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  1. Article ; Online: Two zinc finger proteins with functions in m

    Zhang, Mi / Bodi, Zsuzsanna / Mackinnon, Katarzyna / Zhong, Silin / Archer, Nathan / Mongan, Nigel P / Simpson, Gordon G / Fray, Rupert G

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1127

    Abstract: The methyltransferase complex ( ... ...

    Abstract The methyltransferase complex (m
    MeSH term(s) Animals ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Methylation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Writing ; Zinc Fingers
    Chemical Substances Arabidopsis Proteins ; RNA, Messenger
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-28753-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Detection and Quantification of N

    Bodi, Zsuzsanna / Fray, Rupert G

    Methods in molecular biology (Clifton, N.J.)

    2017  Volume 1562, Page(s) 79–87

    Abstract: The base-modified nucleotide, ... ...

    Abstract The base-modified nucleotide, N
    MeSH term(s) Adenosine/analogs & derivatives ; Chromatography, Thin Layer/methods ; Epigenesis, Genetic ; Hydrolysis ; Isotope Labeling ; Methylation ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; Single-Strand Specific DNA and RNA Endonucleases ; Transcriptome
    Chemical Substances RNA, Messenger ; N-methyladenosine (CLE6G00625) ; Single-Strand Specific DNA and RNA Endonucleases (EC 3.1.30.1) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2017-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-6807-7_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The importance of m

    Baron, Francis / Zhang, Mi / Archer, Nathan / Bellows, Eleanor / Knight, Helen M / Welham, Simon / Rutland, Catrin S / Mongan, Nigel P / Hayes, Christopher J / Fray, Rupert G / Bodi, Zsuzsa

    RNA (New York, N.Y.)

    2023  Volume 29, Issue 6, Page(s) 777–789

    Abstract: ... ...

    Abstract N6
    MeSH term(s) Animals ; Chick Embryo ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Actins/genetics ; Chickens/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; RNA/metabolism ; Antibodies ; Nucleotides/metabolism
    Chemical Substances RNA, Messenger ; Actins ; RNA-Binding Proteins ; RNA (63231-63-0) ; Antibodies ; Nucleotides
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1241540-6
    ISSN 1469-9001 ; 1355-8382
    ISSN (online) 1469-9001
    ISSN 1355-8382
    DOI 10.1261/rna.079615.123
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4777: Show issues Location:
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  4. Article ; Online: Two zinc finger proteins with functions in m6A writing interact with HAKAI

    Mi Zhang / Zsuzsanna Bodi / Katarzyna Mackinnon / Silin Zhong / Nathan Archer / Nigel P. Mongan / Gordon G. Simpson / Rupert G. Fray

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: The components of m6A writer and their interactions are still far from fully understood. Here, the authors identify two HAKAI-interacting zinc finger proteins, HIZ1 and HIZ2, as components of the Arabidopsis m6A writer complex, and show that hiz2 mutant ... ...

    Abstract The components of m6A writer and their interactions are still far from fully understood. Here, the authors identify two HAKAI-interacting zinc finger proteins, HIZ1 and HIZ2, as components of the Arabidopsis m6A writer complex, and show that hiz2 mutant plants have an 85% reduction in m6A abundance and severe developmental defects.
    Keywords Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The Arabidopsis epitranscriptome.

    Fray, Rupert G / Simpson, Gordon G

    Current opinion in plant biology

    2015  Volume 27, Page(s) 17–21

    Abstract: The most prevalent internal modification of plant messenger RNAs, N(6)-methyladenosine (m(6)A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, ...

    Abstract The most prevalent internal modification of plant messenger RNAs, N(6)-methyladenosine (m(6)A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention. mRNA methylation is required for normal Arabidopsis development and the first methylation maps reveal that thousands of Arabidopsis mRNAs are methylated. Arabidopsis is likely to be a model of wide utility in understanding the biological impacts of the epitranscriptome. We review recent progress and look ahead with questions awaiting answers to reveal an entire layer of gene regulation that has until recently been overlooked.
    MeSH term(s) Arabidopsis/genetics ; Arabidopsis/metabolism ; Epigenesis, Genetic ; Gene Expression Regulation, Plant ; Methylation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcriptome
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2015-06-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2015.05.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2005/717: Show issues

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  6. Article: Clinical and molecular significance of the RNA m

    Lothion-Roy, Jennifer / Haigh, Daisy B / Harris, Anna E / Metzler, Veronika M / Alsaleem, Mansour / Toss, Michael S / Kariri, Yousif / Ntekim, Atara / Robinson, Brian D / Khani, Francesca / Gudas, Lorraine J / Allegrucci, Cinzia / James, Victoria H / Madhusudan, Srinivasan / Mather, Melissa / Emes, Richard D / Archer, Nathan / Fray, Rupert G / Rakha, Emad /
    Jeyapalan, Jennie N / Rutland, Catrin S / Mongan, Nigel P / Woodcock, Corinne L

    Frontiers in genetics

    2023  Volume 13, Page(s) 1096071

    Abstract: ... ...

    Abstract N
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.1096071
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  7. Article: The Arabidopsis epitranscriptome

    Fray, Rupert G / Gordon G Simpson

    Current opinion in plant biology. 2015 Oct., v. 27

    2015  

    Abstract: The most prevalent internal modification of plant messenger RNAs, N6-methyladenosine (m6A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has ...

    Abstract The most prevalent internal modification of plant messenger RNAs, N6-methyladenosine (m6A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention. mRNA methylation is required for normal Arabidopsis development and the first methylation maps reveal that thousands of Arabidopsis mRNAs are methylated. Arabidopsis is likely to be a model of wide utility in understanding the biological impacts of the epitranscriptome. We review recent progress and look ahead with questions awaiting answers to reveal an entire layer of gene regulation that has until recently been overlooked.
    Keywords Arabidopsis ; eukaryotic cells ; genes ; messenger RNA ; methylation ; models
    Language English
    Dates of publication 2015-10
    Size p. 17-21.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2015.05.015
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2005/717: Show issues

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  8. Article ; Online: Exogenous N-acyl-homoserine lactones enhance the expression of flagella of Pseudomonas syringae and activate defence responses in plants.

    Cheng, Feifei / Ma, Anzhou / Zhuang, Guoqiang / Fray, Rupert G

    Molecular plant pathology

    2016  Volume 19, Issue 1, Page(s) 104–115

    Abstract: In order to cope with pathogens, plants have evolved sophisticated mechanisms to sense pathogenic attacks and to induce defence responses. The N-acyl-homoserine lactone (AHL)-mediated quorum sensing in bacteria regulates diverse physiological processes, ... ...

    Abstract In order to cope with pathogens, plants have evolved sophisticated mechanisms to sense pathogenic attacks and to induce defence responses. The N-acyl-homoserine lactone (AHL)-mediated quorum sensing in bacteria regulates diverse physiological processes, including those involved in pathogenicity. In this work, we study the interactions between AHL-producing transgenic tobacco plants and Pseudomonas syringae pv. tabaci 11528 (P. syringae 11528). Both a reduced incidence of disease and decrease in the growth of P. syringae 11528 were observed in AHL-producing plants compared with wild-type plants. The present data indicate that plant-produced AHLs enhance disease resistance against this pathogen. Subsequent RNA-sequencing analysis showed that the exogenous addition of AHLs up-regulated the expression of P. syringae 11528 genes for flagella production. Expression levels of plant defence genes in AHL-producing and wild-type plants were determined by quantitative real-time polymerase chain reaction. These data showed that plant-produced AHLs activated a wide spectrum of defence responses in plants following inoculation, including the oxidative burst, hypersensitive response, cell wall strengthening, and the production of certain metabolites. These results demonstrate that exogenous AHLs alter the gene expression patterns of pathogens, and plant-produced AHLs either directly or indirectly enhance plant local immunity during the early stage of plant infection.
    MeSH term(s) Acyl-Butyrolactones/pharmacology ; Cell Count ; Disease Resistance/drug effects ; Disease Resistance/immunology ; Flagella/drug effects ; Flagella/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Bacterial/drug effects ; Green Fluorescent Proteins/metabolism ; Plant Diseases/microbiology ; Plant Leaves/drug effects ; Plant Leaves/microbiology ; Pseudomonas syringae/drug effects ; Pseudomonas syringae/genetics ; Pseudomonas syringae/growth & development ; Pseudomonas syringae/metabolism ; Nicotiana/immunology ; Nicotiana/microbiology ; Up-Regulation/drug effects ; Up-Regulation/genetics
    Chemical Substances Acyl-Butyrolactones ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2016-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020755-4
    ISSN 1364-3703 ; 1364-3703
    ISSN (online) 1364-3703
    ISSN 1364-3703
    DOI 10.1111/mpp.12502
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  9. Article: The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.

    Haigh, Daisy B / Woodcock, Corinne L / Lothion-Roy, Jennifer / Harris, Anna E / Metzler, Veronika M / Persson, Jenny L / Robinson, Brian D / Khani, Francesca / Alsaleem, Mansour / Ntekim, Atara / Madhusudan, Srinivasan / Davis, Melissa B / Laursen, Kristian B / Gudas, Lorraine J / Rutland, Catrin S / Toss, Michael S / Archer, Nathan / Bodi, Zsuzsanna / Rakha, Emad A /
    Fray, Rupert G / Jeyapalan, Jennie N / Mongan, Nigel P

    Cancers

    2022  Volume 14, Issue 20

    Abstract: Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing ... ...

    Abstract Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing androgen biosynthesis or via AR signalling inhibition (ARSi) are common treatments. The
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14205148
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  10. Article: Altering plant-microbe interaction through artificially manipulating bacterial quorum sensing.

    Fray, Rupert G

    Annals of botany

    2002  Volume 89, Issue 3, Page(s) 245–253

    Abstract: Many bacteria regulate diverse physiological processes in concert with their population size. Bacterial cell-to-cell communication utilizes small diffusible signal molecules, which the bacteria both produce and perceive. The bacteria couple gene ... ...

    Abstract Many bacteria regulate diverse physiological processes in concert with their population size. Bacterial cell-to-cell communication utilizes small diffusible signal molecules, which the bacteria both produce and perceive. The bacteria couple gene expression to cell density by eliciting a response only when the signalling molecules reach a critical threshold (a point at which the population is said to be 'quorate'). The population as a whole is thus able to modify its behaviour as a single unit. Amongst Gram-negative bacteria, the quorum sensing signals most commonly used are N-acylhomoserine lactones (AHLs). It is now apparent that AHLs are used for regulating diverse behaviours in epiphytic, rhizosphere-inhabiting and plant pathogenic bacteria and that plants may produce their own metabolites that interfere with this signalling. Transgenic plants that produce high levels of AHLs or which can degrade bacterial-produced AHLs have been made. These plants have dramatically altered susceptibilities to infection by pathogenic Erwinia species. In addition, such plants will prove useful tools in determining the roles of AHL-regulated density-dependent behaviour in growth promoting, biological control and pathogenic plant-associated bacterial species.
    MeSH term(s) 4-Butyrolactone/analogs & derivatives ; 4-Butyrolactone/biosynthesis ; 4-Butyrolactone/chemistry ; Immunity, Innate ; Molecular Structure ; Mutation ; Pectobacterium carotovorum/genetics ; Pectobacterium carotovorum/growth & development ; Pectobacterium carotovorum/metabolism ; Plant Diseases/microbiology ; Plant Roots/microbiology ; Plants/microbiology ; Plants, Genetically Modified ; Signal Transduction/physiology ; Solanum tuberosum/microbiology ; Nicotiana/microbiology
    Chemical Substances homoserine lactone (1192-20-7) ; 4-Butyrolactone (OL659KIY4X)
    Language English
    Publishing date 2002-07-01
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1461328-1
    ISSN 1095-8290 ; 0305-7364
    ISSN (online) 1095-8290
    ISSN 0305-7364
    DOI 10.1093/aob/mcf039
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