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  1. Article ; Online: Collision Energy Analysis within the Vertical Shaft Impact Crusher Based on the Computational Fluid Dynamics-Discrete Element Method.

    Wu, Canhui / Zhao, Limei / Cao, Zhen

    ACS omega

    2024  Volume 9, Issue 7, Page(s) 7967–7975

    Abstract: Particles in the vertical shaft impact crusher absorb and dissipate collision energy in the impact breakage. The distribution of the collision energy determines the breakage rate of materials and breakage energy consumption of the entire system. In this ... ...

    Abstract Particles in the vertical shaft impact crusher absorb and dissipate collision energy in the impact breakage. The distribution of the collision energy determines the breakage rate of materials and breakage energy consumption of the entire system. In this paper, the gas-solid coupling method is used to explore the regional distribution of collision energy, collision frequency, and collision energy spectrum of the material particle groups. Hence, a theoretical basis is provided for the efficient and energy-saving design of the crusher. First, a coupling mathematical model of the computational fluid dynamics and discrete element method is established to describe the interaction between material and fluid in the crushing chamber. Moreover, the experiment is carried out using a PL8500 VSI crusher and compared with the simulation results to verify the model's reliability. Finally, the effects of different working conditions on the energy dissipation distribution and energy spectrum are explored. The results show that the collision energy within the crushing chamber can be accurately predicted by using the fluid-solid coupling model. Moreover, increasing the rotational speed can effectively transform low-energy collision events into high-energy collisions and increase the collision frequency with energy dissipation above the threshold energy. Thus, the probability of material breakage is increased. Last, increasing the feed rate minorly affects the material breakage rate, while the specific energy of the entire system is reduced.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Spatiotemporal Transcriptome Analysis Reveals Activation of the AP1 Pathway in the Ovarian Microenvironment during the Transition from Premenopause to Postmenopause.

    Pei, Wendi / Cao, Xiaomin / Zhang, Puyao / Fu, Lin / Zhou, Ping / Liu, Ye / Fan, Yong / Xu, Fengqin / Cao, Canhui / Yu, Yang

    Aging and disease

    2024  Volume 15, Issue 2, Page(s) 445–448

    MeSH term(s) Female ; Humans ; Premenopause/physiology ; Postmenopause/physiology ; Perimenopause ; Ovary ; Gene Expression Profiling
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2625789-0
    ISSN 2152-5250 ; 2152-5250
    ISSN (online) 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2023.0707-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome.

    Zhou, Ping / Feng, Penghui / Liao, Baoying / Fu, Lin / Shan, Hongying / Cao, Canhui / Luo, Renxin / Peng, Tianliu / Liu, Fenting / Li, Rong

    Journal of ovarian research

    2024  Volume 17, Issue 1, Page(s) 69

    Abstract: Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic condition in women of childbearing age and a major cause of anovulatory infertility. The pathophysiology of PCOS is complex. Recent studies have reported that apart from ... ...

    Abstract Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic condition in women of childbearing age and a major cause of anovulatory infertility. The pathophysiology of PCOS is complex. Recent studies have reported that apart from hyperandrogenism, insulin resistance, systemic chronic inflammation, and ovarian dysfunction, gut microbiota dysbiosis is also involved in PCOS development and may aggravate inflammation and metabolic dysfunction, forming a vicious cycle. As naturally occurring plant secondary metabolites, polyphenols have been demonstrated to have anticancer, antibacterial, vasodilator, and analgesic properties, mechanistically creating putative bioactive, low-molecular-weight metabolites in the human gut. Here, we summarize the role of gut microbiota dysbiosis in the development of PCOS and demonstrate the ability of different polyphenols - including anthocyanin, catechins, and resveratrol - to regulate gut microbes and alleviate chronic inflammation, thus providing new insights that may assist in the development of novel therapeutic strategies to treat women with PCOS.
    MeSH term(s) Female ; Humans ; Polycystic Ovary Syndrome/complications ; Gastrointestinal Microbiome/physiology ; Polyphenols/pharmacology ; Polyphenols/therapeutic use ; Dysbiosis/complications ; Hyperandrogenism ; Insulin Resistance/physiology ; Inflammation/drug therapy ; Inflammation/metabolism
    Chemical Substances Polyphenols
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2455679-8
    ISSN 1757-2215 ; 1757-2215
    ISSN (online) 1757-2215
    ISSN 1757-2215
    DOI 10.1186/s13048-024-01354-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Single-cell transcriptome analysis of the mouse and primate ovaries reveals oocyte-specific expression patterns of risk genes in ovarian aging.

    Wei, Ye / Xu, Miaochun / Liu, Xiaoyu / Lin, Shitong / Pei, Wendi / Zhou, Ping / Liu, He / Wu, Peng / Yu, Yang / Cao, Canhui

    MedComm

    2023  Volume 4, Issue 2, Page(s) e209

    Language English
    Publishing date 2023-02-16
    Publishing country China
    Document type Journal Article
    ISSN 2688-2663
    ISSN (online) 2688-2663
    DOI 10.1002/mco2.209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dose-dense regimen versus conventional three-weekly paclitaxel combination with carboplatin chemotherapy in first-line ovarian cancer treatment: a systematic review and meta-analysis.

    Gong, Wenjian / Yu, Ruidi / Cao, Canhui / Fang, Yong / Zhao, Xuejiao / Gao, Qinglei

    Journal of ovarian research

    2023  Volume 16, Issue 1, Page(s) 136

    Abstract: Background: Paclitaxel dose-dense regimen has been controversial in clinical trials in recent years. This systematic review and meta-analysis tried to evaluate the efficacy and safety of paclitaxel dose-dense chemotherapy in primary epithelial ovarian ... ...

    Abstract Background: Paclitaxel dose-dense regimen has been controversial in clinical trials in recent years. This systematic review and meta-analysis tried to evaluate the efficacy and safety of paclitaxel dose-dense chemotherapy in primary epithelial ovarian cancer.
    Methods: An electronic search following PRISMA guidelines was conducted (Prospero registration number: CRD42020187622), and then a systematic review and meta-analysis of included literature were initiated to determine which regimen was better.
    Results: Four randomized controlled trials were included in the qualitative evaluation, and 3699 ovarian cancer patients were included in the meta-analysis. The meta-analysis revealed that the dose-dense regimen could prolong PFS (HR0.88, 95%CI 0.81-0.96; p = 0.002) and OS (HR0.90, 95%CI 0.81-1.02; p = 0.09), but it also increased the overall toxicity (OR = 1.102, 95%CI 0.864-1.405; p = 0.433), especially toxicity of anemia (OR = 1.924, 95%CI 1.548-2.391; p < 0.001), neutropenia (OR = 2.372, 95%CI 1.674-3.361; p < 0.001). Subgroup analysis indicated that the dose-dense regimen could significantly prolong not only PFS (HR0.76, 95%CI 0.63-0.92; p = 0.005 VS HR0.91, 95%CI 0.83-1.00; p = 0.046) but also OS (HR0.75, 95%CI 0.557-0.98; p = 0.037 VS HR0.94, 95%CI 0.83-1.07; p = 0.371) in Asian, and overall toxicity was significantly increased in Asians (OR = 1.28, 95%CI: 0.877-1.858, p = 0.202) compared to non-Asians (OR = 1.02, 95%CI 0.737-1.396, p = 0.929).
    Conclusion: Paclitaxel dose-dense regimen could prolong PFS and OS, but it also increased the overall toxicity. Therapeutic benefits and toxicity of dose-dense are more obvious in Asians compared to non-Asians, which need to be further confirmed in clinical trials.
    MeSH term(s) Humans ; Female ; Carboplatin/therapeutic use ; Paclitaxel ; Ovarian Neoplasms/drug therapy ; Carcinoma, Ovarian Epithelial/drug therapy ; Randomized Controlled Trials as Topic
    Chemical Substances Carboplatin (BG3F62OND5) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2455679-8
    ISSN 1757-2215 ; 1757-2215
    ISSN (online) 1757-2215
    ISSN 1757-2215
    DOI 10.1186/s13048-023-01216-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Structural Variations of the 3D Genome Architecture in Cervical Cancer Development.

    Adeel, Muhammad Muzammal / Jiang, Hao / Arega, Yibeltal / Cao, Kai / Lin, Da / Cao, Canhui / Cao, Gang / Wu, Peng / Li, Guoliang

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 706375

    Abstract: Human papillomavirus (HPV) integration is the major contributor to cervical cancer (CC) development by inducing structural variations (SVs) in the human genome. SVs are directly associated with the three-dimensional (3D) genome structure leading to ... ...

    Abstract Human papillomavirus (HPV) integration is the major contributor to cervical cancer (CC) development by inducing structural variations (SVs) in the human genome. SVs are directly associated with the three-dimensional (3D) genome structure leading to cancer development. The detection of SVs is not a trivial task, and several genome-wide techniques have greatly helped in the identification of SVs in the cancerous genome. However, in cervical cancer, precise prediction of SVs mainly translocations and their effects on 3D-genome and gene expression still need to be explored. Here, we have used high-throughput chromosome conformation capture (Hi-C) data of cervical cancer to detect the SVs, especially the translocations, and validated it through whole-genome sequencing (WGS) data. We found that the cervical cancer 3D-genome architecture rearranges itself as compared to that in the normal tissue, and 24% of the total genome switches their A/B compartments. Moreover, translocation detection from Hi-C data showed the presence of high-resolution
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.706375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Interfacial Electrostatic Self-Assembly of Amyloid Fibrils into Multifunctional Protein Films.

    Han, Yangyang / Cao, Yiping / Zhou, Jiangtao / Yao, Yang / Wu, Xiaodong / Bolisetty, Sreenath / Diener, Michael / Handschin, Stephan / Lu, Canhui / Mezzenga, Raffaele

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 9, Page(s) e2206867

    Abstract: Amyloid fibrils have generated steadily increasing traction in the development of natural and artificial materials. However, it remains a challenge to construct bulk amyloid films directly from amyloid fibrils due to their intrinsic brittleness. Here, a ... ...

    Abstract Amyloid fibrils have generated steadily increasing traction in the development of natural and artificial materials. However, it remains a challenge to construct bulk amyloid films directly from amyloid fibrils due to their intrinsic brittleness. Here, a facile and general methodology to fabricate macroscopic and tunable amyloid films via fast electrostatic self-assembly of amyloid fibrils at the air-water interface is introduced. Benefiting from the excellent templating properties of amyloid fibrils for nanoparticles (such as conductive carbon nanotubes or magnetic Fe
    MeSH term(s) Amyloid/metabolism ; Static Electricity ; Nanotubes, Carbon ; Amyloidogenic Proteins ; Nanoparticles
    Chemical Substances Amyloid ; Nanotubes, Carbon ; Amyloidogenic Proteins
    Language English
    Publishing date 2023-01-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202206867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: HGR-Net: Hierarchical Graph Reasoning Network for Arbitrary Shape Scene Text Detection.

    Bi, Hengyue / Xu, Canhui / Shi, Cao / Liu, Guozhu / Zhang, Honghong / Li, Yuteng / Dong, Junyu

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2023  Volume 32, Page(s) 4142–4155

    Abstract: As a prerequisite step of scene text reading, scene text detection is known as a challenging task due to natural scene text diversity and variability. Most existing methods either adopt bottom-up sub-text component extraction or focus on top-down text ... ...

    Abstract As a prerequisite step of scene text reading, scene text detection is known as a challenging task due to natural scene text diversity and variability. Most existing methods either adopt bottom-up sub-text component extraction or focus on top-down text contour regression. From a hybrid perspective, we explore hierarchical text instance-level and component-level representation for arbitrarily-shaped scene text detection. In this work, we propose a novel Hierarchical Graph Reasoning Network (HGR-Net), which consists of a Text Feature Extraction Network (TFEN) and a Text Relation Learner Network (TRLN). TFEN adaptively learns multi-grained text candidates based on shared convolutional feature maps, including instance-level text contours and component-level quadrangles. In TRLN, an inter-text graph is constructed to explore global contextual information with position-awareness between text instances, and an intra-text graph is designed to estimate geometric attributes for establishing component-level linkages. Next, we bridge the cross-feed interaction between instance-level and component-level, and it further achieves hierarchical relational reasoning by learning complementary graph embeddings across levels. Experiments conducted on three publicly available benchmarks SCUT-CTW1500, Total-Text, and ICDAR15 have demonstrated that HGR-Net achieves state-of-the-art performance on arbitrary orientation and arbitrary shape scene text detection.
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2023.3294822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Single‐cell transcriptome analysis of the mouse and primate ovaries reveals oocyte‐specific expression patterns of risk genes in ovarian aging

    Ye Wei / Miaochun Xu / Xiaoyu Liu / Shitong Lin / Wendi Pei / Ping Zhou / He Liu / Peng Wu / Yang Yu / Canhui Cao

    MedComm, Vol 4, Iss 2, Pp n/a-n/a (2023)

    2023  

    Keywords Medicine ; R
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: A novel cuproptosis-related gene signature for overall survival prediction in uterine corpus endometrial carcinoma (UCEC).

    Lin, Shitong / Xu, Yashi / Liu, Binghan / Zheng, Lingling / Cao, Canhui / Wu, Peng / Ding, Wencheng / Ren, Fang

    Heliyon

    2023  Volume 9, Issue 4, Page(s) e14613

    Abstract: Cuproptosis is a copper-dependent model of cell death involved in tumor genesis and progression. Its roles in uterine corpus endometrial carcinoma (UCEC) remains elusive. Here, we aimed to explore the expression and prognostic values of cuprotosis- ... ...

    Abstract Cuproptosis is a copper-dependent model of cell death involved in tumor genesis and progression. Its roles in uterine corpus endometrial carcinoma (UCEC) remains elusive. Here, we aimed to explore the expression and prognostic values of cuprotosis-related genes (CRGs) in UCEC. Expression profiles and clinical data of UCEC were downloaded from The Cancer Genome Atlas (TCGA), and randomly divided into testing or training cohort (1:1 ratio). The CRG signature was identified by LASSO regression analysis. The differentially expressed genes and their functional enrichment analysis were performed by the "limma" R package and Metascape, respectively. The immunocytes infiltration was measured by TIMER, and "GSVA" R package. In total, seven differentially expressed prognostic genes of CRGs in UCEC were identified, and four genes (
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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