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  1. Article: Sensitivity and specificity of neuroimaging for the diagnosis of Alzheimer's disease.

    Wollman, Daniel E / Prohovnik, Isak

    Dialogues in clinical neuroscience

    2011  Volume 5, Issue 1, Page(s) 89–99

    Abstract: Alzheimer's disease (AD) is one of the most devastating and cosily disorders affecting the aging population. Structural imaging (computed tomography [CT] and magnetic resonance imaging [MRI]) and functional imaging (single photon emission computed ... ...

    Abstract Alzheimer's disease (AD) is one of the most devastating and cosily disorders affecting the aging population. Structural imaging (computed tomography [CT] and magnetic resonance imaging [MRI]) and functional imaging (single photon emission computed tomography [SPECT] and positron emission tomography [PET]) have been evaluated for their roles in the imaqinq diagnosis of AD. We have reviewed the recent literature to determine the capabilities of these neuroimaging techniques in comparison to current standards of clinical diagnosis. Our results indicate that there is wide variability in the accuracy of clinical assessments, in contrast to a more limited ranqe of variability of the accuracy of neuroimaqinq measurements. These results suggest that neuroimaging may serve an adjunctive role in raising this lower bound of diagnostic accuracy. Furthermore, we suggest that neuroimaging should be considered: (I) when clinical expertise is insufficient; (il) as a complement to specific likelihood ratios; and (iii) in specific types of patients, for whom clinical evaluation is inappropriate or inadequate.
    Language English
    Publishing date 2011-10-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 2188781-0
    ISSN 1294-8322
    ISSN 1294-8322
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    Zs.A 6188: Show issues Location:
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  2. Article: Iodine-123-iomazenil SPECT in Alzheimer's disease.

    Prohovnik, I

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    1998  Volume 39, Issue 5, Page(s) 927

    MeSH term(s) Alzheimer Disease/diagnostic imaging ; Flumazenil/analogs & derivatives ; Humans ; Iodine Radioisotopes ; Radiopharmaceuticals ; Sensitivity and Specificity ; Technetium Tc 99m Exametazime ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Iodine Radioisotopes ; Radiopharmaceuticals ; Technetium Tc 99m Exametazime (3B744AG22N) ; Flumazenil (40P7XK9392) ; iomazenil (7DVX185FLQ)
    Language English
    Publishing date 1998-05
    Publishing country United States
    Document type Comparative Study ; Letter ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  3. Article: Discriminant value of semiquantitative SPECT data in mild Alzheimer's disease.

    Prohovnik, I

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    1996  Volume 37, Issue 2, Page(s) 404

    MeSH term(s) Alzheimer Disease/diagnostic imaging ; Brain/diagnostic imaging ; Discriminant Analysis ; Humans ; Sensitivity and Specificity ; Tomography, Emission-Computed, Single-Photon/methods
    Language English
    Publishing date 1996-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
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  4. Article: Possible utility of bilateral simultaneous TCD.

    Prohovnik, I

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    1995  Volume 15, Issue 4, Page(s) 718

    MeSH term(s) Blood Flow Velocity ; Cerebral Arteries/physiology ; Cerebrovascular Circulation ; Humans ; Mental Processes/physiology
    Language English
    Publishing date 1995-07
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1038/jcbfm.1995.89
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    Zs.A 1663: Show issues Location:
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  5. Article: Lack of blindness procedures in Alzheimer's study.

    Prohovnik, I

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    1994  Volume 35, Issue 9, Page(s) 1566

    MeSH term(s) Adult ; Aged ; Alzheimer Disease ; Bias ; Data Interpretation, Statistical ; Humans ; Middle Aged ; Research Design
    Language English
    Publishing date 1994-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
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  6. Article: Cross-validation of brain segmentation by SPM5 and SIENAX.

    Lee, Hedok / Prohovnik, Isak

    Psychiatry research

    2008  Volume 164, Issue 2, Page(s) 172–177

    Abstract: Volumes of cerebral grey (GM) or white matter (WM) are often used as clinical observations or statistical covariates. Several automated segmentation tools can be used for this purpose, but they have not been validated against each other. We used the most ...

    Abstract Volumes of cerebral grey (GM) or white matter (WM) are often used as clinical observations or statistical covariates. Several automated segmentation tools can be used for this purpose, but they have not been validated against each other. We used the most common ones, SPM5 and SIENAX 2.4, to derive volumes of grey and white matter in 56 healthy subjects (mean age 49+/-13, range 22-80) and compared the two methods. Both methods yielded significant correlations with age in the expected directions, and estimates of parenchymal volumes were highly correlated. However, without use of prior probability maps, or priors, in SIENAX, GM was significantly underestimated in comparison to SPM (0.52+/-.06 vs 0.66+/-.07 L) and WM was significantly overestimated (0.48+/-.07 vs 0.46+/-.07 L). This error was associated with misclassification of GM as cerebrospinal fluid, especially in deep grey matter. Invoking prior probabilities in SIENAX resulted in excellent agreement with SPM: GM and WM volumes were found to be 0.64+/-0.07 L and 0.47+/-0.07 L, respectively. We conclude that SIENAX requires priors for accurate volumetric estimates, and then provides close agreement with SPM5.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Brain/anatomy & histology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged
    Language English
    Publishing date 2008-11-30
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0165-1781 ; 0925-4927
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0165-1781 ; 0925-4927
    DOI 10.1016/j.pscychresns.2007.12.008
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  7. Article: Prevalence of Alzheimer's disease.

    Prohovnik, I

    JAMA

    1990  Volume 264, Issue 23, Page(s) 2996

    MeSH term(s) Aged ; Alzheimer Disease/epidemiology ; Humans ; Massachusetts/epidemiology ; Prevalence
    Language English
    Publishing date 1990-12-19
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0098-7484 ; 0254-9077 ; 0002-9955
    ISSN (online) 1538-3598
    ISSN 0098-7484 ; 0254-9077 ; 0002-9955
    DOI 10.1001/jama.1990.03450230028021
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    Ua VI Zs.88: Show issues Location:
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  8. Article: Web-based multi-center data management system for clinical neuroscience research.

    Pozamantir, Alexander / Lee, Hedok / Chapman, Joab / Prohovnik, Isak

    Journal of medical systems

    2010  Volume 34, Issue 1, Page(s) 25–33

    Abstract: Modern clinical research often involves multicenter studies, large and heterogeneous data flux, and intensive demands of collaboration, security and quality assurance. In the absence of commercial or academic management systems, we designed an open- ... ...

    Abstract Modern clinical research often involves multicenter studies, large and heterogeneous data flux, and intensive demands of collaboration, security and quality assurance. In the absence of commercial or academic management systems, we designed an open-source system to meet these requirements. Based on the Apache-PHP-MySQL platform on a Linux server, the system allows multiple users to access the database from any location on the internet using a web browser, and requires no specialized computer skills. Multi-level security system is implemented to safeguard the protected health information and allow partial or full access to the data by individual or class privilege. The system stores and manipulates various types of data including images, scanned documents, laboratory data and clinical ratings. Built-in functionality allows for various search, quality control, analytic data operations, visit scheduling and visit reminders. This approach offers a solution to a growing need for management of large multi-center clinical studies.
    MeSH term(s) Biomedical Research ; Creutzfeldt-Jakob Syndrome/genetics ; Database Management Systems ; Humans ; Internet ; Neurosciences/methods ; Quality Control
    Language English
    Publishing date 2010-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 423488-1
    ISSN 1573-689X ; 0148-5598
    ISSN (online) 1573-689X
    ISSN 0148-5598
    DOI 10.1007/s10916-008-9212-2
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    Zs.A 1426: Show issues Location:
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  9. Article: Cortical perfusion in Alzheimer's disease: beyond diagnosis.

    Prohovnik, I

    Psychiatry research

    1989  Volume 29, Issue 3, Page(s) 301–302

    MeSH term(s) Aged ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/psychology ; Arousal/physiology ; Cerebral Cortex/blood supply ; Humans ; Neuropsychological Tests ; Radionuclide Imaging ; Regional Blood Flow/physiology ; Xenon Radioisotopes
    Chemical Substances Xenon Radioisotopes
    Language English
    Publishing date 1989-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0165-1781 ; 0925-4927
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0165-1781 ; 0925-4927
    DOI 10.1016/0165-1781(89)90071-1
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  10. Article: Analysis of regional blood flow data.

    Prohovnik, I

    Stroke

    1988  Volume 19, Issue 1, Page(s) 123

    MeSH term(s) Cerebrovascular Circulation ; Humans ; Methods
    Language English
    Publishing date 1988-01
    Publishing country United States
    Document type Letter
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/01.str.19.1.123
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