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  1. Article ; Online: Alternative interpretation to the findings reported in visualization of severe acute respiratory syndrome coronavirus 2 invading the human placenta using electron microscopy.

    Kniss, Douglas A

    American journal of obstetrics and gynecology

    2020  Volume 223, Issue 5, Page(s) 785–786

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; Humans ; Microscopy, Electron ; Pandemics ; Placenta/diagnostic imaging ; Pneumonia, Viral ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2020.06.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Alternative interpretation to the findings reported in visualization of severe acute respiratory syndrome coronavirus 2 invading the human placenta using electron microscopy

    Kniss, Douglas A

    Am. j. obstet. gynecol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #592443
    Database COVID19

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  3. Article: Progesterone Receptor Signaling Selectively Modulates Cytokine-Induced Global Gene Expression in Human Cervical Stromal Cells.

    Kniss, Douglas A / Summerfield, Taryn L

    Frontiers in genetics

    2020  Volume 11, Page(s) 883

    Abstract: Preterm birth (PTB) is the leading cause of morbidity and mortality in infants <1 year of age. Intrauterine inflammation is a hallmark of preterm and term parturition; however, this alone cannot fully explain the pathobiology of PTB. For example, the ... ...

    Abstract Preterm birth (PTB) is the leading cause of morbidity and mortality in infants <1 year of age. Intrauterine inflammation is a hallmark of preterm and term parturition; however, this alone cannot fully explain the pathobiology of PTB. For example, the cervix undergoes a prolonged series of biochemical and biomechanical events, including extracellular matrix (ECM) remodeling and mechanochemical changes, culminating in ripening. Vaginal progesterone (P
    Language English
    Publishing date 2020-09-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2020.00883
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  4. Article ; Online: Aspirin modulates production of pro-inflammatory and pro-resolving mediators in endothelial cells.

    Rood, Kara M / Patel, Niharika / DeVengencie, Ivana M / Quinn, John P / Gowdy, Kymberly M / Costantine, Maged M / Kniss, Douglas A

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0283163

    Abstract: Endothelial cells synthesize biochemical signals to coordinate a response to insults, resolve inflammation and restore barrier integrity. Vascular cells release a variety of vasoactive bioactive lipid metabolites during the inflammatory response and ... ...

    Abstract Endothelial cells synthesize biochemical signals to coordinate a response to insults, resolve inflammation and restore barrier integrity. Vascular cells release a variety of vasoactive bioactive lipid metabolites during the inflammatory response and produce pro-resolving mediators (e.g., Lipoxin A4, LXA4) in cooperation with leukocytes and platelets to bring a halt to inflammation. Aspirin, used in a variety of cardiovascular and pro-thrombotic disorders (e.g., atherosclerosis, angina, preeclampsia), potently inhibits proinflammatory eicosanoid formation. Moreover, aspirin stimulates the synthesis of pro-resolving lipid mediators (SPM), so-called Aspirin-Triggered Lipoxins (ATL). We demonstrate that cytokines stimulated a time- and dose-dependent increase in PGI2 (6-ketoPGF1α) and PGE2 formation that is blocked by aspirin. Eicosanoid production was caused by cytokine-induced expression of cyclooxygenase-2 (COX-2). We also detected increased production of pro-resolving LXA4 in cytokine-stimulated endothelial cells. The R-enantiomer of LXA4, 15-epi-LXA4, was enhanced by aspirin, but only in the presence of cytokine challenge, indicating dependence on COX-2 expression. In contrast to previous reports, we detected arachidonate 5-lipoxygenase (ALOX5) mRNA expression and its cognate protein (5-lipoxygenase, 5-LOX), suggesting that endothelial cells possess the enzymatic machinery necessary to synthesize both pro-inflammatory and pro-resolving lipid mediators independent of added leukocytes or platelets. Finally, we observed that, endothelial cells produced LTB4 in the absence of leukocytes. These results indicate that endothelial cells produce both pro-inflammatory and pro-resolving lipid mediators in the absence of other cell types and aspirin exerts pleiotropic actions influencing both COX and LOX pathways.
    MeSH term(s) Humans ; Aspirin/pharmacology ; Aspirin/metabolism ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Endothelial Cells/metabolism ; Lipoxins/pharmacology ; Inflammation/metabolism ; Eicosanoids/metabolism ; Cytokines/metabolism
    Chemical Substances Aspirin (R16CO5Y76E) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Lipoxins ; Eicosanoids ; Cytokines
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0283163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: The physiologic basis of gynecology and obstetrics

    Seifer, David B. / Samuels, Philip / Kniss, Douglas A.

    2001  

    Author's details David B. Seifer ; Philip Samuels ; Douglas A. Kniss
    Keywords Genital Diseases, Female / physiopathology ; Genitalia, Female / physiology ; Pregnancy / physiology ; Pregnancy Complications / physiopathology
    Language English
    Size XI, 608 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT012972036
    ISBN 0-683-30249-3 ; 978-0-683-30249-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 A 2070 order for loan Magazin

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  6. Article ; Online: Discovery of HeLa Cell Contamination in HES Cells: Call for Cell Line Authentication in Reproductive Biology Research.

    Kniss, Douglas A / Summerfield, Taryn L

    Reproductive sciences (Thousand Oaks, Calif.)

    2014  Volume 21, Issue 8, Page(s) 1015–1019

    Abstract: Continuous cell lines are used frequently in reproductive biology research to study problems in early pregnancy events and parturition. It has been recognized for 50 years that many mammalian cell lines contain inter- or intraspecies contaminations with ... ...

    Abstract Continuous cell lines are used frequently in reproductive biology research to study problems in early pregnancy events and parturition. It has been recognized for 50 years that many mammalian cell lines contain inter- or intraspecies contaminations with other cells. However, most investigators do not routinely test their culture systems for cross-contamination. The most frequent contributor to cross-contamination of cell lines is the HeLa cell isolated from an aggressive cervical adenocarcinoma. We report on the discovery of HeLa cell contamination of the human endometrial epithelial cell line HES isolated in our laboratory. Short tandem repeat analysis of 9 unique genetic loci demonstrated molecular identity between HES and HeLa cells. In addition, we verified that WISH cells, isolated originally from human amnion epithelium, were also contaminated with HeLa cells. Inasmuch as our laboratory did not culture HeLa cells at the time of HES cell derivations, the source of contamination was the WISH cell line. These data highlight the need for continued diligence in authenticating cell lines used in reproductive biology research.
    Language English
    Publishing date 2014-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1177/1933719114522518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4113: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Low-dose aspirin increases 15-epi-lipoxins A

    Gonzalez-Brown, Veronica M / Ma'ayeh, Marwan / Kniss, Douglas A / Cackovic, Michael / Landon, Mark B / Rood, Kara M

    Pregnancy hypertension

    2021  Volume 26, Page(s) 75–78

    Abstract: Background: LDA triggers biosynthesis of endogenous anti-inflammatory molecules, aspirin-triggered 15-epi-lipoxin A: Objective: Investigate the effects of daily LDA on levels of 15-epi-LXA: Materials and methods: Secondary analysis of multi- ... ...

    Abstract Background: LDA triggers biosynthesis of endogenous anti-inflammatory molecules, aspirin-triggered 15-epi-lipoxin A
    Objective: Investigate the effects of daily LDA on levels of 15-epi-LXA
    Materials and methods: Secondary analysis of multi-centered randomized controlled trial investigating effects of daily LDA (60 mg) in high-risk pregnancies. Maternal samples were drawn at three points: before LDA initiation (13-26 weeks' gestation), 24-28 weeks' gestation (at least two weeks after LDA) and 34-36 weeks' gestation. 15-epi-LXA
    Results: Analysis included 82 patients: 63 receiving daily LDA and 29 receiving daily placebo starting between 13 and 25 weeks gestation. Prior to randomization, baseline 15-epi-LXA
    Conclusion: Daily LDA administration increases 15-epi-LXA
    MeSH term(s) Adult ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Aspirin/administration & dosage ; Aspirin/pharmacology ; Female ; Humans ; Lipoxins/biosynthesis ; Lipoxins/blood ; Pre-Eclampsia/prevention & control ; Pregnancy ; Pregnancy, High-Risk
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Lipoxins ; lipoxin A4 ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2021-09-15
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2584464-7
    ISSN 2210-7797 ; 2210-7789
    ISSN (online) 2210-7797
    ISSN 2210-7789
    DOI 10.1016/j.preghy.2021.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Novel Interventions for the Prevention of Preeclampsia.

    Ma'ayeh, Marwan / Rood, Kara M / Kniss, Douglas / Costantine, Maged M

    Current hypertension reports

    2020  Volume 22, Issue 2, Page(s) 17

    Abstract: Purpose of review: To review the rationale and biological plausibility and discuss the current research on novel interventions for the prevention of preeclampsia.: Recent findings: Preeclampsia affects up to 8% of pregnancies worldwide and remains a ... ...

    Abstract Purpose of review: To review the rationale and biological plausibility and discuss the current research on novel interventions for the prevention of preeclampsia.
    Recent findings: Preeclampsia affects up to 8% of pregnancies worldwide and remains a major cause of maternal and neonatal morbidity and mortality. Multiple medications have been investigated or repurposed as potential effective interventions for preeclampsia prevention. Aspirin is currently the only drug for which there is some evidence of benefit for preeclampsia prevention, and its use is recommended by professional societies for pregnancies at risk. Statins have shown promise for prevention of preeclampsia in animal models and human pilot studies, without any trend or concerns for safety signals or teratogenicity. The use of metformin has also gained popularity in experimental studies, but observations from randomized clinical trials were not consistent on its utility as a possible intervention for preeclampsia prevention. While initial studies evaluating esomeprazole were promising, randomized trials failed to show benefit. Contemporary research shows exciting new opportunities for prophylactic treatment for preeclampsia, to prevent this debilitating and life-threatening disease.
    MeSH term(s) Animals ; Aspirin/therapeutic use ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypertension ; Pre-Eclampsia/prevention & control ; Pregnancy
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2020-02-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-020-1026-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5522: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Myoferlin regulates epithelial cancer cell plasticity and migration through autocrine TGF-β1 signaling.

    Barnhouse, Victoria R / Weist, Jessica L / Shukla, Vasudha C / Ghadiali, Samir N / Kniss, Douglas A / Leight, Jennifer L

    Oncotarget

    2018  Volume 9, Issue 27, Page(s) 19209–19222

    Abstract: Epithelial cancer cells can undergo an epithelial-mesenchymal transition (EMT), a complex genetic program that enables cells to break free from the primary tumor, breach the basement membrane, invade through the stroma and metastasize to distant organs. ... ...

    Abstract Epithelial cancer cells can undergo an epithelial-mesenchymal transition (EMT), a complex genetic program that enables cells to break free from the primary tumor, breach the basement membrane, invade through the stroma and metastasize to distant organs. Myoferlin (MYOF), a protein involved in plasma membrane function and repair, is overexpressed in several invasive cancer cell lines. Depletion of myoferlin in the human breast cancer cell line MDA-MB-231 (MDA-231
    Language English
    Publishing date 2018-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.24971
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  10. Article ; Online: Exposure and seroconversion to severe acute respiratory syndrome coronavirus 2 among obstetrical healthcare providers following a contained outbreak.

    Kiefer, Miranda K / McKiever, Monique E / Russo, Jessica R / Ma'ayeh, Marwan / Gee, Stephen E / Smith, Devin D / Kniss, Douglas A / Cackovic, Michael / Costantine, Maged M / Landon, Mark B / Rood, Kara M

    American journal of obstetrics and gynecology

    2020  Volume 223, Issue 4, Page(s) 601–603.e2

    MeSH term(s) Adult ; Antibodies, Viral/blood ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Outbreaks ; Female ; Health Personnel ; Humans ; Middle Aged ; Obstetrics ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Polymerase Chain Reaction ; Prospective Studies ; SARS-CoV-2 ; Seroconversion
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Letter
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2020.06.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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