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  1. Article ; Online: Fracture Risk After Initiation of Use of Canagliflozin.

    Padmanabhan, Hema

    Annals of internal medicine

    2019  Volume 171, Issue 1, Page(s) 79–80

    MeSH term(s) Canagliflozin ; Cohort Studies ; Fractures, Bone ; Humans ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
    Chemical Substances Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Canagliflozin (0SAC974Z85)
    Language English
    Publishing date 2019-06-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L19-0319
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  2. Article ; Online: REDUCTION IN THYMOMA SIZE AFTER PITUITARY SURGERY FOR GROWTH HORMONE-SECRETING TUMOR.

    Padmanabhan, Hema

    AACE clinical case reports

    2018  Volume 5, Issue 2, Page(s) e164–e167

    Abstract: Objective: A thymoma is a rare tumor of the anterior mediastinum and may be under the control of prolactin and growth hormone (GH), as well as GH-insulin-like growth factor 1 (IGF-1)-mediated paracrine and autocrine pathways. The following case report ... ...

    Abstract Objective: A thymoma is a rare tumor of the anterior mediastinum and may be under the control of prolactin and growth hormone (GH), as well as GH-insulin-like growth factor 1 (IGF-1)-mediated paracrine and autocrine pathways. The following case report highlights the unexpected outcome in a patient with a mediastinal thymoma after pituitary surgery for a GH-producing macroadenoma.
    Methods: A 58-year-old Caucasian man with a history of acromegaly caused by a pituitary macroadenoma presented with a mediastinal thymoma (proven by biopsy). The thymoma was monitored annually by imaging studies, as the patient was asymptomatic and had declined surgery. The octreotide scan was negative and tests ruled out a GH-releasing hormone (GHRH)-producing tumor. Transsphenoidal surgery for removal of the pituitary tumor was performed.
    Results: Following surgery, the patient's IGF-1 levels normalized and GH was adequately suppressed in an oral glucose tolerance test. Follow-up imaging after 6 weeks and 10 months of surgery showed the absence of a pituitary tumor and a marked reduction in size of the mediastinal thymoma.
    Conclusion: In a patient with acromegaly and a thymoma, surgical treatment of the GH-producing tumor might be expected to cause a reduction in thymoma size. Therefore, such tumors in patients with acromegaly may simply be monitored clinically.
    Language English
    Publishing date 2018-11-01
    Publishing country United States
    Document type Case Reports
    ISSN 2376-0605
    ISSN (online) 2376-0605
    DOI 10.4158/ACCR-2018-0288
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  3. Article ; Online: Low health literacy.

    Padmanabhan, Hema

    Annals of internal medicine

    2011  Volume 155, Issue 11, Page(s) 794; author reply 795

    MeSH term(s) Health Literacy ; Health Services/utilization ; Humans ; Outcome Assessment (Health Care)
    Language English
    Publishing date 2011-12-06
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-155-11-201112060-00019
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  4. Article ; Online: Outpatient management of primary hyperparathyroidism.

    Padmanabhan, Hema

    The American journal of medicine

    2011  Volume 124, Issue 10, Page(s) 911–914

    Abstract: Primary hyperparathyroidism is the most common cause of hypercalcemia in an outpatient setting. Most patients are asymptomatic with mild hypercalcemia and only require periodic follow-up. Symptomatic patients and those with end-organ damage should ... ...

    Abstract Primary hyperparathyroidism is the most common cause of hypercalcemia in an outpatient setting. Most patients are asymptomatic with mild hypercalcemia and only require periodic follow-up. Symptomatic patients and those with end-organ damage should undergo surgery according to the National Institutes of Health guidelines. No medical therapy has been approved for treatment of this disorder. Treatment with bisphosphonate, calcimimetic drugs, or alcohol ablation techniques has been used in select patients.
    MeSH term(s) Adenoma/complications ; Adenoma/surgery ; Humans ; Hypercalcemia/etiology ; Hyperparathyroidism/complications ; Hyperparathyroidism/etiology ; Hyperparathyroidism/surgery ; Outpatients ; Parathyroid Neoplasms/complications ; Parathyroid Neoplasms/surgery ; Parathyroidectomy
    Language English
    Publishing date 2011-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2010.12.028
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  5. Article ; Online: Superior vena cava syndrome: a presentation of anaplastic thyroid carcinoma.

    Padmanabhan, Hema

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2010  Volume 28, Issue 10, Page(s) e151–4

    MeSH term(s) Aged ; Fatal Outcome ; Humans ; Male ; Positron-Emission Tomography ; Superior Vena Cava Syndrome/complications ; Superior Vena Cava Syndrome/diagnosis ; Superior Vena Cava Syndrome/pathology ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/diagnosis
    Language English
    Publishing date 2010-04-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2009.24.8740
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  6. Article ; Online: Cinacalcet in the treatment of intractable hypercalcemia following two neck exploration surgeries for primary hyperparathyroidism.

    Padmanabhan, Hema

    Southern medical journal

    2010  Volume 103, Issue 3, Page(s) 272–275

    Abstract: Primary hyperparathyroidism is commonly due to a single, sporadic parathyroid adenoma, and surgery is considered the treatment of choice based on guidelines established by the National Institutes of Health consensus panel. While there is no established ... ...

    Abstract Primary hyperparathyroidism is commonly due to a single, sporadic parathyroid adenoma, and surgery is considered the treatment of choice based on guidelines established by the National Institutes of Health consensus panel. While there is no established medical therapy for this condition, pharmacotherapy with agents such as cinacalcet could be a preferred alternative in a subset of patients with persistent hypercalcemia after one or more surgical interventions.
    MeSH term(s) Aged, 80 and over ; Biomimetic Materials/therapeutic use ; Cinacalcet Hydrochloride ; Humans ; Hypercalcemia/drug therapy ; Hypercalcemia/etiology ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/surgery ; Male ; Naphthalenes/therapeutic use ; Parathyroid Neoplasms/complications ; Parathyroid Neoplasms/surgery ; Receptors, Calcium-Sensing/agonists
    Chemical Substances Naphthalenes ; Receptors, Calcium-Sensing ; Cinacalcet Hydrochloride (1K860WSG25)
    Language English
    Publishing date 2010-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.1097/SMJ.0b013e3181ce0f30
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  7. Article ; Online: Amiodarone and thyroid dysfunction.

    Padmanabhan, Hema

    Southern medical journal

    2010  Volume 103, Issue 9, Page(s) 922–930

    Abstract: Amiodarone is a potent antiarrhythmic drug associated with thyroid dysfunction. Its high iodine content causes inhibition of 5'-deiodinase activity. Most patients remain euthyroid. Amiodarone-induced thyrotoxicosis (AIT) or amiodarone-induced ... ...

    Abstract Amiodarone is a potent antiarrhythmic drug associated with thyroid dysfunction. Its high iodine content causes inhibition of 5'-deiodinase activity. Most patients remain euthyroid. Amiodarone-induced thyrotoxicosis (AIT) or amiodarone-induced hypothyroidism (AIH) may occur depending on the iodine status of individuals and prior thyroid disease. AIT is caused by excess iodine-induced thyroid hormone synthesis (type I AIT) or by destructive thyroiditis (type II AIT). If the medical condition allows it, discontinuation of the drug is recommended in type I AIT. Otherwise, large doses of thioamides are required. Type II AIT is treated with corticosteroids. Mixed cases require a combination of both drugs. Potassium perchlorate has been used to treat resistant cases of type I AIT but use is limited by toxicity. Thyroidectomy, plasmapheresis, lithium, and radioiodine are used in select cases of AIT. AIH is successfully treated with levothyroxine. Screening for thyroid disease before starting amiodarone and periodic monitoring of thyroid function tests are advocated.
    MeSH term(s) Amiodarone/administration & dosage ; Amiodarone/adverse effects ; Amiodarone/pharmacokinetics ; Anti-Arrhythmia Agents/administration & dosage ; Anti-Arrhythmia Agents/adverse effects ; Anti-Arrhythmia Agents/pharmacokinetics ; Antithyroid Agents/therapeutic use ; Continuity of Patient Care ; Glucocorticoids/therapeutic use ; Hormone Replacement Therapy ; Humans ; Hypothyroidism/chemically induced ; Hypothyroidism/diagnosis ; Hypothyroidism/therapy ; Iodine Radioisotopes/therapeutic use ; Methimazole/therapeutic use ; Perchlorates/administration & dosage ; Plasmapheresis ; Risk Factors ; Thyroid Gland/diagnostic imaging ; Thyroid Hormones/blood ; Thyroidectomy ; Thyrotoxicosis/chemically induced ; Thyrotoxicosis/classification ; Thyrotoxicosis/diagnosis ; Thyrotoxicosis/therapy ; Thyroxine/therapeutic use ; Ultrasonography
    Chemical Substances Anti-Arrhythmia Agents ; Antithyroid Agents ; Glucocorticoids ; Iodine Radioisotopes ; Perchlorates ; Thyroid Hormones ; Methimazole (554Z48XN5E) ; Amiodarone (N3RQ532IUT) ; Thyroxine (Q51BO43MG4) ; perchlorate (VLA4NZX2P4)
    Language English
    Publishing date 2010-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.1097/SMJ.0b013e3181e90500
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  8. Article ; Online: Eye Pain During Hemodialysis in Severe Proliferative Diabetic Retinopathy With Neovascular Glaucoma.

    Ahmad, Tessnim R / Padmanabhan, Sriranjani / Jung, Jesse J

    Journal of vitreoretinal diseases

    2024  Volume 8, Issue 2, Page(s) 203–204

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Case Reports
    ISSN 2474-1272
    ISSN (online) 2474-1272
    DOI 10.1177/24741264241230147
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  9. Article ; Online: Cellular collection by apheresis.

    Padmanabhan, Anand

    Transfusion

    2018  Volume 58 Suppl 1, Page(s) 598–604

    Abstract: ... white blood cells, and are used to collect hematopoietic progenitor cells, specific cell populations ... such as T-lymphocytes), and granulocytes. Hematopoietic progenitor cell apheresis and T-lymphocyte collection are ... performed by procedures that enrich for mononuclear cells. Hematopoietic progenitor cells are used ...

    Abstract Cellular collection is an important and increasingly used apheresis procedure. These collections are performed by leukocytapheresis, a procedure involving the removal of a patient's or donor's white blood cells, and are used to collect hematopoietic progenitor cells, specific cell populations (such as T-lymphocytes), and granulocytes. Hematopoietic progenitor cell apheresis and T-lymphocyte collection are performed by procedures that enrich for mononuclear cells. Hematopoietic progenitor cells are used for autologous and allogeneic hematopoietic stem cell transplantation, whereas T-cell collection is being used increasingly in novel cellular therapy approaches and for donor lymphocyte infusions to induce graft-versus-leukemia effect. Granulocytes are collected from healthy donors to treat severe sepsis in patients who are refractory to antimicrobial therapies. Less frequently, cellular depletion of leukocytes may be indicated in leukemic patients who have severe hyperleukocytosis resulting in leukoaggregation and decreased tissue perfusion. In these procedures, establishing and maintaining adequate vascular access are critical prerequisites to ensuring a successful procedure. For most types of leukocytapheresis procedures, efforts should be made to ensure that they are performed using peripheral veins, and the use of an intravascular access device should be considered only after it is determined that peripheral access is not feasible or desirable. However, in some settings (such as in patients undergoing autologous hematopoietic stem cell transplantation), intravascular access devices are often used to facilitate both the leukocytapheresis procedure and the subsequent transplant. Here, different types of vascular access approaches used in cellular collections are discussed, and this information is supplemented by the author's experience and practice in areas where published information is limited.
    MeSH term(s) Catheterization, Central Venous/instrumentation ; Catheterization, Central Venous/methods ; Catheterization, Peripheral/instrumentation ; Catheterization, Peripheral/methods ; Humans ; Leukapheresis/instrumentation ; Leukapheresis/methods ; Vascular Access Devices
    Language English
    Publishing date 2018-02-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.14502
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  10. Article ; Online: Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway.

    Prasad, Sahdeo / Yadav, Vivek R / Sundaram, Chitra / Reuter, Simone / Hema, Padmanabhan S / Nair, Mangalam S / Chaturvedi, Madan M / Aggarwal, Bharat B

    The Journal of biological chemistry

    2016  Volume 291, Issue 32, Page(s) 16921

    Language English
    Publishing date 2016-08-04
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.A110.121061
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