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  1. Article: Junying Yuan: changing avenues without losing focus. Interview by Nicole LeBrasseur.

    Yuan, Junying

    The Journal of cell biology

    2007  Volume 179, Issue 2, Page(s) 174–175

    Abstract: An interest in neurodegenerative diseases drove Junying Yuan to study cell death as a graduate ... student at Harvard University. Now a full professor at the hallowed institute, Yuan is moved by the same ...

    Abstract An interest in neurodegenerative diseases drove Junying Yuan to study cell death as a graduate student at Harvard University. Now a full professor at the hallowed institute, Yuan is moved by the same interest in a new direction--the removal of misfolded proteins.
    MeSH term(s) Animals ; Apoptosis ; Awards and Prizes ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/enzymology ; Caenorhabditis elegans/genetics ; Caspases/metabolism ; China ; History, 20th Century ; History, 21st Century ; Massachusetts ; Protein Folding
    Chemical Substances Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2007-10-22
    Publishing country United States
    Document type Biography ; Historical Article ; Interview
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.1792pi
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.190: Show issues Location:
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  2. Article ; Online: RIPK1 and RIPK3 form mosaic necrosomes.

    Qi, Weiwei / Yuan, Junying

    Nature cell biology

    2022  Volume 24, Issue 4, Page(s) 406–407

    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-022-00879-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5169: Show issues Location:
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    Zs.MG 12: Show issues

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  3. Article ; Online: Targeting RIPK1 kinase for modulating inflammation in human diseases.

    Li, Wanjin / Yuan, Junying

    Frontiers in immunology

    2023  Volume 14, Page(s) 1159743

    Abstract: Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) is a master regulator of TNFR1 signaling in controlling cell death and survival. While the scaffold of RIPK1 participates in the canonical NF-κB pathway, the activation of RIPK1 kinase ... ...

    Abstract Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) is a master regulator of TNFR1 signaling in controlling cell death and survival. While the scaffold of RIPK1 participates in the canonical NF-κB pathway, the activation of RIPK1 kinase promotes not only necroptosis and apoptosis, but also inflammation by mediating the transcriptional induction of inflammatory cytokines. The nuclear translocation of activated RIPK1 has been shown to interact BAF-complex to promote chromatin remodeling and transcription. This review will highlight the proinflammatory role of RIPK1 kinase with focus on human neurodegenerative diseases. We will discuss the possibility of targeting RIPK1 kinase for the treatment of inflammatory pathology in human diseases.
    MeSH term(s) Humans ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Apoptosis ; Cell Death ; Signal Transduction ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Inflammation/metabolism
    Chemical Substances Receptors, Tumor Necrosis Factor, Type I ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; RIPK1 protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1159743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A guide to cell death pathways.

    Yuan, Junying / Ofengeim, Dimitry

    Nature reviews. Molecular cell biology

    2023  Volume 25, Issue 5, Page(s) 379–395

    Abstract: Regulated cell death mediated by dedicated molecular machines, known as programmed cell death, plays important roles in health and disease. Apoptosis, necroptosis and pyroptosis are three such programmed cell death modalities. The caspase family of ... ...

    Abstract Regulated cell death mediated by dedicated molecular machines, known as programmed cell death, plays important roles in health and disease. Apoptosis, necroptosis and pyroptosis are three such programmed cell death modalities. The caspase family of cysteine proteases serve as key regulators of programmed cell death. During apoptosis, a cascade of caspase activation mediates signal transduction and cellular destruction, whereas pyroptosis occurs when activated caspases cleave gasdermins, which can then form pores in the plasma membrane. Necroptosis, a form of caspase-independent programmed necrosis mediated by RIPK3 and MLKL, is inhibited by caspase-8-mediated cleavage of RIPK1. Disruption of cellular homeostatic mechanisms that are essential for cell survival, such as normal ionic and redox balance and lysosomal flux, can also induce cell death without invoking programmed cell death mechanisms. Excitotoxicity, ferroptosis and lysosomal cell death are examples of such cell death modes. In this Review, we provide an overview of the major cell death mechanisms, highlighting the latest insights into their complex regulation and execution, and their relevance to human diseases.
    MeSH term(s) Humans ; Animals ; Signal Transduction ; Necroptosis ; Apoptosis/physiology ; Cell Death/physiology ; Pyroptosis/physiology ; Lysosomes/metabolism ; Caspases/metabolism ; Ferroptosis/physiology
    Chemical Substances Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2023-12-18
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-023-00689-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5446: Show issues Location:
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    Zs.MG 26: Show issues

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  5. Article ; Online: Digital cross-mounting of intraoral scan casts from a virtual articulator to a mechanical articulator by using a custom transfer plate: A dental technique.

    Yang, Shengtao / Wu, Lei / Alabkaa, Baraa / Yuan, Quan / Yue, Li / Li, Junying

    The Journal of prosthetic dentistry

    2024  

    Abstract: With the development of digital dental technologies, a complete digital workflow without using physical casts has become possible. However, for certain clinical and dental laboratory procedures, especially in complex rehabilitation treatments, physically ...

    Abstract With the development of digital dental technologies, a complete digital workflow without using physical casts has become possible. However, for certain clinical and dental laboratory procedures, especially in complex rehabilitation treatments, physically mounted casts in an ideal location in a mechanical articulator are still necessary for treatment planning and restoration fabrication. This technique report describes a digital approach to fabricating a custom transfer plate to cross mount intraoral scan casts from a virtual articulator to the corresponding mechanical articulator. This technique eliminates the need for conventional physical facebow transfer processes and offers a straightforward approach to integrating virtual procedures with analog workflows.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218157-5
    ISSN 1097-6841 ; 0022-3913
    ISSN (online) 1097-6841
    ISSN 0022-3913
    DOI 10.1016/j.prosdent.2024.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul III Zs.145: Show issues Location:
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  6. Article ; Online: Visualizing Endogenous Necrosomes in Necrosomes by In Situ Proximity Ligation Assay.

    Liang, Wei / Yuan, Junying

    Current protocols

    2022  Volume 2, Issue 2, Page(s) e388

    Abstract: Necroptosis is a regulated form of necrosis that has been shown to participate in the pathogenesis of major human inflammatory and neurodegenerative diseases. Formation of a necrosome, composed of the RIPK1/RIPK3 complex, drives the execution of ... ...

    Abstract Necroptosis is a regulated form of necrosis that has been shown to participate in the pathogenesis of major human inflammatory and neurodegenerative diseases. Formation of a necrosome, composed of the RIPK1/RIPK3 complex, drives the execution of necroptosis. Although the co-immunoprecipitation (co-IP) assay has been widely used as a biochemical protocol for studying necrosomes, the technical limitations of co-IP prevent its use for identifying necrosomes in complex tissues and for investigating the subcellular localization of necrosomes. The development of a specific assay for visualizing necrosomes in situ is needed. Here, we developed an in situ proximity ligation assay (PLA), which converts the detection of protein-protein interaction to detection of DNA product by rolling-circle amplification for investigating the endogenous necrosome in situ and in tissues. This protocol describes an in situ PLA that we have developed for visualizing endogenous necrosomes in necroptosis in both human and mouse cells and in mouse embryos with sensitivity and specificity. © 2022 Wiley Periodicals LLC. Basic Protocol 1: Detection of RIPK1/RIPK3 interaction by in situ proximity ligation assay in human and mouse cells.
    MeSH term(s) Animals ; Mice ; Necroptosis ; Necrosis
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction to: PINK1 mediates neuronal survival in monkey.

    Sun, Ziyu / Ye, Jianyu / Yuan, Junying

    Protein & cell

    2021  Volume 13, Issue 4, Page(s) 308

    Language English
    Publishing date 2021-12-13
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2543451-2
    ISSN 1674-8018 ; 1674-800X
    ISSN (online) 1674-8018
    ISSN 1674-800X
    DOI 10.1007/s13238-021-00899-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Multiplexed strategies toward clinical translation of extracellular vesicles.

    Song, Junying / Song, Baoqiang / Yuan, Lijun / Yang, Guodong

    Theranostics

    2022  Volume 12, Issue 15, Page(s) 6740–6761

    Abstract: Extracellular vesicles (EVs), of which exosomes are a representative subgroup, are naturally secreted nanoparticles with a variety of payloads. With the intrinsic merits of stability, biocompatibility, low immunogenicity, and large capacity, EVs are ... ...

    Abstract Extracellular vesicles (EVs), of which exosomes are a representative subgroup, are naturally secreted nanoparticles with a variety of payloads. With the intrinsic merits of stability, biocompatibility, low immunogenicity, and large capacity, EVs are widely regarded as effective carriers of drug delivery. However, disadvantages, such as low yield, complicated isolation procedures, and low loading efficiency, hinder its clinical translation. In this review, we systematically summarize the advances in EV (especially exosomes) engineering for clinical application, focusing on strategies toward high yield, facile isolation, efficient cargo loading, improved delivery, and optimized manufacturing, which might unleash the infinite power of EVs in clinical translation.
    MeSH term(s) Cell Communication ; Drug Delivery Systems/methods ; Exosomes ; Extracellular Vesicles ; Nanoparticles
    Language English
    Publishing date 2022-09-21
    Publishing country Australia
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.75899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: PINK1 mediates neuronal survival in monkey.

    Sun, Zhiyu / Ye, Jiangyu / Yuan, Junying

    Protein & cell

    2021  Volume 13, Issue 1, Page(s) 4–5

    MeSH term(s) Animals ; Cell Survival ; Disease Models, Animal ; Dopaminergic Neurons/enzymology ; Haplorhini ; Parkinson Disease/enzymology ; Protein Kinases/metabolism
    Chemical Substances Protein Kinases (EC 2.7.-) ; PTEN-induced putative kinase (EC 2.7.11.1)
    Language English
    Publishing date 2021-11-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2543451-2
    ISSN 1674-8018 ; 1674-800X
    ISSN (online) 1674-8018
    ISSN 1674-800X
    DOI 10.1007/s13238-021-00889-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Human milk sphingomyelin: Function, metabolism, composition and mimicking.

    Yuan, Yuying / Zhao, Junying / Liu, Qian / Liu, Yan / Tian, Xiaoyan / Qiao, Weicang / Zhao, Yanyan / Liu, Yanpin / Chen, Lijun

    Food chemistry

    2024  Volume 447, Page(s) 138991

    Abstract: Human milk, which contains various nutrients, is the "gold standard" for infant nutrition. Healthy human milk meets all the nutritional needs of early infant development. Polar lipids mainly exist in the milk fat globule membrane, accounting for ... ...

    Abstract Human milk, which contains various nutrients, is the "gold standard" for infant nutrition. Healthy human milk meets all the nutritional needs of early infant development. Polar lipids mainly exist in the milk fat globule membrane, accounting for approximately 1-2% of human milk lipids; sphingomyelin (SM) accounts for approximately 21-24% of polar lipids. SM plays an important role in promoting the development of the brain and nervous system, regulating intestinal flora, and improving skin barriers. Though SM could be synthesized de novo, SM nutrition from dietary is also important for infants. The content and composition of SM in human milk has been reported, however, the molecular mechanisms of nutritional functions of SM for infants required further research. This review summarizes the functional mechanisms, metabolic pathways, and compositional, influencing factors, and mimicking of SM in human milk, and highlights the challenges of improving maternal and infant early/long-term nutrition.
    MeSH term(s) Infant ; Child ; Humans ; Sphingomyelins ; Milk, Human ; Diet ; Nutritional Status ; Infant Nutritional Physiological Phenomena
    Chemical Substances Sphingomyelins
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.138991
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