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Article ; Online: Exploring the genetic landscape of HCV-related B-cell lymphomas using whole exome sequencing.

Armand, Marine / Degaud, Michaël / Tesson, Bruno / Laurent, Cécile / Vavasseur, Manon / Parisot, Mélanie / Hoareau-Coudert, Bénédicte / Canioni, Danielle / Michot, Jean Marie / Charlotte, Frédéric / Meignin, Véronique / Laurent, Camille / Traverse-Gléhen, Alexandra / Damotte, Diane / Bachy, Emmanuel / Besson, Caroline / Hermine, Olivier / Davi, Frédéric / Couronné, Lucile

Leukemia

2023 Volume 37, Issue 6, Page(s) 1388–1391

MeSH term(s)	Humans ; Exome Sequencing ; Lymphoma, Large B-Cell, Diffuse/genetics ; Hepatitis C/genetics
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-023-01868-2
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Zs.A 2295: Show issues

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Article ; Online: A natural genetic variant of granzyme B confers lethality to a common viral infection.

Andoniou, Christopher E / Sutton, Vivien R / Wikstrom, Matthew E / Fleming, Peter / Thia, Kevin Y T / Matthews, Antony Y / Kaiserman, Dion / Schuster, Iona S / Coudert, Jerome D / Eldi, Preethi / Chaudhri, Geeta / Karupiah, Gunasegaran / Bird, Phillip I / Trapani, Joseph A / Degli-Esposti, Mariapia A

PLoS pathogens

2014 Volume 10, Issue 12, Page(s) e1004526

Abstract: ... to pathogenic micro-organisms. While extensive polymorphism has been reported for the granzyme B (GzmB) gene, its relevance ...

Abstract	Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have identified many genetic variants that confer susceptibility or resistance to pathogenic micro-organisms. While extensive polymorphism has been reported for the granzyme B (GzmB) gene, its relevance to pathogen immunity is unexplored. Here, we describe the biochemical and cytotoxic functions of a common allele of GzmB (GzmBW) common in wild mouse. While retaining 'Asp-ase' activity, GzmBW has substrate preferences that differ considerably from GzmBP, which is common to all inbred strains. In vitro, GzmBW preferentially cleaves recombinant Bid, whereas GzmBP activates pro-caspases directly. Recombinant GzmBW and GzmBP induced equivalent apoptosis of uninfected targets cells when delivered with perforin in vitro. Nonetheless, mice homozygous for GzmBW were unable to control murine cytomegalovirus (MCMV) infection, and succumbed as a result of excessive liver damage. Although similar numbers of anti-viral CD8 T cells were generated in both mouse strains, GzmBW-expressing CD8 T cells isolated from infected mice were unable to kill MCMV-infected targets in vitro. Our results suggest that known virally-encoded inhibitors of the intrinsic (mitochondrial) apoptotic pathway account for the increased susceptibility of GzmBW mice to MCMV. We conclude that different natural variants of GzmB have a profound impact on the immune response to a common and authentic viral pathogen.
MeSH term(s)	Alleles ; Amino Acid Sequence ; Animals ; Apoptosis ; CD8-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/virology ; Caspases/metabolism ; Disease Models, Animal ; Genetic Variation/genetics ; Granzymes/analysis ; Granzymes/deficiency ; Granzymes/genetics ; Herpesviridae Infections/immunology ; Herpesviridae Infections/mortality ; Herpesviridae Infections/pathology ; Immunity, Innate/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Sequence Data ; Muromegalovirus/immunology ; Virus Diseases/immunology ; Virus Diseases/mortality ; Virus Diseases/pathology
Chemical Substances	Granzymes (EC 3.4.21.-) ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1004526
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Article ; Online: A natural genetic variant of granzyme B confers lethality to a common viral infection.

Christopher E Andoniou / Vivien R Sutton / Matthew E Wikstrom / Peter Fleming / Kevin Y T Thia / Antony Y Matthews / Dion Kaiserman / Iona S Schuster / Jerome D Coudert / Preethi Eldi / Geeta Chaudhri / Gunasegaran Karupiah / Phillip I Bird / Joseph A Trapani / Mariapia A Degli-Esposti

PLoS Pathogens, Vol 10, Iss 12, p e

2014 Volume 1004526

Abstract: ... to pathogenic micro-organisms. While extensive polymorphism has been reported for the granzyme B (GzmB) gene, its relevance ...

Abstract	Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have identified many genetic variants that confer susceptibility or resistance to pathogenic micro-organisms. While extensive polymorphism has been reported for the granzyme B (GzmB) gene, its relevance to pathogen immunity is unexplored. Here, we describe the biochemical and cytotoxic functions of a common allele of GzmB (GzmBW) common in wild mouse. While retaining 'Asp-ase' activity, GzmBW has substrate preferences that differ considerably from GzmBP, which is common to all inbred strains. In vitro, GzmBW preferentially cleaves recombinant Bid, whereas GzmBP activates pro-caspases directly. Recombinant GzmBW and GzmBP induced equivalent apoptosis of uninfected targets cells when delivered with perforin in vitro. Nonetheless, mice homozygous for GzmBW were unable to control murine cytomegalovirus (MCMV) infection, and succumbed as a result of excessive liver damage. Although similar numbers of anti-viral CD8 T cells were generated in both mouse strains, GzmBW-expressing CD8 T cells isolated from infected mice were unable to kill MCMV-infected targets in vitro. Our results suggest that known virally-encoded inhibitors of the intrinsic (mitochondrial) apoptotic pathway account for the increased susceptibility of GzmBW mice to MCMV. We conclude that different natural variants of GzmB have a profound impact on the immune response to a common and authentic viral pathogen.
Keywords	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2014-12-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article: T and B lymphocytes exert distinct effects on the homeostasis of NK cells.

Jeannet, Grégoire / Coudert, Jérôme D / Held, Werner

European journal of immunology

2006 Volume 36, Issue 10, Page(s) 2725–2734

Abstract: ... phenotypically and functionally altered in the absence of B and/or T cells. Here we show that T cell deficiency ... cell compartments. In contrast, B cell deficiency reduces splenic NK cell survival. In the absence of T and B ... effects. Even though NK cell homeostasis is significantly altered, NK cells from T and/or B cell-deficient ...

Abstract	There is growing evidence that lymphocytes impact the development and/or function of other lymphocyte populations. Based on such observations we have tested whether the NK cell compartment was phenotypically and functionally altered in the absence of B and/or T cells. Here we show that T cell deficiency significantly accelerates BM NK cell production and the subsequent seeding of splenic and liver NK cell compartments. In contrast, B cell deficiency reduces splenic NK cell survival. In the absence of T and B cells, the size of the NK cell compartments is determined by the combination of these positive and negative effects. Even though NK cell homeostasis is significantly altered, NK cells from T and/or B cell-deficient mice show a normal capacity to kill a susceptible target cell line and to produce IFN. Nevertheless, we noted that the usage of MHC class I-specific Ly49 family receptors was significantly altered in the absence of T and/or B cells. In general, B cell deficiency expanded Ly49 receptor usage, while T cell deficiency exerted both positive and negative effects. These findings show that B and T cells significantly and differentially influence the homeostasis and the phenotype of NK cells.
MeSH term(s)	Adoptive Transfer ; Animals ; Antigens, Ly/immunology ; Antigens, Ly/metabolism ; B-Lymphocytes/immunology ; Bone Marrow/immunology ; Cell Differentiation/immunology ; Flow Cytometry ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/metabolism ; Homeostasis/immunology ; Killer Cells, Natural/cytology ; Killer Cells, Natural/immunology ; Lectins, C-Type/immunology ; Lectins, C-Type/metabolism ; Lymphocyte Activation/immunology ; Lymphocyte Subsets/cytology ; Lymphocyte Subsets/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phenotype ; Receptors, NK Cell Lectin-Like ; Spleen/cytology ; Spleen/immunology ; T-Lymphocytes/immunology
Chemical Substances	Antigens, Ly ; Histocompatibility Antigens Class I ; Lectins, C-Type ; Receptors, NK Cell Lectin-Like
Language	English
Publishing date	2006-10
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.200636011
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 85: Show issues

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Article: DNA interaction and cytotoxicity of a new series of indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole derivatives.

Arimondo, P B / Baldeyrou, B / Laine, W / Bal, C / Alphonse, F A / Routier, S / Coudert, G / Mérour, J Y / Colson, P / Houssier, C / Bailly, C

Chemico-biological interactions

2001 Volume 138, Issue 1, Page(s) 59–75

Abstract: ... the interaction with DNA of a series of 16 tricyclic and tetracyclic compounds related to the antiviral agent B ... 220. The relative DNA affinity of the test compounds containing an indolo[2,3-b]quinoxaline ... pyridopyrazino[2,3-b]indoles or pyrazino[2,3-b]indole planar chromophore varies significantly depending ...

Abstract	Absorption, melting temperature and linear dichroism measurements were performed to investigate the interaction with DNA of a series of 16 tricyclic and tetracyclic compounds related to the antiviral agent B-220. The relative DNA affinity of the test compounds containing an indolo[2,3-b]quinoxaline, pyridopyrazino[2,3-b]indoles or pyrazino[2,3-b]indole planar chromophore varies significantly depending on the nature of the side chain grafted onto the indole nitrogen. Compounds with a dimethylaminoethyl chain strongly bind to DNA and exhibit a preference for GC-rich DNA sequences, as revealed by DNase I footprinting. Weaker DNA interactions were detected with those bearing a morpholinoethyl side chain. The incorporation of a 2,3-dihydroxypropyl side chain does not reinforce the DNA interaction compared with the unsubstituted analogues. Both the DNA relaxation assay and cytotoxicity study using two human leukemia cell lines sensitive (HL-60) or resistant (HL-60/MX2) to the antitumor drug mitoxantrone, indicate that topoisomerase II is not a privileged target for the test compounds which only weakly interfere with the catalytic activity of the DNA cleaving enzyme. Cytometry studies showed that the most cytotoxic compounds induce a massive accumulation of cells in the G2/M phase of the cell cycle. Collectively, the data show a relationship between DNA binding and cytotoxicity in the indolo[2,3-b]quinoxaline series.
MeSH term(s)	Animals ; Cattle ; Cell Cycle/drug effects ; Cell Division/drug effects ; DNA/chemistry ; DNA Footprinting ; Dose-Response Relationship, Drug ; Flow Cytometry ; HL-60 Cells/drug effects ; Humans ; Indoles/chemistry ; Indoles/pharmacology ; Intercalating Agents/chemistry ; Quinoxalines/chemistry ; Quinoxalines/pharmacology
Chemical Substances	Indoles ; Intercalating Agents ; Quinoxalines ; DNA (9007-49-2)
Language	English
Publishing date	2001-09-11
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/s0009-2797(01)00260-5
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Zs.A 686: Show issues

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Article: Molecular genotyping of four chicken B-complex haplotypes with B-L beta, B-F, and B-G probes.

Chaussé, A M / Coudert, F / Dambrine, G / Guillemot, F / Miller, M M / Auffray, C

Immunogenetics

1989 Volume 29, Issue 2, Page(s) 127–130

MeSH term(s)	Animals ; Blotting, Southern ; Chickens/genetics ; DNA Probes ; Haplotypes ; Histocompatibility Antigens Class I/genetics ; Major Histocompatibility Complex ; Polymorphism, Restriction Fragment Length
Chemical Substances	DNA Probes ; Histocompatibility Antigens Class I
Language	English
Publishing date	1989
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	186560-2
ISSN	1432-1211 ; 0093-7711
ISSN (online)	1432-1211
ISSN	0093-7711
DOI	10.1007/bf00395863
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Zs.A 1052: Show issues

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Article ; Online: Proof of Concept of an Affordable, Compact and Transcranial Submillimeter Accurate Ultrasound-Based Tracking System.

Zarader, Pierre / Francois, Quentin / Coudert, Antoine / Duplat, Bertrand / Haliyo, Sinan / Couture, Olivier

IEEE transactions on bio-medical engineering

2024 Volume 71, Issue 3, Page(s) 893–903

Abstract: In neurosurgery, a current challenge is to provide localized therapy in deep and difficult-to-access brain areas with millimeter accuracy. In this prospect, new surgical devices such as microrobots are being developed, which require controlled inbrain ... ...

Abstract	In neurosurgery, a current challenge is to provide localized therapy in deep and difficult-to-access brain areas with millimeter accuracy. In this prospect, new surgical devices such as microrobots are being developed, which require controlled inbrain navigation to ensure the safety and efficiency of the intervention. In this context, the device tracking technology has to answer a three-sided challenge: invasiveness, performance, and facility of use. Although ultrasound seems appropriate for transcranial tracking, the skull remains an obstacle because of its significant acoustic perturbations. A compact and affordable ultrasound-based tracking system that minimizes skull-related disturbances is proposed here. This system consists of three emitters fixed on the patient's head and a one-millimeter receiver embedded in the surgical device. The 3D position of the receiver is obtained by trilateration based on time of flight measurements. The system demonstrates a submillimeter tracking accuracy through an 8.9 mm thick skull plate phantom. This result opens multiple perspectives in terms of millimeter accurate navigation for a large number of neurobiomedical devices.
MeSH term(s)	Humans ; Ultrasonography ; Skull/diagnostic imaging ; Head ; Brain/diagnostic imaging ; Brain/surgery ; Phantoms, Imaging
Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2023.3322302
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Zs.A 425: Show issues

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Article ; Online: Alchemical Osmostat for Monte Carlo Simulation: Sampling Aqueous Electrolyte Solution in Open Systems.

Izarra, Ambroise de / Coudert, François-Xavier / Fuchs, Alain H / Boutin, Anne

The journal of physical chemistry. B

2023 Volume 127, Issue 3, Page(s) 766–776

Abstract: Molecular simulations involving electrolytes are usually performed at a fixed amount of salt ions in the simulation box, reproducing macroscopic concentration. Although this statement is valid in the bulk, the concentration of an electrolyte confined in ... ...

Abstract	Molecular simulations involving electrolytes are usually performed at a fixed amount of salt ions in the simulation box, reproducing macroscopic concentration. Although this statement is valid in the bulk, the concentration of an electrolyte confined in nanoporous materials such as MOFs or zeolites is greatly affected and remains
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.2c07902
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Analysis of five B complex haplotypes with class I (B-F), class II (B-L) and class IV (B-G) probes.

Chaussé, A M / Coudert, F / Dambrine, G / Auffray, C

Progress in clinical and biological research

1989 Volume 307, Page(s) 197–202

MeSH term(s)	Animals ; Chickens/genetics ; Chromosome Mapping ; Cloning, Molecular ; DNA/analysis ; DNA Probes ; Haplotypes ; Histocompatibility Antigens/genetics ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class II/genetics ; Major Histocompatibility Complex ; Nucleic Acid Hybridization ; Polymorphism, Restriction Fragment Length
Chemical Substances	DNA Probes ; Histocompatibility Antigens ; Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II ; DNA (9007-49-2)
Language	English
Publishing date	1989
Publishing country	United States
Document type	Journal Article
ISSN	0361-7742
ISSN	0361-7742
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Article: Analysis of B complex polymorphism in Rous sarcoma progressor and regressor chickens with B-G, B-F, and B-L beta probes.

Chaussé, A M / Thoraval, P / Coudert, F / Auffray, C / Dambrine, G

Avian diseases

1990 Volume 34, Issue 4, Page(s) 934–940

Abstract: Molecular polymorphism of the B complex was studied in serologically defined B19 haplotypes by use ...

Abstract	Molecular polymorphism of the B complex was studied in serologically defined B19 haplotypes by use of class I, class II, and class IV probes in Southern blot experiments in chickens. All chickens studied shared identical class IV restriction patterns. In contrast, class I and class II probes revealed six and five subtypes of B19 haplotype, respectively. These subtypes may be resolved in three homozygous genotypes and their corresponding heterozygous combinations. Previous genetic selection allowed us to distinguish two subpopulations in these B19 chickens with regard to the fate of Rous sarcoma virus (RSV)-induced tumors. Molecular genotyping was applied to B19 chickens challenged with RSV in order to determine whether there is a correlation between one of the molecularly defined subtypes and the progressor/regressor phenotypes of the chickens. None of the molecularly defined subtypes correlated with the progressor or regressor phenotype of the challenged birds.
MeSH term(s)	Animals ; Chickens/genetics ; Cloning, Molecular ; DNA/analysis ; DNA Probes ; Genotype ; Haplotypes/genetics ; Histocompatibility Antigens/genetics ; Nucleic Acid Hybridization ; Polymorphism, Restriction Fragment Length ; Restriction Mapping ; Sarcoma, Avian/genetics
Chemical Substances	DNA Probes ; Histocompatibility Antigens ; DNA (9007-49-2)
Language	English
Publishing date	1990-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	40871-2
ISSN	1938-4351 ; 0005-2086
ISSN (online)	1938-4351
ISSN	0005-2086
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 526: Show issues

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