LIVIVO - Search results -

Search results

Result 1 - 10 of total 58

Search options

Article ; Online: Intravital Microscopy Evidence That Methylene Blue Should Be a Vasopressor-Sparing Agent in Sepsis Vasoplegia.

Mestriner, Fabiola Leslie Antunes Cardoso / Dantas, Pedro Brüch / Barbosa, Jéssyca Michelon / Evora, Paulo Roberto B / Becari, Christiane

Brazilian journal of cardiovascular surgery

2024 Volume 39, Issue 3, Page(s) e20230066

Abstract: Microvasculature failure is expected in sepsis and at higher amine concentrations. Therefore, special attention focused individually on microcirculation is needed. Here, we present that methylene blue can prevent leukocytes from adhering to the ... ...

Abstract	Microvasculature failure is expected in sepsis and at higher amine concentrations. Therefore, special attention focused individually on microcirculation is needed. Here, we present that methylene blue can prevent leukocytes from adhering to the endothelium in a rat model of lipopolysaccharide-induced endotoxemia. As hypothesis evidence, an intravital microscopy image is presented.
MeSH term(s)	Rats ; Animals ; Methylene Blue/pharmacology ; Methylene Blue/therapeutic use ; Vasoconstrictor Agents ; Vasoplegia/drug therapy ; Sepsis/drug therapy ; Intravital Microscopy
Chemical Substances	Methylene Blue (T42P99266K) ; Vasoconstrictor Agents
Language	English
Publishing date	2024-04-03
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2031026-2
ISSN	1678-9741 ; 1678-9741
ISSN (online)	1678-9741
ISSN	1678-9741
DOI	10.21470/1678-9741-2023-0066
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Impact of angiotensin-converting enzyme inhibition on hemodynamic and autonomic profile of elastase-2 knockout mice.

Prates-Costa, T C / Oliveira, M de / Fazan, R / Salgado, H C / Becari, C

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2022 Volume 55, Page(s) e11774

Abstract: Elastase-2 (ELA-2) is an angiotensin II-generating enzyme that participates in the cardiovascular system. ELA-2 is involved in hemodynamic and autonomic control and is upregulated in myocardial infarction and hypertension. The inhibition of angiotensin- ... ...

Abstract	Elastase-2 (ELA-2) is an angiotensin II-generating enzyme that participates in the cardiovascular system. ELA-2 is involved in hemodynamic and autonomic control and is upregulated in myocardial infarction and hypertension. The inhibition of angiotensin-converting enzyme (ACE) increased ELA-2 expression in the carotid arteries and heart of spontaneously hypertensive rats. In this study, we sought to investigate the role of ACE inhibition in hemodynamic and autonomic balance in elastase-2 knockout (ELA-2 KO) mice. Male ELA-2 KO and C57BL/6 mice were treated with the ACE inhibitor enalapril or saline for 10 days. After treatment, mice underwent surgery for cannulation of the femoral artery and arterial pressure recordings were made five days later in awake animals. The variability of systolic blood pressure (SBP) and pulse interval (PI) was evaluated in the time and frequency domain. Spontaneous baroreflex was assessed by the sequencing method. ACE inhibition caused a significant decrease in mean arterial pressure (117±2.2 vs 100±2.8 mmHg) and an increase in heart rate (570±32 vs 655±15 bpm) in ELA-2 KO mice. Despite a tendency towards reduction in the overall heart rate variability (standard deviation of successive values: 7.6±1.1 vs 4.7±0.6 ms, P=0.08), no changes were found in the root of the mean sum of squares or in the power of the high-frequency band. ACE inhibition did not change the spontaneous baroreflex indices (gain and baroreflex effectiveness index) in ELA-2 KO mice. Altogether, this data suggested that ACE played a role in the maintenance of hemodynamic function in ELA-2 KO mice.
MeSH term(s)	Angiotensin II ; Animals ; Hemodynamics/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Pancreatic Elastase
Chemical Substances	Angiotensin II (11128-99-7) ; Pancreatic Elastase (EC 3.4.21.36)
Language	English
Publishing date	2022-03-21
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/1414-431X2022e11774
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1359: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice.

Becari, Luca / Fonseca, Maria Luiza A / Gonçalves, Sthéfanie C A / Bader, Michael / Santos, Robson A S / Campagnole-Santos, Maria José / Kangussu, Lucas M

Acta neuropsychiatrica

2022 Volume 35, Issue 1, Page(s) 27–34

Abstract: Objectives: To evaluate the impact of genetic deletion of receptors of the counterregulatory arms of the renin-angiotensin system in depressive-like behaviours.: Methods: 8-12 weeks-old male mice wild type (WT, C57BL/6J) and mice with genetic ... ...

Abstract	Objectives: To evaluate the impact of genetic deletion of receptors of the counterregulatory arms of the renin-angiotensin system in depressive-like behaviours. Methods: 8-12 weeks-old male mice wild type (WT, C57BL/6J) and mice with genetic deletion of MrgD (MrgD KO) or Mas receptors (Mas KO) were subjected to the Forced Swim Test (FST) and the Tail Suspension Test (TST). Brain-derived neurotrophic factor (BDNF) levels were measured by enzyme-linked immunosorbent assay (ELISA). Blockade of Mas was performed by acute intracerebroventricular ( Results: No statistical difference in immobility time was observed between MrgD KO and WT male animals subjected to FST and TST. However, acute Conclusion: Our data showed that Mas plays an important role in the neurobiology of depression probably by modulating BDNF expression. On the contrary, lack of MrgD did not alter depressive-like behaviour, which was supported by the lack of alterations in BDNF levels.
MeSH term(s)	Mice ; Male ; Animals ; Depression/genetics ; Depression/metabolism ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Mice, Inbred C57BL ; Hindlimb Suspension ; Prefrontal Cortex/metabolism ; Hippocampus/metabolism
Chemical Substances	Brain-Derived Neurotrophic Factor
Language	English
Publishing date	2022-08-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1154361-9
ISSN	1601-5215 ; 0924-2708
ISSN (online)	1601-5215
ISSN	0924-2708
DOI	10.1017/neu.2022.20
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3708: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis.

Albuquerque, Agnes Afrodite S / Celotto, Andrea Carla / Becari, Christiane / Prandi, Marelaine / Barbosa, Jessyca M / Moreira, Francisco / Jordani, Maria Cecília / Evora, Paulo Roberto B

Brazilian journal of cardiovascular surgery

2022 Volume 37, Issue 1, Page(s) 20–28

Abstract: Introduction: There are many reasons to believe that the nitric oxide/guanosine 3'5' - cyclic monophosphate (or NO/cGMP) pathway on vasoplegic states is underestimated. To study indigo carmine (IC) as an alternative to methylene blue was the ... ...

Abstract	Introduction: There are many reasons to believe that the nitric oxide/guanosine 3'5' - cyclic monophosphate (or NO/cGMP) pathway on vasoplegic states is underestimated. To study indigo carmine (IC) as an alternative to methylene blue was the investigation rationale. Methods: The IC (3mg/kg intravenous infusion) study protocol included five experimental groups; 1) Control group - saline was injected at 0 and 10 minutes; 2) IC group - IC was injected at 0 and saline at 10 minutes; 3) compound 48/80 (C48/80) group - C48/80 was injected at 0 minute and saline at 10 minutes; 4) C48/80 + IC group - C48/80 was injected at 0 minute and IC at 10 minutes; and 5) IC + C48/80 group - IC was injected at 0 minute and C48/80 at 10 minutes. The studies were carried out by registering and measuring hemodynamic and blood gasometric parameters, including continuous cardiac output. Results: 1) The effects of the drugs (IC and C48/80) were more evident in the first 20 minutes of recording; 2) hypotensive responses were more pronounced in the C48/80 groups; 3) IC isolated or applied before C48/80 caused transient pulmonary hypertension; and 4) after the first 20 minutes, the pressure responses showed stability with apparent hypotension more pronounced in the C48/80 groups. Clinical observations showed significant hemodynamic instability and catastrophic anaphylactic reactions (agitation, pulmonary hypertension, severe bronchospasm, urticaria, high-intensity cyanosis, violent gastric hypersecretion, and ascites). Conclusion: A global results analysis showed differences between groups only in the first 20 minutes of the experiments.
MeSH term(s)	Anaphylaxis/drug therapy ; Animals ; Hemodynamics ; Humans ; Indigo Carmine/adverse effects ; Nitric Oxide ; Swine ; Vasoplegia ; p-Methoxy-N-methylphenethylamine/adverse effects
Chemical Substances	Nitric Oxide (31C4KY9ESH) ; p-Methoxy-N-methylphenethylamine (4091-50-3) ; Indigo Carmine (D3741U8K7L)
Language	English
Publishing date	2022-03-10
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2183753-3
ISSN	1678-9741 ; 1678-9741
ISSN (online)	1678-9741
ISSN	1678-9741
DOI	10.21470/1678-9741-2020-0622
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Incidence of hospital acquired pressure injury in critically ill patients with COVID-19 in prone position admitted to the intensive care unit.

Sato, Lucas / Heck, Letícia Olandin / Bimbatti, Karina de Fátima / Petroski-Moraes, Bruno Cesar / Becari, Christiane / Basile-Filho, Anibal / Auxiliadora-Martins, Maria / Gonçalves Menegueti, Mayra

Medicine

2023 Volume 102, Issue 18, Page(s) e33615

Abstract: Critical patients have conditions that may favor the occurrence of hospital-acquired pressure injury (HAPI). The objective of this study was to identify the incidence and factors associated with the occurrence of HAPI in patients with coronavirus disease ...

Abstract	Critical patients have conditions that may favor the occurrence of hospital-acquired pressure injury (HAPI). The objective of this study was to identify the incidence and factors associated with the occurrence of HAPI in patients with coronavirus disease 2019 admitted to the intensive care unit (ICU) who used the prone position. Retrospective cohort study carried out in an ICU of a tertiary university hospital. Two hundred four patients with positive real-time polymerase chain reactions were evaluated, of which 84 were placed in the prone position. All patients were sedated and submitted to invasive mechanical ventilation. Of the prone patients, 52 (62%) developed some type of HAPI during hospitalization. The main place of occurrence of HAPI was the sacral region, followed by the gluteus and thorax. Of the patients who developed HAPI, 26 (50%) had this event in places possibly associated with the prone position. The factors associated with the occurrence of HAPI in patients prone to coronavirus disease 2019 were the Braden Scale and the length of stay in the ICU. The incidence of HAPI in prone patients was extremely high (62%), which denotes the need to implement protocols in order to prevent the occurrence of these events.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Retrospective Studies ; Pressure Ulcer/epidemiology ; Pressure Ulcer/prevention & control ; Critical Illness/epidemiology ; Incidence ; Prone Position ; Hospitalization ; Intensive Care Units ; Hospitals
Language	English
Publishing date	2023-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033615
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.171: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cytokine storm in individuals with severe COVID-19 decreases endothelial cell antioxidant defense via downregulation of the Nrf2 transcriptional factor.

Rodrigues, Daniel / Machado, Mirele R / Alves, Juliano V / Fraga-Silva, Thais F C / Martins, Ronaldo B / Campos, Ligia C B / Francisco, Daniely F / Couto, Ariel E S / Bonato, Vânia L D / Arruda, Eurico / Becari, Christiane / Auxiliadora-Martins, Maria / Louzada-Júnior, Paulo / Costa, Rafael M / Tostes, Rita C

American journal of physiology. Heart and circulatory physiology

2023 Volume 325, Issue 2, Page(s) H252–H263

Abstract: The cytokine storm in SARS-CoV-2 infection contributes to the onset of inflammation and target-organ damage. The endothelium is a key player in COVID-19 pathophysiology and it is an important target for cytokines. Considering that cytokines trigger ... ...

Abstract	The cytokine storm in SARS-CoV-2 infection contributes to the onset of inflammation and target-organ damage. The endothelium is a key player in COVID-19 pathophysiology and it is an important target for cytokines. Considering that cytokines trigger oxidative stress and negatively impact endothelial cell function, we sought to determine whether serum from individuals with severe COVID-19 decreases endothelial cells' main antioxidant defense, i.e., the antioxidant transcriptional factor Nrf2. Human umbilical vein endothelial cells (HUVECs) were incubated with serum from patients with severe COVID-19 at different time points and the effects on redox balance and Nrf2 activity were determined. Serum from individuals with COVID-19 increased oxidant species, as indicated by higher DHE (dihydroethydine) oxidation, increased protein carbonylation, and induced mitochondrial reactive oxygen species (ROS) generation and dysfunction. Serum from patients with COVID-19, but not serum from healthy individuals, induced cell death and diminished nitric oxide (NO) bioavailability. In parallel, Nrf2 nuclear accumulation and the expression of Nrf2-targeted genes were decreased in endothelial cells exposed to serum from individuals with COVID-19. In addition, these cells exhibited higher expression of Bach-1, a negative regulator of Nrf2 that competes for DNA binding. All events were prevented by tocilizumab, an IL-6 receptor blocker, indicating that IL-6 is key to the impairment of endothelial antioxidant defense. In conclusion, endothelial dysfunction related to SARS-CoV-2 infection is linked to decreased endothelial antioxidant defense via IL-6-dependent mechanisms. Pharmacological activation of Nrf2 may decrease endothelial cell damage in individuals with severe COVID-19.
MeSH term(s)	Humans ; Antioxidants/pharmacology ; Antioxidants/metabolism ; NF-E2-Related Factor 2/metabolism ; Down-Regulation ; Cytokine Release Syndrome ; Interleukin-6/metabolism ; Cells, Cultured ; COVID-19 ; SARS-CoV-2/metabolism ; Oxidative Stress ; Human Umbilical Vein Endothelial Cells/metabolism ; Reactive Oxygen Species/metabolism ; Cytokines/metabolism
Chemical Substances	Antioxidants ; NF-E2-Related Factor 2 ; Interleukin-6 ; Reactive Oxygen Species ; Cytokines
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00096.2023
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.89: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Inhibition of IL-6 signaling prevents serum-induced umbilical cord artery dysfunction from patients with severe COVID-19.

Almeida, Cellyne R / Lima, Júlia F / Machado, Mirele R / Alves, Juliano V / Couto, Ariel E S / Campos, Ligia C B / Avila-Mesquita, Carolina D / Auxiliadora-Martins, Maria / Becari, Christiane / Louzada-Júnior, Paulo / Tostes, Rita C / Lobato, Núbia S / Costa, Rafael M

American journal of physiology. Regulatory, integrative and comparative physiology

2023 Volume 324, Issue 4, Page(s) R435–R445

Abstract: Coronavirus disease 2019 (COVID-19) infection has a negative impact on the cytokine profile of pregnant women. Increased levels of proinflammatory cytokines seem to be correlated with the severity of the disease, in addition to predisposing to ... ...

Abstract	Coronavirus disease 2019 (COVID-19) infection has a negative impact on the cytokine profile of pregnant women. Increased levels of proinflammatory cytokines seem to be correlated with the severity of the disease, in addition to predisposing to miscarriage or premature birth. Proinflammatory cytokines increase the generation of reactive oxygen species (ROS). It is unclear how interleukin-6 (IL-6) found in the circulation of patients with severe COVID-19 might affect gestational health, particularly concerning umbilical cord function. This study tested the hypothesis that IL-6 present in the circulation of women with severe COVID-19 causes umbilical cord artery dysfunction by increasing ROS generation and activating redox-sensitive proteins. Umbilical cord arteries were incubated with serum from healthy women and women with severe COVID-19. Vascular function was assessed using concentration-effect curves to serotonin in the presence or absence of pharmacological agents, such as tocilizumab (antibody against the IL-6 receptor), tiron (ROS scavenger), ML171 (Nox1 inhibitor), and Y27632 (Rho kinase inhibitor). ROS generation was assessed by the dihydroethidine probe and Rho kinase activity by an enzymatic assay. Umbilical arteries exposed to serum from women with severe COVID-19 were hyperreactive to serotonin. This effect was abolished in the presence of tocilizumab, tiron, ML171, and Y27632. In addition, serum from women with severe COVID-19 increased Nox1-dependent ROS generation and Rho kinase activity. Increased Rho kinase activity was abolished by tocilizumab and tiron. Serum cytokines in women with severe COVID-19 promote umbilical artery dysfunction. IL-6 is key to Nox-linked vascular oxidative stress and activation of the Rho kinase pathway.
MeSH term(s)	Female ; Humans ; Pregnancy ; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt ; Arteries/metabolism ; COVID-19 ; Cytokines ; Interleukin-6 ; Reactive Oxygen Species/metabolism ; rho-Associated Kinases ; Serotonin ; Umbilical Cord
Chemical Substances	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt (4X87R5T106) ; 2-acetylphenothiazine ; Cytokines ; Interleukin-6 ; Reactive Oxygen Species ; rho-Associated Kinases (EC 2.7.11.1) ; Serotonin (333DO1RDJY) ; Y 27632 (138381-45-0) ; IL6 protein, human
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00154.2022
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.89: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Effect of methylene blue on hemodynamic response in the early phase of septic shock: A case series.

Luis-Silva, Fabio / Menegueti, Mayra Gonçalves / Sato, Lucas / Peres, Leandro Moreira / Dos Reis Sepeda, Corina / Petroski-Moraes, Bruno C / Donadel, Mariana Dermínio / Gallo, Gabriela Bortoleto / Jordani, Maria Cecília / Mestriner, Fabiola / Becari, Christiane / Basile-Filho, Anibal / Evora, Paulo R B / Martins-Filho, Olindo Assis / Auxiliadora-Martins, Maria

Medicine

2023 Volume 102, Issue 4, Page(s) e32743

Abstract: Rationale: Methylene blue (MB) has been used to increase blood pressure in septic shock, acting on the activity of guanylate cyclase and nitric oxide synthase.: Patience concerns: The aim of this study is to demonstrate the benefit of MB in early ... ...

Abstract	Rationale: Methylene blue (MB) has been used to increase blood pressure in septic shock, acting on the activity of guanylate cyclase and nitric oxide synthase. Patience concerns: The aim of this study is to demonstrate the benefit of MB in early phase of septic shock.Diagnoses: We report 6 cases of patients with septic shock with up to 72 hours of evolution. Interventions: We used MB after fluid replacement, use of norepinephrine and vasopressin. Patients received a loading dose of MB and maintenance for 48 hours. Outcomes: All patients presented a reduction in the dose of vasopressors and lactate levels soon after the administration of the loading dose of MB, an effect that was maintained with the maintenance dose for 48 hours. Interleukin 6 and interleukin 8 were elevated at the beginning of the septic condition, with a progressive and marked reduction after the beginning of MB infusion, demonstrating a role of MB in reducing the inflammatory activity. Lessons: This case series suggests that MB used early in the treatment of septic shock may be useful in reducing vasopressor dose and lactate levels. Further studies are still required to further validate these findings.
MeSH term(s)	Humans ; Methylene Blue/pharmacology ; Methylene Blue/therapeutic use ; Shock, Septic ; Hemodynamics ; Blood Pressure/physiology ; Vasoconstrictor Agents/therapeutic use ; Norepinephrine/therapeutic use ; Lactates
Chemical Substances	Methylene Blue (T42P99266K) ; Vasoconstrictor Agents ; Norepinephrine (X4W3ENH1CV) ; Lactates
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000032743
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.171: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Impact of angiotensin-converting enzyme inhibition on hemodynamic and autonomic profile of elastase-2 knockout mice

T.C. Prates-Costa / M. de Oliveira / R. Fazan Jr / H.C. Salgado / C. Becari

Brazilian Journal of Medical and Biological Research, Vol

2022 Volume 55

Abstract	Elastase-2 (ELA-2) is an angiotensin II-generating enzyme that participates in the cardiovascular system. ELA-2 is involved in hemodynamic and autonomic control and is upregulated in myocardial infarction and hypertension. The inhibition of angiotensin-converting enzyme (ACE) increased ELA-2 expression in the carotid arteries and heart of spontaneously hypertensive rats. In this study, we sought to investigate the role of ACE inhibition in hemodynamic and autonomic balance in elastase-2 knockout (ELA-2 KO) mice. Male ELA-2 KO and C57BL/6 mice were treated with the ACE inhibitor enalapril or saline for 10 days. After treatment, mice underwent surgery for cannulation of the femoral artery and arterial pressure recordings were made five days later in awake animals. The variability of systolic blood pressure (SBP) and pulse interval (PI) was evaluated in the time and frequency domain. Spontaneous baroreflex was assessed by the sequencing method. ACE inhibition caused a significant decrease in mean arterial pressure (117±2.2 vs 100±2.8 mmHg) and an increase in heart rate (570±32 vs 655±15 bpm) in ELA-2 KO mice. Despite a tendency towards reduction in the overall heart rate variability (standard deviation of successive values: 7.6±1.1 vs 4.7±0.6 ms, P=0.08), no changes were found in the root of the mean sum of squares or in the power of the high-frequency band. ACE inhibition did not change the spontaneous baroreflex indices (gain and baroreflex effectiveness index) in ELA-2 KO mice. Altogether, this data suggested that ACE played a role in the maintenance of hemodynamic function in ELA-2 KO mice.
Keywords	ACE ; Elastase-2 ; ELA-2 knockout mice ; Blood pressure ; Heart rate variability ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Associação Brasileira de Divulgação Científica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Honeymoon Period in Newborn Rats With CDH Is Associated With Changes in the VEGF Signaling Pathway.

Miura da Costa, Karina / Fabro, Alexandre Todorovic / Becari, Christiane / Figueira, Rebeca Lopes / Schmidt, Augusto F / Ruano, Rodrigo / Sbragia, Lourenço

Frontiers in pediatrics

2021 Volume 9, Page(s) 698217

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-07-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.698217
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito