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  1. Article ; Online: Involvement of RhoA/Rho-kinase in l-cysteine/H

    Aydinoglu, Fatma / Adıbelli, Elif Özveren / Yılmaz-Oral, Didem / Ogulener, Nuran

    Nitric oxide : biology and chemistry

    2019  Volume 85, Page(s) 54–60

    Abstract: ... detumescense. Also, importance of l-cysteine/H ...

    Abstract Rho-kinase activity is a key regulator in the maintenance of corporal vasoconstriction and penile detumescense. Also, importance of l-cysteine/H
    MeSH term(s) Animals ; Cysteine/metabolism ; Cysteine/pharmacology ; Hydrogen Sulfide/metabolism ; Hydrogen Sulfide/pharmacology ; Male ; Mice ; Muscle Contraction/drug effects ; Phenylephrine/antagonists & inhibitors ; Phenylephrine/pharmacology ; rho GTP-Binding Proteins/metabolism ; rho-Associated Kinases/metabolism
    Chemical Substances Phenylephrine (1WS297W6MV) ; rho-Associated Kinases (EC 2.7.11.1) ; RhoA protein, mouse (EC 3.6.5.2) ; rho GTP-Binding Proteins (EC 3.6.5.2) ; Cysteine (K848JZ4886) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2019-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1362794-6
    ISSN 1089-8611 ; 1089-8603
    ISSN (online) 1089-8611
    ISSN 1089-8603
    DOI 10.1016/j.niox.2019.02.001
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    Zs.A 4677: Show issues Location:
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  2. Article ; Online: Serum levels and H/L gene polymorphism of mannose-binding lectin in primary open angle glaucoma.

    Dursun, Ozer / Yilmaz, Ayça / Ayaz, Lokman / Tamer, Lülüfer

    Current eye research

    2012  Volume 37, Issue 3, Page(s) 212–217

    Abstract: Purpose: To analyze the serum levels and H/L gene polymorphisms of mannose-binding lectin-2 (MBL-2 ... in real-time PCR. Chi-square or Fisher's Exact Tests were used to evaluate the distribution of MBL-2 H/L ... genotypes among patients and control subjects. Associations between the H/L genotype and POAG risk were ...

    Abstract Purpose: To analyze the serum levels and H/L gene polymorphisms of mannose-binding lectin-2 (MBL-2) in primary open angle glaucoma (POAG) cases and control subjects to investigate whether MBL-2 has a possible role in the development and pathogenesis of POAG.
    Materials and methods: In 45 POAG cases and age and sex-matched 45 healthy controls, Elisa Kit was used to determine serum levels of MBL-2. The genomic DNA of patient and control groups was extracted from whole blood using High Pure PCR template preparation kit. Genotyping of MBL-2 polymorphisms were detected by using a MBL-2 mutation detection kit in real-time PCR. Chi-square or Fisher's Exact Tests were used to evaluate the distribution of MBL-2 H/L genotypes among patients and control subjects. Associations between the H/L genotype and POAG risk were analyzed by using binary logistic regression. The serum MBL-2 levels of both groups were compared with Independent Sample t-test.
    Results: Mean MBL-2 serum levels in the patient group (21.30 ± 4.97 µg/mL) was significantly higher than the control group (17.48 ± 3.66 µg/mL), (p < 0.001). The distribution of alleles in the patient group was 28.9% for LL, 44.4% for HL, 26.7% for HH and in controls was 33.3% for LL, 37.8% for HL, 28.3% for HH. According to genotype ratios, the two groups were not different from each other.
    Conclusions: Our findings may suggest an association between high serum MBL-2 levels and POAG, but H/L gene polymorphism of MBL-2 seems not to be associated with POAG.
    MeSH term(s) DNA Mutational Analysis ; DNA Probes/chemistry ; Enzyme-Linked Immunosorbent Assay ; Female ; Genotype ; Genotyping Techniques ; Glaucoma, Open-Angle/blood ; Glaucoma, Open-Angle/genetics ; Humans ; Male ; Mannose-Binding Lectin/blood ; Mannose-Binding Lectin/genetics ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide/genetics
    Chemical Substances DNA Probes ; MBL2 protein, human ; Mannose-Binding Lectin
    Language English
    Publishing date 2012-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 82079-9
    ISSN 1460-2202 ; 0271-3683
    ISSN (online) 1460-2202
    ISSN 0271-3683
    DOI 10.3109/02713683.2011.639124
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  3. Article ; Online: ed-Dürretü’l-Mudıyye fi’l-Lugati’t-Türkiyye’nin Kıpçak ve Oğuz Nüshalarındaki Bazı Arkaik Kelimeler

    Recep Yılmaz

    Din ve Bilim Muş Alparslan Üniversitesi İslami İlimler Fakültesi Dergisi, Vol 5, Iss 2, Pp 310-

    2022  Volume 341

    Abstract: ... Mısır ve Suriye sahasında yazılmış sözlüklerinden biri olan ed-Dürretü’l-Mudiyye ile aynı adı taşıyan ...

    Abstract Çalışmamız Türk dilinin önemli kollarından birini teşkil eden Kıpçakça’nın XIII-XV. yüzyıllar arası Mısır ve Suriye sahasında yazılmış sözlüklerinden biri olan ed-Dürretü’l-Mudiyye ile aynı adı taşıyan Türkmence sözlüğün karşılaştırılmasını içermektedir. Çalışmayla XI. yüzyılda Kaşgarlı Mahmud’un adlarını birlikte zikrettiği, Batı’ya doğru ilerleme sürecinde biri kuzeye diğeri güneye göç ederek birbirinden ayrılan ve söz konusu yüzyıllarda yolları Memlük sahasında birleşen Oğuz ve Kıpçak boyları arasındaki etkileşime ayna tutulması amaçlanmıştır. Dolayısıyla Türkçenin tarihi bir dönemiyle ilgili olan çalışmanın ilk bölümünde, her iki eserdeki söz varlığının karşılaştırılması hedeflenmiş, eserlerin Arapça kavramları karşılama tavırlarını daha kolay göstermek amacıyla veriler tablolar halinde sunulmuştur. Örtüşen tematik bölümlerin temel alındığı çalışmada yapılan karşılaştırmalar, fikir vermesi açısından tematik bölümlerden ilki ve en büyüğü olan “gök ve yerdeki varlıklar” bölümü üzerinden gösterilmiştir. Çalışmamızın ikinci bölümünde ise Arapça kelimeler mukabilinde her iki sözlükçe verilen sözcükler Arapça karşılıklarının sağladığı teyit ve mukayese avantajından yararlanılarak anlamlandırılmış, bunlardan form yahut anlam bakımından değişikliğe uğrayarak arkaik özellikler gösteren dört adedi ele alınıp bu kelimeler için yeni izahlar teklif edilmiştir.
    Keywords türk i̇slam edebiyatı ; karşılaştırmalı sözlük çalıştırmaları ; memlük kıpçakça’sı ; ed-dürretü’l-mudiyye ; oğuz – türkmence ; arkaik kelimeler ; turkish islamic literature ; comparative dictionary studies ; mamluk kipchak language ; ed-dürretü ; oghuz – turkmen language ; archaic words ; Religion (General) ; BL1-50 ; Social Sciences ; H ; Science ; Q
    Language Arabic
    Publishing date 2022-12-01T00:00:00Z
    Publisher Muş Alparslan University
    Document type Article ; Online
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  4. Article ; Online: Latîfe ez-Zeyyât’ın el-Bâbu’l-Meftûh Adlı Romanında Gelenekle Modernite Arasında Kadın Tipolojileri

    Fetiye Yılmaz

    Din ve Bilim Muş Alparslan Üniversitesi İslami İlimler Fakültesi Dergisi, Vol 5, Iss 2, Pp 361-

    2022  Volume 382

    Abstract: ... başyapıtı el-Bâbu’l-Meftûh, 1960 yılında yayınlandığı zaman Mısır’da büyük yankı uyandırır. 1963 yılında ...

    Abstract 17. yüzyıldan itibaren Avrupa’nın kendi iç dinamikleriyle başlayan, siyasal, sosyal, ekonomik ve kültürel alanda yaşanan değişiklikleri ifade eden modernizm, batı dışı ülkeleri de etkisi altına almayı başarmıştır. 1789’da Fransa’nın işgali sonrasında modern batıyla tanışan Mısır, birçok alanda batılılaşma yoluna gider. Bu süreçte ülkeye giren ve modern bir tür olan roman, Mısır’ın modernleşmesi yolunda kullanılan etkin bir araç olmuştur. Modern Mısır romanının önde gelen isimlerinden Latîfe ez-Zeyyât’ın başyapıtı el-Bâbu’l-Meftûh, 1960 yılında yayınlandığı zaman Mısır’da büyük yankı uyandırır. 1963 yılında sinemaya uyarlanan ve halkın hafızasında derin iz bırakan eserin hem kendisi hem de filmi, günümüzde Mısır gençlerini yönlendirmeye devam etmektedir. Yazarın biyografisinden önemli ölçüde izler taşıyan roman, Mısırlı orta sınıf ailede yetişen bir genç kız olan Leyla’nın gözünden antiemperyalist mücadeleyi anlatırken modernitenin temel değerlerinden olan otorite karşıtlığı, özgürlük, bireysellik ve geleneği reddetme gibi konuları ele almıştır. Mısır’ın ilk feminist yazarlarından kabul edilen Latîfe ez-Zeyyât’ın başyapıtında ele aldığı en önemli konulardan biri kadının özgürleşmesi ve kendi kimliğini oluşturmasıdır. Romanın kadın kahramanı Leyla’nın kimlik arayış serüveni romanın ana konularından biridir.
    Keywords egyptian novel ; latifa ez-zeyyat ; woman ; tradition ; modernism ; mısır romanı ; latife ez-zeyyat ; kadın ; gelenek ; modernizm ; Religion (General) ; BL1-50 ; Social Sciences ; H ; Science ; Q
    Language Arabic
    Publishing date 2022-12-01T00:00:00Z
    Publisher Muş Alparslan University
    Document type Article ; Online
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  5. Article ; Online: The Effects of Active Warming on Core Body Temperature and Thermal Comfort in Patients After Transurethral Resection of the Prostate: A Randomized Clinical Trial.

    Yılmaz, Hülya / Khorshid, Leyla

    Clinical nursing research

    2022  Volume 32, Issue 2, Page(s) 313–322

    Abstract: Prevention and treatment of hypothermia by active warming in perioperative period care is recommended but scientific evidence of its effectiveness in a clinical setting is scarce. The purpose of this study was to determine the effects of warmed ... ...

    Abstract Prevention and treatment of hypothermia by active warming in perioperative period care is recommended but scientific evidence of its effectiveness in a clinical setting is scarce. The purpose of this study was to determine the effects of warmed intravenous fluids (WIVF) on the core body temperature and the patients' thermal comfort. Baseline data of 105 male patients undergoing TUR-P surgery and bladder irrigation were analyzed. The experimental group was warmed using active WIVF, and the control group's routine care was conducted using a cotton blanket. Body temperature was higher in patients in the experimental group than those in the control group. Repeated measures Manova revealed significantly different core temperature changes between groups (
    MeSH term(s) Humans ; Male ; Body Temperature ; Transurethral Resection of Prostate ; Hypothermia/prevention & control ; Perioperative Care ; Patients
    Language English
    Publishing date 2022-04-30
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1146553-0
    ISSN 1552-3799 ; 1054-7738
    ISSN (online) 1552-3799
    ISSN 1054-7738
    DOI 10.1177/10547738221090593
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    Zs.A 3652: Show issues Location:
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  6. Article ; Online: fNIRS-based evaluation of the impact of SARS-CoV-2 infection central auditory processing.

    Yaman, Handan / Yılmaz, Oğuz / Hanoğlu, Lütfü / Bayazıt, Yıldırım

    Brain and behavior

    2023  Volume 13, Issue 12, Page(s) e3303

    Abstract: Objectives: Coronavirus disease-2019 due to SARS-CoV-2 infection has been associated with neurological and neuropsychiatric illnesses as well as auditory system problems. In this study, we aimed to evaluate the impact of SARS-CoV-2 infection on the ... ...

    Abstract Objectives: Coronavirus disease-2019 due to SARS-CoV-2 infection has been associated with neurological and neuropsychiatric illnesses as well as auditory system problems. In this study, we aimed to evaluate the impact of SARS-CoV-2 infection on the central auditory system by assessing the hemodynamic activation changes using functional near-infrared spectroscopy (fNIRS).
    Methods: Three participants who had SARS-CoV-2 infection (study group) and four participants who had no SARS-CoV-2 infection (control group) were included in the study. During the auditory oddball task in which two different frequencies of tonal stimulation were presented at 80 dB HL, the participants were asked to pay attention to the rare tonal stimulation and mentally count these target stimuli throughout the task. During this task, oxygenated hemodynamic response functions were evaluated with fNIRS.
    Results: Significantly increased oxygenated hemodynamic responses were observed in both groups during the task (p < .05), which was significantly higher in the study group (p < .05). Significantly more HbO activation was observed in the vmPFC, superior temporal gyrus, and medial temporal gyrus in the study group compared to controls (p < .05). Significantly higher hemodynamic activation was observed in the right hemisphere in both groups, which was significantly higher in the study group (p < .05).
    Conclusion: SARS-CoV-2 infections may impact on central auditory processing or auditory attention due to changes in oxyhemoglobin levels in the frontal and temporal brain regions. It seems that SARS-CoV-2 infection is associated with an additional load on neural activity, and difficulties in focusing in auditory attention, following speech and hearing in noise as well as increased effort to perceive auditory cues.
    MeSH term(s) Humans ; Brain Mapping/methods ; Acoustic Stimulation ; Spectroscopy, Near-Infrared/methods ; COVID-19 ; SARS-CoV-2 ; Auditory Perception
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.3303
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  7. Article ; Online: Comparison of the targeted metabolomics and nutritional quality indices of the probiotic cheese enriched with microalgae.

    Yilmaz-Ersan, Lutfiye / Suna, Gizem

    Talanta

    2024  Volume 272, Page(s) 125801

    Abstract: The objective of this study is to evaluate the influence of mixed L. acidophilus LA-5 and ... such as EAAI, NI, BV, MUFA/SFA, h/H, and DFA. The chemometric analysis (e.g. HCA and PCA) presented ...

    Abstract The objective of this study is to evaluate the influence of mixed L. acidophilus LA-5 and enrichment with microalgae (C. vulgaris and A. platensis) on metabolomic formation in a brined cheese matrix. Microbiological, compositional, and metabolomic characterization were investigated during the ripening. It was found that the nutritional quality indices of the samples were based on amino acid and fatty acid characterization. Fifty-six metabolomics including fatty acids, amino acids, organic acids, minerals, and vitamins were detected using the HPLC-DAD, GC-MS, and ICP-OES-based methods. The results indicated that the enrichment with probiotic strain and microalgae led to an increase in the nutritional quality indices such as EAAI, NI, BV, MUFA/SFA, h/H, and DFA. The chemometric analysis (e.g. HCA and PCA) presented the variance between the cheese samples based on their attributes. The identification of cheese metabolomics throughout the ripening could be used for a better understanding of the functional ingredients-cheese matrix relationships and as a directive approach for novel dairy products in other metabolomic-related studies.
    MeSH term(s) Amino Acids/analysis ; Cheese/analysis ; Fatty Acids/analysis ; Lactobacillus acidophilus/metabolism ; Microalgae ; Nutritive Value ; Probiotics/metabolism
    Chemical Substances Amino Acids ; Fatty Acids
    Language English
    Publishing date 2024-02-22
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.125801
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  8. Article ; Online: Sunflower Oil-Polyglycerol Stearate Oleogels: Alternative Deep-fat Frying Media for Onion Rings.

    Aydeniz-Guneser, Buket / Yılmaz, Emin

    Journal of oleo science

    2022  Volume 71, Issue 5, Page(s) 651–662

    Abstract: ... in oleogels were compared with those fried in control sunflower oil. Free fatty acids at the end of 6 h were ... weight gain from the fried products. There were no negative effects of oleogel usage on the L* value, aroma ...

    Abstract Sunflower oil oleogels consisting of 3% and 8% polyglycerol stearate (PGSO) were studied as an alternative frying media for onion rings. The physicochemical properties and thermo-rheological characteristics of oleogels were provided. The sensorial quality and texture profiles of onion rings fried in oleogels were compared with those fried in control sunflower oil. Free fatty acids at the end of 6 h were determined, and decreasing trend was reported in order as PGSO-8, control (sunflower) oil, and PGSO-3. The oxidation induction time for PGSO-8 was significantly lower (1.46 min) than those of the control and PGSO-3 samples following frying. Compared to the control group, the onion ring samples fried in oleogels absorbed approximately 33-37% less oil. It was thought that this reduction would help consumers to less total calorie and weight gain from the fried products. There were no negative effects of oleogel usage on the L* value, aroma, crispness/texture, and overall acceptability scores for the onion ring samples fried in the oleogels.
    MeSH term(s) Glycerol ; Onions ; Organic Chemicals ; Polymers ; Stearates ; Sunflower Oil/chemistry
    Chemical Substances Organic Chemicals ; Polymers ; Stearates ; Sunflower Oil ; oleogels ; polyglycerol (25618-55-7) ; Glycerol (PDC6A3C0OX)
    Language English
    Publishing date 2022-03-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2218264-0
    ISSN 1347-3352 ; 1345-8957
    ISSN (online) 1347-3352
    ISSN 1345-8957
    DOI 10.5650/jos.ess21446
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  9. Article ; Online: Evaluation of the effect of hyperchloremia on the prognosis and mortality of medical intensive care patients: a single-center study.

    Yılmaz, Habip / Güney, Başak Çakır

    Turkish journal of medical sciences

    2022  Volume 52, Issue 5, Page(s) 1689–1696

    Abstract: ... in the MICU for under 48 h were excluded. Comorbidity status, complete blood count, biochemistry tests, and ... performed to determine the discriminating power of Cl levels with a cut-off value of >98 mEq/L in relation ...

    Abstract Background: While chloride (Cl) is the most abundant anion in the serum, it is unfortunately one of the most commonly disregarded laboratory test results routinely drawn upon admission into the medical intensive care unit (MICU). We aimed to investigate the relation between in-hospital mortality, different pathologies requiring admission to the MICU, serum Cl levels, and other biochemical tests in a tertiary center.
    Methods: The prospective study included data from 373 patients admitted to the ICU of a tertiary care center between 2017 and 2019. Data of patients under 18, pregnant patients or patients who were in the MICU for under 48 h were excluded. Comorbidity status, complete blood count, biochemistry tests, and blood gas analysis results of all patients included in the study were collected and recorded. Univariate and multivariate analyses were performed with the obtained data.
    Results: : Of the patients included in the study, 158 (42.4%) were discharged, and 215 (57.6%) died. In the receiver operator characteristics curve analysis performed to determine the discriminating power of Cl levels with a cut-off value of >98 mEq/L in relation to mortality, its sensitivity was found to be 84% and specificity 60%. According to Kaplan-Meier analysis results, mortality rate was higher (60% vs 46%) and survival time was lower (19.0 ± 1.46 vs. 23.0 ± 4.36 days; p = 0.035) in the patient group with high Cl levels compared to the patient group with normal or low Cl levels. In the Cox regression analysis, it was found that the survival time of the patients hospitalized in the MICU was associated with the variables of Cl, presence of cancer diagnosis and pCO2 (hazard ratio: 1.030 (1.008-1.049), 2.260(1.451-3.500), and 1.020 (1.003-1.029); p < 0.05, respectively).
    Discussion: Mortality in MICU patients were found to increase in association with higher Cl levels at admission, presence of cancer disease, and higher pCO2 levels. In addition, it should not be ignored that there may be an important relationship between renal failure and hyperchloremia in MICU patients.
    MeSH term(s) Humans ; Prospective Studies ; Critical Care ; Prognosis ; Intensive Care Units ; Water-Electrolyte Imbalance
    Language English
    Publishing date 2022-10-19
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.55730/1300-0144.5510
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    Zs.A 3242: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Association of trochlear dysplasia with knee meniscal-cartilage damage and anterior cruciate ligament mucoid degeneration.

    Atay, M / Yılmaz, T F / Sarı, L / Toprak, H

    Clinical radiology

    2022  

    Abstract: Aim: The purpose of this study was to evaluate meniscal and tibiofemoral cartilage injury in patients with trochlear dysplasia (TD) and investigate whether there were correlations between TD grade and meniscal and cartilage injury. In addition, the ... ...

    Abstract Aim: The purpose of this study was to evaluate meniscal and tibiofemoral cartilage injury in patients with trochlear dysplasia (TD) and investigate whether there were correlations between TD grade and meniscal and cartilage injury. In addition, the relationship between TD and mucoid degeneration of the anterior cruciate ligament (ACL-MD) was investigated. MATERİALS AND METHODS: Magnetic resonance imaging (MRI) examinations of 133 patients with TD were included in the study. TD was graded (types A, B, C, D). The tibial tuberosity (TT)-TG distance was also measured. The ACL was assessed for ACL-MD. Both menisci were evaluated for the degeneration and tears. Medial-lateral tibial plateau (MTP-LTP), medial-lateral femoral condyles (MFC-LFC), and trochlear cartilage were examined for focal cartilage defect (FCD).
    Results: ACL-MD was present in 42 of the patients with TD (31.6%). There was a significant positive relationship between ACL-MD and TT-TG distance. Meniscal tear was detected in 40 (30.1%) of all patients. FCD were detected in the tibiofemoral compartments in 41 (30.8%) of 133 patients. There was a significant positive relationship between the presence of FCD in the LFC and the type of TD (p<0.01). FCD was present in the LFC of all cases in the type D. A significant positive relationship was found between the TT-TG distance and the presence of FCD, especially in the anterior part of LFC (p<0.01). There was a significant relationship between the lateral trochlear cartilage defect and the type of dysplasia (p=0.037). CONCLUSİON: TD is a significant risk factor for ACL-MD, meniscal, and tibiofemoral cartilage injury.
    Language English
    Publishing date 2022-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2022.08.123
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    ab Jg. 2022: Lesesaal (EG)

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