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Article ; Online: #mybestmidlife: Profiles of photo-based social media use and body image among midlife women.

Rodgers, Rachel F / Nowicki, Gennevieve P

2023 Volume 48, Page(s) 101646

Abstract: ... comparison). Differences by cluster emerged according to indices of social media use (e.g., photo editing ...

Abstract	Empirical data, predominantly from young women, suggest photo-based social media use is associated with greater body dissatisfaction. The present study aimed to extend these findings to midlife women and identify risk profiles for maladaptive appearance-focused social media use. A convenience sample of female Instagram users aged 40 or over (M= 50.92 years) (n = 192) was collected. Most participants were partnered, white, highly educated, and heterosexual. A cluster analysis in cross-sectional data grouped participants into four categories according to body image indices (following body positive or fitness accounts, body appreciation and dissatisfaction, thin and muscular ideal internalization, and appearance comparison). Differences by cluster emerged according to indices of social media use (e.g., photo editing, social media rumination), although following appearance-related content across types seemed to distinguish risk profiles more than the types of appearance-related content engaged with (i.e., body positive vs fitness). Furthermore, results indicated that higher social media use was associated with greater perceived negative effects of social media, suggesting that awareness alone may be insufficient to reduce behavioral risk. Findings indicate that some midlife women who use photo-based social media may be at high risk for appearance concerns, warranting further research and resource development for this group.
MeSH term(s)	Female ; Humans ; Body Image/psychology ; Social Media ; Cross-Sectional Studies ; Body Dissatisfaction ; Emotions
Language	English
Publishing date	2023-11-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2211449-X
ISSN	1873-6807 ; 1740-1445
ISSN (online)	1873-6807
ISSN	1740-1445
DOI	10.1016/j.bodyim.2023.101646
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Article ; Online: LP2, a stable lanthipeptide derived from cAng-(1-7), exerts myeloprotective action in mice.

Namsolleck, P / Rodgers, K E / Franklin, R / Moll, G N

European journal of haematology

2023 Volume 110, Issue 5, Page(s) 534–539

Abstract: ... angiotensin-(1-7) yielded cyclic angiotensin-(2-7) and cyclic angiotensin-(3-7). LP2 significantly (p < .0001 ... significantly (p < .05) countered anemia in tumor-bearing mice treated with erlotinib.: Conclusions: LP2 ...

Abstract	Objectives: Linear unstable angiotensins stimulate hematopoiesis. Here we address: (1) Is cyclic angiotensin-(1-7) myeloprotective in mice? (2) Is cyclic angiotensin-(1-7) stable in rat? (3) Does LP2, a cyclic angiotensin-(1-7) with an N-terminal d-lysine, exert myeloprotective action in tumor-bearing mice? Materials and methods: Cyclic angiotensin-(1-7)'s capacity to restore levels of blood platelets and white blood cells was studied in gemcitabine-treated mice. The stability of cyclic angiotensin-(1-7) in rat was measured in blood samples taken after injection or infusion. The capacity of LP2 to restore total bone marrow cell levels in mice after treatment with 5-fluoruracil was measured. In addition, the capacity of LP2 to counter anemia in tumor-bearing mice treated with erlotinib was measured. Results: Cyclic angiotensin-(1-7) dose-dependently restored blood platelet levels in gemcitabine-treated mice, whereas its capacity to restore levels of white blood cells was less. In vivo aminoterminal breakdown of cyclic angiotensin-(1-7) yielded cyclic angiotensin-(2-7) and cyclic angiotensin-(3-7). LP2 significantly (p < .0001 at 100 μg/kg/day) restored bone marrow cell counts in mice after treatment with 5-fluoruracil. LP2 also significantly (p < .05) countered anemia in tumor-bearing mice treated with erlotinib. Conclusions: LP2 exerts myeloprotective action with perspectives for continuation of its clinical development.
MeSH term(s)	Mice ; Rats ; Animals ; Erlotinib Hydrochloride ; Blood Platelets ; Hematopoiesis ; Bone Marrow Cells ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use
Chemical Substances	Erlotinib Hydrochloride (DA87705X9K) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2023-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13927
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Zs.A 323: Show issues

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Article ; Online: Achieving Health Equity Through Digestive Diseases Research and Scientific Workforce Diversity.

Singh, Megan E / James, Stephen P / Germino, Gregory G / Rodgers, Griffin P

Gastroenterology

2022 Volume 162, Issue 6, Page(s) 1597–1601.e1

MeSH term(s)	Health Equity ; Humans ; Minority Groups ; Workforce
Language	English
Publishing date	2022-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2022.01.005
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Zs.MO 572: Show issues

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Article ; Online: Triumph of Pneumococcal Conjugate Vaccines: Overcoming a Common Foe.

Rodgers, Gail L / Whitney, Cynthia G / Klugman, Keith P

The Journal of infectious diseases

2021 Volume 224, Issue 12 Suppl 2, Page(s) S352–S359

Abstract: Pneumococcal conjugate vaccine (PCV) has reduced the burden of pneumococcal disease by the near elimination of vaccine serotypes from countries giving a booster dose at >9 months of life. Herd protection, induced by interruption of pneumococcal vaccine ... ...

Abstract	Pneumococcal conjugate vaccine (PCV) has reduced the burden of pneumococcal disease by the near elimination of vaccine serotypes from countries giving a booster dose at >9 months of life. Herd protection, induced by interruption of pneumococcal vaccine type transmission has protected children too young to be immunized, children and adults with underlying risk conditions for invasive pneumococcal disease, and the elderly. PCV has rolled out in most poor countries, but millions of children remain un-immunized especially in middle income countries because of cost constraints. These are being met by considering fewer doses to maintain herd protection, and support for more affordable vaccine from developing country manufacturers. While 3rd generation PCV's with potential inclusion of 20+ serotypes are close to market in adults, it will be their introduction into childhood immunization and herd protection that is most likely to maximize the public health benefits of these vaccines.
MeSH term(s)	Adult ; Aged ; Child ; Humans ; Infant ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines ; Public Health ; Serogroup ; Vaccines, Conjugate
Chemical Substances	Pneumococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiaa535
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Article ; Online: Understanding the exploratory/confirmatory data analysis continuum: Moving beyond the "replication crisis".

Fife, Dustin A / Rodgers, Joseph Lee

The American psychologist

2021 Volume 77, Issue 3, Page(s) 453–466

Abstract: ... Wagenmakers et al., 2012). However, some (e.g., Baumeister, 2016; Goldin-Meadow, 2016) suggest ... p-hacking, HARKing, and data mining, which are situated in a (graphical) framework that clarifies ...

Abstract	In light of the "replication crisis," some advocate for stricter standards and greater transparency in research methods. These efforts push toward a data analysis approach called "confirmatory data analysis" (CDA; see Wagenmakers et al., 2012). However, some (e.g., Baumeister, 2016; Goldin-Meadow, 2016) suggest that emphasizing CDA may restrict creativity and discovery. These scholars argued (sometimes inadvertently) for greater freedom to pursue "exploratory data analysis" (EDA; see Tukey, 1977). Ironically and unfortunately, many who push against stricter CDA standards do not realize EDA exists, or misunderstand the philosophy and proper tools for exploration. In this article, the meaning, tools, philosophy, and ethics associated with EDA, CDA, and a relatively unknown but important approach called "rough CDA" are clarified. Important distinctions are developed between EDA/rough CDA/CDA and other (some problematic) analysis activities including p-hacking, HARKing, and data mining, which are situated in a (graphical) framework that clarifies relationships and ethical boundaries with each. In short, the proper data analytic approach depends on (a) intentions and (b) transparency. Most psychological research is not at a maturity level to justify CDA; researchers have historically used tools mismatched to their research agenda. In the conclusion, recommendations are presented about how these typologies can be integrated into graduate training programs and how a cumulative research program can help psychology move beyond the replication crisis. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
MeSH term(s)	Data Analysis ; Humans ; Intention ; Philosophy ; Research Design ; Research Personnel
Language	English
Publishing date	2021-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	209464-2
ISSN	1935-990X ; 0003-066X
ISSN (online)	1935-990X
ISSN	0003-066X
DOI	10.1037/amp0000886
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Zs.A 997: Show issues

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Article ; Online: Just-in-Time: A Caregiver-Mediated Intervention for Toddlers With Autism.

Bailey, Kathryn M / Rodgers, Mary E / Quinn, Emily D / Thompson, Suzanne / Nietfeld, Jennifer / Kaiser, Ann P

American journal of speech-language pathology

2024 Volume 33, Issue 3, Page(s) 1209–1225

Abstract: ... strategies (e.g., matched turns, target talk, expansions, play actions, milieu episodes). Generalization and ...

Abstract	Purpose: We investigated effects of an adaptive telehealth coaching model on caregiver implementation of enhanced milieu teaching (EMT) with newly diagnosed toddlers with autism. Method: Three caregiver-child dyads participated in a multiple-baseline-across-behaviors, single-case design. Caregivers were taught EMT via telehealth using the teach-model-coach-review approach. EMT strategies were taught sequentially in four components corresponding to design tiers. Caregivers reported their needs for support and adaptation via weekly surveys. Primary outcomes were measures of caregiver's implementation, including (a) a fidelity checklist for wholistic use of EMT and (b) a percentage of correct use of a subset of key EMT strategies (e.g., matched turns, target talk, expansions, play actions, milieu episodes). Generalization and maintenance of caregiver strategy use in uncoached home activities were measured. The number of different words used by children was measured as a secondary, descriptive outcome. Social validity data were collected through ratings and interviews at the end of the study. Results: There was a functional relation between the intervention and caregiver's implementation of EMT for all dyads. Caregiver's use of EMT strategies often generalized and maintained post-intervention. Child response to intervention was variable. Social validity data indicated that the model was beneficial to caregivers and children. Conclusions: An adaptive telehealth coaching model is effective for teaching caregivers of toddlers with autism to implement EMT and potentially helps to bridge the gap between diagnosis and comprehensive intervention. Further exploration of the relation between caregiver fidelity and dosage of active ingredients and child spoken language outcomes is needed. Supplemental material: https://doi.org/10.23641/asha.25156223.
MeSH term(s)	Humans ; Caregivers/education ; Caregivers/psychology ; Male ; Female ; Child, Preschool ; Telemedicine/methods ; Infant ; Autistic Disorder/therapy ; Autistic Disorder/psychology ; Treatment Outcome
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1154406-5
ISSN	1558-9110 ; 1058-0360
ISSN (online)	1558-9110
ISSN	1058-0360
DOI	10.1044/2023_AJSLP-23-00279
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Zs.A 3716: Show issues

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Article ; Online: Reply to 'Inadequate study designs for the evaluation of blood pressure monitoring devices and their potential misleading conclusions'.

Schutte, Aletta E / Tan, Isabella / Gnanenthiran, Sonali R / Chan, Justine / Kyriakoulis, Konstantinos G / Schlaich, Markus P / Rodgers, Anthony / Stergiou, George S

Journal of hypertension

2023 Volume 41, Issue 8, Page(s) 1349–1350

Language	English
Publishing date	2023-07-05
Publishing country	Netherlands
Document type	Journal Article ; Comment
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000003462
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Zs.MO 614: Show issues

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Article ; Online: Illuminating the druggable genome: Pathways to progress.

Sharma, Karlie R / Colvis, Christine M / Rodgers, Griffin P / Sheeley, Douglas M

Drug discovery today

2023 Volume 29, Issue 3, Page(s) 103805

Abstract: ... subset of druggable proteins are largely uncharacterized or understudied, with many falling within G ...

Abstract	There are ∼4500 genes within the 'druggable genome', the subset of the human genome that expresses proteins able to bind drug-like molecules, yet existing drugs only target a few hundred. A substantial subset of druggable proteins are largely uncharacterized or understudied, with many falling within G protein-coupled receptor (GPCR), ion channel, and kinase protein families. To improve scientific understanding of these three understudied protein families, the US National Institutes of Health launched the Illuminating the Druggable Genome Program. Now, as the program draws to a close, this review will lay out resources developed by the program that are intended to equip the scientific community with the tools necessary to explore previously understudied biology with the potential to rapidly impact human health.
MeSH term(s)	Humans ; Genome, Human ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Receptors, G-Protein-Coupled
Language	English
Publishing date	2023-10-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2023.103805
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Article ; Online: A novel approach to model cumulative stress: Area under the s-factor curve.

Mann, Frank D / Cuevas, Adolfo G / Clouston, Sean A P / Freilich, Colin D / Krizan, Zlatan / Zuber, Sascha / Wänström, Linda / Muniz-Terrera, Graciela / O'Keefe, Patrick / Voll, Stacey / Hofer, Scott / Rodgers, Joseph L / Krueger, Robert F

Social science & medicine (1982)

2024 Volume 348, Page(s) 116787

Abstract: Objective: Using a large longitudinal sample of adults from the Midlife in the United States (MIDUS) study, the present study extended a recently developed hierarchical model to determine how best to model the accumulation of stressors, and to determine ...

Abstract	Objective: Using a large longitudinal sample of adults from the Midlife in the United States (MIDUS) study, the present study extended a recently developed hierarchical model to determine how best to model the accumulation of stressors, and to determine whether the rate of change in stressors or traditional composite scores of stressors are stronger predictors of health outcomes. Method: We used factor analysis to estimate a stress-factor score and then, to operationalize the accumulation of stressors we examined five approaches to aggregating information about repeated exposures to multiple stressors. The predictive validity of these approaches was then assessed in relation to different health outcomes. Results: The prediction of chronic conditions, body mass index, difficulty with activities of daily living, executive function, and episodic memory later in life was strongest when the accumulation of stressors was modeled using total area under the curve (AUC) of estimated factor scores, compared to composite scores that have traditionally been used in studies of cumulative stress, as well as linear rates of change. Conclusions: Like endogenous, biological markers of stress reactivity, AUC for individual trajectories of self-reported stressors shows promise as a data reduction technique to model the accumulation of stressors in longitudinal studies. Overall, our results indicate that considering different quantitative models is critical to understanding the sequelae and predictive power of psychosocial stressors from midlife to late adulthood.
MeSH term(s)	Humans ; Stress, Psychological/psychology ; Male ; Female ; Middle Aged ; Longitudinal Studies ; United States/epidemiology ; Aged ; Area Under Curve ; Factor Analysis, Statistical ; Adult ; Activities of Daily Living/psychology ; Chronic Disease/psychology ; Body Mass Index
Language	English
Publishing date	2024-03-24
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2024.116787
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Article ; Online: Evaluation of the ability of a commercially available cuffless wearable device to track blood pressure changes.

Tan, Isabella / Gnanenthiran, Sonali R / Chan, Justine / Kyriakoulis, Konstantinos G / Schlaich, Markus P / Rodgers, Anthony / Stergiou, George S / Schutte, Aletta E

Journal of hypertension

2023 Volume 41, Issue 6, Page(s) 1003–1010

Abstract: ... average SBP for 24-h (difference 4.9 mmHg, 95% CI [1.9, 7.9]) and night-time (15.5[11.8, 19.1] mmHg; all P ... 0.01), but similar daytime (1.0 [-1.8, 3.8] mmHg; P = 0.48). Similarly, average cuffless DBP was ... higher for 24-h (4.2 [2.3, 6.0] mmHg) and night-time (11.8 [9.5, 14.1] mmHg; both P < 0.001 ...

Abstract	Objectives: Cuffless wearable blood pressure (BP) devices may allow detailed evaluation of BP for prolonged periods, but their ability to accurately track BP changes is uncertain. We investigated whether a commercially available cuffless wearable device tracks: 24-h systolic (SBP) and diastolic BP (DBP) compared to conventional ambulatory monitoring (ABPM); and antihypertensive medication-induced BP changes compared to cuff-based home BP monitoring (HBPM). Methods: We fitted 41 participants (32% females, 58 ± 14 years, 80% hypertensive) with a wrist-wearable cuffless BP device (Aktiia) continuously for 6-12 days. At the beginning and the end of this period, 24-h ABPM was performed. Three participants with hypertension (one female; 60 ± 8 years) wore the Aktiia device and performed HBPM continuously one week before and 2 weeks after antihypertensive medication uptitration. Results: Compared to ABPM, Aktiia reported higher average SBP for 24-h (difference 4.9 mmHg, 95% CI [1.9, 7.9]) and night-time (15.5[11.8, 19.1] mmHg; all P ≤ 0.01), but similar daytime (1.0 [-1.8, 3.8] mmHg; P = 0.48). Similarly, average cuffless DBP was higher for 24-h (4.2 [2.3, 6.0] mmHg) and night-time (11.8 [9.5, 14.1] mmHg; both P < 0.001), but similar during daytime (1.4 [-0.4, 3.23] mmHg; P = 0.13). Aktiia also reported reduced night-time dip for SBP (difference 14.2 [12.1, 16.3] mmHg) and DBP (10.2 [8.5, 11.9] mmHg; both P < 0.001). The average medication-induced SBP/DBP decline after 2 weeks of uptitration was -1.0/-0.8 mmHg with Aktiia vs. -19.7/-11.5 mmHg with HBPM ( P = 0.03 for difference). Conclusion: This cuffless wearable device did not accurately track night-time BP decline and results suggested it was unable to track medication-induced BP changes.
MeSH term(s)	Humans ; Female ; Male ; Blood Pressure/physiology ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Blood Pressure Determination/methods ; Hypertension/diagnosis ; Hypertension/drug therapy ; Blood Pressure Monitoring, Ambulatory ; Wearable Electronic Devices
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2023-04-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000003428
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