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  1. Article ; Online: ACR Presidential Address: Rheumatologists-Folks You Can Trust.

    Saag, Kenneth G

    Arthritis & rheumatology (Hoboken, N.J.)

    2023  Volume 75, Issue 5, Page(s) 645–649

    MeSH term(s) Humans ; Rheumatologists ; Trust ; Rheumatology ; Societies, Medical
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42475
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  2. Article: GLUCOCORTICOIDS IN CHRONIC DISEASE: THE GOOD, THE BAD, THE BONE.

    Saag, Kenneth G

    Transactions of the American Clinical and Climatological Association

    2023  Volume 133, Page(s) 69–80

    Abstract: Despite the advent of more targeted therapies, glucocorticoids (steroids) remain in chronic use (defined as > 3 months or more) by an estimated 0.5% of the population. Steroids yield symptomatic benefits for systemic and local inflammation as well as ... ...

    Abstract Despite the advent of more targeted therapies, glucocorticoids (steroids) remain in chronic use (defined as > 3 months or more) by an estimated 0.5% of the population. Steroids yield symptomatic benefits for systemic and local inflammation as well as disease-modifying properties in rheumatoid arthritis, the most common disorder for their chronic use. Despite their many benefits, steroids have been associated with a myriad of common side effects. Observational studies of steroid safety are limited by confounding by indication, and randomized controlled trials have been too short and too small to understand their true safety profile. Glucocorticoid-induced osteoporosis (GIOP) occurs in a time- and dose-dependent way and is associated with both a reduction in bone formation and an increase in bone resorption. Numerous anti-osteoporotic therapies have efficacy for improving bone health among chronic glucocorticoid users, but implementation science approaches are needed to achieve adequate GIOP prevention and to reduce fracture outcomes.
    MeSH term(s) Humans ; Glucocorticoids/adverse effects ; Chronic Disease ; Arthritis, Rheumatoid/drug therapy ; Drug-Related Side Effects and Adverse Reactions ; Inflammation
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603823-2
    ISSN 0065-7778
    ISSN 0065-7778
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  3. Book: Best practices in systems based interventions to reduce the burden of fractures

    Saag, Kenneth G.

    Washington, DC, 9 - 10 Decmber 2010

    (Osteoporosis international ; 22, Suppl. 3)

    2011  

    Title variant Best practices in systems-based interventions to reduce the burden of fractures
    Author's details guest ed.: Kenneth G. Saag
    Series title Osteoporosis international ; 22, Suppl. 3
    Collection
    Language English
    Size S. S441 - S500 : Ill., graph. Darst.
    Publisher Springer
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016955385
    Database Catalogue ZB MED Medicine, Health

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  4. Book: Osteoporosis

    Saag, Kenneth G.

    (Best practice & research : Clinical rheumatology ; 23,6)

    2009  

    Author's details Kenneth G. Saag ..., guest ed
    Series title Best practice & research : Clinical rheumatology ; 23,6
    Best practice & research
    Best practice & research ; Clinical rheumatology
    Collection Best practice & research
    Best practice & research ; Clinical rheumatology
    Language English
    Size S. 709 - 811 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016182172
    Database Catalogue ZB MED Medicine, Health

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    Se 1036 -23,6- verfügbar in Königswinter Königswinter

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  5. Book: Quality of care in rheumatology

    Saag, Kenneth G.

    opportunities and challenges

    (Clinical and experimental rheumatology : Suppl. ; 47 ; Clinical and experimental rheumatology : Annual supplement on contemporary topics in rheumatology ; 2007)

    2007  

    Author's details guest ed. K. Saag
    Series title Clinical and experimental rheumatology : Suppl. ; 47
    Clinical and experimental rheumatology : Annual supplement on contemporary topics in rheumatology ; 2007
    Clinical and experimental rheumatology
    Clinical and experimental rheumatology
    Clinical and experimental rheumatology ; Suppl.
    Clinical and experimental rheumatology ; Annual supplement on contemporary topics in rheumatology
    Collection Clinical and experimental rheumatology
    Clinical and experimental rheumatology
    Clinical and experimental rheumatology ; Suppl.
    Clinical and experimental rheumatology ; Annual supplement on contemporary topics in rheumatology
    Language English
    Size IV, S-177 S. : graph. Darst.
    Publishing place Pisa
    Publishing country Italy
    Document type Book
    HBZ-ID HT015444930
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2002 -Suppl.47- not available for loan Zeitschriften-Lesesaal

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  6. Book ; Conference proceedings: Case studies in gouty arthritis

    Saag, Kenneth G.

    based on a Symposium Entitled, "Management of Hyperuricemia and Gout Expert Opinion Meeting," held May 1 - 3, 2005, in New York, New York

    (The American journal of medicine ; 119,11A = Suppl.)

    2006  

    Event/congress Symposium Entitled Management of Hyperuricemia and Gout Expert Opinion Meeting (2005, NewYorkNY)
    Author's details guest ed. Kenneth G. Saag
    Series title The American journal of medicine ; 119,11A = Suppl.
    Collection
    Language English
    Size S31 S. : graph. Darst.
    Publisher Elsevier
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014913033
    Database Catalogue ZB MED Medicine, Health

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    Ua VI Zs 289 -119,11A- verfügbar in Königswinter Königswinter

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  7. Article ; Online: What's new on the front-line of gout pharmacotherapy?

    Blake, Kurt E G / Saag, Jordan L / Saag, Kenneth G

    Expert opinion on pharmacotherapy

    2022  Volume 23, Issue 4, Page(s) 453–464

    Abstract: Introduction: Gout is the most common form of inflammatory arthritis affecting millions of persons around the world. Painful flares and tophaceous deposits are debilitating, reduce quality of life and put strain on health-care systems.: Areas covered!# ...

    Abstract Introduction: Gout is the most common form of inflammatory arthritis affecting millions of persons around the world. Painful flares and tophaceous deposits are debilitating, reduce quality of life and put strain on health-care systems.
    Areas covered: This review provides an overview of the treatment of gout flares and lowering serum urate. First line agents are discussed with emphasis on emerging evidence. Novel therapies are also covered.
    Expert opinion: Lifestyle modifications form a part of gout prevention. NSAIDs, colchicine, and glucocorticoids are first line agents for gout flares. The IL-1β antagonists are highly effective for arresting flares but their cost-effectiveness render them salvage therapies. Allopurinol is an agent of first choice for urate lowering therapy. In Southeast Asian and Black populations, screening for HLA*B58:01 mutation is a cost-effective approach to decrease the occurrence of allopurinol hypersensitivity syndrome. Febuxostat is another efficacious urate lowering therapy, but has received a U.S. FDA black box warning for cardiovascular safety. Novel uricosurics are a class for continued drug development; verinurad and arhalofenate are agents with future promise. For patients with recalcitrant gout, pegloticase is effective. Its immunogenicity significantly threatens the achievement of sustained urate lowering responses. Abrogating pegloticase's immunogenicity with immunomodulatory co-therapy may lend to sustained efficacy.
    MeSH term(s) Allopurinol ; Febuxostat/therapeutic use ; Gout/drug therapy ; Gout Suppressants/therapeutic use ; Humans ; Quality of Life ; Uric Acid
    Chemical Substances Gout Suppressants ; Febuxostat (101V0R1N2E) ; Uric Acid (268B43MJ25) ; Allopurinol (63CZ7GJN5I)
    Language English
    Publishing date 2022-01-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2021.2020249
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  8. Article ; Online: Risk for osteoporosis and fracture with glucocorticoids.

    Urquiaga, Mariana / Saag, Kenneth G

    Best practice & research. Clinical rheumatology

    2022  Volume 36, Issue 3, Page(s) 101793

    Abstract: Glucocorticoid use is ubiquitous and is associated with multiple adverse reactions. Among them, osteoporosis and bone fractures are of our concern. In this review, we present current evidence on the effect of glucocorticoids on bone mineral density and ... ...

    Abstract Glucocorticoid use is ubiquitous and is associated with multiple adverse reactions. Among them, osteoporosis and bone fractures are of our concern. In this review, we present current evidence on the effect of glucocorticoids on bone mineral density and the risk of fractures, the mechanisms underlying those effects, and the recommendations for monitoring and treating patients who take them. The bone mineral density of the lumbar spine and total hip is lower, and the risk of fractures is higher in glucocorticoid users than non-users. These effects have a rapid onset, are dose-dependent, and improve soon after discontinuation of glucocorticoids. They also appear to occur even with non-systemic routes of administration and with low doses. Glucocorticoids reduce bone mineral density by increasing osteoclast activity and decreasing osteoblast and osteocyte activity. Calcium metabolism and parathyroid hormone activity are less important than was initially thought. Treatment decisions are on risk stratification using clinical, radiographic, and prediction tools. Our armamentarium for the treatment and prevention of glucocorticoid-induced osteoporosis includes calcium and vitamin D, bisphosphonates, recombinant parathyroid hormone, monoclonal antibodies against receptor activator of nuclear factor kappa-B ligand, and hormone treatments.
    Language English
    Publishing date 2022-11-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2022.101793
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  9. Article ; Online: Defining the key clinician skills and attributes for competency in managing patients with osteoporosis and fragility fractures.

    Jackson, Lesley E / Saag, Kenneth G / Johnson, Sindhu R / Danila, Maria I

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2024  

    Abstract: Osteoporosis and fragility fractures are managed by clinicians across many medical specialties. The key competencies of clinicians delivering bone health care have not been systematically established. We aimed to develop a decision rule to define the ... ...

    Abstract Osteoporosis and fragility fractures are managed by clinicians across many medical specialties. The key competencies of clinicians delivering bone health care have not been systematically established. We aimed to develop a decision rule to define the threshold of adequate skills and attributes associated with clinical competency in bone health for a clinician serving as a referral source for bone health care. Using a modified-Delphi method, we invited clinicians with expertise in treating osteoporosis and representatives of patient advocacy groups focused on bone health to create a list of desirable characteristics of a clinician with bone health competency. Characteristics were defined as "attributes" with "levels" within each attribute. Participants prioritized levels by perceived importance. To identify the cut points for defining adequate competency, participants next ranked 20 hypothetical clinicians defined by various levels of attributes from highest to lowest likelihood of having adequate bone health competency. Lastly, we conducted a discrete choice experiment (DCE) to generate a weighted score for each attribute/level. The threshold for competency was a priori determined as the total weighted score at which ≥70% of participants agreed a clinician had adequate bone health competency. Thirteen participants generated lists of desirable characteristics, and 30 participants ranked hypothetical scenarios and participated in the DCE. The modified-Delphi exercise generated 108 characteristics, which were reduced to 8 categories with 20 levels with associated points. The maximum possible score was 25 points. A summed threshold score of >12 points classified a clinician as having adequate bone health competency. We developed a numeric additive decision rule to define clinicians across multiple specialties as having adequate competency in managing bone health/osteoporosis. Our data provides a rigorously defined criteria for a clinician with competency in bone health and can be used to quantitate the skills of clinicians participating in bone health research and clinical care.
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1093/jbmr/zjae019
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  10. Article ; Online: "Burnout" Coupled with Workforce Shortages Spells Trouble: Innovative Solutions Are Essential for More Satisfying Rheumatology Practice.

    Calabrese, Lenny / Battafarano, Daniel F / Stamatos, Christine / Saag, Kenneth G

    Arthritis & rheumatology (Hoboken, N.J.)

    2023  Volume 75, Issue 9, Page(s) 1499–1502

    MeSH term(s) Humans ; Rheumatology ; Workforce ; Burnout, Professional
    Language English
    Publishing date 2023-06-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42537
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