LIVIVO - Search results -

Search results

Result 1 - 10 of total 23

Search options

Article ; Online: Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections.

Deffert, Christine / Cachat, Julien / Krause, Karl-Heinz

2014 Volume 16, Issue 8, Page(s) 1168–1178

Abstract: Infection of humans with Mycobacterium tuberculosis remains frequent and may still lead to death. After primary infection, the immune system is often able to control M. tuberculosis infection over a prolonged latency period, but a decrease in immune ... ...

Abstract	Infection of humans with Mycobacterium tuberculosis remains frequent and may still lead to death. After primary infection, the immune system is often able to control M. tuberculosis infection over a prolonged latency period, but a decrease in immune function (from HIV to immunosenescence) leads to active disease. Available vaccines against tuberculosis are restricted to BCG, a live vaccine with an attenuated strain of M. bovis. Immunodeficiency may not only be associated with an increased risk of tuberculosis, but also with local or disseminated BCG infection. Genetic deficiency in the reactive oxygen species (ROS)-producing phagocyte NADPH oxidase NOX2 is called chronic granulomatous disease (CGD). CGD is among the most common primary immune deficiencies. Here we review our knowledge on the importance of NOX2-derived ROS in mycobacterial infection. A literature review suggests that human CGD patient frequently have an increased susceptibility to BCG and to M. tuberculosis. In vitro studies and experiments with CGD mice are incomplete and yielded - at least in part - contradictory results. Thus, although observations in human CGD patients leave little doubt about the role of NOX2 in the control of mycobacteria, further studies will be necessary to unequivocally define and understand the role of ROS.
MeSH term(s)	Animals ; Apoptosis/immunology ; Extracellular Traps/immunology ; Granulomatous Disease, Chronic/immunology ; Humans ; Membrane Glycoproteins/immunology ; Mice ; Mycobacterium Infections/immunology ; Mycobacterium bovis/immunology ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; NADPH Oxidase 2 ; NADPH Oxidases/immunology ; Phagocytosis/immunology ; Phagosomes/immunology ; Reactive Oxygen Species/immunology ; Tuberculosis, Pulmonary/immunology ; Tuberculosis, Pulmonary/pathology ; Tuberculosis, Pulmonary/prevention & control
Chemical Substances	Membrane Glycoproteins ; Reactive Oxygen Species ; CYBB protein, human (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-) ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2014-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1468320-9
ISSN	1462-5822 ; 1462-5814
ISSN (online)	1462-5822
ISSN	1462-5814
DOI	10.1111/cmi.12322
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5288: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Phagocyte NADPH oxidase and specific immunity.

Cachat, Julien / Deffert, Christine / Hugues, Stephanie / Krause, Karl-Heinz

Clinical science (London, England : 1979)

2015 Volume 128, Issue 10, Page(s) 635–648

Abstract: The phagocyte NADPH oxidase NOX2 produces reactive oxygen species (ROS) and is a well-known player in host defence. However, there is also increasing evidence for a regulatory role of NOX2 in adaptive immunity. Deficiency in phagocyte NADPH oxidase ... ...

Abstract	The phagocyte NADPH oxidase NOX2 produces reactive oxygen species (ROS) and is a well-known player in host defence. However, there is also increasing evidence for a regulatory role of NOX2 in adaptive immunity. Deficiency in phagocyte NADPH oxidase causes chronic granulomatous disease (CGD) in humans, a condition that can also be studied in CGD mice. Clinical observations in CGD patients suggest a higher susceptibility to autoimmune diseases, in particular lupus, idiopathic thrombocytopenic purpura and rheumatoid arthritis. In mice, a strong correlation exists between a polymorphism in a NOX2 subunit and the development of autoimmune arthritis. NOX2 deficiency in mice also favours lupus development. Both CGD patients and CGD mice exhibit increased levels of immunoglobulins, including autoantibodies. Despite these phenotypes suggesting a role for NOX2 in specific immunity, mechanistic explanations for the typical increase of CGD in autoimmune disease and antibody levels are still preliminary. NOX2-dependent ROS generation is well documented for dendritic cells and B-lymphocytes. It is unclear whether T-lymphocytes produce ROS themselves or whether they are exposed to ROS derived from dendritic cells during the process of antigen presentation. ROS are signalling molecules in virtually any cell type, including T- and B-lymphocytes. However, knowledge about the impact of ROS-dependent signalling on T- and B-lymphocyte phenotype and response is still limited. ROS might contribute to Th1/Th2/Th17 cell fate decisions during T-lymphocyte activation and might enhance immunoglobulin production by B-lymphocytes. In dendritic cells, NOX2-derived ROS might be important for antigen processing and cell activation.
MeSH term(s)	Adaptive Immunity/immunology ; Animals ; Granulomatous Disease, Chronic/immunology ; Granulomatous Disease, Chronic/metabolism ; Humans ; Immunity, Innate/immunology ; Lymphocytes/cytology ; Lymphocytes/metabolism ; Membrane Glycoproteins/deficiency ; Membrane Glycoproteins/immunology ; Mice ; Myelin-Oligodendrocyte Glycoprotein/immunology ; NADPH Oxidase 2 ; NADPH Oxidases/deficiency ; NADPH Oxidases/immunology ; Phagocytes/enzymology ; Phagocytes/immunology ; Reactive Oxygen Species/metabolism ; Signal Transduction/immunology
Chemical Substances	MOG protein, human ; Membrane Glycoproteins ; Myelin-Oligodendrocyte Glycoprotein ; Reactive Oxygen Species ; CYBB protein, human (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-) ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2015-05-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	206835-7
ISSN	1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
ISSN (online)	1470-8736
ISSN	0301-0538 ; 0009-0360 ; 0143-5221
DOI	10.1042/CS20140635
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.220: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Serum NGAL, BNP, PTH, and albumin do not improve glomerular filtration rate estimating formulas in children.

Mouron-Hryciuk, Julie / Cachat, François / Parvex, Paloma / Perneger, Thomas / Chehade, Hassib

European journal of pediatrics

2021 Volume 180, Issue 7, Page(s) 2223–2228

Abstract: Glomerular filtration rate (GFR) is difficult to measure, and estimating formulas are notorious for lacking precision. This study aims to assess if the inclusion of additional biomarkers improves the performance of eGFR formulas. A hundred and sixteen ... ...

Abstract	Glomerular filtration rate (GFR) is difficult to measure, and estimating formulas are notorious for lacking precision. This study aims to assess if the inclusion of additional biomarkers improves the performance of eGFR formulas. A hundred and sixteen children with renal diseases were enrolled. Data for age, weight, height, inulin clearance (iGFR), serum creatinine, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) were collected. These variables were added to the revised and combined (serum creatinine and cystatin C) Schwartz formulas, and the quadratic and combined quadratic formulas. We calculated the adjusted r-square (r
MeSH term(s)	Albumins ; Biomarkers ; Child ; Creatinine ; Glomerular Filtration Rate ; Humans ; Lipocalin-2 ; Natriuretic Peptide, Brain ; Parathyroid Hormone
Chemical Substances	Albumins ; Biomarkers ; Lipocalin-2 ; Parathyroid Hormone ; Natriuretic Peptide, Brain (114471-18-0) ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2021-03-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-021-04019-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Um IV Zs.75: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells.

Cachat, Julien / Deffert, Christine / Alessandrini, Marco / Roux-Lombard, Pascale / Le Gouellec, Audrey / Stasia, Marie-José / Hugues, Stéphanie / Krause, Karl-Heinz

Frontiers in immunology

2018 Volume 9, Page(s) 1555

Abstract: Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from loss of function mutations in the reactive oxygen species generating phagocyte NADPH oxidase (NOX2). CGD patients are prone to infection, but also have an increased ... ...

Abstract	Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from loss of function mutations in the reactive oxygen species generating phagocyte NADPH oxidase (NOX2). CGD patients are prone to infection, but also have an increased susceptibility to autoimmune diseases. The aim of this study was to investigate the role of NOX2 in the regulation of specific immunity. In both CGD patients and NOX2-deficient mice, we observed an alteration in the basal proportions of IgG subtypes. Upon immunization with curdlan-a dectin 1 agonist-NOX2-deficient mice showed increased production of IgG2c compared to controls, and restimulation of lymph node-derived cells led to increased production of IFNγ, but not IL-5, indicative hallmark of an enhanced Th1 response. T cell activation was increased in NOX2-deficient mice and a similar trend was observed
Language	English
Publishing date	2018
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.01555
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: The Inhibition of Complement System in Formal and Emerging Indications: Results from Parallel One-Stage Pairwise and Network Meta-Analyses of Clinical Trials and Real-Life Data Studies.

Bernuy-Guevara, Coralina / Chehade, Hassib / Muller, Yannick D / Vionnet, Julien / Cachat, François / Guzzo, Gabriella / Ochoa-Sangrador, Carlos / Álvarez, F Javier / Teta, Daniel / Martín-García, Débora / Adler, Marcel / de Paz, Félix J / Lizaraso-Soto, Frank / Pascual, Manuel / Herrera-Gómez, Francisco

Biomedicines

2020 Volume 8, Issue 9

Abstract: This manuscript presents quantitative findings on the actual effectiveness of terminal complement component 5 (C5) inhibitors and complement component 1 (C1) esterase inhibitors through their formal and common "off-label" (compassionate) indications. The ...

Abstract	This manuscript presents quantitative findings on the actual effectiveness of terminal complement component 5 (C5) inhibitors and complement component 1 (C1) esterase inhibitors through their formal and common "off-label" (compassionate) indications. The results emanated from pairwise and network meta-analyses to present evidence until September 2019. Clinical trials (CT) and real-life non-randomized studies of the effects of interventions (NRSI) are consistent on the benefits of C5 inhibitors and of the absence of effects of C1 esterase inhibitors (
Language	English
Publishing date	2020-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines8090355
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Inhibition of Complement System in Formal and Emerging Indications

Coralina Bernuy-Guevara / Hassib Chehade / Yannick D. Muller / Julien Vionnet / François Cachat / Gabriella Guzzo / Carlos Ochoa-Sangrador / F. Javier Álvarez / Daniel Teta / Débora Martín-García / Marcel Adler / Félix J. de Paz / Frank Lizaraso-Soto / Manuel Pascual / Francisco Herrera-Gómez

Biomedicines, Vol 8, Iss 355, p

Results from Parallel One-Stage Pairwise and Network Meta-Analyses of Clinical Trials and Real-Life Data Studies

2020 Volume 355

Abstract	This manuscript presents quantitative findings on the actual effectiveness of terminal complement component 5 (C5) inhibitors and complement component 1 (C1) esterase inhibitors through their formal and common “off-label” (compassionate) indications. The results emanated from pairwise and network meta-analyses to present evidence until September 2019. Clinical trials (CT) and real-life non-randomized studies of the effects of interventions (NRSI) are consistent on the benefits of C5 inhibitors and of the absence of effects of C1 esterase inhibitors ( n = 7484): Mathematically, eculizumab (surface under the cumulative ranking area (SUCRA) >0.6) and ravulizumab (SUCRA ≥ 0.7) were similar in terms of their protective effect on hemolysis in paroxysmal nocturnal hemoglobinuria (PNH), thrombotic microangiopathy (TMA) in atypical hemolytic uremic syndrome (aHUS), and acute kidney injury (AKI) in aHUS, in comparison to pre-/off-treatment state and/or placebo (SUCRA < 0.01), and eculizumab was efficacious on thrombotic events in PNH (odds ratio (OR)/95% confidence interval (95% CI) in CT and real-life NRSI, 0.07/0.03 to 0.19, 0.24/0.17 to 0.33) and chronic kidney disease (CKD) occurrence/progression in PNH (0.31/0.10 to 0.97, 0.66/0.44 to 0.98). In addition, meta-analysis on clinical trials shows that eculizumab mitigates a refractory generalized myasthenia gravis (rgMG) crisis (0.29/0.13 to 0.61) and prevents new acute antibody-mediated rejection (AMR) episodes in kidney transplant recipients (0.25/0.13 to 0.49). The update of findings from this meta-analysis will be useful to promote a better use of complement inhibitors, and to achieve personalization of treatments with this class of drugs.
Keywords	complement inactivating agents ; meta-analysis as topic ; biological products ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Les souris ne sont pas des hommes et pourtant… ce que les souris humanisées nous apprennent sur les maladies infectieuses.

Cachat, Anne / Villaudy, Julien / Rigal, Dominique / Gazzolo, Louis / Duc Dodon, Madeleine

Medecine sciences : M/S

2012 Volume 28, Issue 1, Page(s) 63–68

Abstract: The study of human pathologies is often limited by the absence of animal models which are robust, cost-effective and reproduce the hallmarks of human infections. While mice have been frequently employed to study human diseases, many of important ... ...

Title translation	Mice are not Men and yet… how humanized mice inform us about human infectious diseases.
Abstract	The study of human pathologies is often limited by the absence of animal models which are robust, cost-effective and reproduce the hallmarks of human infections. While mice have been frequently employed to study human diseases, many of important pathogens display unique human tropism. These last two decades the graft of human progenitor cells or tissues into -immunodeficient mice has allowed the elaboration of so called humanized mice. Humanized mouse technology has made rapid progress, and it is now possible to achieve high levels of human chimerism in various organs and tissues, particularly the immune system and the liver. The review briefly summarizes the different models of humanized mice available for in vivo experiments. With a focus on lymphotropic, monocytotropic and hepatotropic viruses, we here discuss the current status and future prospects of these models for studying the pathogenesis of infectious diseases. Furthermore, they provide a powerful tool for the development of innovative therapies.
MeSH term(s)	Animals ; Chimera/genetics ; Chimera/immunology ; Communicable Diseases ; Crosses, Genetic ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/genetics ; Disease Models, Animal ; Forecasting ; Hepatocytes/transplantation ; Humans ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/immunology ; Interleukin Receptor Common gamma Subunit/deficiency ; Interleukin Receptor Common gamma Subunit/genetics ; Liver/embryology ; Liver Transplantation ; Mice ; Mice, Inbred BALB C ; Mice, Mutant Strains/genetics ; Mice, Mutant Strains/immunology ; Radiation Chimera ; Species Specificity ; Thymus Gland/embryology ; Thymus Gland/transplantation ; Transplantation, Heterologous ; Virus Diseases/drug therapy ; Virus Diseases/immunology ; Virus Diseases/virology
Chemical Substances	DNA-Binding Proteins ; Il2rg protein, mouse ; Interleukin Receptor Common gamma Subunit ; Rag2 protein, mouse
Language	French
Publishing date	2012-01
Publishing country	France
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2012281018
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2872: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Comparison of the glomerular filtration rate in children by the new revised Schwartz formula and a new generalized formula.

Gao, Anja / Cachat, Francois / Faouzi, Mohamed / Bardy, Daniel / Mosig, Dolores / Meyrat, Blaise-Julien / Girardin, Eric / Chehade, Hassib

Kidney international

2013 Volume 83, Issue 3, Page(s) 524–530

Abstract: The most widely used formula for estimating glomerular filtration rate (eGFR) in children is the Schwartz formula. It was revised in 2009 using iohexol clearances with measured GFR (mGFR) ranging between 15 and 75 ml/min × 1.73 m(2). Here we assessed the ...

Abstract	The most widely used formula for estimating glomerular filtration rate (eGFR) in children is the Schwartz formula. It was revised in 2009 using iohexol clearances with measured GFR (mGFR) ranging between 15 and 75 ml/min × 1.73 m(2). Here we assessed the accuracy of the Schwartz formula using the inulin clearance (iGFR) method to evaluate its accuracy for children with less renal impairment comparing 551 iGFRs of 392 children with their Schwartz eGFRs. Serum creatinine was measured using the compensated Jaffe method. In order to find the best relationship between iGFR and eGFR, a linear quadratic regression model was fitted and a more accurate formula was derived. This quadratic formula was: 0.68 × (Height (cm)/serum creatinine (mg/dl))-0.0008 × (height (cm)/serum creatinine (mg/dl))(2)+0.48 × age (years)-(21.53 in males or 25.68 in females). This formula was validated using a split-half cross-validation technique and also externally validated with a new cohort of 127 children. Results show that the Schwartz formula is accurate until a height (Ht)/serum creatinine value of 251, corresponding to an iGFR of 103 ml/min × 1.73 m(2), but significantly unreliable for higher values. For an accuracy of 20 percent, the quadratic formula was significantly better than the Schwartz formula for all patients and for patients with a Ht/serum creatinine of 251 or greater. Thus, the new quadratic formula could replace the revised Schwartz formula, which is accurate for children with moderate renal failure but not for those with less renal impairment or hyperfiltration.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Creatinine/blood ; Cystatin C/blood ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Mathematics
Chemical Substances	Cystatin C ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2013-03
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1038/ki.2012.388
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 797: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: New combined serum creatinine and cystatin C quadratic formula for GFR assessment in children.

Chehade, Hassib / Cachat, Francois / Jannot, Anne-Sophie / Meyrat, Blaise-Julien / Mosig, Dolores / Bardy, Daniel / Parvex, Paloma / Girardin, Eric

Clinical journal of the American Society of Nephrology : CJASN

2013 Volume 9, Issue 1, Page(s) 54–63

Abstract: Background and objectives: The estimated GFR (eGFR) is important in clinical practice. To find the best formula for eGFR, this study assessed the best model of correlation between sinistrin clearance (iGFR) and the solely or combined cystatin C (CysC)- ... ...

Abstract	Background and objectives: The estimated GFR (eGFR) is important in clinical practice. To find the best formula for eGFR, this study assessed the best model of correlation between sinistrin clearance (iGFR) and the solely or combined cystatin C (CysC)- and serum creatinine (SCreat)-derived models. It also evaluated the accuracy of the combined Schwartz formula across all GFR levels. Design, setting, participants, & measurements: Two hundred thirty-eight iGFRs performed between January 2012 and April 2013 for 238 children were analyzed. Regression techniques were used to fit the different equations used for eGFR (i.e., logarithmic, inverse, linear, and quadratic). The performance of each model was evaluated using the Cohen κ correlation coefficient and the percentage reaching 30% accuracy was calculated. Results: The best model of correlation between iGFRs and CysC is linear; however, it presents a low κ coefficient (0.24) and is far below the Kidney Disease Outcomes Quality Initiative targets to be validated, with only 84% of eGFRs reaching accuracy of 30%. SCreat and iGFRs showed the best correlation in a fitted quadratic model with a κ coefficient of 0.53 and 93% accuracy. Adding CysC significantly (P<0.001) increased the κ coefficient to 0.56 and the quadratic model accuracy to 97%. Therefore, a combined SCreat and CysC quadratic formula was derived and internally validated using the cross-validation technique. This quadratic formula significantly outperformed the combined Schwartz formula, which was biased for an iGFR≥91 ml/min per 1.73 m(2). Conclusions: This study allowed deriving a new combined SCreat and CysC quadratic formula that could replace the combined Schwartz formula, which is accurate only for children with moderate chronic kidney disease.
MeSH term(s)	Adolescent ; Age Factors ; Biomarkers/blood ; Child ; Child, Preschool ; Creatinine/blood ; Cystatin C/blood ; Female ; Glomerular Filtration Rate ; Humans ; Kidney/physiopathology ; Linear Models ; Logistic Models ; Male ; Models, Cardiovascular ; Predictive Value of Tests ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/physiopathology ; Reproducibility of Results ; Severity of Illness Index
Chemical Substances	Biomarkers ; CST3 protein, human ; Cystatin C ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2013-11-07
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Validation Study
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.00940113
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6584: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: AI for social good: unlocking the opportunity for positive impact.

Tomašev, Nenad / Cornebise, Julien / Hutter, Frank / Mohamed, Shakir / Picciariello, Angela / Connelly, Bec / Belgrave, Danielle C M / Ezer, Daphne / Haert, Fanny Cachat van der / Mugisha, Frank / Abila, Gerald / Arai, Hiromi / Almiraat, Hisham / Proskurnia, Julia / Snyder, Kyle / Otake-Matsuura, Mihoko / Othman, Mustafa / Glasmachers, Tobias / Wever, Wilfried de /

Teh, Yee Whye / Khan, Mohammad Emtiyaz / Winne, Ruben De / Schaul, Tom / Clopath, Claudia

Nature communications

2020 Volume 11, Issue 1, Page(s) 2468

Abstract: Advances in machine learning (ML) and artificial intelligence (AI) present an opportunity to build better tools and solutions to help address some of the world's most pressing challenges, and deliver positive social impact in accordance with the ... ...

Abstract	Advances in machine learning (ML) and artificial intelligence (AI) present an opportunity to build better tools and solutions to help address some of the world's most pressing challenges, and deliver positive social impact in accordance with the priorities outlined in the United Nations' 17 Sustainable Development Goals (SDGs). The AI for Social Good (AI4SG) movement aims to establish interdisciplinary partnerships centred around AI applications towards SDGs. We provide a set of guidelines for establishing successful long-term collaborations between AI researchers and application-domain experts, relate them to existing AI4SG projects and identify key opportunities for future AI applications targeted towards social good.
Language	English
Publishing date	2020-05-18
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-15871-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito