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Article ; Online: Individualized spectral filters alleviate persistent photophobia, headaches and migraines in active duty military and Veterans following brain trauma.

Tosta, Sandra / Ferreira, Mauricio / Lewine, Jeffrey / Anderson, Adam

2024 Volume 38, Issue 3, Page(s) 177–185

Abstract: Purpose: Consistent with association between photophobia and headache, growing evidence suggests an underlying causal relationship between light sensitivity and central pain. We investigated whether an intervention to regulate light sensitivity by ... ...

Abstract	Purpose: Consistent with association between photophobia and headache, growing evidence suggests an underlying causal relationship between light sensitivity and central pain. We investigated whether an intervention to regulate light sensitivity by filtering only wavelengths causing difficulties for the specific individual could alleviate headaches/migraines resulting from traumatic brain injury (TBI). Methods: Secondary data analysis of a clinical database including Results: Monthly migraine frequency decreased significantly from an average of 14.8 to 1.9, with 74% reporting no migraines post-intervention. Prescription and over-the-counter medication use decreased by more than 70%. Individuals also reported significant improvement in light sensitivity, headaches/migraine severity, and physical and perceptual symptoms. Conclusions: Wearing individualized spectral filters was associated with symptom relief, increased subjective quality of reported health and well-being, and decreased objective medication use for TBI-related persistent headaches/migraines. These results support a suggested relationship between dysregulated light sensitivity and central regulation of pain.
MeSH term(s)	Male ; Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Veterans ; Military Personnel ; Photophobia/therapy ; Photophobia/complications ; Headache ; Migraine Disorders/therapy ; Brain Injuries, Traumatic/complications ; Pain
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	639115-1
ISSN	1362-301X ; 0269-9052
ISSN (online)	1362-301X
ISSN	0269-9052
DOI	10.1080/02699052.2024.2309253
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Article ; Online: Viral clearance capability of monoclonal antibody purification.

Cai, Kang / Anderson, Jennifer / Utiger, Etienne / Ferreira, Gisela

Biologicals : journal of the International Association of Biological Standardization

2024 Volume 85, Page(s) 101751

Abstract: Viral clearance steps are routinely included in monoclonal antibody purification processes to safeguard product from potential virus contamination. These steps are often experimentally studied using product-specific feeds and parameters for each project ... ...

Abstract	Viral clearance steps are routinely included in monoclonal antibody purification processes to safeguard product from potential virus contamination. These steps are often experimentally studied using product-specific feeds and parameters for each project to demonstrate viral clearance capability. However, published evidence suggests that viral clearance capability of many of these steps are not significantly impacted by variations in feed material or process parameter within commonly used ranges. The current investigation confirms robust retrovirus inactivation by low pH treatment and parvovirus removal by second-generation virus filters, independent to individual antibody molecules. Our results also reveal robust retrovirus removal by flowthrough anion exchange chromatography, inside the limits of protein load and host cell protein content. The cumulative viral clearance capability from these steps leads to an excess clearance safety factor of 10,000-fold for endogenous retrovirus-like particles. These results further justify the use of prior knowledge-based modular viral clearance estimation as opposed to repetitive experimentation.
MeSH term(s)	Antibodies, Monoclonal ; Viruses ; Parvovirus ; Filtration ; Endogenous Retroviruses
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1017370-5
ISSN	1095-8320 ; 1045-1056
ISSN (online)	1095-8320
ISSN	1045-1056
DOI	10.1016/j.biologicals.2024.101751
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Article ; Online: SLO3: A Conserved Regulator of Sperm Membrane Potential.

Lyon, Maximilian D / Ferreira, Juan J / Li, Ping / Bhagwat, Shweta / Butler, Alice / Anderson, Kelsey / Polo, Maria / Santi, Celia M

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Sperm cells must undergo a complex maturation process after ejaculation to be able to fertilize an egg. One component of this maturation is hyperpolarization of the membrane potential to a more negative value. The ion channel responsible for this ... ...

Abstract	Sperm cells must undergo a complex maturation process after ejaculation to be able to fertilize an egg. One component of this maturation is hyperpolarization of the membrane potential to a more negative value. The ion channel responsible for this hyperpolarization, SLO3, was first cloned in 1998, and since then much progress has been made to determine how the channel is regulated and how its function intertwines with various signaling pathways involved in sperm maturation. Although
MeSH term(s)	Animals ; Male ; Humans ; Membrane Potentials/physiology ; Large-Conductance Calcium-Activated Potassium Channels/metabolism ; Semen/metabolism ; Spermatozoa/metabolism ; Signal Transduction ; Mammals/metabolism
Chemical Substances	Large-Conductance Calcium-Activated Potassium Channels
Language	English
Publishing date	2023-07-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241311205
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Article ; Online: Evaluating Readability, Understandability, and Actionability of Online Printable Patient Education Materials for Cholesterol Management: A Systematic Review.

Bhatt, Chaitanya / Lin, Ethan / Ferreira-Legere, Laura E / Jackevicius, Cynthia A / Ko, Dennis T / Lee, Douglas S / Schade, Kathryn / Johnston, Sharon / Anderson, Todd J / Udell, Jacob A

Journal of the American Heart Association

2024 Volume 13, Issue 8, Page(s) e030140

Abstract: Background: Dyslipidemia management is a cornerstone in cardiovascular disease prevention and relies heavily on patient adherence to lifestyle modifications and medications. Numerous cholesterol patient education materials are available online, but it ... ...

Abstract	Background: Dyslipidemia management is a cornerstone in cardiovascular disease prevention and relies heavily on patient adherence to lifestyle modifications and medications. Numerous cholesterol patient education materials are available online, but it remains unclear whether these resources are suitable for the majority of North American adults given the prevalence of low health literacy. This review aimed to (1) identify printable cholesterol patient education materials through an online search, and (2) evaluate the readability, understandability, and actionability of each resource to determine its utility in practice. Methods and results: We searched the MEDLINE database for peer-reviewed educational materials and the websites of Canadian and American national health organizations for gray literature. Readability was measured using the Flesch-Kincaid Grade Level, and scores between fifth- and sixth-grade reading levels were considered Conclusions: The readability of online cholesterol patient education materials consistently exceeds the health literacy level of the average North American adult. Many resources also inadequately describe action items for individuals to self-manage their cholesterol, representing an implementation gap in cardiovascular disease prevention.
MeSH term(s)	Adult ; Humans ; Comprehension ; Cardiovascular Diseases/prevention & control ; Canada ; Patient Education as Topic ; Health Literacy ; Internet
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.030140
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biomass and carbon balance in a dry tropical forest area in northeast Brazil.

Salami, Gabriela / Ferreira, Rinaldo L C / Freire, Fernando J / Silva, José A A / Pessoa, Mayara M L / Silva, Anderson F

Anais da Academia Brasileira de Ciencias

2023 Volume 95, Issue 4, Page(s) e20191250

Abstract: Forest ecosystems play an important role in mitigating the concentration increase of carbon dioxide (CO2) in the atmosphere through carbon sequestration by plants and its storage in biomass and soil. The objective was to determine the aerial biomass ... ...

Abstract	Forest ecosystems play an important role in mitigating the concentration increase of carbon dioxide (CO2) in the atmosphere through carbon sequestration by plants and its storage in biomass and soil. The objective was to determine the aerial biomass carbon stock in a dry tropical forest in Brazil. It was developed between 2012 to 2015, in an area with an advanced regeneration stage (50 years) in the semi-arid region of Pernambuco and it was used 40 permanent plots (400 m²) distant 80 m apart, with 50 m from the border, totaling 1.6 ha of the area to sample the shrubby-arboreal component, where all individuals with circumference at breast height (1.30 m of the soil) equal or greater than 6 cm were identified, measured and labeled in 2012 and remeasured in 2015. It was calculated the biomass and carbon stocks through developed equations available in the literature. The results showed that the total biomass and carbon stock in the first year was 27.97 e 12.92 Mg.ha-1 while in 2015 it was 18.49 and 8.39 Mg.ha-1 respectively. The results showed a biomass and carbon stock reduction of more than 30% in the period evaluated, even this, the area manages to present values within the expected pattern for the region, assuring the importance of sustainable forest management of these native/natural vegetation areas.
MeSH term(s)	Humans ; Ecosystem ; Biomass ; Brazil ; Forests ; Trees ; Soil
Chemical Substances	Soil
Language	English
Publishing date	2023-11-20
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2046885-4
ISSN	1678-2690 ; 0001-3765
ISSN (online)	1678-2690
ISSN	0001-3765
DOI	10.1590/0001-3765202320191250
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SLO3

Maximilian D. Lyon / Juan J. Ferreira / Ping Li / Shweta Bhagwat / Alice Butler / Kelsey Anderson / Maria Polo / Celia M. Santi

International Journal of Molecular Sciences, Vol 24, Iss 11205, p

A Conserved Regulator of Sperm Membrane Potential

2023 Volume 11205

Abstract	Sperm cells must undergo a complex maturation process after ejaculation to be able to fertilize an egg. One component of this maturation is hyperpolarization of the membrane potential to a more negative value. The ion channel responsible for this hyperpolarization, SLO3, was first cloned in 1998, and since then much progress has been made to determine how the channel is regulated and how its function intertwines with various signaling pathways involved in sperm maturation. Although Slo3 was originally thought to be present only in the sperm of mammals, recent evidence suggests that a primordial form of the gene is more widely expressed in some fish species. Slo3 , like many reproductive genes, is rapidly evolving with low conservation between closely related species and different regulatory and pharmacological profiles. Despite these differences, SLO3 appears to have a conserved role in regulating sperm membrane potential and driving large changes in response to stimuli. The effect of this hyperpolarization of the membrane potential may vary among mammalian species just as the regulation of the channel does. Recent discoveries have elucidated the role of SLO3 in these processes in human sperm and provided tools to target the channel to affect human fertility.
Keywords	membrane hyperpolarization ; SLO3 ; contraception ; potassium channels ; sperm ; acrosomal exocytosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Oxygen Uptake Kinetics and Time Limit at Maximal Aerobic Workload in Tethered Swimming.

Massini, Danilo A / Espada, Mário C / Macedo, Anderson G / Santos, Fernando J / Castro, Eliane A / Ferreira, Cátia C / Robalo, Ricardo A M / Dias, Amândio A P / Almeida, Tiago A F / Pessôa Filho, Dalton M

Metabolites

2023 Volume 13, Issue 7

Abstract: This study aimed to apply an incremental tethered swimming test (ITT) with workloads (WL) based on individual rates of front crawl mean tethered force (Fmean) for the identification of the upper boundary of heavy exercise (by means of respiratory ... ...

Abstract	This study aimed to apply an incremental tethered swimming test (ITT) with workloads (WL) based on individual rates of front crawl mean tethered force (Fmean) for the identification of the upper boundary of heavy exercise (by means of respiratory compensation point, RCP), and therefore to describe oxygen uptake kinetics (VO
Language	English
Publishing date	2023-06-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13070773
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Article ; Online: Effects of a kinetic barrier on limited-mobility interface growth models.

Pereira, Anderson J / Alves, Sidiney G / Ferreira, Silvio C

Physical review. E

2019 Volume 99, Issue 4-1, Page(s) 42802

Abstract: ... by Leal et al. [J. Phys.: Condens. Matter 23, 292201 (2011)JCOMEL0953-898410.1088/0953-8984/23/29/292201 ...

Abstract	The role played by a kinetic barrier originated by out-of-plane step edge diffusion, introduced by Leal et al. [J. Phys.: Condens. Matter 23, 292201 (2011)JCOMEL0953-898410.1088/0953-8984/23/29/292201], is investigated in the Wolf-Villain and Das Sarma-Tamborenea models with short-range diffusion. Using large-scale simulations, we observe that this barrier is sufficient to produce growth instability, forming quasiregular mounds in one and two dimensions. The characteristic surface length saturates quickly indicating a uncorrelated growth of the three-dimensional structures, which is also confirmed by a growth exponent β=1/2. The out-of-plane particle current shows a large reduction of the downward flux in the presence of the kinetic barrier enhancing, consequently, the net upward diffusion and the formation of three-dimensional self-assembled structures.
Language	English
Publishing date	2019-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.99.042802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Changing Clinical Epidemiology of Plasmodium vivax Malaria as Transmission Decreases: Population-Based Prospective Panel Survey in the Brazilian Amazon.

Fontoura, Pablo S / Macedo, Evelyn G / Calil, Priscila R / Corder, Rodrigo M / Rodrigues, Priscila T / Tonini, Juliana / Esquivel, Fabiana D / Ladeia, Winni A / Fernandes, Anderson R J / Johansen, Igor C / Silva, Marcos F / Fernandes, Amanda O S / Ladeia-Andrade, Simone / Castro, Marcia C / Ferreira, Marcelo U

The Journal of infectious diseases

2024 Volume 229, Issue 4, Page(s) 947–958

Abstract: Background: Malarial infections are often missed by microscopy, and most parasite carriers are asymptomatic in low-endemicity settings. Whether parasite detectability and its ability to elicit symptoms change as transmission declines remains unclear.: ...

Abstract	Background: Malarial infections are often missed by microscopy, and most parasite carriers are asymptomatic in low-endemicity settings. Whether parasite detectability and its ability to elicit symptoms change as transmission declines remains unclear. Methods: We performed a prospective panel survey with repeated measurements on the same participants over 12 months to investigate whether Plasmodium vivax detectability by microscopy and risk of symptoms upon infection varied during a community-wide larviciding intervention in the Amazon basin of Brazil that markedly reduced vector density. We screened 1096 to 1400 residents in the intervention site for malaria by microscopy and quantitative TaqMan assays at baseline and twice during intervention. Results: We found that more P vivax infections than expected from their parasite densities measured by TaqMan assays were missed by microscopy as transmission decreased. At lower transmission, study participants appeared to tolerate higher P vivax loads without developing symptoms. We hypothesize that changes in the ratio between circulating parasites and those that accumulate in the bone marrow and spleen, by avoiding peripheral blood microscopy detection, account for decreased parasite detectability and lower risk of symptoms under low transmission. Conclusions: P vivax infections are more likely to be subpatent and remain asymptomatic as malaria transmission decreases.
MeSH term(s)	Humans ; Malaria, Vivax/parasitology ; Brazil/epidemiology ; Prospective Studies ; Malaria, Falciparum/parasitology ; Prevalence ; Plasmodium vivax ; Malaria ; Plasmodium falciparum
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiad456
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Article ; Online: Delivery of Plasmid DNA by Ionizable Lipid Nanoparticles to Induce CAR Expression in T Cells.

Prazeres, Pedro Henrique Dias Moura / Ferreira, Heloísa / Costa, Pedro Augusto Carvalho / da Silva, Walison / Alves, Marco Túllio / Padilla, Marshall / Thatte, Ajay / Santos, Anderson Kenedy / Lobo, Anderson Oliveira / Sabino, Adriano / Del Puerto, Helen Lima / Mitchell, Michael J / Guimaraes, Pedro Pires Goulart

International journal of nanomedicine

2023 Volume 18, Page(s) 5891–5904

Abstract: Introduction: Chimeric antigen receptor (CAR) cell therapy represents a hallmark in cancer immunotherapy, with significant clinical results in the treatment of hematological tumors. However, current approved methods to engineer T cells to express CAR ... ...

Abstract	Introduction: Chimeric antigen receptor (CAR) cell therapy represents a hallmark in cancer immunotherapy, with significant clinical results in the treatment of hematological tumors. However, current approved methods to engineer T cells to express CAR use viral vectors, which are integrative and have been associated with severe adverse effects due to constitutive expression of CAR. In this context, non-viral vectors such as ionizable lipid nanoparticles (LNPs) arise as an alternative to engineer CAR T cells with transient expression of CAR. Methods: Here, we formulated a mini-library of LNPs to deliver pDNA to T cells by varying the molar ratios of excipient lipids in each formulation. LNPs were characterized and screened in vitro using a T cell line (Jurkat). The optimized formulation was used ex vivo to engineer T cells derived from human peripheral blood mononuclear cells (PBMCs) for the expression of an anti-CD19 CAR (CAR-CD19BBz). The effectiveness of these CAR T cells was assessed in vitro against Raji (CD19 Results: LNPs formulated with different molar ratios of excipient lipids efficiently delivered pDNA to Jurkat cells with low cytotoxicity compared to conventional transfection methods, such as electroporation and lipofectamine. We show that CAR-CD19BBz expression in T cells was transient after transfection with LNPs. Jurkat cells transfected with our top-performing LNPs underwent activation when exposed to CD19 Conclusion: Collectively, our results show that LNP-mediated delivery of pDNA is a suitable method to engineer human T cells to express CAR, which holds promise for improving the production methods and broader application of this therapy in the future.
MeSH term(s)	Humans ; Excipients ; Leukocytes, Mononuclear ; Plasmids/genetics ; Nanoparticles ; DNA/genetics ; Lipids
Chemical Substances	Lipid Nanoparticles ; Excipients ; DNA (9007-49-2) ; Lipids
Language	English
Publishing date	2023-10-18
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S424723
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