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Article ; Online: Similar SARS-CoV-2 Ct Value Distributions in Anterior Nares versus Nasopharyngeal Samples from Symptomatic Children during Delta and Omicron Surges.

Rattan, Ankit / Joerger, Jill / Williams, David / Pollock, Nira R

Journal of the Pediatric Infectious Diseases Society

2022 Volume 12, Issue 2, Page(s) 109–112

Abstract: In symptomatic children tested for COVID-19 by PCR during both Delta and Omicron surges, Cycle threshold value medians and distributions in anterior nares (AN) and nasopharyngeal (NP) samples were very similar, suggesting similar yield of NP and AN ... ...

Abstract	In symptomatic children tested for COVID-19 by PCR during both Delta and Omicron surges, Cycle threshold value medians and distributions in anterior nares (AN) and nasopharyngeal (NP) samples were very similar, suggesting similar yield of NP and AN sampling for SARS-CoV-2 PCR testing in symptomatic children.
MeSH term(s)	Humans ; Child ; SARS-CoV-2 ; COVID-19 ; Polymerase Chain Reaction
Language	English
Publishing date	2022-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2668791-4
ISSN	2048-7207 ; 2048-7193
ISSN (online)	2048-7207
ISSN	2048-7193
DOI	10.1093/jpids/piac130
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Article ; Online: Cats undergoing spay with medetomidine, ketamine and butorphanol develop arterial oxygen desaturation independent of surgical positioning and increased intraocular pressure in Trendelenburg position.

Corona, D / Ranninger, E / Jörger, F / Goldinger, E / Stefan, A / Torgerson, P R / Bettschart-Wolfensberger, R

Schweizer Archiv fur Tierheilkunde

2020 Volume 162, Issue 9, Page(s) 539–550

Abstract: Introduction: This study observed the effects of three different surgical positions on arterial blood oxygenation measured noninvasively by pulse oximetry (SpO2) and on intraocular pressure (IOP) in anaesthetised cats undergoing spay. A total of 222 ... ...

Title translation	Kastration von Katzen mit Medetomidin, Ketamin und Butorphanol führen unabhängig von der chirurgischen Positionierung zur arteriellen Hypoxaemie und in der Trendelenburg- Position zu einem erhöhten Augen innendruck.
Abstract	Introduction: This study observed the effects of three different surgical positions on arterial blood oxygenation measured noninvasively by pulse oximetry (SpO2) and on intraocular pressure (IOP) in anaesthetised cats undergoing spay. A total of 222 female feral cats were anaesthetised for a large-scale trap-neuter-return program with an intramuscular combination of medetomidine (0.03 - 0.05 mg/kg), ketamine (7 - 10 mg/kg) and butorphanol (0.4 mg/kg). Cats were randomly allocated to undergo spay in either Trendelenburg (70° downward head tilt), lateral or dorsal recumbency. SpO2 and pulse rate were measured at baseline, prior to surgical positioning, after one minute in surgical position and in one-minute intervals after surgical incision. Intraocular pressure was measured before positioning and at the end of surgery. At the end of surgery, all cats were placed into left lateral recumbency and all parameters were revaluated after five minutes. No significant differences between the three positions were found regarding SpO2, but an increase over time was observed. In total, 52 ± 10% (mean ± SD) of cats were hypoxaemic (SpO2 < 90%) at baseline. SpO2 improved over time, but 27 ± 3% (mean ± SD) of the cats remained hypoxaemic at the end of surgery. Trendelenburg position increased IOP during surgery (mean 31 ± 6 mmHg, individual max. 48 mmHg, versus 17 ± 4 mmHg in dorsal/lateral recumbency) but normalised after 5 mins in lateral recumbence. All cats recovered well from surgery and were released within 24 hours post-anaesthesia. Surgical position was shown to have no notable influence on SpO2 during anaesthesia in cats not receiving oxygen supplementation, whereas Trendelenburg position led to increased IOP. Oxygen supplementation is recommended with this anaesthetic protocol, as hypoxaemia is frequently observed.
MeSH term(s)	Analgesics/administration & dosage ; Analgesics/adverse effects ; Animals ; Butorphanol/administration & dosage ; Butorphanol/adverse effects ; Cats ; Intraocular Pressure/drug effects ; Ketamine/administration & dosage ; Ketamine/adverse effects ; Medetomidine/administration & dosage ; Medetomidine/adverse effects ; Patient Positioning/veterinary ; Sterilization, Reproductive/adverse effects ; Sterilization, Reproductive/veterinary
Chemical Substances	Analgesics ; Ketamine (690G0D6V8H) ; Medetomidine (MR15E85MQM) ; Butorphanol (QV897JC36D)
Language	English
Publishing date	2020-06-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	391726-5
ISSN	1664-2848 ; 0036-7281
ISSN (online)	1664-2848
ISSN	0036-7281
DOI	10.17236/sat00271
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Article ; Online: Early Identification of Patients at Risk of Cabazitaxel-induced Severe Neutropenia.

Agema, Bram C / Buck, Stefan A J / Viskil, Mano / Isebia, Khrystany T / de Neijs, Micha J / Sassen, Sebastiaan D T / Koch, Birgit C P / Joerger, Markus / de Wit, Ronald / Koolen, Stijn L W / Mathijssen, Ron H J

European urology oncology

2023

Abstract: Background: Cabazitaxel frequently causes severe neutropenia. A higher cabazitaxel systemic exposure is related to a lower nadir absolute neutrophil count (ANC).: Objective: To describe the effect of cabazitaxel systemic exposure on ANC by a ... ...

Abstract	Background: Cabazitaxel frequently causes severe neutropenia. A higher cabazitaxel systemic exposure is related to a lower nadir absolute neutrophil count (ANC). Objective: To describe the effect of cabazitaxel systemic exposure on ANC by a population pharmacokinetic/pharmacodynamic (POP-PK/PD) model, and to identify patients at risk of severe neutropenia early in their treatment course using a PK threshold. Design, setting, and participants: Data from five clinical studies were pooled to develop a POP-PK/PD model using NONMEM, linking both patient characteristics and cabazitaxel systemic exposure directly to ANC. Outcome measurements and statistical analysis: A PK threshold, predictive of severe neutropenia (grade ≥3), was determined using a receiver operating characteristic curve. Results and limitations: Ninety-six patients were included with a total of 1726 PK samples and 1081 ANCs. The POP-PK/PD model described both cabazitaxel PK and ANC accurately. A cabazitaxel plasma concentration of >4.96 ng/ml at 6 h after the start of infusion was found to be predictive of severe neutropenia, with a sensitivity of 76% and a specificity of 65%. Conclusions: Early cabazitaxel plasma levels are predictive of severe neutropenia. Implementation of the proposed PK threshold results in early identification of almost 76% of all severe neutropenias. If prospectively validated, patients at risk could benefit from prophylactic administration of granulocyte colony stimulating factors, preventing severe neutropenia in an early phase of treatment. Implementation of this threshold permits a less restricted use of the 25 mg/m Patient summary: Treatment with cabazitaxel chemotherapy often causes neutropenia, leading to susceptibility to infections, which might be life threatening. We found that a systemic cabazitaxel concentration above 4.96 ng/ml 6 h after the start of infusion is predictive of the occurrence of severe neutropenia. Measurement of systemic cabazitaxel levels provides clinicians with the opportunity to prophylactically stimulate neutrophil growth.
Language	English
Publishing date	2023-11-02
Publishing country	Netherlands
Document type	Journal Article
ISSN	2588-9311
ISSN (online)	2588-9311
DOI	10.1016/j.euo.2023.10.015
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Article ; Online: Contribution of the hdeB-like gene (SEN1493) to survival of Salmonella enterica enteritidis Nal(R) at pH 2.

Joerger, Rolf D / Choi, Steven

Foodborne pathogens and disease

2015 Volume 12, Issue 4, Page(s) 353–359

Abstract: ... deleted in Salmonella enterica Enteritidis Nal(R) and Salmonella enterica Kentucky 3795. When grown ... was found. Salmonella enterica Enteritidis Nal(R) carrying its own or the intragenic region upstream ...

Abstract	Periplasmic proteins are particularly vulnerable to denaturation upon entry into a highly acid environment. In Escherichia coli, a level of protection of these proteins is afforded by acid-inducible chaperonins encoded by hdeAB. In contrast, Salmonella enterica only harbors an hdeB-like gene and it is currently not known what function it plays in this genus. In the present study, the hdeB-like gene was deleted in Salmonella enterica Enteritidis Nal(R) and Salmonella enterica Kentucky 3795. When grown overnight in tryptic soy broth (TSB) medium buffered at pH 5.5 and then exposed to TSB pH 2 for 20 min, Enteritidis wild-type strain experienced a 0.5-log10 reduction in colony-forming units, whereas the deletion strain's surviving cells were reduced by 1.6 log10. No difference in survival was observed in the corresponding Salmonella enterica Kentucky 3795 strains treated the same way. Exposure of the strains to pH 2.5 or 3 resulted in the same log reduction regardless of the presence of the hdeB-like gene. When wild-type and deletion strains of both serovars were grown in medium buffered at pH 7 prior to exposure to the acidic pHs, no difference in survival with respect to serovar or presence/absence of the hdeB-like gene was found. Salmonella enterica Enteritidis Nal(R) carrying its own or the intragenic region upstream of the hdeB-like from Salmonella enterica Kentucky 3795 cloned in front of the gfp gene from pFPV25 showed maximum fluorescence when grown at pH 5.5, whereas the corresponding plasmid-carrying Salmonella enterica Kentucky strains did not exhibit fluorescence regardless of the pH of the growth medium. Therefore, the hdeB-like gene in Salmonella enterica Enteritidis, but not in Salmonella enterica Kentucky 3795, contributed to survival at pH 2 and its expression is responsive to the pH of the medium.
MeSH term(s)	Acids/chemistry ; Colony Count, Microbial ; Culture Media/chemistry ; Genes, Bacterial ; Hydrogen-Ion Concentration ; Salmonella enterica/genetics ; Salmonella enteritidis/genetics
Chemical Substances	Acids ; Culture Media
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2148479-X
ISSN	1556-7125 ; 1535-3141
ISSN (online)	1556-7125
ISSN	1535-3141
DOI	10.1089/fpd.2014.1878
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Article ; Online: LC3A positive "stone like structures" are differentially associated with survival outcomes and CD68 macrophage infiltration in patients with lung adenocarcinoma and squamous cell carcinoma.

Gachechiladze, M / Uberall, I / Skanderova, D / Matchavariani, J / Ibrahim, M / Shani, I / Smickova, P / Kolek, V / Cierna, L / Klein, J / Stahel, R / Joerger, M / Soltermann, A / Skarda, J

Lung cancer (Amsterdam, Netherlands)

2021 Volume 156, Page(s) 129–135

Abstract: Aims: The aim of the study was to analyse the prognostic and predictive value of LC3A positive' 'Stone Like Structures'' (SLSs) in a large cohort of patients with non-small cell lung carcinoma (NSCLC) and to check its relationship with tumor ... ...

Abstract	Aims: The aim of the study was to analyse the prognostic and predictive value of LC3A positive' 'Stone Like Structures'' (SLSs) in a large cohort of patients with non-small cell lung carcinoma (NSCLC) and to check its relationship with tumor infiltrating lymphocytes (TILs) and PD-L1 expression. Methods: Tissue microarrays from 1015 patients diagnosed at the Institute of Pathology and Molecular Pathology, University Hospital Zurich, Switzerland, were stained for LC3A, PD-L1, CD3 and CD68 using automated tissue stainer Ventana Benchmark Ultra (Roche). TILs were assessed in matched haematoxylin and eosin stained slides. Results: LC3A positive SLSs, were significantly associated with worse overall (OS) and disease-free survival (DFS) outcomes in patients with lung adenocarcinoma (LADC) (HR = 2.4, 95 %CI(.994-1.008, p = 0.029) and HR = 3.9, 95 %CI (1.002-1.014), p = 0.002 respectively), whilst it was associated with better OS and DFS in patients with lung squamous cell carcinoma (LUSC), with marginal significance (HR = .99, 95 %CI(.975-1.011),p = 0.042 and HR = .99, 95 %CI (.975-1.008), p = 0.026). Multivariate analysis showed that LC3A SLSs are independent poor prognostic factor only in patients with LADC. In addition, LC3A SLSs, were negatively associated with CD68 count in LADC, whilst there was a positive correlation in LSCC. Conclusions: LC3A SLSs are differentially associated with the survival outcomes and CD68 count in LADC and LSCC. Further studies are justified for the understanding the underlying biological mechanisms of this phenomenon.
MeSH term(s)	Adenocarcinoma of Lung ; Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; B7-H1 Antigen ; Carcinoma, Squamous Cell ; Humans ; Lung Neoplasms ; Lymphocytes, Tumor-Infiltrating ; Macrophages ; Microtubule-Associated Proteins ; Prognosis ; Switzerland
Chemical Substances	Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; B7-H1 Antigen ; CD68 antigen, human ; MAP1LC3A protein, human ; Microtubule-Associated Proteins
Language	English
Publishing date	2021-04-15
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2021.04.008
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Zs.A 2135: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Structure-Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation.

Pichon, Maëva M / Drelinkiewicz, Dawid / Lozano, David / Moraru, Ruxandra / Hayward, Laura J / Jones, Megan / McCoy, Michael A / Allstrum-Graves, Samuel / Balourdas, Dimitrios-Ilias / Joerger, Andreas C / Whitby, Richard J / Goldup, Stephen M / Wells, Neil / Langley, Graham J / Herniman, Julie M / Baud, Matthias G J

Bioconjugate chemistry

2023 Volume 34, Issue 9, Page(s) 1679–1687

Abstract: Protein arylation has attracted much attention for developing new classes of bioconjugates with improved properties. Here, we have evaluated 2-sulfonylpyrimidines as covalent warheads for the mild, chemoselective, and metal free ... ...

Abstract	Protein arylation has attracted much attention for developing new classes of bioconjugates with improved properties. Here, we have evaluated 2-sulfonylpyrimidines as covalent warheads for the mild, chemoselective, and metal free cysteine
MeSH term(s)	Cysteine ; Mutant Proteins ; Crystallography, X-Ray ; Sulfones
Chemical Substances	Cysteine (K848JZ4886) ; Mutant Proteins ; Sulfones
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1024041-x
ISSN	1520-4812 ; 1043-1802
ISSN (online)	1520-4812
ISSN	1043-1802
DOI	10.1021/acs.bioconjchem.3c00322
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Article: Alternatives to antibiotics: bacteriocins, antimicrobial peptides and bacteriophages.

Joerger, R D

Poultry science

2003 Volume 82, Issue 4, Page(s) 640–647

Abstract: Bacteriocins, antimicrobial peptides, and bacteriophage have attracted attention as potential substitutes for, or as additions to, currently used antimicrobial compounds. This publication will review research on the potential application of these ... ...

Abstract	Bacteriocins, antimicrobial peptides, and bacteriophage have attracted attention as potential substitutes for, or as additions to, currently used antimicrobial compounds. This publication will review research on the potential application of these alternative antimicrobial agents to poultry production and processing. Bacteriocins are proteinaceous compounds of bacterial origin that are lethal to bacteria other than the producing strain. It is assumed that some of the bacteria in the intestinal tract produce bacteriocins as a means to achieve a competitive advantage, and bacteriocin-producing bacteria might be a desirable part of competitive exclusion preparations. Purified or partially purified bacteriocins could be used as preservatives or for the reduction or elimination of certain pathogens. Currently only nisin, produced by certain strains of Lactococcus lactis subsp. lactis, has regulatory approval for use in certain foods, and its use for poultry products has been studied extensively. Exploration of the application of antimicrobial peptides from sources other than bacteria to poultry has not yet commenced to a significant extent. Evidence for the ability of chickens to produce such antimicrobial peptides has been provided, and it is likely that these peptides play an important role in the defense against various pathogens. Bacteriophages have received renewed attention as possible agents against infecting bacteria. Evidence from several trials indicates that phage therapy can be effective under certain circumstances. Numerous obstacles for the use of phage as antimicrobials for poultry or poultry products remain. Chiefly among them are the narrow host range of many phages, the issue of phage resistance, and the possibility of phage-mediated transfer of genetic material to bacterial hosts. Regulatory issues and the high cost of producing such alternative antimicrobial agents are also factors that might prevent application of these agents in the near future.
MeSH term(s)	Animals ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/virology ; Bacteriocins/adverse effects ; Bacteriocins/pharmacology ; Bacteriophages/pathogenicity ; Food Preservation/methods ; Humans ; Microbial Sensitivity Tests ; Peptides
Chemical Substances	Anti-Bacterial Agents ; Bacteriocins ; Peptides
Language	English
Publishing date	2003-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1093/ps/82.4.640
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Article ; Online: Population pharmacokinetic analyses of regorafenib and capecitabine in patients with locally advanced rectal cancer (SAKK 41/16 RECAP).

Schmulenson, Eduard / Bovet, Cédric / Theurillat, Regula / Decosterd, Laurent Arthur / Largiadèr, Carlo R / Prost, Jean-Christophe / Csajka, Chantal / Bärtschi, Daniela / Guckenberger, Matthias / von Moos, Roger / Bastian, Sara / Joerger, Markus / Jaehde, Ulrich

British journal of clinical pharmacology

2022 Volume 88, Issue 12, Page(s) 5336–5347

Abstract: Aims: Locally advanced rectal cancer (LARC) is an area of unmet medical need with one third of patients dying from their disease. With response to neoadjuvant chemo-radiotherapy being a major prognostic factor, trial SAKK 41/16 assessed potential ... ...

Abstract	Aims: Locally advanced rectal cancer (LARC) is an area of unmet medical need with one third of patients dying from their disease. With response to neoadjuvant chemo-radiotherapy being a major prognostic factor, trial SAKK 41/16 assessed potential benefits of adding regorafenib to capecitabine-amplified neoadjuvant radiotherapy in LARC patients. Methods: Patients received regorafenib at three dose levels (40/80/120 mg once daily) combined with capecitabine 825 mg/m Results: Plasma concentrations of capecitabine, regorafenib and metabolites were characterized by one and two compartment models and absorption was described by parallel first- and zero-order processes and transit compartments, respectively. Apparent capecitabine clearance was 286 L/h (relative standard error [RSE] 14.9%, interindividual variability [IIV] 40.1%) and was reduced by regorafenib cumulative area under the plasma concentration curve (median reduction of 45.6%) as exponential covariate (estimate -4.10 × 10 Conclusions: This work informs the clinical development of regorafenib and capecitabine combination treatment and underlines the importance of studying potential DDI with new anticancer drug combinations.
MeSH term(s)	Humans ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Capecitabine ; Fluorouracil/therapeutic use ; Phenylurea Compounds ; Pyridines ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/chemically induced
Chemical Substances	Capecitabine (6804DJ8Z9U) ; Fluorouracil (U3P01618RT) ; Phenylurea Compounds ; Pyridines ; regorafenib (24T2A1DOYB)
Language	English
Publishing date	2022-07-23
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15461
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Article ; Online: Identification of the major yeasts isolated from high moisture corn and corn silages in the United States using genetic and biochemical methods.

Santos, M C / Golt, C / Joerger, R D / Mechor, G D / Mourão, Gerson B / Kung, L

Journal of dairy science

2017 Volume 100, Issue 2, Page(s) 1151–1160

Abstract: The objective of this study was to identify species of yeasts in samples of high moisture corn (HMC) and corn silage (CS) collected from farms throughout the United States. Samples were plated and colonies were isolated for identification using DNA ... ...

Abstract	The objective of this study was to identify species of yeasts in samples of high moisture corn (HMC) and corn silage (CS) collected from farms throughout the United States. Samples were plated and colonies were isolated for identification using DNA analysis. Randomly selected colonies were also identified by fatty acid methyl esters (FAME) and by physiological substrate profiling (ID 32C). For CS, Candida ethanolica, Saccharomyces bulderi, Pichia anomala, Kazachstania unispora, and Saccharomyces cerevisiae were the predominant yeasts. Pichia anomala, Issatchenkia orientalis, S. cerevisiae, and Pichia fermentans were the prevalent species in HMC. The 3 identification methods were in agreement at the species level for 16.6% of the isolates and showed no agreement for 25.7%. Agreement in species identification between ID 32C and DNA analysis, FAME and ID 32C, and FAME and DNA analysis was 41.1, 14.4, and 2.2%, respectively. Pichia anomala and I. orientalis were able to grow on lactic acid, whereas S. cerevisiae metabolized sugars (galactose, sucrose, and glucose) but failed to use lactic acid. The yeast diversity in CS and HMC varied due to type of feed and location. Differences in species assignments were seen among methods, but identification using substrate profiling generally corresponded with that based on DNA analysis. These findings provide information about the species that may be expected in silages, and this knowledge may lead to interventions that control unwanted yeasts.
MeSH term(s)	Animals ; Fermentation ; Saccharomyces cerevisiae/metabolism ; Saccharomycetales ; Silage/microbiology ; United States ; Yeasts/genetics ; Zea mays
Language	English
Publishing date	2017-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2016-11450
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Article ; Online: Precision Dosing of Targeted Therapies Is Ready for Prime Time.

Groenland, Stefanie L / Verheijen, Remy B / Joerger, Markus / Mathijssen, Ron H J / Sparreboom, Alex / Beijnen, Jos H / Beumer, Jan H / Steeghs, Neeltje / Huitema, Alwin D R

Clinical cancer research : an official journal of the American Association for Cancer Research

2021 Volume 27, Issue 24, Page(s) 6644–6652

Abstract: Fixed dosing of oral targeted therapies is inadequate in the era of precision medicine. Personalized dosing, based on pharmacokinetic (PK) exposure, known as therapeutic drug monitoring (TDM), is rational and supported by increasing evidence. The purpose ...

Abstract	Fixed dosing of oral targeted therapies is inadequate in the era of precision medicine. Personalized dosing, based on pharmacokinetic (PK) exposure, known as therapeutic drug monitoring (TDM), is rational and supported by increasing evidence. The purpose of this perspective is to discuss whether randomized studies are needed to confirm the clinical value of precision dosing in oncology. PK-based dose adjustments are routinely made for many drugs and are recommended by health authorities, for example, for patients with renal impairment or for drug-drug interaction management strategies. Personalized dosing simply extrapolates this paradigm from selected patient populations to each individual patient with suboptimal exposure, irrespective of the underlying cause. If it has been demonstrated that exposure is related to a relevant clinical outcome, such as efficacy or toxicity, and that exposure can be optimized by PK-guided dosing, it could be logically assumed that PK-guided dosing would result in better treatment outcomes without the need for randomized confirmatory trials. We propose a path forward to demonstrate the clinical relevance of individualized dosing of molecularly-targeted anticancer drugs.
MeSH term(s)	Drug Interactions ; Drug Monitoring ; Humans ; Medical Oncology ; Precision Medicine
Language	English
Publishing date	2021-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-20-4555
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