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  1. Article: Les pneumopathies infiltrantes diffuses d'origine médicamenteuse: un problème avant tout diagnostique.

    Mayaud, Charles / Fartoukh, Muriel / Parrot, Antoine / Cadranel, Jacques / Milleron, Bernard / Akoun, Georges

    Revue de pneumologie clinique

    2005  Volume 61, Issue 3, Page(s) 179–185

    Abstract: Drugs are frequently incriminated as the cause of interstitial pneumonia. There are two major mechanisms of drug-associated interstitial lung disease: direct toxicity and immunoallergic reaction. When a drug is suspected, the difficulty lies in obtaining ...

    Title translation Drug-associated interstitial lung disease: a diagnostic challenge.
    Abstract Drugs are frequently incriminated as the cause of interstitial pneumonia. There are two major mechanisms of drug-associated interstitial lung disease: direct toxicity and immunoallergic reaction. When a drug is suspected, the difficulty lies in obtaining proof. The chronology of the disease and its manifestations together with earlier evidence reported in the literature can lead to a tentative diagnosis of drug-associated interstitial pneumonia. Proof is obtained through surveillance during the disease course. In nearly all patients, therapeutic decisions must be taken on the basis of suspected drug involvement.
    MeSH term(s) Bronchoalveolar Lavage ; Diagnosis, Differential ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/diagnosis
    Language French
    Publishing date 2005-09-01
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 605736-6
    ISSN 1776-2561 ; 0761-8417 ; 0032-5821
    ISSN (online) 1776-2561
    ISSN 0761-8417 ; 0032-5821
    DOI 10.1016/s0761-8417(05)84810-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Isotretinoin-related eosinophilic pleural effusion.

    Milleron, B J / Valcke, J / Akoun, G M / Mayaud, C M

    Chest

    1996  Volume 110, Issue 4, Page(s) 1128

    MeSH term(s) Eosinophilia/chemically induced ; Humans ; Isotretinoin/adverse effects ; Keratolytic Agents/adverse effects ; Pleural Effusion/chemically induced
    Chemical Substances Keratolytic Agents ; Isotretinoin (EH28UP18IF)
    Language English
    Publishing date 1996-10
    Publishing country United States
    Document type Letter
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
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  3. Article: [Leukocyte migration inhibition test in drug-induced pneumonitis].

    Suzuki, K / Rahman, S G / Akoun, G M

    Nihon Kyobu Shikkan Gakkai zasshi

    1992  Volume 30, Issue 1, Page(s) 76–81

    Abstract: The leukocyte migration inhibition test (LMIT) was performed in 8 cases of presumed drug-induced pneumonitis. The drugs involved were amiodarone in 3 cases, methotrexate in 2 cases, and fenofibrate, nadolol, and gold salt, each in one case. The agarose ... ...

    Abstract The leukocyte migration inhibition test (LMIT) was performed in 8 cases of presumed drug-induced pneumonitis. The drugs involved were amiodarone in 3 cases, methotrexate in 2 cases, and fenofibrate, nadolol, and gold salt, each in one case. The agarose microdroplet technique for photoelectric readings of leukocyte migration inhibition was applied in the presence of a wide range of drug concentrations. LMIT was found to be positive in 6 of the 8 cases (75%). The presence of a positive LMIT indicates the elaboration of leukocyte migration inhibitory factor. These results suggest that cell-mediated immunity may play a role in the pathogenesis of drug-induced pneumonitis and that LMIT may be useful for the detection of causative drugs in patients with this condition.
    MeSH term(s) Aged ; Cell Migration Inhibition ; Female ; Humans ; Male ; Middle Aged ; Pneumonia/chemically induced
    Language Japanese
    Publishing date 1992-01
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604106-1
    ISSN 0301-1542
    ISSN 0301-1542
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  4. Article: Diagnostic value of broncho-alveolar lavage in certain interstitial and/or immunological pneumonia.

    Akoun, G M / Mayaud, C M / Milleron, B J

    Bulletin of the International Union against Tuberculosis and Lung Disease

    1988  Volume 63, Issue 3, Page(s) 32–34

    MeSH term(s) Bronchoalveolar Lavage Fluid ; Humans ; Pneumonia/diagnosis ; Pneumonia/etiology ; Pulmonary Fibrosis/diagnosis ; Pulmonary Fibrosis/etiology
    Language English
    Publishing date 1988-09
    Publishing country France
    Document type Journal Article
    ZDB-ID 639151-5
    ISSN 1011-789X ; 0074-9249
    ISSN 1011-789X ; 0074-9249
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  5. Article: Epidémiologie des germes responsables au cours des pneumopathies communautaires.

    Mayaud, C / Parrot, A / Houacine, S / Denis, M / Akoun, G

    Revue de pneumologie clinique

    1992  Volume 48, Issue 3, Page(s) 101–110

    Abstract: Pneumonias occupy a prominent situation among lower respiratory tract infections where they are remarkable for their potential mortality and for our relative knowledge of the responsible micro-organisms. Analysis and synthesis of each series published ... ...

    Title translation Epidemiology of micro-organisms responsible for community-acquired pneumonia.
    Abstract Pneumonias occupy a prominent situation among lower respiratory tract infections where they are remarkable for their potential mortality and for our relative knowledge of the responsible micro-organisms. Analysis and synthesis of each series published must answer several questions, such as: what are the lung diseases considered? which investigations have been performed? which criteria of imputability have been used? in which patients has the study been carried out? in which place, which period and which structure? In spite of methodological lacunae and of the inhomogeneous answers to the questions asked, there is some concordance between the series found in the literature. Thus, more than 90% of community-acquired pneumonias with microbiological identification are caused by Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, Chlamydia psittaci (or pneumoniae), or Influenza A virus.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Female ; Haemophilus influenzae ; Humans ; Legionnaires' Disease/epidemiology ; Male ; Middle Aged ; Pneumonia/epidemiology ; Pneumonia/microbiology ; Pneumonia, Mycoplasma/epidemiology ; Streptococcus pneumoniae
    Language French
    Publishing date 1992
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 605736-6
    ISSN 1776-2561 ; 0761-8417 ; 0032-5821
    ISSN (online) 1776-2561
    ISSN 0761-8417 ; 0032-5821
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  6. Article: La pathologie pulmonaire d'origine médicamenteuse.

    Akoun, G M / Milleron, B J / Cadranel, J L / Mayaud, C M

    La Revue du praticien

    1992  Volume 42, Issue 20, Page(s) 2593–2599

    Abstract: Over the past ten years, there has been an impressively growing number of reports about drug-induced pneumonitis (DIP) due to more than one hundred different drugs. The most troublesome question is how to establish with certainty the diagnosis. Usually, ... ...

    Title translation Pulmonary pathology of drug origin.
    Abstract Over the past ten years, there has been an impressively growing number of reports about drug-induced pneumonitis (DIP) due to more than one hundred different drugs. The most troublesome question is how to establish with certainty the diagnosis. Usually, five criteria are necessary. 1) The administration of a drug on a more or less long term basis. 2) Newly occurrence of an interstitial pneumonitis (defined on symptomatology, radiological features, pulmonary function test results). 3) Elimination of all other causes of pneumonitis (haemodynamic, infectious, systemic, environmental diseases). 4) Broncho-alveolar lavage (BAL) cell data showing in most cases a lymphocyte alveolitis with an inverted CD4/CD8 ratio. In a certain number of ambiguous circumstances, coupling a provocation test with a sequentially performed BAL could firmly establish the diagnosis. 5) Rapid resolution within a few days or months of the pneumonitis as early as the incriminated drug administration is stopped. Nevertheless sometimes one or more of these criteria are not met, mainly when the pneumonitis is a fibrosis directly induced by a fibrosing toxic mechanism.
    MeSH term(s) Humans ; Lung Diseases/chemically induced ; Lung Diseases/diagnosis ; Lung Diseases/physiopathology ; Lung Diseases/therapy
    Language French
    Publishing date 1992-12-15
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  7. Article: Current concepts of small-cell lung cancer.

    Akoun, G M / Milleron, B J / Mayaud, C M

    Clinical therapeutics

    1986  Volume 8, Issue 2, Page(s) 138–143

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Small Cell/diagnosis ; Carcinoma, Small Cell/drug therapy ; Carcinoma, Small Cell/pathology ; Carcinoma, Small Cell/radiotherapy ; Carcinoma, Small Cell/surgery ; Combined Modality Therapy ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/surgery ; Neoplasm Staging ; Prognosis
    Language English
    Publishing date 1986
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
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  8. Article: Assessment of drug-induced pneumonitis in the 1980s.

    Akoun, G M / Mayaud, C M / Milleron, B J

    Clinical therapeutics

    1985  Volume 7, Issue 5, Page(s) 526–528

    MeSH term(s) Drug Hypersensitivity/diagnosis ; Humans ; Pneumonia/chemically induced ; Pneumonia/diagnosis ; Skin Tests ; Therapeutic Irrigation
    Language English
    Publishing date 1985
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
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  9. Article: Diagnosis by bronchoalveolar lavage of cause of pulmonary infiltrates in haematological malignancies.

    Akoun, G M / Milleron, B J / Mayaud, C M

    British medical journal (Clinical research ed.)

    1985  Volume 290, Issue 6481, Page(s) 1589–1590

    MeSH term(s) Humans ; Pulmonary Fibrosis/chemically induced ; Therapeutic Irrigation
    Language English
    Publishing date 1985-05-25
    Publishing country England
    Document type Letter
    ZDB-ID 80088-0
    ISSN 0267-0623 ; 0959-8138 ; 0959-8146 ; 0007-1447
    ISSN 0267-0623 ; 0959-8138 ; 0959-8146 ; 0007-1447
    DOI 10.1136/bmj.290.6481.1589-b
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  10. Article: L'histoire naturelle et les critères diagnostiques des pneumopathies médicamenteuses.

    Akoun, G M / Mayaud, C / Milleron, B

    Therapie

    1986  Volume 41, Issue 4, Page(s) 233–236

    Title translation Natural history and diagnostic criteria in drug-induced pneumopathies.
    MeSH term(s) Drug Hypersensitivity/etiology ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Iatrogenic Disease ; Lung Diseases/chemically induced ; Pleural Diseases/chemically induced ; Pulmonary Fibrosis/chemically induced
    Language French
    Publishing date 1986-07
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
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