retained activity against the Omicron and Omicron + R346K variants in both pseudotype and live virus neutralization assays. Furthermore, STI-9167 nAb administered intranasally or intravenously provided protection against weight loss and reduced virus lung titers to levels below the limit of quantitation in Omicron-infected K18-hACE2 transgenic mice. With this established activity profile, a cGMP cell line has been developed and used to produce cGMP drug product intended for use in human clinical trials.
Keywords	covid19
Language	English
Publishing date	2022-01-20
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2022.01.19.476998
Database	COVID19

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Article: Effects of phencyclidines on signal transfer from the entorhinal cortex to the hippocampus in rats.

Dugladze, Tamar / Lepsveridze, Eka / Breustedt, Jörg / Kehrer, Colin / Heinemann, Uwe / Gloveli, Tengis

Neuroscience letters

2003 Volume 354, Issue 3, Page(s) 185–188

Abstract: The information transfer from the superficial layers of the entorhinal cortex (EC) to the hippocampus is regulated in a frequency dependent manner. Phencyclidine and related compounds such as MK-801 produce psychotic symptoms that closely resemble ... ...

Abstract	The information transfer from the superficial layers of the entorhinal cortex (EC) to the hippocampus is regulated in a frequency dependent manner. Phencyclidine and related compounds such as MK-801 produce psychotic symptoms that closely resemble schizophrenia. We studied the effects of systemic administration of MK-801 on the signal transfer from the EC layer III to the hippocampal area CA1. High frequency (above 10 Hz) activation of the bi-synaptic entorhinal input in control animals results in a strong suppression of the field potentials in the stratum lacunosum-moleculare of the area CA1. In contrast, in MK-801 pretreated rats the field response was less reduced. The field potential responses evoked in these two groups of animals by high-frequency activation of the monosynaptic input were similar suggesting selective alterations in layer III of the medial EC. We suggest, that MK-801 causes disinhibition of layer III projection cells and, therefore, may cause strong, pathological activation of direct layer III-CA1 pathway.
MeSH term(s)	Action Potentials/drug effects ; Animals ; Animals, Newborn ; Dizocilpine Maleate/pharmacology ; Dose-Response Relationship, Radiation ; Electric Stimulation/methods ; Entorhinal Cortex/anatomy & histology ; Entorhinal Cortex/drug effects ; Entorhinal Cortex/physiology ; Excitatory Amino Acid Antagonists/pharmacology ; Female ; Hippocampus/anatomy & histology ; Hippocampus/drug effects ; Hippocampus/physiology ; In Vitro Techniques ; Neural Conduction/drug effects ; Neural Pathways/anatomy & histology ; Neural Pathways/drug effects ; Neural Pathways/physiology ; Phencyclidine/pharmacology ; Rats
Chemical Substances	Excitatory Amino Acid Antagonists ; Dizocilpine Maleate (6LR8C1B66Q) ; Phencyclidine (J1DOI7UV76)
Language	English
Publishing date	2003-10-17
Publishing country	Ireland
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2003.10.008
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Zs.A 1166: Show issues

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Article ; Online: Juvenile metachromatic leukodystrophy 10 years post transplant compared with a non-transplanted cohort.

Krägeloh-Mann, I / Groeschel, S / Kehrer, C / Opherk, K / Nägele, T / Handgretinger, R / Müller, I

Bone marrow transplantation

2012 Volume 48, Issue 3, Page(s) 369–375

Abstract: ... demonstrated a reversal of the initial choline increase and N-acetyl-aspartate (NAA) decrease. Only axonal ...

Abstract	Metachromatic leukodystrophy (MLD) is a rare inborn error of metabolism leading to severe neurological symptoms and early death. Hematopoietic SCT (HSCT) is considered a treatment option, but results are inconsistent and comparison with natural history is practically missing. We compare a girl with juvenile MLD 10 years after allogeneic HSCT not only with her untreated sister, but also with a large cohort of untreated patients. The girl received HSCT at the age of 5 years when first motor signs appeared. Over 10 years she was stable with respect to her clinical course and gained cognitive abilities. Magnetic resonance imaging (MRI) showed clear regression of white matter changes and magnetic resonance spectroscopy (MRS) demonstrated a reversal of the initial choline increase and N-acetyl-aspartate (NAA) decrease. Only axonal demyelinating neuropathy showed some progression. Her gross motor function and MRI-scores were clearly better compared with her sister and the cohort of untreated patients. Difference to her sister became apparent only 4 years after HSCT. We conclude that HSCT, early in the course of disease, can lead to stabilization of juvenile MLD with a course clearly different from the natural history. HSCT may prevent disease progression, if performed sufficient time before loss of walking, which typically initiates rapid deterioration.
MeSH term(s)	Adolescent ; Cohort Studies ; Disease Progression ; Female ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukodystrophy, Metachromatic/diagnosis ; Leukodystrophy, Metachromatic/pathology ; Leukodystrophy, Metachromatic/surgery ; Male ; Treatment Outcome
Language	English
Publishing date	2012-09-03
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/bmt.2012.155
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Article: Free radicals: a potential pathogenic mechanism in inherited muscular dystrophy.

Murphy, M E / Kehrer, J P

Life sciences

1986 Volume 39, Issue 24, Page(s) 2271–2278

Abstract: Despite years of intensive work, the biochemical defect responsible for the pathogenesis of inherited muscular dystrophy has not been identified either in humans or animal models. This review examines evidence in support of the hypothesis that free ... ...

Abstract	Despite years of intensive work, the biochemical defect responsible for the pathogenesis of inherited muscular dystrophy has not been identified either in humans or animal models. This review examines evidence in support of the hypothesis that free radicals may be responsible for muscle degeneration in this disorder. A variety of cellular abnormalities noted in dystrophic muscles can be accounted for by free radical mediated damage. In addition, chemical by-products associated with free radical damage are found in dystrophic muscle tissue from humans and animals with this disease. Various enzymatic antioxidant systems can be enhanced as a normal cellular response to oxidative stress, and such changes are seen both in dystrophic muscle cells and certain other tissues of dystrophic animals. An increased level of free radical damage would follow from either: enhanced production of free radical species, or a deficient component of the cellular antioxidant system, such as vitamin E. The free radical hypothesis of muscular dystrophy can account for data supporting several alternative theories of the pathogenesis of this disease, as well as other observations which have not previously been explained.
MeSH term(s)	Calcium/metabolism ; Collagen/metabolism ; Free Radicals ; Glycerylphosphorylcholine/metabolism ; Membranes/physiology ; Microcirculation ; Muscles/blood supply ; Muscles/cytology ; Muscular Dystrophies/complications ; Muscular Dystrophies/physiopathology ; Serotonin/metabolism ; Vitamin E Deficiency/complications
Chemical Substances	Free Radicals ; Serotonin (333DO1RDJY) ; Glycerylphosphorylcholine (60M22SGW66) ; Collagen (9007-34-5) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	1986-12-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/0024-3205(86)90657-0
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Article: Phospholipase A secreted by Legionella pneumophila destroys alveolar surfactant phospholipids.

Flieger, A / Gongab, S / Faigle, M / Mayer, H A / Kehrer, U / Mussotter, J / Bartmann, P / Neumeister, B

FEMS microbiology letters

2000 Volume 188, Issue 2, Page(s) 129–133

Abstract: ... serogroup 6. Free fatty acids and lysophosphatidylcholine were formed, the latter is known to be highly ...

Abstract	Destruction of alveolar surfactant phospholipids by bacterial phospholipases is suggested to be a major virulence factor involved in bacterial pneumonia. Since Legionella pneumophila secretes phospholipase A, we analyzed phospholipid degradation in natural bovine surfactant by L. pneumophila. Phospholipids were reduced in amount after incubation with bacteria or culture supernatant of L. pneumophila serogroup 6. Free fatty acids and lysophosphatidylcholine were formed, the latter is known to be highly cytotoxic. Surface tension of surfactant as determined by pulsating bubble surfactometer increased significantly compared to the control. Phospholipase A activity seems to be a powerful agent of legionellae in causing lung disease.
MeSH term(s)	Animals ; Cattle ; Fatty Acids/analysis ; Legionella pneumophila/enzymology ; Legionella pneumophila/growth & development ; Lysophosphatidylcholines/analysis ; Magnetic Resonance Spectroscopy ; Phosphatidylcholines/analysis ; Phosphatidylglycerols/analysis ; Phospholipases A/metabolism ; Pulmonary Surfactants/analysis ; Pulmonary Surfactants/chemistry ; Pulmonary Surfactants/metabolism ; Surface Tension ; Time Factors
Chemical Substances	Fatty Acids ; Lysophosphatidylcholines ; Phosphatidylcholines ; Phosphatidylglycerols ; Pulmonary Surfactants ; Phospholipases A (EC 3.1.1.32)
Language	English
Publishing date	2000-07-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752343-9
ISSN	1574-6968 ; 0378-1097
ISSN (online)	1574-6968
ISSN	0378-1097
DOI	10.1111/j.1574-6968.2000.tb09183.x
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