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Article ; Online: A unique report of breast intravascular NK/T-cell lymphoma mimicking breast carcinoma.

Zhou, Luting / Wang, Chaofu

2022 Volume 140, Issue 1, Page(s) 78

MeSH term(s)	Breast Neoplasms/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Lymphoma, Extranodal NK-T-Cell/diagnosis ; Lymphoma, Extranodal NK-T-Cell/pathology ; Lymphoma, T-Cell, Peripheral
Language	English
Publishing date	2022-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2022016228
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Article ; Online: TET (Ten-eleven translocation) family proteins: structure, biological functions and applications.

Zhang, Xinchao / Zhang, Yue / Wang, Chaofu / Wang, Xu

Signal transduction and targeted therapy

2023 Volume 8, Issue 1, Page(s) 297

Abstract: Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxycytosine (5caC), and ... ...

Abstract	Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxycytosine (5caC), and then two of these intermediates (5fC and 5caC) can be excised and return to unmethylated cytosines by thymine-DNA glycosylase (TDG)-mediated base excision repair. Because DNA methylation and demethylation play an important role in numerous biological processes, including zygote formation, embryogenesis, spatial learning and immune homeostasis, the regulation of TETs functions is complicated, and dysregulation of their functions is implicated in many diseases such as myeloid malignancies. In addition, recent studies have demonstrated that TET2 is able to catalyze the hydroxymethylation of RNA to perform post-transcriptional regulation. Notably, catalytic-independent functions of TETs in certain biological contexts have been identified, further highlighting their multifunctional roles. Interestingly, by reactivating the expression of selected target genes, accumulated evidences support the potential therapeutic use of TETs-based DNA methylation editing tools in disorders associated with epigenetic silencing. In this review, we summarize recent key findings in TETs functions, activity regulators at various levels, technological advances in the detection of 5hmC, the main TETs oxidative product, and TETs emerging applications in epigenetic editing. Furthermore, we discuss existing challenges and future directions in this field.
MeSH term(s)	Dioxygenases/genetics ; Dioxygenases/metabolism ; Epigenesis, Genetic/genetics ; DNA Methylation/genetics ; Gene Expression Regulation ; Oxidation-Reduction
Chemical Substances	Dioxygenases (EC 1.13.11.-)
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-023-01537-x
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Article ; Online: EBV-Associated Smooth Muscle Tumors With Autoimmune Hemolytic Anemia and Hepatitis B Infection: Report of a Previously Undescribed Neoplasm With Review.

Zheng, Qiaoli / Wang, Chaofu / Zhang, Yuxiu / Xu, Haimin / Yuan, Fei / Yi, Hongmei

International journal of surgical pathology

2024 , Page(s) 10668969231217631

Abstract: Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is rare in adults. The presence of intratumoral T lymphocytes and primitive rounded cells characterized this neoplasm. We report a 24-year-old Chinese man who developed EBV-SMT in the right ... ...

Abstract	Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is rare in adults. The presence of intratumoral T lymphocytes and primitive rounded cells characterized this neoplasm. We report a 24-year-old Chinese man who developed EBV-SMT in the right adrenal gland with hepatitis B infection and autoimmune hemolytic anemia without a history of HIV infection, primary immune deficiency, organ transplantation, or malignant tumor. This patient had an unknown immunodeficient state. EBV-SMTs are commonly located in the liver, lung, and gastrointestinal tract but rarely in the adrenal gland. We reviewed 10 reported literature on EBV-SMT in the adrenal gland. It is imperative to distinguish EBV-SMT from conventional somatic smooth muscle tumors. The discovery of EBV-SMT forces the clinician to conduct a thorough evaluation of immune function and immune status surveillance, and these patients are vulnerable to subsequent malignant tumors.
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/10668969231217631
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Article: Acquired cystic disease-associated renal cell carcinoma with PTCH1 mutation: a case report.

Zhou, Luting / Xu, Haimin / Liu, Yang / Li, Xiangyun / Li, Chuanying / Yang, Xiaoqun / Wang, Chaofu

Frontiers in oncology

2024 Volume 14, Page(s) 1349610

Abstract: Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is an extremely rare kidney tumor seen mainly in patients with end-stage renal disease. Currently, there are few reports on this type of tumor. We describe the case of a 58-year-old man ... ...

Abstract	Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is an extremely rare kidney tumor seen mainly in patients with end-stage renal disease. Currently, there are few reports on this type of tumor. We describe the case of a 58-year-old man who had been receiving peritoneal dialysis for more than nine years due to chronic renal insufficiency and uremia. One year after undergoing left renal clear cell renal cell carcinoma resection, a space-occupying lesion was found in the right kidney for which he underwent right nephrectomy. The histopathology of this tumor showed solid or tubular cell arrangements, with some areas of cyst formation. Vacuoles of varying sizes were present in the cytoplasm, and varying amounts of calcium oxalate crystals were found in the tumor cells or interstitium. The pathological diagnosis was ACD-RCC. Next-generation sequencing detected mutations in the PTCH1, MTOR, FAT1, SOS1, RECQL4, and CDC73 genes in the right renal tumor. This is a rare case of a patient with ACD-RCC in the right kidney and clear cell renal cell carcinoma in the left kidney. The findings suggest that mutations in PTCH1 associated with ACD-RCC may have acted as oncogenic drivers for the development of ACKD-RCC, together with providing insight into mechanisms underlying ACD-RCC development, as well as diagnostic and treatment options.
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1349610
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Article: [Study on Clinical Application and Supervision of LC-MS in

Ye, Chaofu / Zhang, Lan / Kou, Yanqin / Wang, Yuhang / Yang, Xiaohe

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

2023 Volume 47, Issue 6, Page(s) 690–694

Abstract: From the perspective of technical evaluation, this study reviewed the current situation of application and clinical application of medical device products were detected by liquid chromatography-tandem mass spectrometry in the market in recent years. The ... ...

Abstract	From the perspective of technical evaluation, this study reviewed the current situation of application and clinical application of medical device products were detected by liquid chromatography-tandem mass spectrometry in the market in recent years. The regulatory requirements of these products in China, USA, EU and Japan were compared and analyzed, and the monitoring situation of adverse events after listing, the standards for reference and the domestic and foreign regulatory documents were combined, the clinical application and regulatory risks of the product were analyzed. The problems such as pre-treatment, system matching, adequacy of performance index requirements, inter-room consistency, reference interval and registration unit were discussed and suggestions for supervision were given, with a view to the field of product R&D and production, review and approval of supervision to provide technical reference.
MeSH term(s)	Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Reference Standards ; Japan
Language	Chinese
Publishing date	2023-12-12
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1671-7104
ISSN	1671-7104
DOI	10.3969/j.issn.1671-7104.2023.06.019
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Article ; Online: Semiparametric regression analysis of length-biased and partly interval-censored data with application to an AIDS cohort study.

Feng, Fan / Li, Shuwei / Wang, Peijie / Sun, Jianguo / Ke, Chaofu

Statistics in medicine

2023 Volume 42, Issue 14, Page(s) 2293–2310

Abstract: Length-biased data occur often in many scientific fields, including clinical trials, epidemiology surveys and genome-wide association studies, and many methods have been proposed for their analysis under various situations. In this article, we consider ... ...

Abstract	Length-biased data occur often in many scientific fields, including clinical trials, epidemiology surveys and genome-wide association studies, and many methods have been proposed for their analysis under various situations. In this article, we consider the situation where one faces length-biased and partly interval-censored failure time data under the proportional hazards model, for which it does not seem to exist an established method. For the estimation, we propose an efficient nonparametric maximum likelihood method by incorporating the distribution information of the observed truncation times. For the implementation of the method, a flexible and stable EM algorithm via two-stage data augmentation is developed. By employing the empirical process theory, we establish the asymptotic properties of the resulting estimators. A simulation study conducted to assess the finite-sample performance of the proposed method suggests that it works well and is more efficient than the conditional likelihood approach. An application to an AIDS cohort study is also provided.
MeSH term(s)	Humans ; Models, Statistical ; Likelihood Functions ; Acquired Immunodeficiency Syndrome/drug therapy ; Acquired Immunodeficiency Syndrome/epidemiology ; Cohort Studies ; Genome-Wide Association Study ; Regression Analysis ; Computer Simulation
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	843037-8
ISSN	1097-0258 ; 0277-6715
ISSN (online)	1097-0258
ISSN	0277-6715
DOI	10.1002/sim.9724
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Article ; Online: The prognostic value of CA9 expression in clear cell renal cell carcinoma

XU Jiankun / ZHOU Luting / ZHANG Wenjing / XU Haimin / WANG Chaofu

Zhenduanxue lilun yu shijian, Vol 22, Iss 01, Pp 37-

2023 Volume 43

Abstract: Objective: To evaluate the prognostic value of CA9 in predicting postoperative recurrence， metastasis or survival in patients with clear cell renal cell carcinoma(ccRCC). Methods: The clinical pathological data from 231 patients with ccRCC who underwent ... ...

Abstract	Objective: To evaluate the prognostic value of CA9 in predicting postoperative recurrence， metastasis or survival in patients with clear cell renal cell carcinoma(ccRCC). Methods: The clinical pathological data from 231 patients with ccRCC who underwent radical or partial nephrectomy from January 1, 2017 to December 31, 2020 in Ruijin Hospital,Shanghai Jiao Tong University were retrospectively analyzed. The patients were followed up for the overall survival (OS),disease-free survival (DFS),and tumor recurrence or metastasis. All pathological sections and wax blocks of tumor issue were collected to make tissue microarray, and immunohistochemical analysis of tissue microarray was performed using CA9 polyclonal antibody. SPSS statistical software multivariate Cox and Kaplan-Meier were used to evaluate the correlation of CA9 expression with clinicopathological features, OS and DFS. Results: Of the 231 ccRCC patients had a median follow-up of 37 months (13-54 months). It revealed that postoperative recurrence and/or metastasis occurred in 38 cases, inclu-ding 6 cases with both recurrence and metastasis, 3 cases with only recurrence, 29 cases with only metastasis, and 8 deaths. Among 231 patients, CA9 positive expression rate was 94%(217/231), of which 153 (66%) were with cells stained with CA9 ≥85% and 78 (34%) were stained with CA9 <85%. Chi-square analysis showed that the expression of CA9 was not only correlated with T stage, ISUP nuclear grade, sarcomatoid or rhabdomyoid differentiation, necrosis, capsule invasion, vascular infiltration, but also correlated with tumor recurrence, metastasis and survival status. There was no relationship between CA9 expression and age, sex and tumor location (P>0.05). Univariate Kaplan-Meier analysis and multiva-riate Cox analysis showed that low expression of CA9 (<85%) was a poor prognostic factor for postoperative overall survival (OS) and disease-free survival (DFS) in patients with ccRCC, with hazard ratios of 6.211 (P=0.002) and 8.980 (P<0.001), respectively. ...
Keywords	\|clear cell renal cell carcinoma\|carbonic anhydrase 9\|immunohistochemistry\|the prognosis ; Medicine ; R
Subject code	616
Language	Chinese
Publishing date	2023-02-01T00:00:00Z
Publisher	Editorial Office of Journal of Diagnostics Concepts & Practice
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A novel method for diaphragm-based electrode belt position of electrical impedance tomography by ultrasound.

Yue, Chaofu / He, Huaiwu / Su, Longxiang / Wang, Jun / Yuan, Siyi / Long, Yun / Zhao, Zhanqi

Journal of intensive care

2023 Volume 11, Issue 1, Page(s) 41

Abstract: Background: This aim of study was to introduce a diaphragm-based EIT-belt placement method based on diaphragm position by ultrasound, and to evaluate the difference between diaphragm-based EIT-belt placement and conventional EIT-belt placement.: ... ...

Abstract	Background: This aim of study was to introduce a diaphragm-based EIT-belt placement method based on diaphragm position by ultrasound, and to evaluate the difference between diaphragm-based EIT-belt placement and conventional EIT-belt placement. Method: The diaphragm position (L Result: The highest TV was achieved at L Conclusions: The diaphragm-based EIT-belt position by ultrasound was feasible and resulted in different belt positions compared to the conventional position in > 50% of the examined subjects, especially in patients with higher BMI. Further study is required to validate the impact on EIT images with this novel method on clinical management.
Language	English
Publishing date	2023-09-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2739853-5
ISSN	2052-0492
ISSN	2052-0492
DOI	10.1186/s40560-023-00691-2
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Article ; Online: Exploration of Morphological Features of Clear Cell Renal Cell Carcinoma With

Liu, Yang / Li, Yunhao / Xu, Haimin / Zhou, Luting / Yang, Xiaoqun / Wang, Chaofu

International journal of surgical pathology

2023 Volume 31, Issue 8, Page(s) 1485–1494

Abstract: The last decade has seen great advances in genomic profiling and prognosis-associated factors of clear cell renal cell carcinoma (RCC), the most common entity in kidney cancer. ... ...

Abstract	The last decade has seen great advances in genomic profiling and prognosis-associated factors of clear cell renal cell carcinoma (RCC), the most common entity in kidney cancer. Following
MeSH term(s)	Humans ; Carcinoma, Renal Cell/pathology ; Tumor Suppressor Proteins/genetics ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Mutation ; DNA-Binding Proteins/genetics ; Transcription Factors/genetics ; Ubiquitin Thiolesterase/genetics ; Histone Demethylases/genetics
Chemical Substances	Tumor Suppressor Proteins ; PBRM1 protein, human ; DNA-Binding Proteins ; Transcription Factors ; BAP1 protein, human ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; KDM5C protein, human (EC 1.14.11.-) ; Histone Demethylases (EC 1.14.11.-)
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/10668969231157317
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Article ; Online: Mutated ASXL1 upregulates mTOR expression in renal cell carcinoma with fibromyomatous stroma.

Liu, Yang / Zhou, Luting / Xu, Haimin / Gu, Yijin / Dong, Lei / Yang, Xiaoqun / Wang, Chaofu

Virchows Archiv : an international journal of pathology

2023

Abstract: Renal cell carcinoma with fibromyomatous stroma (RCC FMS), defined as an "emerging entity" in the 2016 WHO classification and recommended to be a novel entity by GUPS, is represented by tumor cells with clear to mildly eosinophilic cytoplasm displaying ... ...

Abstract	Renal cell carcinoma with fibromyomatous stroma (RCC FMS), defined as an "emerging entity" in the 2016 WHO classification and recommended to be a novel entity by GUPS, is represented by tumor cells with clear to mildly eosinophilic cytoplasm displaying elongated and branching tubules and papillae. A fibromyomatous stroma could be observed in these tumors. These tumors are immunopositive for CK7 and featured by ELOC and/or TSC/mTOR gene mutations. In the 2022 WHO classification, ELOC mutated RCC is classified as a molecularly defined RCCs as an individual renal entity. However, there are limited descriptions of TSC/mTOR alterations in RCC FMS. Herein, we reported a case of 28-year-old woman with RCC FMS with intact ELOC and TSC/mTOR genes but ASXL1 mutation. The tumor cells were positive for mTOR expression. This case may indicate that altered mTOR expression, but not limited to mutated TSC/mTOR gene, that participates in the pathogenesis of RCC FMS.
Language	English
Publishing date	2023-12-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-023-03667-7
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