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Article ; Online: Central diabetes insipidus (Infundibuloneuro hypophysitis): A late complication of COVID-19 infection.

Misgar, R A / Rasool, A / Wani, A I / Bashir, M I

Journal of endocrinological investigation

2021 Volume 44, Issue 12, Page(s) 2855–2856

MeSH term(s)	Antidiuretic Agents/administration & dosage ; COVID-19/blood ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19/therapy ; Deamino Arginine Vasopressin/administration & dosage ; Diabetes Insipidus, Neurogenic/blood ; Diabetes Insipidus, Neurogenic/etiology ; Diabetes Insipidus, Neurogenic/physiopathology ; Diabetes Insipidus, Neurogenic/therapy ; Diagnosis, Differential ; Female ; Humans ; Hypophysitis/diagnosis ; Hypophysitis/physiopathology ; Hypophysitis/virology ; Magnetic Resonance Imaging/methods ; Middle Aged ; Pituitary Gland/diagnostic imaging ; SARS-CoV-2/isolation & purification ; Treatment Outcome
Chemical Substances	Antidiuretic Agents ; Deamino Arginine Vasopressin (ENR1LLB0FP)
Language	English
Publishing date	2021-07-03
Publishing country	Italy
Document type	Case Reports ; Letter
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-021-01627-z
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Article ; Online: Cardiac structural and functional abnormalities in primary hyperparathyroidism.

Purra, S / Lone, A A / Bhat, M H / Misgar, R A / Wani, A I / Bashir, M I / Masoodi, S R / Purra, W

Journal of endocrinological investigation

2021 Volume 45, Issue 2, Page(s) 327–335

Abstract: Purpose: Studies on cardiac structural and functional abnormalities in primary hyperparathyroidism (PHPT) have yielded conflicting and inconsistent results. In this prospective case-control study, we sought to compare cardiac structure and function in ... ...

Abstract	Purpose: Studies on cardiac structural and functional abnormalities in primary hyperparathyroidism (PHPT) have yielded conflicting and inconsistent results. In this prospective case-control study, we sought to compare cardiac structure and function in symptomatic PHPT patients and controls. Methods: One hundred consecutive symptomatic PHPT patients and 113 matched controls underwent echocardiographic evaluation by the same operator. Results: Left ventricular mass index (LVMI) was significantly higher in patients as compared to controls, (median of 90.95 g/m Conclusions: Symptomatic patients with PHPT have substantial cardiac structural and functional abnormalities. These abnormalities include elevated LVMI, diastolic dysfunction, and aortic valve, mitral annular, septal and myocardial calcifications. We strongly suggest and conclude that the evaluation of PHPT patients should not only include traditional end organs like bones and kidneys but also the cardiovascular system in the form of echocardiography to detect subclinical cardiac dysfunction so that the cardiovascular health of such patients can be optimized.
MeSH term(s)	Calcinosis/blood ; Calcinosis/diagnostic imaging ; Calcinosis/etiology ; Calcium/blood ; Cardiomyopathies/diagnosis ; Cardiomyopathies/etiology ; Cardiomyopathies/physiopathology ; Case-Control Studies ; Early Diagnosis ; Echocardiography/methods ; Echocardiography/statistics & numerical data ; Female ; Heart Valve Diseases/etiology ; Heart Valve Diseases/pathology ; Heart Valve Diseases/physiopathology ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Humans ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/diagnosis ; Male ; Middle Aged ; Organ Size ; Parathyroid Hormone/blood
Chemical Substances	Parathyroid Hormone ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-07-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-021-01645-x
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Article ; Online: Clinical, hormonal and radiological features of partial Sheehan's syndrome: an Indian experience.

Laway, Bashir / Misgar, Raiz / Mir, Shahnaz / Wani, Arshad

Archives of endocrinology and metabolism

2016 Volume 60, Issue 2, Page(s) 125–129

Abstract: Objective The objective of this study was to describe clinical presentation, hormonal profile and imaging characteristics of 21 patients with partial Sheehan's syndrome. Subjects and methods This prospective study was carried out over a period of six ... ...

Abstract	Objective The objective of this study was to describe clinical presentation, hormonal profile and imaging characteristics of 21 patients with partial Sheehan's syndrome. Subjects and methods This prospective study was carried out over a period of six years (2008-2013). The evaluation of patients included clinical assessment, hormone estimations and contrast enhanced magnetic resonance imaging of pituitary. Results We documented preservation of gonadotroph, corticotroph and lactotroph function in 71.4, 61.9, and 9.5% of patients respectively. Conclusion To conclude some of the pituitary functions can be preserved in Sheehan's syndrome and this has important implications from the treatment and long term morbidity point of view.
MeSH term(s)	Adult ; Female ; Human Growth Hormone/blood ; Human Growth Hormone/deficiency ; Humans ; Hydrocortisone/blood ; Hydrocortisone/deficiency ; Hypopituitarism/blood ; Hypopituitarism/diagnostic imaging ; Magnetic Resonance Imaging ; Middle Aged ; Pituitary Gland, Anterior/physiopathology ; Pituitary Hormones/blood ; Pituitary Hormones/deficiency ; Postpartum Hemorrhage ; Postpartum Period ; Prospective Studies ; Reference Values ; Thyroxine/blood ; Thyroxine/deficiency
Chemical Substances	Pituitary Hormones ; Human Growth Hormone (12629-01-5) ; Thyroxine (Q51BO43MG4) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2016-04
Publishing country	Brazil
Document type	Journal Article
ISSN	2359-4292
ISSN (online)	2359-4292
DOI	10.1590/2359-3997000000137
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Article: Amelogenesis Imperfecta with Distal Renal Tubular Acidosis: A Novel Syndrome?

Misgar, R A / Hassan, Z / Wani, A I / Bashir, M I

Indian journal of nephrology

2017 Volume 27, Issue 3, Page(s) 225–227

Abstract: Amelogenesis imperfecta (AI) is a heterogeneous group of inherited dental enamel defects. It has rarely been reported in association with multiorgan syndromes and metabolic disorders. The metabolic disorders that have been reported in association with AI ...

Abstract	Amelogenesis imperfecta (AI) is a heterogeneous group of inherited dental enamel defects. It has rarely been reported in association with multiorgan syndromes and metabolic disorders. The metabolic disorders that have been reported in association with AI include hypocalciuria, impaired urinary concentrating ability, and Bartter-like syndrome. In literature, only three cases of AI and distal renal tubular acidosis (dRTA) have been described: two cases in adults and a solitary case in the pediatric age group. Here, we report a child with AI presenting with dRTA; to the best of our knowledge, our reported case is the only second such case in pediatric age group. Our case highlights the importance of recognizing the possibility of renal abnormalities in patients with AI as it will affect the long-term prognosis.
Language	English
Publishing date	2017-05-09
Publishing country	India
Document type	Case Reports
ZDB-ID	2134388-3
ISSN	1998-3662 ; 0971-4065
ISSN (online)	1998-3662
ISSN	0971-4065
DOI	10.4103/0971-4065.202826
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Article ; Online: Primary hyperparathyroidism and pancreatitis.

Misgar, R A / Bhat, M H / Rather, T A / Masoodi, S R / Wani, A I / Bashir, M I / Wani, M A / Malik, A A

Journal of endocrinological investigation

2020 Volume 43, Issue 10, Page(s) 1493–1498

Abstract: Purpose: The true association between primary hyperparathyroidism (PHPT) and pancreatitis continues to be controversial. In this study, we present clinical data, investigative profile, management and follow-up of PHPT patients with pancreatitis and ... ...

Abstract	Purpose: The true association between primary hyperparathyroidism (PHPT) and pancreatitis continues to be controversial. In this study, we present clinical data, investigative profile, management and follow-up of PHPT patients with pancreatitis and compare this group with PHPT patients without pancreatitis. Methods: Records of 242 patients with PHPT managed at our center over 24 years were retrospectively analyzed for demographic and laboratory data. The diagnosis of pancreatitis was entertained in the presence of at least two of the three following features: abdominal pain, levels of serum amylase greater than three times the normal or characteristic features at imaging. Results: Fifteen (6.19%) of the 242 consecutive patients with PHPT had had pancreatitis. Fourteen patients (93.3%) had acute pancreatitis (AP), while one patient had chronic calcific pancreatitis. Over half (8 of 14) of the patients with AP had at least two episodes of pancreatitis. Pancreatitis was the presenting symptom in 14 (93.3%) patients. None of the pancreatitis cases had additional risk factors for pancreatitis. PHPT patients with pancreatitis had significantly higher serum calcium and ALP than PHPT patients without pancreatitis. After successful parathyroidectomy, 14 patients had no further attacks of pancreatitis during a median follow-up of 16 months (range 2-41 months), while recurrence of pancreatitis was seen in one patient. Conclusions: We conclude that pancreatitis can be the only presenting complaint of PHPT. Our study highlights the importance of fully investigating for PHPT in any pancreatitis patient with high normal or raised serum calcium level, especially in the absence of other common causes of pancreatitis.
MeSH term(s)	Adult ; Aged ; Calcium/blood ; Case-Control Studies ; Child ; Diagnosis, Differential ; Female ; Humans ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/diagnosis ; Hyperparathyroidism, Primary/epidemiology ; Hyperparathyroidism, Primary/therapy ; Male ; Middle Aged ; Pancreatitis/complications ; Pancreatitis/diagnosis ; Pancreatitis/epidemiology ; Pancreatitis/therapy ; Parathyroid Hormone/blood ; Parathyroidectomy ; Retrospective Studies ; Young Adult
Chemical Substances	Parathyroid Hormone ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-04-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-020-01233-5
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Article ; Online: Efficacy and safety of various oral regimens (three oral doses) and schedules (daily

Ganie, Mohd Ashraf / Sidana, Shivani / Baba, Mohammad Salem / Sahar, Tajali / Rashid, Aafia / Asrar, Mir Mahmood / Marwaha, R K / Wani, Ishfaq Ahmad / Misgar, Riyaz A / Wani, Imtiyaz Ahmad

The British journal of nutrition

2022 Volume 129, Issue 10, Page(s) 1732–1739

Abstract: Vitamin D (VD) deficiency (serum 25 hydroxy vitamin D (25(OH)D) concentration of < 20 ng/ml), in endemic proportions, demands a supplementation strategy with optimal dosing regimens. A randomised parallel-group, active-controlled trial was conducted ... ...

Abstract	Vitamin D (VD) deficiency (serum 25 hydroxy vitamin D (25(OH)D) concentration of < 20 ng/ml), in endemic proportions, demands a supplementation strategy with optimal dosing regimens. A randomised parallel-group, active-controlled trial was conducted among apparently healthy, VD-deficient subjects, aged 18-60 years who received 600 μg/d (Group A), 1000 μg/d (Group B), 2000 μg/d (Group C) and 60 000 μg/month (Group D) of oral cholecalciferol. The intervention was carried in two phases (I and II) of 12 weeks each, with same dose, separated by a washout phase of 12 weeks. Serum 25(OH)D, intact parathyroid hormones (iPTH), Ca, phosphorous (PO4), alkaline phosphatase (ALP) and spot urine Ca/Cr were measured at baseline, 12, 24 and 36 weeks following the intervention, and adverse events were recorded at each occurrence and at 12, 24 and 36 weeks. A statistically significant time-group interaction was found in serum 25(OH)D concentration (
MeSH term(s)	Adult ; Humans ; Cholecalciferol/adverse effects ; Calcium ; Vitamin D ; Vitamin D Deficiency/drug therapy ; Parathyroid Hormone ; Alkaline Phosphatase ; Dietary Supplements
Chemical Substances	Cholecalciferol (1C6V77QF41) ; Calcium (SY7Q814VUP) ; Vitamin D (1406-16-2) ; Parathyroid Hormone ; Alkaline Phosphatase (EC 3.1.3.1)
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114522002641
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Article ; Online: Amelogenesis imperfecta with distal renal tubular acidosis

R A Misgar / Z Hassan / A I Wani / M I Bashir

Indian Journal of Nephrology, Vol 27, Iss 3, Pp 225-

A novel syndrome?

2017 Volume 227

Abstract	Amelogenesis imperfecta (AI) is a heterogeneous group of inherited dental enamel defects. It has rarely been reported in association with multiorgan syndromes and metabolic disorders. The metabolic disorders that have been reported in association with AI include hypocalciuria, impaired urinary concentrating ability, and Bartter-like syndrome. In literature, only three cases of AI and distal renal tubular acidosis (dRTA) have been described: two cases in adults and a solitary case in the pediatric age group. Here, we report a child with AI presenting with dRTA; to the best of our knowledge, our reported case is the only second such case in pediatric age group. Our case highlights the importance of recognizing the possibility of renal abnormalities in patients with AI as it will affect the long-term prognosis.
Keywords	Amelogenesis imperfecta ; distal renal tubular acidosis ; inherited enamel defects ; nephrocalcinosis ; renal tubular disorders ; Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	616
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Distal renal tubular acidosis caused by tryptophan-aspartate repeat domain 72 (WDR72) mutations.

Rungroj, N / Nettuwakul, C / Sawasdee, N / Sangnual, S / Deejai, N / Misgar, R A / Pasena, A / Khositseth, S / Kirdpon, S / Sritippayawan, S / Vasuvattakul, S / Yenchitsomanus, P T

Clinical genetics

2018 Volume 94, Issue 5, Page(s) 409–418

Abstract: Hereditary distal renal tubular acidosis (dRTA) is a rare genetic disease that is caused by mutations in SLC4A1, ATP6V1B1, or ATP6V0A4. However, there are many families with hereditary dRTA in whom the disease-causing genes are unknown. Accordingly, we ... ...

Abstract	Hereditary distal renal tubular acidosis (dRTA) is a rare genetic disease that is caused by mutations in SLC4A1, ATP6V1B1, or ATP6V0A4. However, there are many families with hereditary dRTA in whom the disease-causing genes are unknown. Accordingly, we performed whole exome sequencing and genetic studies of the members of a family with autosomal recessive dRTA of an unknown genetic etiology. Here, we report compound heterozygous pathogenic variations in tryptophan-aspartate repeat domain 72 (WDR72) (c.1777A>G [p.R593G] and c.2522T>A [p.L841Q]) in three affected siblings of a family with dRTA. Both variants segregated with dRTA in the family and were not observed in normal control subjects. Homologous modeling and in silico mutagenesis indicated that R593G and L841Q alter the H-bond formations in the nearby residues, affecting the WDR72 protein structure. All these evidences indicate that the identified WDR72 variations were probably to have caused hereditary dRTA in the reported family. In addition, homozygous nonsense mutation (c.2686C>T [p.R896X]) was identified in another family, strongly supporting the causal role of WDR72 in dRTA. Based on our literature review, WDR72 mutations associated with dRTA have not been previously described. This is the first identification of pathogenic variations in WDR72 as a cause of hereditary dRTA.
MeSH term(s)	Acidosis, Renal Tubular/diagnosis ; Acidosis, Renal Tubular/genetics ; Adolescent ; Adult ; Amino Acid Sequence ; Biomarkers ; Case-Control Studies ; Child ; Computational Biology/methods ; DNA Mutational Analysis ; Female ; Genetic Association Studies/methods ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Models, Molecular ; Mutation ; Pedigree ; Phenotype ; Protein Conformation ; Proteins/chemistry ; Proteins/genetics ; Whole Exome Sequencing ; Young Adult
Chemical Substances	Biomarkers ; Proteins ; WDR72 protein, human
Language	English
Publishing date	2018-08-09
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	221209-2
ISSN	1399-0004 ; 0009-9163
ISSN (online)	1399-0004
ISSN	0009-9163
DOI	10.1111/cge.13418
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Article ; Online: Primary hyperparathyroidism presenting as recurrent acute pancreatitis

Raiz A Misgar / Vivek Mathew / Kaushik Pandit / Subhankar Chowdhury

Indian Journal of Endocrinology and Metabolism, Vol 15, Iss 1, Pp 54-

A case report and review of literature

2011 Volume 56

Abstract: The association between pancreatitis and primary hyperparathyroidism (PHPT) is controversial. We report a 32-year-old man who presented with recurrent episodes of acute pancreatitis. Primary hyperparathyroidism was diagnosed after the fourth episode of ... ...

Abstract	The association between pancreatitis and primary hyperparathyroidism (PHPT) is controversial. We report a 32-year-old man who presented with recurrent episodes of acute pancreatitis. Primary hyperparathyroidism was diagnosed after the fourth episode of pancreatitis. He had no additional risk factors for pancreatitis. Eighteen months after successful parathyroid surgery, there has been no recurrence of abdominal pain and his serum calcium is within the normal range.
Keywords	Pancreatitis ; primary hyperparathyroidism ; parathyroid surgery ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Endocrine Society of India
Document type	Article ; Online
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Article ; Online: Profile of leptin, adiponectin, and body fat in patients with hyperprolactinemia

Nazir Ahmad Pala / Bashir Ahmad Laway / Raiz Ahmad Misgar / Zaffar Amin Shah / Tariq A Gojwari / Tariq A Dar

Indian Journal of Endocrinology and Metabolism, Vol 20, Iss 2, Pp 177-

Response to treatment with cabergoline

2016 Volume 181

Abstract: Introduction: Though hypoadiponectinemia and leptin resistance have been proposed as potential factors for weight gain in patients with hyperprolactinemia (HPL), the effects of HPL and cabergoline on these adipocyte-derived hormones are not clear. Aims ... ...

Abstract	Introduction: Though hypoadiponectinemia and leptin resistance have been proposed as potential factors for weight gain in patients with hyperprolactinemia (HPL), the effects of HPL and cabergoline on these adipocyte-derived hormones are not clear. Aims of this study were (i) to assess the alterations of body fat, leptin, and adiponectin in patients with HPL (ii) effect of cabergoline treatment on these parameters. Methods: Nineteen consecutive patients with prolactinoma (median prolactin [PRL] 118.6 (interquartile range: 105.3) μg/L) and 20 controls were studied in a nonrandomized matched prospective design. The controls were age, gender, and body mass index (BMI) matched. Anthropometric data, metabolic variables, leptin, and adiponectin were studied at baseline and 3 and 6 months after cabergoline treatment. Results: Patients with prolactinoma had increased level of fasting plasma glucose (P < 0.001) as compared to age-, gender-, and BMI-matched healthy controls. Estradiol concentration of controls was higher than that of patients (P = 0.018). Patients with prolactinoma had higher levels of leptin (P = 0.027) as compared to healthy controls without a significant difference in adiponectin levels. There was a significant decrease of body weight at 3 months (P = 0.029), with a further decline at 6 months (P < 0.001) of cabergoline therapy. Furthermore, there was a significant decrement of BMI (P < 0.001), waist circumference (P = 0.003), waist-hip ratio (P = 0.03), total body fat (P = 0.003), plasma glucose (P < 0.001), leptin levels (P = 0.013), and an increase in estradiol concentration (P = 0.03) at 6 months of cabergoline treatment. Conclusion: Patients with prolactinoma have adverse metabolic profile compared to matched controls. Normalization of PRL with cabergoline corrects all the metabolic abnormalities.
Keywords	Adiponectin ; body fat ; cabergoline ; hyperprolactinemia ; leptin ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Endocrine Society of India
Document type	Article ; Online
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