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Article: Mapping the Anti-Cancer Activity of α-Connexin Carboxyl-Terminal (aCT1) Peptide in Resistant HER2+ Breast Cancer.

Baker, Kimberly M / Abt, Melissa / Doud, Emma H / Oblak, Adrian L / Yeh, Elizabeth S

2024 Volume 16, Issue 2

Abstract: Connexin 43 (Cx43) is a protein encoded by ... ...

Abstract	Connexin 43 (Cx43) is a protein encoded by the
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16020423
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Article ; Online: Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.

Benzow, Kellie / Karanjeet, Kul / Oblak, Adrian L / Carter, Gregory W / Sasner, Michael / Koob, Michael D

Alzheimer's & dementia : the journal of the Alzheimer's Association

2024 Volume 20, Issue 4, Page(s) 3080–3087

Abstract: Introduction: Genetic studies conducted over the past four decades have provided us with a detailed catalog of genes that play critical roles in the etiology of Alzheimer's disease (AD) and related dementias (ADRDs). Despite this progress, as a field we ...

Abstract	Introduction: Genetic studies conducted over the past four decades have provided us with a detailed catalog of genes that play critical roles in the etiology of Alzheimer's disease (AD) and related dementias (ADRDs). Despite this progress, as a field we have had only limited success in incorporating this rich complexity of human AD/ADRD genetics findings into our animal models of these diseases. Our primary goal for the gene replacement (GR)-AD project is to develop mouse lines that model the genetics of AD/ADRD as closely as possible. Methods: To do this, we are generating mouse lines in which the genes of interest are precisely and completely replaced in the mouse genome by their full human orthologs. Results: Each model set consists of a control line with a wild-type human allele and variant lines that precisely match the human genomic sequence in the control line except for a high-impact pathogenic mutation or risk variant.
MeSH term(s)	Humans ; Animals ; Mice ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; tau Proteins/genetics ; Mutation ; Presenilin-1/genetics ; Amyloid beta-Protein Precursor/genetics
Chemical Substances	tau Proteins ; Presenilin-1 ; Amyloid beta-Protein Precursor
Language	English
Publishing date	2024-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13730
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Article ; Online: Peripheral HMGB1 is linked to O

Ahmed, Chandrama / Greve, Hendrik J / Garza-Lombo, Carla / Malley, Jamie A / Johnson, James A / Oblak, Adrian L / Block, Michelle L

Alzheimer's & dementia : the journal of the Alzheimer's Association

2024

Abstract: Introduction: Ozone (O: Methods: The O: Results: O: Discussion: Astrocytes and peripheral myeloid cells are critical lung-brain axis interactors. HMGB1 loss in peripheral myeloid cells regulates the O: Highlights: Astrocytes are part of the ... ...

Abstract	Introduction: Ozone (O Methods: The O Results: O Discussion: Astrocytes and peripheral myeloid cells are critical lung-brain axis interactors. HMGB1 loss in peripheral myeloid cells regulates the O Highlights: Astrocytes are part of the lung-brain axis, regulating how air pollution affects plaque pathology. Ozone (O
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13825
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Article ; Online: Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer.

Dilday, Tinslee / Abt, Melissa / Ramos-Solís, Nicole / Dayal, Neetu / Larocque, Elizabeth / Oblak, Adrian L / Sintim, Herman O / Yeh, Elizabeth S

Cell chemical biology

2024

Abstract: Human epidermal growth factor receptor 2 (HER2)-targeted agents have proven to be effective, however, the development of resistance to these agents has become an obstacle in treating HER2+ breast cancer. Evidence implicates HUNK as an anti-cancer target ... ...

Abstract	Human epidermal growth factor receptor 2 (HER2)-targeted agents have proven to be effective, however, the development of resistance to these agents has become an obstacle in treating HER2+ breast cancer. Evidence implicates HUNK as an anti-cancer target for primary and resistant HER2+ breast cancers. In this study, a selective inhibitor of HUNK is characterized alongside a phosphorylation event in a downstream substrate of HUNK as a marker for HUNK activity in HER2+ breast cancer. Rubicon has been established as a substrate of HUNK that is phosphorylated at serine (S) 92. Findings indicate that HUNK-mediated phosphorylation of Rubicon at S92 promotes both autophagy and tumorigenesis in HER2/neu+ breast cancer. HUNK inhibition prevents Rubicon S92 phosphorylation in HER2/neu+ breast cancer models and inhibits tumorigenesis. This study characterizes a downstream phosphorylation event as a measure of HUNK activity and identifies a selective HUNK inhibitor that has meaningful efficacy toward HER2+ breast cancer.
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ISSN	2451-9448
ISSN (online)	2451-9448
DOI	10.1016/j.chembiol.2024.01.001
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Article ; Online: Mind Gaps and Bone Snaps: Exploring the Connection Between Alzheimer's Disease and Osteoporosis.

Wang, Hannah S / Karnik, Sonali J / Margetts, Tyler J / Plotkin, Lilian I / Movila, Alexandru / Fehrenbacher, Jill C / Kacena, Melissa A / Oblak, Adrian L

Current osteoporosis reports

2024

Abstract: Purpose of review: This comprehensive review discusses the complex relationship between Alzheimer's disease (AD) and osteoporosis, two conditions that are prevalent in the aging population and result in adverse complications on quality of life. The ... ...

Abstract	Purpose of review: This comprehensive review discusses the complex relationship between Alzheimer's disease (AD) and osteoporosis, two conditions that are prevalent in the aging population and result in adverse complications on quality of life. The purpose of this review is to succinctly elucidate the many commonalities between the two conditions, including shared pathways, inflammatory and oxidative mechanisms, and hormonal deficiencies. Recent findings: AD and osteoporosis share many aspects of their respective disease-defining pathophysiology. These commonalities include amyloid beta deposition, the Wnt/β-catenin signaling pathway, and estrogen deficiency. The shared mechanisms and risk factors associated with AD and osteoporosis result in a large percentage of patients that develop both diseases. Previous literature has established that the progression of AD increases the risk of sustaining a fracture. Recent findings demonstrate that the reverse may also be true, suggesting that a fracture early in the life course can predispose one to developing AD due to the activation of these shared mechanisms. The discovery of these commonalities further guides the development of novel therapeutics in which both conditions are targeted. This detailed review delves into the commonalities between AD and osteoporosis to uncover the shared players that bring these two seemingly unrelated conditions together. The discussion throughout this review ultimately posits that the occurrence of fractures and the mechanism behind fracture healing can predispose one to developing AD later on in life, similar to how AD patients are at an increased risk of developing fractures. By focusing on the shared mechanisms between AD and osteoporosis, one can better understand the conditions individually and as a unit, thus informing therapeutic approaches and further research. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-023-00851-1
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Article ; Online: From the Mind to the Spine: The Intersecting World of Alzheimer's and Osteoporosis.

Margetts, Tyler J / Wang, Hannah S / Karnik, Sonali J / Plotkin, Lilian I / Movila, Alexandru / Oblak, Adrian L / Fehrenbacher, Jill C / Kacena, Melissa A

Current osteoporosis reports

2024 Volume 22, Issue 1, Page(s) 152–164

Abstract: Purpose of review: This comprehensive review delves into the intricate interplay between Alzheimer's disease (AD) and osteoporosis, two prevalent conditions with significant implications for individuals' quality of life. The purpose is to explore their ... ...

Abstract	Purpose of review: This comprehensive review delves into the intricate interplay between Alzheimer's disease (AD) and osteoporosis, two prevalent conditions with significant implications for individuals' quality of life. The purpose is to explore their bidirectional association, underpinned by common pathological processes such as aging, genetic factors, inflammation, and estrogen deficiency. Recent findings: Recent advances have shown promise in treating both Alzheimer's disease (AD) and osteoporosis by targeting disease-specific proteins and bone metabolism regulators. Monoclonal antibodies against beta-amyloid and tau for AD, as well as RANKL and sclerostin for osteoporosis, have displayed therapeutic potential. Additionally, ongoing research has identified neuroinflammatory genes shared between AD and osteoporosis, offering insight into the interconnected inflammatory mechanisms. This knowledge opens avenues for innovative dual-purpose therapies that could address both conditions, potentially revolutionizing treatment approaches for AD and osteoporosis simultaneously. This review underscores the potential for groundbreaking advancements in early diagnosis and treatment by unraveling the intricate connection between AD and bone health. It advocates for a holistic, patient-centered approach to medical care that considers both cognitive and bone health, ultimately aiming to enhance the overall well-being of individuals affected by these conditions. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.
MeSH term(s)	Humans ; Alzheimer Disease/therapy ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Artificial Intelligence ; Quality of Life ; Amyloid beta-Peptides ; Osteoporosis/therapy
Chemical Substances	Amyloid beta-Peptides
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-023-00848-w
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Article ; Online: Mind the Gap: Unraveling the Intricate Dance Between Alzheimer's Disease and Related Dementias and Bone Health.

Karnik, Sonali J / Margetts, Tyler J / Wang, Hannah S / Movila, Alexandru / Oblak, Adrian L / Fehrenbacher, Jill C / Kacena, Melissa A / Plotkin, Lilian I

Current osteoporosis reports

2024 Volume 22, Issue 1, Page(s) 165–176

Abstract: Purpose of review: This review examines the linked pathophysiology of Alzheimer's disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis is on "inflammaging"-a low-level inflammation common to both, and its implications in ...

Abstract	Purpose of review: This review examines the linked pathophysiology of Alzheimer's disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis is on "inflammaging"-a low-level inflammation common to both, and its implications in an aging population. Recent findings: Aging intensifies both ADRD and bone deterioration. Notably, ADRD patients have a heightened fracture risk, impacting morbidity and mortality, though it is uncertain if fractures worsen ADRD. Therapeutically, agents targeting inflammation pathways, especially Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and TNF-α, appear beneficial for both conditions. Additionally, treatments like Sirtuin 1 (SIRT-1), known for anti-inflammatory and neuroprotective properties, are gaining attention. The interconnectedness of AD/ADRD and bone health necessitates a unified treatment approach. By addressing shared mechanisms, we can potentially transform therapeutic strategies, enriching our understanding and refining care in our aging society. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.
MeSH term(s)	Humans ; Aged ; Alzheimer Disease/epidemiology ; Alzheimer Disease/therapy ; Dementia/epidemiology ; Dementia/therapy ; Artificial Intelligence ; Bone Density ; Inflammation
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-023-00847-x
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Article ; Online: Use of AI Language Engine ChatGPT 4.0 to Write a Scientific Review Article Examining the Intersection of Alzheimer's Disease and Bone.

Margetts, Tyler J / Karnik, Sonali J / Wang, Hannah S / Plotkin, Lilian I / Oblak, Adrian L / Fehrenbacher, Jill C / Kacena, Melissa A / Movila, Alexandru

Current osteoporosis reports

2024 Volume 22, Issue 1, Page(s) 177–181

Abstract: Purpose of review: This Comment represents three review articles on the relationship between Alzheimer's disease, osteoporosis, and fracture in an exploration of the benefits that AI can provide in scientific writing. The first drafts of the articles ... ...

Abstract	Purpose of review: This Comment represents three review articles on the relationship between Alzheimer's disease, osteoporosis, and fracture in an exploration of the benefits that AI can provide in scientific writing. The first drafts of the articles were written (1) entirely by humans; (2) entirely by ChatGPT 4.0 (AI-only or AIO); and (3) by humans and ChatGPT 4.0 whereby humans selected literature references, but ChatGPT 4.0 completed the writing (AI-assisted or AIA). Importantly, each review article was edited and carefully checked for accuracy by all co-authors resulting in a final manuscript which was significantly different from the original draft. Recent findings: The human-written article took the most time from start to finish, the AI-only article took the least time, and the AI-assisted article fell between the two. When comparing first drafts to final drafts, the AI-only and AI-assisted articles had higher percentages of different text than the human article. The AI-only paper had a higher percentage of incorrect references in the first draft than the AI-assisted paper. The first draft of the AI-assisted article had a higher similarity score than the other two articles when examined by plagiarism identification software. This writing experiment used time tracking, human editing, and comparison software to examine the benefits and risks of using AI to assist in scientific writing. It showed that while AI may reduce total writing time, hallucinations and plagiarism were prevalent issues with this method and human editing was still necessary to ensure accuracy.
MeSH term(s)	Humans ; Alzheimer Disease ; Fractures, Bone ; Language ; Writing ; Artificial Intelligence
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-023-00853-z
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Article ; Online: Morphology and unbiased stereology of the lateral superior olive in the short-beaked common dolphin, Delphinus delphis (Cetacea, Delphinidae).

Nieder, Carolin / Rosene, Douglas L / Mortazavi, Farzad / Oblak, Adrian L / Ketten, Darlene R

Journal of morphology

2022 Volume 283, Issue 4, Page(s) 446–461

Abstract: In all mammals, the superior olivary complex (SOC) comprises a group of auditory brainstem nuclei that are important for sound localization. Its principal nuclei, the lateral superior olive (LSO) and the medial superior olive (MSO) process interaural ... ...

Abstract	In all mammals, the superior olivary complex (SOC) comprises a group of auditory brainstem nuclei that are important for sound localization. Its principal nuclei, the lateral superior olive (LSO) and the medial superior olive (MSO) process interaural time and intensity differences, which are the main cues for sound localization in the horizontal plane. Toothed whales (odontocetes) rely heavily on hearing and echolocation for foraging, orientation, and communication and localize sound with great acuity. The investigation of the SOC in odontocetes provides insight into adaptations to underwater hearing and echolocation. However, quantitative anatomical data for odontocetes are currently lacking. We quantified the volume, total neuron number, and neuron density of the LSO of six common dolphins (Delphinus delphis) using the Cavalieri principle and the unbiased stereology optical fractionator. Our results show that the LSO in D. delphis has a volume of 150 + (SD = 27) mm
MeSH term(s)	Animals ; Cetacea ; Common Dolphins ; Echolocation/physiology ; Olivary Nucleus/anatomy & histology ; Olivary Nucleus/physiology ; Superior Olivary Complex
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3084-3
ISSN	1097-4687 ; 0022-2887 ; 0362-2525
ISSN (online)	1097-4687
ISSN	0022-2887 ; 0362-2525
DOI	10.1002/jmor.21453
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Article: Corrigendum: Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging.

Maharjan, Surendra / Tsai, Andy P / Lin, Peter B / Ingraham, Cynthia / Jewett, Megan R / Landreth, Gary E / Oblak, Adrian L / Wang, Nian

Frontiers in neuroscience

2022 Volume 16, Page(s) 1025457

Abstract: This corrects the article DOI: 10.3389/fnins.2022.964654.]. ...

Abstract	[This corrects the article DOI: 10.3389/fnins.2022.964654.].
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2022.1025457
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