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  1. Article: Prevention of postoperative atrial fibrillation: what is the best approach?

    Podrid, P J

    Journal of the American College of Cardiology

    1999  Volume 34, Issue 2, Page(s) 340–342

    MeSH term(s) Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/etiology ; Atrial Fibrillation/prevention & control ; Coronary Artery Bypass/adverse effects ; Humans ; Sotalol/therapeutic use
    Chemical Substances Anti-Arrhythmia Agents ; Sotalol (A6D97U294I)
    Language English
    Publishing date 1999-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/s0735-1097(99)00218-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Redefining the role of antiarrhythmic drugs.

    Podrid, P J

    The New England journal of medicine

    1999  Volume 340, Issue 24, Page(s) 1910–1912

    MeSH term(s) Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/therapy ; Chemotherapy, Adjuvant ; Defibrillators, Implantable ; Electric Countershock ; Humans ; Premedication ; Sotalol/therapeutic use ; Sulfonamides/therapeutic use ; Tachycardia/therapy
    Chemical Substances Anti-Arrhythmia Agents ; Sulfonamides ; ibutilide (2436VX1U9B) ; Sotalol (A6D97U294I)
    Language English
    Publishing date 1999-06-17
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJM199906173402409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Atrial fibrillation in the elderly.

    Podrid, P J

    Cardiology clinics

    1999  Volume 17, Issue 1, Page(s) 173–88, ix–x

    Abstract: Atrial fibrillation is the most common sustained arrhythmia seen in clinical practice. Although it occurs in any age patients, its frequency increases with age and is very common in the elderly. Atrial fibrillation causes substantial symptoms and ... ...

    Abstract Atrial fibrillation is the most common sustained arrhythmia seen in clinical practice. Although it occurs in any age patients, its frequency increases with age and is very common in the elderly. Atrial fibrillation causes substantial symptoms and morbidity and is an important cause of thromboembolism and stroke. The two approaches for therapy in those patients with intermittent or persistent atrial fibrillation are (1) maintenance of sinus rhythm with an antiarrhythmic drug or nonpharmacologic therapy, and (2) maintenance of atrial fibrillation with rate control. At the present time there are no data about the best approach and therapy must therefore be individualized.
    MeSH term(s) Aged ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/therapy ; Female ; Heart Failure/epidemiology ; Humans ; Male ; Prevalence ; Prognosis
    Language English
    Publishing date 1999-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1196385-2
    ISSN 1558-2264 ; 0733-8651
    ISSN (online) 1558-2264
    ISSN 0733-8651
    DOI 10.1016/s0733-8651(05)70063-1
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  4. Article: Proarrhythmia, a serious complication of antiarrhythmic drugs.

    Podrid, P J

    Current cardiology reports

    1999  Volume 1, Issue 4, Page(s) 289–296

    Abstract: Aggravation of arrhythmia with antiarrhythmic drugs is not an infrequent side effect associated with antiarrhythmic drugs. Defined as the provocation of a new arrhythmia or a significant increase in the frequency of a preexisting arrhythmia, it occurs ... ...

    Abstract Aggravation of arrhythmia with antiarrhythmic drugs is not an infrequent side effect associated with antiarrhythmic drugs. Defined as the provocation of a new arrhythmia or a significant increase in the frequency of a preexisting arrhythmia, it occurs with all antiarrhythmic agents, although the incidence varies from 6% to 23% with the different drugs. In general, arrhythmia aggravation is an early event, occurring within the first several days of initiating drugs therapy. It has been found, however, that this complication can also occur as a late event, particularly in patients who have evidence of ongoing ischemia that may be overt or silent. Although there is no good way to predict the patient who is likely to experience this complication, it has been observed that there several predictors of an increased risk for experiencing arrhythmia aggravation including significant underlying heart disease, congestive heart failure, evidence of active or potentially active ischemia, and electrolyte abnormalities, particularly hypokalemia.
    MeSH term(s) Anti-Arrhythmia Agents/adverse effects ; Anti-Arrhythmia Agents/therapeutic use ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/drug therapy ; Arrhythmias, Cardiac/epidemiology ; Electrocardiography ; Female ; Heart Failure/complications ; Humans ; Male ; Myocardial Ischemia/complications ; Risk Factors ; Sex Factors ; Time Factors ; Torsades de Pointes/chemically induced
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 1999-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1523-3782
    ISSN 1523-3782
    DOI 10.1007/s11886-999-0052-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Arrhythmias after acute myocardial infarction. Evaluation and management of rhythm and conduction abnormalities.

    Podrid, P J

    Postgraduate medicine

    1997  Volume 102, Issue 5, Page(s) 125–8, 131–4, 137–9

    Abstract: Patients with myocardial infarction can experience a wide range of arrhythmias and conduction abnormalities, from transient and relatively innocuous sinus bradycardia to life-threatening ventricular fibrillation. This nut-and-bolts article covers all the ...

    Abstract Patients with myocardial infarction can experience a wide range of arrhythmias and conduction abnormalities, from transient and relatively innocuous sinus bradycardia to life-threatening ventricular fibrillation. This nut-and-bolts article covers all the possibilities, emphasizing the clinical significance of the various arrhythmias and their evaluation and treatment. Also included are indications for temporary and permanent pacemaker placement based on the revised ACC/AHA guidelines.
    MeSH term(s) Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/drug therapy ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/physiopathology ; Electrocardiography ; Heart Block/etiology ; Heart Block/physiopathology ; Humans ; Myocardial Infarction/complications ; Myocardial Infarction/physiopathology
    Language English
    Publishing date 1997-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.3810/pgm.1997.11.363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Amiodarone: reevaluation of an old drug.

    Podrid, P J

    Annals of internal medicine

    1995  Volume 122, Issue 9, Page(s) 689–700

    Abstract: Purpose: To review the pharmacology, electrophysiology, and toxicity of amiodarone and to discuss the clinical results produced when amiodarone is used as therapy for patients with atrial fibrillation, patients with nonsustained ventricular tachycardia ... ...

    Abstract Purpose: To review the pharmacology, electrophysiology, and toxicity of amiodarone and to discuss the clinical results produced when amiodarone is used as therapy for patients with atrial fibrillation, patients with nonsustained ventricular tachycardia and cardiomyopathy, patients who have recently had myocardial infarctions, and patients who have survived out-of-hospital cardiac arrest caused by ventricular tachycardia or ventricular fibrillation.
    Data sources: Animal and clinical studies involving the pharmacology and electrophysiology of amiodarone and clinical trials in which amiodarone was used as therapy for the arrhythmias noted above were reviewed.
    Study selection: Relevant studies that reported on the efficacy and toxicity of amiodarone and on long-term therapy using amiodarone were reviewed, and their data were summarized. Reports of ongoing trials using amiodarone were also reviewed and summarized.
    Results: Amiodarone is useful for the treatment of many rhythm disturbances. Although side effects from this agent are common, serious toxicity necessitating discontinuation of therapy is infrequent. Unlike other antiarrhythmic agents, amiodarone has not been shown to increase mortality in any population studied.
    Conclusion: Amiodarone, a unique antiarrhythmic agent with many pharmacologic actions, is effective in the treatment of a wide range of rhythm abnormalities. Several large, randomized trials will provide further information about the clinical usefulness of this agent.
    MeSH term(s) Amiodarone/adverse effects ; Amiodarone/pharmacokinetics ; Amiodarone/pharmacology ; Animals ; Arrhythmias, Cardiac/drug therapy ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/prevention & control ; Electrophysiology ; Heart/drug effects ; Heart/physiology ; Hemodynamics/drug effects ; Humans
    Chemical Substances Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 1995-05-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-122-9-199505010-00008
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  7. Article: Aggravation of arrhythmia: a complication of antiarrhythmic drugs.

    Podrid, P J

    Journal of cardiovascular electrophysiology

    1993  Volume 4, Issue 3, Page(s) 311–319

    Abstract: Aggravation of arrhythmia, defined as worsening of a preexisting arrhythmia or the occurrence of a new arrhythmia, is a common complication of antiarrhythmic drug therapy. Although it is largely an unpredictable event, patients at greatest risk are those ...

    Abstract Aggravation of arrhythmia, defined as worsening of a preexisting arrhythmia or the occurrence of a new arrhythmia, is a common complication of antiarrhythmic drug therapy. Although it is largely an unpredictable event, patients at greatest risk are those with a history of congestive heart failure due to systolic dysfunction who present with a sustained ventricular tachyarrhythmia. As a rule, aggravation of arrhythmia is an early event, occurring within the first few days of initiating therapy. However, in the Cardiac Arrhythmia Suppression Trial (CAST), the increased sudden death mortality due to drug therapy, which was a result of arrhythmia aggravation, occurred throughout the entire duration of the trial, suggesting that arrhythmia aggravation can also be a late complication of therapy. Also disturbing was the fact that patients in CAST were low risk and did not have congestive heart failure or a serious ventricular tachyarrhythmia. This suggests that another important risk factor is myocardial ischemia and its potentially dangerous interaction with antiarrhythmic drugs. In patients with heart disease, especially those with coronary artery disease, antiarrhythmic drugs must therefore be used cautiously. Close and continuous follow-up is mandatory.
    MeSH term(s) Anti-Arrhythmia Agents/adverse effects ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/physiopathology ; Humans ; Risk Factors
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 1993-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/j.1540-8167.1993.tb01233.x
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  8. Article: Class 1 antiarrhythmic agents for therapy of atrial fibrillation.

    Podrid, P J

    Herz

    1993  Volume 18, Issue 1, Page(s) 9–19

    Abstract: Atrial fibrillation is most the common sustained arrhythmia seen by the cardiologist. Therapy to prevent this arrhythmia is often prescribed so as to eliminate associated symptoms which include palpitations, fatigue, dizziness and presyncope, shortness ... ...

    Abstract Atrial fibrillation is most the common sustained arrhythmia seen by the cardiologist. Therapy to prevent this arrhythmia is often prescribed so as to eliminate associated symptoms which include palpitations, fatigue, dizziness and presyncope, shortness of breath, congestive heart failure and emboli, especially those that result in a cerebrovascular accident. Pharmacologic therapy is the only effective therapy for preventing atrial fibrillation and the class 1 antiarrhythmic drugs remain the most frequently used agents. Although each of these agents has been reported to be effective for preventing atrial fibrillation, they are associated with frequent side effects, some of which are potentially serious, especially aggravation of arrhythmia. Prior to treatment the benefit vs risk of these drugs for each patient must be established.
    MeSH term(s) Animals ; Anti-Arrhythmia Agents/adverse effects ; Anti-Arrhythmia Agents/classification ; Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/physiopathology ; Electrocardiography/drug effects ; Heart Atria/drug effects ; Heart Atria/physiopathology ; Humans
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 1993-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8262-4
    ISSN 1615-6692 ; 0340-9937 ; 0946-1299
    ISSN (online) 1615-6692
    ISSN 0340-9937 ; 0946-1299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 426: Show issues

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  9. Article: Proarrhythmische Effekte von Antiarrhythmika

    Hohnloser, S. H. / Podrid, P. J.

    DMW - Deutsche Medizinische Wochenschrift

    2008  Volume 115, Issue 16, Page(s) 626–628

    Language German
    Publishing date 2008-03-25
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/s-2008-1065057
    Database Thieme publisher's database

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  10. Article: Therapy with and assessment of class III antiarrhythmic agents in different patient populations.

    Podrid, P J

    Journal of cardiovascular pharmacology

    1992  Volume 20 Suppl 2, Page(s) S44–58

    Abstract: The present article reviews the therapeutic efficacy of class III antiarrhythmic agents, particularly amiodarone, in patients with atrial and ventricular arrhythmias in the setting of different cardiac disorders. Both Holter monitoring and ... ...

    Abstract The present article reviews the therapeutic efficacy of class III antiarrhythmic agents, particularly amiodarone, in patients with atrial and ventricular arrhythmias in the setting of different cardiac disorders. Both Holter monitoring and electrophysiologic studies appear to constitute reliable methods for evaluating the effects of class III agents and the long-term outcome in patients with a history of sustained ventricular tachycardia or fibrillation. The efficacy and tolerance of amiodarone in different patient populations is discussed.
    MeSH term(s) Amiodarone/therapeutic use ; Anti-Arrhythmia Agents/therapeutic use ; Arrhythmias, Cardiac/drug therapy ; Drug Evaluation ; Electrocardiography, Ambulatory ; Electrophysiology ; Heart/physiology ; Humans ; Predictive Value of Tests ; Prognosis
    Chemical Substances Anti-Arrhythmia Agents ; Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 1992
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
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