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Article ; Online: Catalytic-dependent and -independent roles of TET3 in the regulation of specific genetic programs during neuroectoderm specification.

Ketchum, Harmony C / Suzuki, Masako / Dawlaty, Meelad M

Communications biology

2024 Volume 7, Issue 1, Page(s) 415

Abstract: The ten-eleven-translocation family of proteins (TET1/2/3) are epigenetic regulators of gene expression. They regulate genes by promoting DNA demethylation (i.e., catalytic activity) and by partnering with regulatory proteins (i.e., non-catalytic ... ...

Abstract	The ten-eleven-translocation family of proteins (TET1/2/3) are epigenetic regulators of gene expression. They regulate genes by promoting DNA demethylation (i.e., catalytic activity) and by partnering with regulatory proteins (i.e., non-catalytic functions). Unlike Tet1 and Tet2, Tet3 is not expressed in mouse embryonic stem cells (ESCs) but is induced upon ESC differentiation. However, the significance of its dual roles in lineage specification is less defined. By generating TET3 catalytic-mutant (Tet3
MeSH term(s)	Animals ; Mice ; Cell Differentiation/genetics ; Dioxygenases/genetics ; Dioxygenases/metabolism ; DNA Methylation ; DNA-Binding Proteins/metabolism ; Neural Plate/metabolism
Chemical Substances	Dioxygenases (EC 1.13.11.-) ; DNA-Binding Proteins ; Tet3 protein, mouse (EC 1.13.11.-)
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-06120-w
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Article ; Online: Social Problems during Pregnancy under the Coronavirus Disease 2019 Epidemic in Japan.

Suzuki, Shunji / Eto, Masako

JMA journal

2021 Volume 4, Issue 2, Page(s) 163–165

Language	English
Publishing date	2021-02-17
Publishing country	Japan
Document type	Journal Article
ZDB-ID	3053329-6
ISSN	2433-3298 ; 2433-328X
ISSN (online)	2433-3298
ISSN	2433-328X
DOI	10.31662/jmaj.2020-0109
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Article ; Online: Galectin-3 Plays a Role in Neuroinflammation in the Visual Pathway in Experimental Optic Neuritis.

Funaki, Masako / Nio-Kobayashi, Junko / Suzuki, Ryoji / Bando, Yoshio

Cells

2024 Volume 13, Issue 7

Abstract: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) featuring numerous neuropathologies, including optic neuritis (ON) in some patients. However, the molecular mechanisms of ON remain unknown. Galectins, β- ...

Abstract	Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) featuring numerous neuropathologies, including optic neuritis (ON) in some patients. However, the molecular mechanisms of ON remain unknown. Galectins, β-galactoside-binding lectins, are involved in various pathophysiological processes. We previously showed that galectin-3 (gal-3) is associated with the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of MS. In the current study, we investigated the expression of gal-3 in the visual pathway in EAE mice to clarify its role in the pathogenesis of ON. Immunohistochemical analysis revealed upregulation of gal-3 in the visual pathway of the EAE mice during the peak stage of the disease, compared with naïve and EAE mice during the chronic stage. Gal-3 was detected mainly in microglia/macrophages and astrocytes in the visual pathway in EAE mice. In addition, gal-3
MeSH term(s)	Animals ; Humans ; Mice ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Galectin 3/metabolism ; Galectins/metabolism ; Multiple Sclerosis/pathology ; Neuroinflammatory Diseases ; NLR Family, Pyrin Domain-Containing 3 Protein ; Optic Neuritis/pathology ; Visual Pathways/pathology
Chemical Substances	Galectin 3 ; Galectins ; NLR Family, Pyrin Domain-Containing 3 Protein
Language	English
Publishing date	2024-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13070612
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Article: Genetic Variations of Vitamin A-Absorption and Storage-Related Genes, and Their Potential Contribution to Vitamin A Deficiency Risks Among Different Ethnic Groups.

Suzuki, Masako / Tomita, Meika

Frontiers in nutrition

2022 Volume 9, Page(s) 861619

Abstract: Vitamin A, an essential fat-soluble micronutrient, plays a critical role in the body, by regulating vision, immune responses, and normal development, for instance. Vitamin A deficiency (VAD) is a major cause of xerophthalmia and increases the risk of ... ...

Abstract	Vitamin A, an essential fat-soluble micronutrient, plays a critical role in the body, by regulating vision, immune responses, and normal development, for instance. Vitamin A deficiency (VAD) is a major cause of xerophthalmia and increases the risk of death from infectious diseases. It is also emerging that prenatal exposure to VAD is associated with disease risks later in life. The overall prevalence of VAD has significantly declined over recent decades; however, the rate of VAD is still high in many low- and mid-income countries and even in high-income countries among specific ethnic/race groups. While VAD occurs when dietary intake is insufficient to meet demands, establishing a strong association between food insecurity and VAD, and vitamin A supplementation is the primary solution to treat VAD, genetic contributions have also been reported to effect serum vitamin A levels. In this review, we discuss genetic variations associated with vitamin A status and vitamin A bioactivity-associated genes, specifically those linked to uptake of the vitamin in the small intestine and its storage in the liver, as well as their potential contribution to vitamin A deficiency risks among different ethnic groups.
Language	English
Publishing date	2022-04-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.861619
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Article: [Validation Study on Developed Methods for Anions and Bromic Acid in Various Mineral Waters by Ion Chromatography].

Sakuragi, Hiroshi / Suzuki, Masako / Ohno, Hiroyuki

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan

2023 Volume 64, Issue 4, Page(s) 161–165

Abstract: Five kinds of anions namely fluoride, chlorate, chlorite, nitrate and nitrite ions, and bromic acid were determined in various mineral waters (MWs), and the methods were validated. MWs are varying in the degree of hardness and contents of carbonate. When ...

Abstract	Five kinds of anions namely fluoride, chlorate, chlorite, nitrate and nitrite ions, and bromic acid were determined in various mineral waters (MWs), and the methods were validated. MWs are varying in the degree of hardness and contents of carbonate. When the five anions were measured based on the official method of tap water, the peak shape of fluoride ion in MWs with high degree of hardness was different from the standard solution, making it difficult to determine. The same phenomenon was also observed when bromic acid was measured. In order to achieve accurate determination, five-fold dilution with ultrapure water was carried out on the samples. With the additional step, the abnormal peak of both analytes was improved, and no difference in the retention times between standard and sample solutions was observed. The validation tests were performed using the developed methods with the additional diluting step, and the results of all target substances met the criteria of the guideline on analytical method validation for MW in Japan. Our results suggested that the methods we developed could be useful for the accurate determination of the anions and bromic acid in various MWs on the market.
MeSH term(s)	Mineral Waters ; Fluorides ; Anions ; Chromatography
Chemical Substances	Mineral Waters ; bromic acid (908X3OZ87J) ; Fluorides (Q80VPU408O) ; Anions
Language	Japanese
Publishing date	2023-08-10
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604314-8
ISSN	1882-1006 ; 0015-6426
ISSN (online)	1882-1006
ISSN	0015-6426
DOI	10.3358/shokueishi.64.161
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Article ; Online: A preliminary study on the development of care staff's Final-Stage Decision-Making Support Scale for older adults with dementia.

Suzuki, Mizue / Asai, Yatami / Sato, Masako / Kanamori, Takuya / Inagaki, Keigo / Kanamori, Masao

Geriatrics & gerontology international

2024 Volume 24 Suppl 1, Page(s) 130–134

Abstract: Aim: This preliminary study aimed to develop a care staff Final Life-Stage Decision-Making Support Scale (FS-DM) for older adults with dementia (OwDs) in geriatric facilities.: Methods: The FS-DM items were developed from focus group interviews with ... ...

Abstract	Aim: This preliminary study aimed to develop a care staff Final Life-Stage Decision-Making Support Scale (FS-DM) for older adults with dementia (OwDs) in geriatric facilities. Methods: The FS-DM items were developed from focus group interviews with care staff and reviewed through discussions with several experts in dementia care. A questionnaire survey was conducted among care staff in geriatric facilities from February to March 2021. Results: In total, 138 carers (110 [79.7%] women and 28 [20.3%] men, mean age: 41.5 ± 2.3 years) participated. Among them, 91 (65.9%) were professional caregivers, and 36 (26.1%) were nurses. The FS-DM was developed using a factor analysis, which resulted in 11 items grouped into three factors', as it is the three factors: (1) support for the realization of the wills of OwDs in their final life-stages through collaboration with families and multiple professionals; (2) consideration of communication regarding the formation and expression of the wills of OwDs in their final life-stages; and (3) support for eliciting the wills of OwDs during their final life-stages according to their decision-making ability and values. The factor loadings ranged from 0.385 to 0.827, and the accumulated contribution ratio was 61.03%. The reliability analysis yielded a Cronbach's α of 0.740-0.855. The first and second factors of the FS-DM were significantly correlated with the Approaches to Dementia Questionnaire item "Nurses' attitudes towards support for decision-making." Conclusion: Our results suggest that the FS-DM could provide supportive care for OwDs to formulate, express, and realize their will, and that it has a degree of reliability and validity. Geriatr Gerontol Int 2024; 24: 130-134.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Dementia/diagnosis ; Dementia/therapy ; Reproducibility of Results ; Caregivers ; Communication ; Surveys and Questionnaires
Language	English
Publishing date	2024-01-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14776
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Article: Non-fentanyl-derived synthetic opioids emerging during recent years.

Hasegawa, Koutaro / Minakata, Kayoko / Suzuki, Masako / Suzuki, Osamu

Forensic toxicology

2022 Volume 40, Issue 2, Page(s) 234–243

Abstract: Purpose: Since the appearance of fentanyl followed by its many kinds of analogues around 1988, North America has been exposed to fierce synthetic opioid pandemic resulting in more than 130,000 deaths due to their overdoses until May 2019, when China ... ...

Abstract	Purpose: Since the appearance of fentanyl followed by its many kinds of analogues around 1988, North America has been exposed to fierce synthetic opioid pandemic resulting in more than 130,000 deaths due to their overdoses until May 2019, when China declared to prohibit the licit fentanyl analog production. However, the Chinese announcement did not go into force in USA due to the adroit strategies of tough traffickers. Thus, contrary to the expectation, the number of synthetic opioid products and their poisoning cases in USA has increased by about 30%; especially, various benzimidazole synthetic opioids have revived on the illicit drug market during a recent few years. In this article, the recent abrupt changes in the situations of illicit synthetic opioid market and their current abuses are described. Methods: Various databases, such as SciFinder, Google, and Google Scholar, were utilized to collect relevant reports referring old but newly appearing synthetic opioids. Results: At the present time, there are several families of new synthetic opioids, which are not fentanyl derivatives; MT-45 and its analogs, benzamide and 2-phenylacetamide opioids (U-series opioids), and benzimidazole opioids. Most of the above substances had been developed in 1950s to 1970s, but had never been used as analgesic medicines, because of their severe adverse effects, such as respiratory depression, physical dependence, and resulting deaths. However, there is possibility that these drugs will become main illicit synthetic opioids in place of the fentanyl analogs during coming several years from this time. Conclusions: All of the above non-fentanyl-derived families had been developed 50-70 years ago to establish them as analgesic medicines, but had been unsuccessful. These drugs largely appeared in the illicit drug markets in North America, Europe, and Australia, during recent years. Pharmacological, toxicological, and metabolic studies are insufficient for benzamide and 2-phenylacetamide opioids, and are very scant especially for benzimidazole opioids. This time we should start studying pharmacotoxicology of the newly emerging synthetic opioids to alert forensic toxicologists in the world and to suppress their rapid and wide spread in the world. Supplementary information: The online version contains supplementary material available at 10.1007/s11419-022-00624-y.
Language	English
Publishing date	2022-04-29
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2274095-8
ISSN	1860-8965
ISSN	1860-8965
DOI	10.1007/s11419-022-00624-y
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Article ; Online: Thromboelastography with platelet mapping to guide anesthetic management of emergency cesarean delivery in a patient with thrombasthenia: a case report.

Akinaga, Chieko / Kawashima, Shingo / Suzuki, Yuji / Matsumoto, Masako / Nakajima, Yoshiki

JA clinical reports

2023 Volume 9, Issue 1, Page(s) 30

Abstract: Background: Perinatal management of congenital platelet dysfunction represents a challenge. One of the major concerns is whether neuraxial anesthesia can be applicable for cesarean delivery. We present a patient with thrombasthenia who underwent ... ...

Abstract	Background: Perinatal management of congenital platelet dysfunction represents a challenge. One of the major concerns is whether neuraxial anesthesia can be applicable for cesarean delivery. We present a patient with thrombasthenia who underwent emergency cesarean delivery. Case presentation: A 34-year-old primipara was diagnosed with autosomal dominant thrombasthenia, which was not classified as any known type. A thorough examination revealed that adenosine diphosphate aggregation and collagen aggregation were suppressed. Platelet mapping of viscoelastic testing was used to observe the trajectory of platelet function during pregnancy, which was found to be normal to hypercoagulable until 38 weeks of gestation. On the basis of the results of testing and physiological status, we commenced spinal anesthesia and avoided prophylactic platelet transfusion. Conclusion: The platelet mapping of viscoelastic testing was rapid and simple, allowing repeated examinations. We could choose the appropriate anesthesia method and determine the necessity of blood transfusion for a pregnant patient with thrombasthenia.
Language	English
Publishing date	2023-05-25
Publishing country	Germany
Document type	Journal Article
ISSN	2363-9024
ISSN (online)	2363-9024
DOI	10.1186/s40981-023-00623-x
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Article ; Online: Age-related variation in coagulation factors in non-valvular atrial fibrillation patients receiving direct oral anticoagulants.

Kumano, Osamu / Suzuki, Shinya / Yamazaki, Masako / An, Yoshimori / Yasaka, Masahiro / Ieko, Masahiro

International journal of hematology

2024 Volume 119, Issue 4, Page(s) 407–415

Abstract: Age is a significant risk factor for ischemic stroke. However, the influence of aging on coagulation parameters in non-valvular atrial fibrillation (NVAF) patients treated with direct oral anticoagulants (DOACs) remains unclear. A total of 775 samples ... ...

Abstract	Age is a significant risk factor for ischemic stroke. However, the influence of aging on coagulation parameters in non-valvular atrial fibrillation (NVAF) patients treated with direct oral anticoagulants (DOACs) remains unclear. A total of 775 samples were collected from 224 NVAF patients receiving apixaban, edoxaban or rivaroxaban. The samples were categorized into three age groups: (i) ≤ 64 years, (ii) 65-74 years, and (iii) ≥ 75 years (apixaban: N = 48, 108, 119; edoxaban: N = 63, 68, 126; rivaroxaban: N = 115, 90, 38, respectively). Coagulation parameters including fibrinogen (Fbg), factor II, factor V, factor VII, factor X, and D-dimer, were compared between the three age groups for each drug. The slopes in the correlation between drug concentrations and modified diluted prothrombin time (mdPT) were also assessed. Fbg and factor V increased with age, while factor II and factor X decreased. Factor VII and D-dimer showed no significant differences across age categories. The slope in response to drug concentrations was similar between the age groups. In NVAF patients treated with apixaban, edoxaban and rivaroxaban, some coagulation parameters exhibited age-related variation. However, the response of mdPT to drug concentration was consistent across age categories.
MeSH term(s)	Humans ; Middle Aged ; Rivaroxaban/adverse effects ; Warfarin ; Anticoagulants ; Hemorrhage/drug therapy ; Stroke/etiology ; Stroke/prevention & control ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/chemically induced ; Dabigatran/adverse effects ; Factor X/therapeutic use ; Factor VII/therapeutic use ; Prothrombin ; Factor V ; Pyridones/therapeutic use ; Administration, Oral ; Pyridines ; Thiazoles
Chemical Substances	edoxaban (NDU3J18APO) ; Rivaroxaban (9NDF7JZ4M3) ; Warfarin (5Q7ZVV76EI) ; Anticoagulants ; Dabigatran (I0VM4M70GC) ; Factor X (9001-29-0) ; Factor VII (9001-25-6) ; Prothrombin (9001-26-7) ; Factor V (9001-24-5) ; Pyridones ; Pyridines ; Thiazoles
Language	English
Publishing date	2024-02-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-024-03712-4
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Article ; Online: Correction: Atypical histological abnormalities in an adult patient with nephronophthisis harboring NPHP1 deletion: a case report.

Akira, Maiko / Suzuki, Hitoshi / Ikeda, Arisa / Iwasaki, Masako / Honda, Daisuke / Takahara, Hisatsugu / Rinno, Hisaki / Tomita, Shigeki / Suzuki, Yusuke

BMC nephrology

2023 Volume 24, Issue 1, Page(s) 327

Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Published Erratum
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-023-03352-6
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