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  1. Article: Ameliorative Effects of Nilotinib on CCl4 Induced Liver Fibrosis Via Attenuation of RAGE/HMGB1 Gene Expression and Oxidative Stress in Rat.

    Khanjarsim, Vahid / Karimi, Jamshid / Khodadadi, Iraj / Mohammadalipour, Adel / Goodarzi, Mohammad Taghi / Solgi, Ghasem / Hashemnia, Mohammad

    Chonnam medical journal

    2017  Volume 53, Issue 2, Page(s) 118–126

    Abstract: Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the anti-fibrotic effects of Nilotinib via RAGE/HMGB1axis ... ...

    Abstract Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the anti-fibrotic effects of Nilotinib via RAGE/HMGB1axis and antioxidant mechanisms. This experimental study was performed in the Hamadan University of Medical Sciences, Iran, from May 2015 to December 2016. Liver fibrosis was induced in Wistar male rats by CCL
    Language English
    Publishing date 2017-05-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2536217-3
    ISSN 2233-7393 ; 2233-7385 ; 0377-9564
    ISSN (online) 2233-7393
    ISSN 2233-7385 ; 0377-9564
    DOI 10.4068/cmj.2017.53.2.118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Protective effects of combined Losartan and Nilotinib on carbon tetrachloride (CCl

    Karimi, Jamshid / Mohammadalipour, Adel / Sheikh, Nasrin / Khodadadi, Iraj / Hashemnia, Mohammad / Goudarzi, Farjam / Khanjarsim, Vahid / Solgi, Ghasem / Hajilooi, Mehrdad / Bahabadi, Majid / Kheiripour, Nejat / Hedayatyanfard, Keshvad

    Drug and chemical toxicology

    2018  Volume 43, Issue 5, Page(s) 468–478

    Abstract: Tyrosine kinase inhibitors (TKIs) have been developed as therapeutic compounds for inhibiting the progression of liver fibrosis. In the present study, the simultaneous treatment of Nilotinib (TKIs) and Losartan was studied. Forty rats were divided into ... ...

    Abstract Tyrosine kinase inhibitors (TKIs) have been developed as therapeutic compounds for inhibiting the progression of liver fibrosis. In the present study, the simultaneous treatment of Nilotinib (TKIs) and Losartan was studied. Forty rats were divided into eight groups of fibrosis induced by carbon tetrachloride (CCl
    MeSH term(s) Angiotensin II Type 1 Receptor Blockers/administration & dosage ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Animals ; Carbon Tetrachloride/toxicity ; Drug Therapy, Combination ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/prevention & control ; Losartan/administration & dosage ; Losartan/pharmacology ; Losartan/therapeutic use ; Male ; Oxidative Stress/drug effects ; Protein-Tyrosine Kinases/administration & dosage ; Protein-Tyrosine Kinases/pharmacology ; Protein-Tyrosine Kinases/therapeutic use ; Pyrimidines/administration & dosage ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Rats ; Rats, Wistar ; Transforming Growth Factor beta1/analysis ; Weight Gain/drug effects
    Chemical Substances Angiotensin II Type 1 Receptor Blockers ; Pyrimidines ; Tgfb1 protein, rat ; Transforming Growth Factor beta1 ; Carbon Tetrachloride (CL2T97X0V0) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; nilotinib (F41401512X) ; Losartan (JMS50MPO89)
    Language English
    Publishing date 2018-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 548368-2
    ISSN 1525-6014 ; 0148-0545
    ISSN (online) 1525-6014
    ISSN 0148-0545
    DOI 10.1080/01480545.2018.1504960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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