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  1. Article: Acute and Subchronic Toxicity Study of Flavonoid Rich Extract of

    Bhide, Ranjit M / Bethapudi, Bharathi / Chalichem, Nehru Sai Suresh / Nithyanantham, Muruganantham / Murugan, Sasi Kumar / Mundkinajeddu, Deepak

    Journal of toxicology

    2022  Volume 2022, Page(s) 8517603

    Abstract: Glycyrrhiza ... ...

    Abstract Glycyrrhiza glabra
    Language English
    Publishing date 2022-03-31
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2495098-1
    ISSN 1687-8205 ; 1687-8191
    ISSN (online) 1687-8205
    ISSN 1687-8191
    DOI 10.1155/2022/8517603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy.

    Chalichem, Nehru Sai Suresh / Bethapudi, Bharathi / Mundkinajeddu, Deepak

    Medical hypotheses

    2020  Volume 144, Page(s) 109984

    Abstract: In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and ... ...

    Abstract In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and clarithromycin etc., have been reported to act against respiratory infections but they lack the ability of immunity enhancement through defensins. The aminoglycosides were proved to have defensin mediated antiviral activity, that could enhance the immunity. So, Consideration of aminoglycosides can be a double edge sword viz., against respiratory infection as well as Immunity enhancer (along with anti-virals) for COVID-19 regimen.
    MeSH term(s) Aminoglycosides/pharmacology ; Aminoglycosides/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/immunology ; Codon, Nonsense/drug effects ; Defensins/biosynthesis ; Defensins/genetics ; Defensins/physiology ; Drug Repositioning ; Humans ; Immunity, Innate/drug effects ; Immunologic Factors/pharmacology ; Immunologic Factors/therapeutic use ; Macrolides/therapeutic use ; Models, Genetic ; Pandemics ; SARS-CoV-2/physiology ; Transcription, Genetic/drug effects ; Virus Internalization
    Chemical Substances Aminoglycosides ; Antiviral Agents ; Codon, Nonsense ; Defensins ; Immunologic Factors ; Macrolides ; theta-defensin
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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  3. Article: Dipeptidyl peptidase-IV inhibitory action of Calebin A: An in silico and in vitro analysis.

    Chalichem, Nehru Sai Suresh / Jupudi, Srikanth / Yasam, Venkata Ramesh / Basavan, Duraiswamy

    Journal of Ayurveda and integrative medicine

    2021  Volume 12, Issue 4, Page(s) 663–672

    Abstract: Background: Dipeptidyl peptidase-IV (DPP-IV) inhibitors, the enhancers of incretin are used for the treatment of diabetes. The non-glycaemic actions of these drugs (under developmental stage) also proved that repurposing of these molecules may be ... ...

    Abstract Background: Dipeptidyl peptidase-IV (DPP-IV) inhibitors, the enhancers of incretin are used for the treatment of diabetes. The non-glycaemic actions of these drugs (under developmental stage) also proved that repurposing of these molecules may be advantageous for other few complicated disorders like cardiovascular diseases, Parkinson's disease, Alzheimer's disease, etc. OBJECTIVE: The present study was aimed to investigate the DPP-IV inhibitory potential of Calebin-A, one of the constituents of Curcuma longa.
    Material and methods: The phytoconstituent was subjected for various in silico studies (using Schrödinger Suite) like, Docking analysis, molecular mechanics combined with generalized Born model and solvent accessibility method (MMGBSA) and Induced fit docking (IFD) after validating the protein using Ramachandran plot. Further, the protein-ligand complex was subjected to molecular dynamic simulation studies for 50 nanoseconds. And finally, the results were confirmed through enzyme inhibition study.
    Results: Insilico results revealed possible inhibitory binding interactions in the catalytic pocket (importantly Glu205, Glu206 and Tyr 662 etc.) and binding affinity in terms of glide g-score and MMGBSA dG bind values were found to be -6.2 kcal/mol and -98.721 kcal/mol. Further, the inhibitory action towards the enzyme was confirmed by an enzyme inhibition assay, in which it showed dose-dependent inhibition, with maximum % inhibition of 55.9 at 26.3 μM. From molecular dynamic studies (50 nanoseconds), it was understood that Calebin A was found to be stable for about 30 nanoseconds in maintaining inhibitory interactions.
    Conclusion: From the in silico and in vitro analysis, the current research emphasizes the consideration of Calebin A to be as a promising or lead compound for the treatment of several ailments where DPP-IV action is culprit.
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Journal Article
    ISSN 0975-9476
    ISSN 0975-9476
    DOI 10.1016/j.jaim.2021.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Aminoglycosides can be a better choice over macrolides in COVID-19 regimen

    Chalichem, Nehru Sai Suresh / Bethapudi, Bharathi / Mundkinajeddu, Deepak

    Medical Hypotheses

    Plausible mechanism for repurposing strategy

    2020  Volume 144, Page(s) 109984

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109984
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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  5. Article: Dipeptidyl peptidase-IV inhibitory action of Calebin A: An in silico and in vitro analysis

    Chalichem, Nehru Sai Suresh / Jupudi, Srikanth / Yasam, Venkata Ramesh / Basavan, Duraiswamy

    Journal of Ayurveda and integrative medicine. 2021 Oct., Dec., v. 12, no. 4

    2021  

    Abstract: Dipeptidyl peptidase-IV (DPP-IV) inhibitors, the enhancers of incretin are used for the treatment of diabetes. The non-glycaemic actions of these drugs (under developmental stage) also proved that repurposing of these molecules may be advantageous for ... ...

    Abstract Dipeptidyl peptidase-IV (DPP-IV) inhibitors, the enhancers of incretin are used for the treatment of diabetes. The non-glycaemic actions of these drugs (under developmental stage) also proved that repurposing of these molecules may be advantageous for other few complicated disorders like cardiovascular diseases, Parkinson's disease, Alzheimer's disease, etc.The present study was aimed to investigate the DPP-IV inhibitory potential of Calebin-A, one of the constituents of Curcuma longa.The phytoconstituent was subjected for various in silico studies (using Schrödinger Suite) like, Docking analysis, molecular mechanics combined with generalized Born model and solvent accessibility method (MMGBSA) and Induced fit docking (IFD) after validating the protein using Ramachandran plot. Further, the protein-ligand complex was subjected to molecular dynamic simulation studies for 50 nanoseconds. And finally, the results were confirmed through enzyme inhibition study.Insilico results revealed possible inhibitory binding interactions in the catalytic pocket (importantly Glu205, Glu206 and Tyr 662 etc.) and binding affinity in terms of glide g-score and MMGBSA dG bind values were found to be −6.2 kcal/mol and −98.721 kcal/mol. Further, the inhibitory action towards the enzyme was confirmed by an enzyme inhibition assay, in which it showed dose-dependent inhibition, with maximum % inhibition of 55.9 at 26.3 μM. From molecular dynamic studies (50 nanoseconds), it was understood that Calebin A was found to be stable for about 30 nanoseconds in maintaining inhibitory interactions.From the in silico and in vitro analysis, the current research emphasizes the consideration of Calebin A to be as a promising or lead compound for the treatment of several ailments where DPP-IV action is culprit.
    Keywords Alzheimer disease ; Ayurvedic medicine ; Curcuma ; Parkinson disease ; computer simulation ; diabetes ; dipeptidyl-peptidase IV ; dose response ; enzyme inhibition ; mechanics ; models ; secretin ; solvents
    Language English
    Dates of publication 2021-10
    Size p. 663-672.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 0975-9476
    DOI 10.1016/j.jaim.2021.08.008
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy

    Chalichem, Nehru Sai Suresh / Bethapudi, Bharathi / Mundkinajeddu, Deepak

    Med Hypotheses

    Abstract: In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and ... ...

    Abstract In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and clarithromycin etc., have been reported to act against respiratory infections but they lack the ability of immunity enhancement through defensins. The aminoglycosides were proved to have defensin mediated antiviral activity, that could enhance the immunity. So, Consideration of aminoglycosides can be a double edge sword viz., against respiratory infection as well as Immunity enhancer (along with anti-virals) for COVID-19 regimen.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #592505
    Database COVID19

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  7. Article ; Online: Possible role of DPP4 inhibitors to promote hippocampal neurogenesis in Alzheimer's disease.

    Chalichem, Nehru Sai Suresh / Sai Kiran, Pindiprolu S S / Basavan, Duraiswamy

    Journal of drug targeting

    2018  Volume 26, Issue 8, Page(s) 670–675

    Abstract: As well-known to the scientific community, Alzheimer's disease (AD) is an irreversible neurodegenerative disease that ends up with impairment of memory and cognition. Patient quality of life can be enhanced by targeting neurogenesis as a therapeutic ... ...

    Abstract As well-known to the scientific community, Alzheimer's disease (AD) is an irreversible neurodegenerative disease that ends up with impairment of memory and cognition. Patient quality of life can be enhanced by targeting neurogenesis as a therapeutic paradigm. Preserving functional activity of SDF-1α and GLP-1 by DPPIV inhibition will enhance the homing of stem cells and modulate cell signalling pathways. The non-invasive approach presented in this article is a major advantage for managing AD, as regular/conventional stem-cell therapy necessarily relies on the application of regenerative stem cells exogenously. Using DPP-4 inhibitors to achieve the SDF-1α/CXCR4 axis stabilisation and augmenting GLP-1 levels, will enhance the homing/recruitment of brain resident and non-resident circulating stem cells/progenitor cells towards the sites of lesion to increase synaptic plasticity, a promising approach and also a novel one as well.
    MeSH term(s) Alzheimer Disease/pathology ; Dipeptidyl Peptidase 4/drug effects ; Hippocampus/drug effects ; Hippocampus/pathology ; Humans ; Neurogenesis/drug effects ; Protease Inhibitors/pharmacology
    Chemical Substances Protease Inhibitors ; DPP4 protein, human (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
    Language English
    Publishing date 2018-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2018.1433682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4481: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: DPP4 Inhibitors Can Be a Drug of Choice for Type 3 Diabetes: A Mini Review.

    Chalichem, Nehru Sai Suresh / Gonugunta, Chaitanya / Krishnamurthy, Praveen Thaggikuppe / Duraiswamy, Basavan

    American journal of Alzheimer's disease and other dementias

    2017  Volume 32, Issue 7, Page(s) 444–451

    Abstract: As well known to the scientific community, Alzheimer's disease (AD) is an irreversible neurodegenerative disease that ends up with impairment of memory and cognition due to neuronal and synapse loss. Patient's quality of life can be enhanced by targeting ...

    Abstract As well known to the scientific community, Alzheimer's disease (AD) is an irreversible neurodegenerative disease that ends up with impairment of memory and cognition due to neuronal and synapse loss. Patient's quality of life can be enhanced by targeting neurogenesis as a therapeutic paradigm. Moreover, several research evidences support the concept that AD is a type of metabolic disorder mediated by impairment in brain insulin responsiveness and energy metabolism. Growing evidence suggests that endogenous peptides such as glucagon-like peptide-1 (GLP-1) and stromal-derived factor-1α (SDF-1α) provide neuroprotection across a range of experimental models of AD. So, preserving functional activity of SDF-1α and GLP-1 by dipeptidyl peptidase-4 inhibition will enhance the homing/recruitment of brain resident and nonresident circulating stem cells/progenitor cells, a noninvasive approach for promoting neurogenesis. So, herewith we provide this in support of dipeptidyl peptidase-4 inhibitors as a new target of attention for treating AD.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Animals ; Brain/metabolism ; Diabetes Mellitus/epidemiology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Glucagon-Like Peptide 1 ; Humans ; Insulin Resistance ; Memory/drug effects ; Neuronal Plasticity
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2017-07-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1283069-0
    ISSN 1938-2731 ; 0895-5336 ; 1082-5207 ; 1533-3175
    ISSN (online) 1938-2731
    ISSN 0895-5336 ; 1082-5207 ; 1533-3175
    DOI 10.1177/1533317517722005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3299: Show issues Location:
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  9. Article: Anti-diarrhoeal activity of a polyherbal formulation in rats and elucidation of its cellular mechanisms.

    Murugan, Sasikumar / Purusothaman, Divya / Richard, Edwin Jothie / Chalichem, Nehru Sai Suresh / Bethapudi, Bharathi / Chandrasekaran, Prasanna Raja / Velusami, Chandrasekaran Chinampudur / D'Souza, Prashanth / Mundkinajeddu, Deepak

    Avicenna journal of phytomedicine

    2020  Volume 10, Issue 4, Page(s) 417–427

    Abstract: Objective: The present study was aimed to study anti-diarrhoeal activity of a polyherbal formulation (PHF) in rats and elucidate its mechanism of action.: Materials and methods: Anti-diarrhoeal activity of PHF was investigated using castor oil- ... ...

    Abstract Objective: The present study was aimed to study anti-diarrhoeal activity of a polyherbal formulation (PHF) in rats and elucidate its mechanism of action.
    Materials and methods: Anti-diarrhoeal activity of PHF was investigated using castor oil-induced diarrhoea, small intestinal transit and enteropooling models in rats. PHF was tested at 75, 150 and 300 mg/kg rat body weight. Loperamide was used as a reference control for
    Results: PHF demonstrated significant (p≤0.05) anti-diarrhoeal activity by increasing the time for first faecal drop and inhibited diarrhoeal episodes by 43, 58 and 60% at 75, 150 and 300 mg/kg body weight, respectively in a dose-dependent manner. Also, the intestinal transit was inhibited upto 33% and the weight of secretory contents induced by castor oil was significantly reduced by PHF, approximately 29% in enteropooling assay. On the other hand, the intestinal loop instilled with PHF and enterotoxin from
    Conclusion: The results suggest that the PHF possesses anti-diarrhoeal activity, evident through reduced faecal output, decreased intestinal transit and anti-secretory activities.
    Language English
    Publishing date 2020-08-11
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2658672-1
    ISSN 2228-7949 ; 2228-7930
    ISSN (online) 2228-7949
    ISSN 2228-7930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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