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  1. Article ; Online: Is deep brain stimulation a treatment option for anorexia nervosa?

    Oudijn, Marloes S / Storosum, Jitschak G / Nelis, Elise / Denys, Damiaan

    BMC psychiatry

    2013  Volume 13, Page(s) 277

    Abstract: ... of the nucleus accumbens (NAc) and other areas associated with reward, e.g. the anterior cingulated cortex (ACC), might be ...

    Abstract Anorexia nervosa (AN) is a severe psychiatric disorder with high rates of morbidity, comorbidity and mortality, which in a subset of patients (21%) takes on a chronic course. Since an evidence based treatment for AN is scarce, it is crucial to investigate new treatment options, preferably focused on influencing the underlying neurobiological mechanisms of AN. The objective of the present paper was to review the evidence for possible neurobiological correlates of AN, and to hypothesize about potential targets for Deep brain stimulation (DBS) as a treatment for chronic, therapy-refractory AN. One avenue for exploring new treatment options based on the neurobiological correlates of AN, is the search for symptomatologic and neurobiologic parallels between AN and other compulsivity- or reward-related disorders. As in other compulsive disorders, the fronto-striatal circuitry, in particular the insula, the ventral striatum (VS) and the prefrontal, orbitofrontal, temporal, parietal and anterior cingulate cortices, are likely to be implicated in the neuropathogenesis of AN. In this paper we will review the few available cases in which DBS has been performed in patients with AN (either as primary diagnosis or as comorbid condition). Given the overlap in symptomatology and neurocircuitry between reward-related disorders such as obsessive compulsive disorder (OCD) and AN, and the established efficacy of accumbal DBS in OCD, we hypothesize that DBS of the nucleus accumbens (NAc) and other areas associated with reward, e.g. the anterior cingulated cortex (ACC), might be an effective treatment for patients with chronic, treatment refractory AN, providing not only weight restoration, but also significant and sustained improvement in AN core symptoms and associated comorbidities and complications. Possible targets for DBS in AN are the ACC, the ventral anterior limb of the capsula interna (vALIC) and the VS. We suggest conducting larger efficacy studies that also explore the functional effects of DBS in AN.
    MeSH term(s) Anorexia Nervosa/physiopathology ; Anorexia Nervosa/therapy ; Cerebral Cortex/physiopathology ; Deep Brain Stimulation ; Humans ; Internal Capsule/physiopathology ; Treatment Outcome ; Ventral Striatum/physiopathology
    Language English
    Publishing date 2013-10-31
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1471-244X
    ISSN (online) 1471-244X
    DOI 10.1186/1471-244X-13-277
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  2. Article ; Online: Deep brain stimulation for obsessive-compulsive disorder is associated with cortisol changes.

    de Koning, Pelle P / Figee, Martijn / Endert, Erik / Storosum, Jitschak G / Fliers, Eric / Denys, Damiaan

    Psychoneuroendocrinology

    2013  Volume 38, Issue 8, Page(s) 1455–1459

    Abstract: Deep brain stimulation (DBS) is an effective treatment for obsessive-compulsive disorder (OCD), but its mechanism of action is largely unknown. Since DBS may induce rapid symptomatic changes and the pathophysiology of OCD has been linked to the ... ...

    Abstract Deep brain stimulation (DBS) is an effective treatment for obsessive-compulsive disorder (OCD), but its mechanism of action is largely unknown. Since DBS may induce rapid symptomatic changes and the pathophysiology of OCD has been linked to the hypothalamic-pituitary-adrenal (HPA) axis, we set out to study whether DBS affects the HPA axis in OCD patients. We compared a stimulation ON and OFF condition with a one-week interval in 16 therapy-refractory OCD patients, treated with DBS for at least one year, targeted at the nucleus accumbens (NAc). We measured changes in 24-h urinary excretion of free cortisol (UFC), adrenaline and noradrenaline and changes in obsessive-compulsive (Y-BOCS), depressive (HAM-D) and anxiety (HAM-A) symptom scores. Median UFC levels increased with 53% in the OFF condition (from 93 to 143nmol/24h, p=0.12). There were no changes in urinary adrenaline or noradrenaline excretion. The increase in Y-BOCS (39%), and HAM-D (78%) scores correlated strongly with increased UFC levels in the OFF condition. Our findings indicate that symptom changes following DBS for OCD patients are associated with changes in UFC levels.
    MeSH term(s) Adult ; Anxiety/complications ; Anxiety/therapy ; Anxiety/urine ; Deep Brain Stimulation ; Depression/complications ; Depression/therapy ; Depression/urine ; Epinephrine/urine ; Female ; Humans ; Hydrocortisone/urine ; Male ; Middle Aged ; Norepinephrine/urine ; Nucleus Accumbens/physiology ; Obsessive-Compulsive Disorder/complications ; Obsessive-Compulsive Disorder/therapy ; Obsessive-Compulsive Disorder/urine ; Psychiatric Status Rating Scales
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Norepinephrine (X4W3ENH1CV) ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Controlled Clinical Trial ; Journal Article
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2012.12.006
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  3. Article ; Online: Nursing Staff Factors Contributing to Seclusion in Acute Mental Health Care - An Explorative Cohort Study.

    Doedens, Paul / Maaskant, Jolanda M / Latour, Corine H M / Meijel, Berno K G van / Koeter, Maarten W J / Storosum, Jitschak G / Barkhof, Emile / de Haan, Lieuwe

    Issues in mental health nursing

    2017  Volume 38, Issue 7, Page(s) 584–589

    Abstract: Background: Seclusion is a controversial intervention. Efficacy with regard to aggressive behaviour has not been demonstrated, and seclusion is only justified for preventing safety hazards. Previous studies indicate that nursing staff factors may be ... ...

    Abstract Background: Seclusion is a controversial intervention. Efficacy with regard to aggressive behaviour has not been demonstrated, and seclusion is only justified for preventing safety hazards. Previous studies indicate that nursing staff factors may be predictors for seclusion, although methodological issues may have led to equivocal results.
    Objective: To perform a prospective cohort study to determine whether nursing staff characteristics are associated with seclusion of adult inpatients admitted to a closed psychiatric ward.
    Method: We studied the association between nurses' demographics and incidence of seclusion during every shift. Data were collected during five months in 2013. Multiple logistic regression was used for analysis.
    Results: In univariable analysis, we found a non-significant association between seclusion and female gender, odds ratio (OR) = 5.27 (0.98-28.49) and a significant association between seclusion and nurses' large physical stature, OR = 0.21 (0.06-0.72). We found that physical stature is the most substantial factor, although not significant: OR
    Conclusion: Nurses' gender may be a predictor for seclusion, but it seems to be mediated by the effect of physical stature. We used a rigorous, census-based, prospective design to collect data on a highly detailed level and found a large effect of physical stature of nurses on seclusion. We found nurses' physical stature to be the most substantial predictor for seclusion. These and other factors need to be explored in further research with larger sample size.
    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 603180-8
    ISSN 1096-4673 ; 0161-2840
    ISSN (online) 1096-4673
    ISSN 0161-2840
    DOI 10.1080/01612840.2017.1297513
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  4. Article ; Online: Does Insight Affect the Efficacy of Antipsychotics in Acute Mania?: An Individual Patient Data Regression Meta-Analysis.

    Welten, Carlijn C M / Koeter, Maarten W J / Wohlfarth, Tamar D / Storosum, Jitschak G / van den Brink, Wim / Gispen-de Wied, Christine C / Leufkens, Hubert G M / Denys, Damiaan A J P

    Journal of clinical psychopharmacology

    2016  Volume 36, Issue 1, Page(s) 71–76

    Abstract: Patients having an acute manic episode of bipolar disorder often lack insight into their condition. Because little is known about the possible effect of insight on treatment efficacy, we examined whether insight at the start of treatment affects the ... ...

    Abstract Patients having an acute manic episode of bipolar disorder often lack insight into their condition. Because little is known about the possible effect of insight on treatment efficacy, we examined whether insight at the start of treatment affects the efficacy of antipsychotic treatment in patients with acute mania. We used individual patient data from 7 randomized, double-blind, placebo-controlled registration studies of 4 antipsychotics in patients with acute mania (N = 1904). Insight was measured with item 11 of the Young Mania Rating Scale (YMRS) at baseline and study endpoint 3 weeks later. Treatment outcome was defined by (a) mean change score, (b) response defined as 50% or more improvement on YMRS, and (c) remission defined as YMRS score less than 8 at study endpoint. We used multilevel mixed effect linear (or logistic) regression analyses of individual patient data to assess the interaction between baseline insight and treatment outcomes. At treatment initiation, 1207 (63.5%) patients had impaired or no insight into their condition. Level of insight significantly modified the efficacy of treatment by mean change score (P = 0.039), response rate (P = 0.033), and remission rate (P = 0.043), with greater improvement in patients with more impaired insight. We therefore recommend that patients experiencing acute mania should be treated immediately and not be delayed until patients regain insight.
    MeSH term(s) Acute Disease ; Adult ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Bipolar Disorder/physiopathology ; Bipolar Disorder/psychology ; Humans ; Male ; Psychiatric Status Rating Scales ; Randomized Controlled Trials as Topic ; Regression Analysis ; Treatment Outcome
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000000435
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    Zs.A 1664: Show issues Location:
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  5. Article ; Online: Early Nonresponse in the Antipsychotic Treatment of Acute Mania: A Criterion for Reconsidering Treatment? Results From an Individual Patient Data Meta-Analysis.

    Welten, Carlijn C M / Koeter, Maarten W J / Wohlfarth, Tamar D / Storosum, Jitschak G / van den Brink, Wim / Gispen-de Wied, Christine C / Leufkens, Hubert G M / Denys, Damiaan A J P

    The Journal of clinical psychiatry

    2016  Volume 77, Issue 9, Page(s) e1117–e1123

    Abstract: Objective: To investigate whether early nonresponse to antipsychotic treatment of acute mania predicts treatment failure and, if so, to establish the best definition or criterion of an early nonresponse.: Data sources: Short-term efficacy studies ... ...

    Abstract Objective: To investigate whether early nonresponse to antipsychotic treatment of acute mania predicts treatment failure and, if so, to establish the best definition or criterion of an early nonresponse.
    Data sources: Short-term efficacy studies assessing antipsychotics that were submitted to the Dutch Medicines Evaluation Board during an 11-year period as part of the marketing authorization application for the indication of acute manic episode of bipolar disorder. Pharmaceutical companies provided their raw patient data, which enabled us to perform an individual patient data meta-analysis.
    Study selection: All double-blind, randomized, placebo-controlled trials assessing the efficacy of antipsychotics for acute manic episode of bipolar disorder were included (10 trials).
    Data extraction: All patients with data available for completer analysis (N = 1,243), symptom severity scores on the Young Mania Rating Scale (YMRS) at weeks 0, 1, and 2 and at study end point (week 3 or 4).
    Results: The a priori chances of nonresponse and nonremission at study end point were 40.9% (95% CI, 38.2%-43.6%) and 65.3% (95% CI, 62.0%-68.6%), respectively. Early nonresponse in weeks 1 and 2, defined by cutoff scores ranging from a ≤ 10% to a ≤ 50% reduction in symptoms compared to baseline on the YMRS, significantly predicted nonresponse (≤ 0% symptom reduction) and nonremission (YMRS score higher than 8) in week 3. The predictive value of early nonresponse (PVnr_se) at week 1 for both nonresponse and nonremission at study end point declined linearly with increasing cutoff scores of early nonresponse; nonresponse: 76.0% (95% CI, 69.7%-82.3%) for a ≤ 10% response to 48.7% (95% CI, 45.5%-51.9%) for a ≤ 50% response; nonremission: 92.2% (95% CI, 88.3%-96.1%) for a ≤ 10% response to 76.8% (95% CI, 74.4%-79.5%) for a ≤ 50% response. A similar linear decline was observed for increasing cutoff scores of early nonresponse at week 2 for nonresponse, but not for nonremission at end point: nonresponse 90.3% (95% CI, 84.6%-96.0%) for a ≤ 10% response to 65.0% (95% CI, 61.4%-68.6%) for a ≤ 50% response; nonremission: 94.2% (95% CI, 89.7%-98.7%) for a ≤ 10% response and 93.2% (95% CI, 93.1%-95.1%) for a ≤ 50% response. Specific antipsychotic characteristics did not modify these findings at either time point (week 1: P = .127; week 2: P = .213).
    Conclusions: When patients fail to respond early (1-2 weeks) after the initiation of antipsychotic treatment for acute mania, clinicians should reconsider their treatment choice using a 2-stage strategy.
    MeSH term(s) Acute Disease ; Adult ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/pharmacology ; Bipolar Disorder/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Outcome Assessment (Health Care)/statistics & numerical data ; Randomized Controlled Trials as Topic/statistics & numerical data ; Treatment Failure
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2016-10-20
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.15r10051
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  6. Article ; Online: Incidence and prevalence of "diagnosed OCD" in a primary care, treatment seeking, population.

    Veldhuis, Joris / Dieleman, Jeanne P / Wohlfarth, Tamar / Storosum, Jitschak G / van Den Brink, Wim / Sturkenboom, Miriam C J M / Denys, Damiaan

    International journal of psychiatry in clinical practice

    2012  Volume 16, Issue 2, Page(s) 85–92

    Abstract: Objective: To obtain valid and accurate estimates of the incidence and prevalence of OCD in a treatment-seeking primary care population and to compare these estimates with estimates from epidemiological community studies.: Methods: A retrospective ... ...

    Abstract Objective: To obtain valid and accurate estimates of the incidence and prevalence of OCD in a treatment-seeking primary care population and to compare these estimates with estimates from epidemiological community studies.
    Methods: A retrospective cohort study (1996-2007) was conducted in a GP research database with longitudinal electronic patient record data of 800,000 patients throughout The Netherlands. OCD was ascertained and classified by systematic review of computerized longitudinal medical records. Age and gender specific incidence rates were calculated per calendar year as the number of newly diagnosed cases per 100 person years.
    Results: Among 577,085 eligible patients, 346 patients were newly diagnosed with OCD resulting in a 1-year treatment-seeking incidence of 0.016% (95% CI: 0.014-0.018). Across the entire study period, a total of 780 patients had a clinical diagnosis of OCD resulting in a treatment-seeking prevalence of 0.14% (95% CI: 0.126-0.145). The incidence rate was highest among women and between the age of 20 and 29. No significant changes over time were observed.
    Conclusions: The incidence rate and prevalence of OCD in treatment-seeking GP patients are at least 3 times lower than estimates known from the most conservative epidemiological community studies, suggesting that OCD may be under recognised and under treated.
    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Epidemiologic Methods ; Family Practice/statistics & numerical data ; Female ; Humans ; Infant ; Male ; Middle Aged ; Netherlands/epidemiology ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/epidemiology ; Patient Acceptance of Health Care/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2012-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1465531-7
    ISSN 1471-1788 ; 1365-1501
    ISSN (online) 1471-1788
    ISSN 1365-1501
    DOI 10.3109/13651501.2011.617454
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    Zs.A 4995: Show issues Location:
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  7. Article ; Online: Viral metagenomics in drug-naïve, first-onset schizophrenia patients with prominent negative symptoms.

    Canuti, Marta / van Beveren, Nico J M / Jazaeri Farsani, Seyed Mohammad / de Vries, Michel / Deijs, Martin / Jebbink, Maarten F / Zaaijer, Hans L / van Schaik, Barbera D C / van Kampen, Antoine H C / van der Kuyl, Antoinette C / de Haan, Lieuwe / Storosum, Jitschak G / van der Hoek, Lia

    Psychiatry research

    2015  Volume 229, Issue 3, Page(s) 678–684

    Abstract: Although several studies suggest a virus or (endogenous) retrovirus involvement at the time of onset of schizophrenia, the unequivocal identification of one or more infectious agents, by means of an undirected catch-all technique, has never been ... ...

    Abstract Although several studies suggest a virus or (endogenous) retrovirus involvement at the time of onset of schizophrenia, the unequivocal identification of one or more infectious agents, by means of an undirected catch-all technique, has never been conducted. In this study VIDISCA, a virus discovery method, was used in combination with Roche-454 high-throughput sequencing as a tool to determine the possible presence of viruses (known or unknown) in blood of first-onset drugs-naïve schizophrenic patients with prominent negative symptoms. Two viruses (the Anellovirus Torque Teno virus and GB virus C) were detected. Both viruses are commonly found in healthy individuals and no clear link with disease was ever established. Viruses from the family Anelloviridae were also identified in the control population (4.8%). Besides, one patient sample was positive for human endogenous retroviruses type K (HML-2) RNA but no specific predominant strain was detected, instead 119 different variants were found. In conclusion, these findings indicate no evidence for viral or endogenous retroviral involvement in sera at the time of onset of schizophrenia.
    MeSH term(s) Adult ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Endogenous Retroviruses/genetics ; Endogenous Retroviruses/isolation & purification ; Female ; GB virus C/genetics ; GB virus C/isolation & purification ; Genome, Viral ; Humans ; Male ; Metagenomics ; Middle Aged ; RNA, Viral/genetics ; Schizophrenia/genetics ; Schizophrenia/virology ; Torque teno virus/genetics ; Torque teno virus/isolation & purification
    Chemical Substances DNA, Viral ; RNA, Viral
    Language English
    Publishing date 2015-10-30
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2015.08.025
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    Zs.A 1541: Show issues Location:
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  8. Article ; Online: Reduced maternal levels of common viruses during pregnancy predict offspring psychosis: potential role of enhanced maternal immune activity?

    Canuti, Marta / Buka, Stephen / Jazaeri Farsani, Seyed Mohammad / Oude Munnink, Bas B / Jebbink, Maarten F / van Beveren, Nico J M / de Haan, Lieuwe / Goldstein, Jill / Seidman, Larry J / Tsuang, Ming T / Storosum, Jitschak G / van der Hoek, Lia

    Schizophrenia research

    2015  Volume 166, Issue 1-3, Page(s) 248–254

    Abstract: Viral infections during the prenatal or early childhood periods are one of the environmental factors which might play an etiological role in psychoses. Several studies report higher antibody levels against viruses during pregnancy in blood of mothers of ... ...

    Abstract Viral infections during the prenatal or early childhood periods are one of the environmental factors which might play an etiological role in psychoses. Several studies report higher antibody levels against viruses during pregnancy in blood of mothers of offspring with psychotic disorders, but the presence of such viruses has never been demonstrated. The goal of this study was to investigate the potential association between viral infections during pregnancy and progeny with psychotic disorders and, for this purpose, we performed a nested case-control study involving pregnant mothers of offspring with schizophrenia or bipolar disorder with psychotic features (cases, N=43) and pregnant women with healthy offspring (controls, N=95). Since several potential viral candidates have been suggested in prior work, a broad-spectrum virus detection system was necessary. A metagenomic analysis performed with the virus discovery method VIDISCA-454 revealed only common blood-associated viruses in all cohorts. However, a significantly lower viral prevalence was detected in the group of cases and in the sub-population of pregnant mothers of offspring with schizophrenia (p<0.05). Consistent with the existing inverse correlation between the level of these viruses and the immunocompetence of an individual, we hypothesized the presence of a higher immune activity during pregnancy in mothers whose offspring later develop a psychotic disorder as compared to controls. Combining our results with previously available literature data on antibody levels during the gestation period suggests that a more prominent maternal immune activity can be considered a risk factor for developing psychosis.
    MeSH term(s) Adolescent ; Adult ; Bipolar Disorder/epidemiology ; Case-Control Studies ; Cohort Studies ; DNA, Viral/blood ; Disease Susceptibility ; Female ; Humans ; Male ; Metagenome ; Middle Aged ; Odds Ratio ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/immunology ; Prenatal Exposure Delayed Effects ; Schizophrenia/epidemiology ; Virus Diseases/epidemiology ; Virus Diseases/immunology ; Young Adult
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2015-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2015.04.037
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  9. Article ; Online: Incidence rates and risk factors of bipolar disorder in the general population: a population-based cohort study.

    Kroon, Jojanneke S / Wohlfarth, Tamar D / Dieleman, Jeanne / Sutterland, Arjen L / Storosum, Jitschak G / Denys, Damiaan / de Haan, Lieuwe / Sturkenboom, Mirjam C J M

    Bipolar disorders

    2013  Volume 15, Issue 3, Page(s) 306–313

    Abstract: Objective: To estimate the incidence rates (IRs) of bipolar I and bipolar II disorders in the general population according to sociodemographic population characteristics.: Methods: A cohort study (during the years 1996-2007) was conducted in a ... ...

    Abstract Objective: To estimate the incidence rates (IRs) of bipolar I and bipolar II disorders in the general population according to sociodemographic population characteristics.
    Methods: A cohort study (during the years 1996-2007) was conducted in a general practitioners research database with a longitudinal electronic record of 800000 patients throughout the Netherlands [the Integrated Primary Care Information (IPCI) database]. Cases of bipolar disorder were identified and classified by systematic review of medical records. Age- and gender-specific IRs were calculated per calendar year, degree of urbanization, and degree of deprivation.
    Results: The overall IR of bipolar disorder was 0.70/10000 person-years (PY) [95% confidence interval (CI): 0.57-0.83]; the IR of bipolar I disorder was 0.43/10000 PY (95% CI: 0.34-0.55) and the IR of bipolar II disorder was 0.19/10000 PY (95% CI: 0.13-0.27). Two peaks in the age at onset of the disorder were noticed: one in early adulthood (15-24 years; 0.68/10000 PY) and a larger peak in later life (45-54 years; 1.2/10000 PY). In bipolar II disorder, only one peak, in the 45-54 year age category (IR 0.42/10000 PY), was found. The IRs of bipolar disorder were significantly higher in deprived areas. Similar rates were found for men compared to women and in urban compared to rural areas. No association was found between the onset of first (hypo)manic episode and month or season of birth.
    Conclusions: We found two peaks in the age at onset of bipolar disorder, one in early adulthood and one in later life, the former consisting mainly of bipolar I disorder subjects. The incidence of bipolar disorder is higher in deprived areas. The onset of bipolar disorder is not associated with gender, urbanization, or month or season of birth.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Age of Onset ; Bipolar Disorder/epidemiology ; Bipolar Disorder/psychology ; Cohort Studies ; Community Health Planning ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Netherlands/epidemiology ; Parturition ; Psychosocial Deprivation ; Retrospective Studies ; Risk Factors ; Sex Factors ; Time Factors ; Young Adult
    Language English
    Publishing date 2013-05
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.12058
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  10. Article ; Online: Annual incidence rate of schizophrenia and schizophrenia spectrum disorders in a longitudinal population-based cohort study.

    Sutterland, Arjen L / Dieleman, Jeanne / Storosum, Jitschak G / Voordouw, Bettie A C / Kroon, Jojanneke / Veldhuis, Joris / Denys, Damiaan A J P / de Haan, Lieuwe / Sturkenboom, Miriam C J M

    Social psychiatry and psychiatric epidemiology

    2013  Volume 48, Issue 9, Page(s) 1357–1365

    Abstract: Background: Longitudinal incidence studies of schizophrenia spectrum disorders (SSD) performed in mental health service organizations are prone to confounding factors not found in research performed in the general population.: Objectives: To estimate ...

    Abstract Background: Longitudinal incidence studies of schizophrenia spectrum disorders (SSD) performed in mental health service organizations are prone to confounding factors not found in research performed in the general population.
    Objectives: To estimate the incidence rates (IRs) over a 10-year period of SSD (broadly defined) and schizophrenia (narrowly defined) in the general population and to analyze associated risk factors.
    Methods: A cohort study (1996-2006) in a large general practitioners research database was conducted with longitudinal medical records of 350,524 patients throughout the Netherlands. Cases of SSD were identified and classified by systematic review of medical records. Age- and gender-specific IRs were calculated per calendar year, date of birth, degree of urbanicity and deprivation.
    Results: Overall IR of SSD in this population was 22/100,000 person years (PY) (95% CI 19-24). IR of schizophrenia was 12/100,000 PY (95% CI 10-14). Period prevalence was 3.5 per 1,000 PY. IRs were higher in men compared to women, had a peak at age 15-25 years, decreasing rapidly after 25 years by 40% per 10 years. IRs of SSD were significantly higher in urban areas, irrespective of deprivation. No association was found between IRs of SSD and living in deprived areas or month of birth. There was no significant time trend of the IR during the period under study.
    Conclusions: IRs of SSD are higher in urban areas, independent of social deprivation. Age- and gender-specific differences in IR were found. The magnitude of these differences was larger in narrowly defined schizophrenia than in SSD.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Female ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Netherlands/epidemiology ; Population Surveillance ; Prevalence ; Proportional Hazards Models ; Psychosocial Deprivation ; Residence Characteristics ; Risk Factors ; Rural Population ; Schizophrenia/epidemiology ; Sex Factors ; Socioeconomic Factors ; Urban Population ; Young Adult
    Language English
    Publishing date 2013-01-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 623071-4
    ISSN 1433-9285 ; 0037-7813 ; 0933-7954
    ISSN (online) 1433-9285
    ISSN 0037-7813 ; 0933-7954
    DOI 10.1007/s00127-013-0651-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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